The Conformation of the Epidermal Growth Factor Receptor Transmembrane Domain Dimer Dynamically Adapts to the Local Membrane Environment

Biochemistry

Volumn 56, Issue 12, 2017, Pages 1697-1705

  Bocharov, Eduard V ^a   Bragin, Pavel E ^a   Pavlov, Konstantin V ^a   Bocharova, Olga V ^a   Mineev, Konstantin S ^a   Polyansky, Anton A ^a,b   Volynsky, Pavel E ^a   Efremov, Roman G ^a,c   Arseniev, Alexander S ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^b UNIVERSITY OF VIENNA   (Austria)

^c NATIONAL RESEARCH UNIVERSITY HIGHER SCHOOL OF ECONOMICS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; BACTERIOPHAGES; DIMERS; MOLECULAR DYNAMICS; PROTEINS; SIGNAL TRANSDUCTION;

EPIDERMAL GROWTH FACTOR RECEPTORS; MOLECULAR DYNAMICS SIMULATIONS; MULTICELLULAR ORGANISMS; NUCLEAR MAGNETIC RESONANCE(NMR); PROTEIN-LIPID INTERACTIONS; RECEPTOR TYROSINE KINASE; SIGNAL TRANSDUCTION MECHANISM; TRANS-MEMBRANE DOMAINS;

NUCLEAR MAGNETIC RESONANCE;

DIMER; EPIDERMAL GROWTH FACTOR RECEPTOR; 1,2-DIHEXADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE; DIMYRISTOYLPHOSPHATIDYLCHOLINE; EGFR PROTEIN, HUMAN; ETHER PHOSPHOLIPID; LIPID BILAYER; MICELLE; PEPTIDE; RECOMBINANT PROTEIN;

ARTICLE; CONFORMATIONAL TRANSITION; DIMERIZATION; LIPID BILAYER; MICELLE; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; AMINO ACID SEQUENCE; CELL MEMBRANE; CHEMICAL PHENOMENA; CHEMISTRY; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; MOLECULAR CLONING; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; CELL MEMBRANE; CLONING, MOLECULAR; DIMYRISTOYLPHOSPHATIDYLCHOLINE; ESCHERICHIA COLI; GENE EXPRESSION; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPID BILAYERS; MICELLES; MOLECULAR DYNAMICS SIMULATION; PEPTIDES; PHOSPHOLIPID ETHERS; PROTEIN DOMAINS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 85016434659     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.6b01085     Document Type: Article

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