Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition

Cancer Research

Volumn 73, Issue 1, 2013, Pages 108-118

  Daly, Christopher ^a   Eichten, Alexandra ^a   Castanaro, Carla ^a   Pasnikowski, Elizabeth ^a   Adler, Alexander ^a   Lalani, Alshad S ^a   Papadopoulos, Nicholas ^a   Kyle, Alastair H ^b   Minchinton, Andrew I ^b   Yancopoulos, George D ^a   Thurston, Gavin ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

^b BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; NESVACUMAB; RECOMBINANT GROWTH FACTOR; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROTECTION; COLORECTAL TUMOR; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EPIDERMOID TUMOR; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE TUMOR; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; TUMOR VASCULARIZATION; TUMOR XENOGRAFT;

ANGIOPOIETIN-2; ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; RECEPTOR, TIE-2; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84871989305     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-2064     Document Type: Article

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