Increased vascularization in mice overexpressing angiopoietin-1

Science

Volumn 282, Issue 5388, 1998, Pages 468-471

  Suri, Chitra ^a   McClain, Joyce ^a   Thurston, Gavin ^b   McDonald, Donald M ^b   Zhou, Hao ^a   Oldmixon, Eben H ^c   Sato, Thomas N ^d   Yancopoulos, George D ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Rogers Imaging Corporation   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; ANGIOPOIETIN 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONTROLLED STUDY; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SKIN; TRANSGENIC MOUSE; VASCULARIZATION;

ANGIOPOIETIN-1; ANIMALS; CAPILLARIES; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; KERATINOCYTES; LYMPHOKINES; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; NEOVASCULARIZATION, PHYSIOLOGIC; SKIN; TRANSGENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VENULES;

ANIMALIA; MUS MUSCULUS;

EID: 0032538385     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.282.5388.468     Document Type: Review

References (30)

1. W. Risau, Nature 386, 631 (1997).
2. T. Mustonen and K. Alitalo, J. Cell Biol. 129, 895 (1995).
3. S. Davis et al., Cell 87, 1161 (1996).
4. F. Shalaby et al., Nature 376, 62 (1995).
5. P. Carmeliet et al., ibid. 380, 435 (1996).
6. N. Ferrara et al., ibid., p. 439.
7. D. J. Dumont et al., Genes Dev. 8, 1897 (1994).
8. T. N. Sato et al., Nature 376, 70 (1995).
9. C. Suri et al., Cell 87, 1171 (1996).
10. P. C. Maisonpierre et al., Science 277, 55 (1997).
11. T. I. Koblizek, C. Weiss, G. D. Yancopoulos, U. Deutsch, W. Risau, Curr. Biol. 8, 529 (1998).
12. R. Vassar, M. Rosenberg, S. Ross, A. Tyner, E. Fuchs, Proc. Natl. Acad. Sci. U.S.A. 86, 1563 (1989).
13. L. E. Benjamin, I. Hemo, E. Keshet, Development 125, 1591 (1998).
14. N. Okamoto et al., Am. J. Pathol. 151, 281 (1997).
15. X. Zeng, S. E. Wert, R. Fereici, K. G. Peters, J. A. Whitsett, Dev. Dyn. 211, 215 (1998).
16. M. Jeltsch et al., Science 276, 1423 (1997).
17. M. L. Robinson et al., Development 121, 505 (1995).
18. C. J. Drake and C. D. Little, Proc. Natl. Acad. Sci. U.S.A. 92, 7657 (1995).
19. M. Detmar et al., J. Invest. Dermatol. 111, 1 (1998).
20. J. M. Rosenstein, N. Mani, W. F. Silverman, J. M. Krum, Proc. Natl. Acad. Sci. U.S.A. 95, 7086 (1998).
21. G. S. Robinson and L. P. Aiello, Int. Ophthalmol. Clin. 38, 89 (1998).
22. J. Viac, S. Palacio, D. Schmitt, A. Claudy, Arch. Dermatol. Res. 289, 158 (1997).
23. J. A. Nagy et al., Cancer Res. 55, 360 (1995).
24. G. Thurston, P. Baluk, A. Hirata, D. McDonald, Am. J. Physiol. 271, H2547 (1996).
25. G. Thurston et al., J. Clin. Invest. 101, 1401 (1998).
26. E. Oldmixon, H. Brismar, J. Lai, B. Ekstein, R. A. Rogers, FASEB J. 8, A691 (1994).
27. K. Takahashi et al., J. Clin. Invest. 93, 2357 (1994).
28. E. Weibel, Practical Methods for Biological Morphometry, vol. 1 of Stereological Methods (Academic Press, New York, 1979), p. 143.
29. E. Oldmixon, J. P. Butler, F. G. Hoppin, J. Appl. Physiol. 67, 1930 (1989).
30. We thank L. S. Schleifer and P. Roy Vagelos for support; M. Detmar, S. Davis, P. Maisonpierre, and P. Jones for discussions; R. Rogers for confocal microscopy; B. Fowle for electron microscopy; M. Simmons and T. Murphy for technical assistance; C. Murphy and E. Burrows for graphics; and E. Fuchs for the K14 promoter/enhancer construct. D.M.M. and G.T. were supported in part by NIH grants HL-59157 and HL-24136.