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Volumn 529, Issue 7585, 2016, Pages 216-220

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(18)  Wilhelm, Kerstin a   Happel, Katharina a   Eelen, Guy b,c   Schoors, Sandra b,c   Oellerich, Mark F a   Lim, Radiance a   Zimmermann, Barbara a   Aspalter, Irene M d   Franco, Claudio A e   Boettger, Thomas a   Braun, Thomas a   Fruttiger, Marcus f   Rajewsky, Klaus g   Keller, Charles h   Brüning, Jens C i   Gerhardt, Holger b,d,g,j,k   Carmeliet, Peter b,c   Potente, Michael a,j,l  


Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; GREEN FLUORESCENT PROTEIN; HISTONE H3; OXYGEN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTOME; VASCULAR ENDOTHELIAL CADHERIN; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; FOXO1 PROTEIN, MOUSE; MYC PROTEIN;

EID: 84955112522     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature16498     Document Type: Article
Times cited : (418)

References (42)
  • 1
    • 84904173553 scopus 로고    scopus 로고
    • Metabolism of stromal and immune cells in health and disease
    • Ghesquire, B., Wong, B. W., Kuchnio, A. & Carmeliet, P. Metabolism of stromal and immune cells in health and disease. Nature 511, 167-176 (2014)
    • (2014) Nature , vol.511 , pp. 167-176
    • Ghesquire, B.1    Wong, B.W.2    Kuchnio, A.3    Carmeliet, P.4
  • 2
    • 34249689753 scopus 로고    scopus 로고
    • Molecular regulation of angiogenesis and lymphangiogenesis
    • Adams, R. H. & Alitalo, K. Molecular regulation of angiogenesis and lymphangiogenesis. Nature Rev. Mol. Cell Biol. 8, 464-478 (2007)
    • (2007) Nature Rev. Mol. Cell Biol. , vol.8 , pp. 464-478
    • Adams, R.H.1    Alitalo, K.2
  • 3
    • 80052933197 scopus 로고    scopus 로고
    • Basic and therapeutic aspects of angiogenesis
    • Potente, M., Gerhardt, H. & Carmeliet, P. Basic and therapeutic aspects of angiogenesis. Cell 146, 873-887 (2011)
    • (2011) Cell , vol.146 , pp. 873-887
    • Potente, M.1    Gerhardt, H.2    Carmeliet, P.3
  • 4
    • 84887456534 scopus 로고    scopus 로고
    • Role of endothelial cell metabolism in vessel sprouting
    • De Bock, K., Georgiadou, M. & Carmeliet, P. Role of endothelial cell metabolism in vessel sprouting. Cell Metab. 18, 634-647 (2013)
    • (2013) Cell Metab. , vol.18 , pp. 634-647
    • De Bock, K.1    Georgiadou, M.2    Carmeliet, P.3
  • 5
    • 84881056831 scopus 로고    scopus 로고
    • MYC metabolism, cell growth, and tumorigenesis
    • Dang, C. V. MYC, metabolism, cell growth, and tumorigenesis. Cold Spring Harb. Perspect. Med. 3, a014217 (2013)
    • (2013) Cold Spring Harb. Perspect. Med. , vol.3 , pp. a014217
    • Dang, C.V.1
  • 6
    • 23144464363 scopus 로고    scopus 로고
    • Transcriptional regulation and transformation by Myc proteins
    • Adhikary, S. & Eilers, M. Transcriptional regulation and transformation by Myc proteins. Nature Rev. Mol. Cell Biol. 6, 635-645 (2005)
    • (2005) Nature Rev. Mol. Cell Biol. , vol.6 , pp. 635-645
    • Adhikary, S.1    Eilers, M.2
  • 7
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033 (2009)
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 8
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate
    • Ward, P. S. & Thompson, C. B. Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell 21, 297-308 (2012)
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 9
    • 41549135942 scopus 로고    scopus 로고
    • FoxO transcription factors in the maintenance of cellular homeostasis during aging
    • Salih, D. A. & Brunet, A. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr. Opin. Cell Biol. 20, 126-136 (2008)
    • (2008) Curr. Opin. Cell Biol. , vol.20 , pp. 126-136
    • Salih, D.A.1    Brunet, A.2
  • 10
    • 84872899284 scopus 로고    scopus 로고
    • FOXOs: Signalling integrators for homeostasis maintenance
    • Eijkelenboom, A. & Burgering, B. M. FOXOs: signalling integrators for homeostasis maintenance. Nature Rev. Mol. Cell Biol. 14, 83-97 (2013)
    • (2013) Nature Rev. Mol. Cell Biol. , vol.14 , pp. 83-97
    • Eijkelenboom, A.1    Burgering, B.M.2
  • 11
    • 2442608732 scopus 로고    scopus 로고
    • Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)
    • Daly, C. et al. Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1). Genes Dev. 18, 1060-1071 (2004)
    • (2004) Genes Dev. , vol.18 , pp. 1060-1071
    • Daly, C.1
  • 12
    • 24644519938 scopus 로고    scopus 로고
    • Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization
    • Potente, M. et al. Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J. Clin. Invest. 115, 2382-2392 (2005)
    • (2005) J. Clin. Invest. , vol.115 , pp. 2382-2392
    • Potente, M.1
  • 13
    • 33846295218 scopus 로고    scopus 로고
    • FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
    • Paik, J. H. et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128, 309-323 (2007)
    • (2007) Cell , vol.128 , pp. 309-323
    • Paik, J.H.1
  • 14
    • 48649101326 scopus 로고    scopus 로고
    • Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    • Taddei, A. et al. Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5. Nature Cell Biol. 10, 923-934 (2008)
    • (2008) Nature Cell Biol. , vol.10 , pp. 923-934
    • Taddei, A.1
  • 15
    • 84858066279 scopus 로고    scopus 로고
    • FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis
    • Tsuchiya, K. et al. FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab. 15, 372-381 (2012)
    • (2012) Cell Metab. , vol.15 , pp. 372-381
    • Tsuchiya, K.1
  • 16
    • 7544243041 scopus 로고    scopus 로고
    • Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: Cooperativity of Ink4a/ARF and Trp53 loss of function
    • Keller, C. et al. Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 18, 2614-2626 (2004)
    • (2004) Genes Dev. , vol.18 , pp. 2614-2626
    • Keller, C.1
  • 17
    • 84858228682 scopus 로고    scopus 로고
    • FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development
    • Sengupta, A., Chakraborty, S., Paik, J., Yutzey, K. E. & Evans-Anderson, H. J. FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development. Dev. Dyn. 241, 803-813 (2012)
    • (2012) Dev. Dyn. , vol.241 , pp. 803-813
    • Sengupta, A.1    Chakraborty, S.2    Paik, J.3    Yutzey, K.E.4    Evans-Anderson, H.J.5
  • 18
    • 84872603163 scopus 로고    scopus 로고
    • Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimers disease
    • Stöhr, O. et al. Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimers disease. Age (Dordr) 35, 83-101 (2013)
    • (2013) Age (Dordr) , vol.35 , pp. 83-101
    • Stöhr, O.1
  • 19
    • 34347357584 scopus 로고    scopus 로고
    • Induction of Mxi1-SRα by FOXO3a contributes to repression of Myc-dependent gene expression
    • Delpuech, O. et al. Induction of Mxi1-SRα by FOXO3a contributes to repression of Myc-dependent gene expression. Mol. Cell. Biol. 27, 4917-4930 (2007)
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 4917-4930
    • Delpuech, O.1
  • 20
    • 78249255491 scopus 로고    scopus 로고
    • FoxOs enforce a progression checkpoint to constrain mTORC1- activated renal tumorigenesis
    • Gan, B. et al. FoxOs enforce a progression checkpoint to constrain mTORC1- activated renal tumorigenesis. Cancer Cell 18, 472-484 (2010)
    • (2010) Cancer Cell , vol.18 , pp. 472-484
    • Gan, B.1
  • 21
    • 81255195809 scopus 로고    scopus 로고
    • FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function
    • Jensen, K. S. et al. FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function. EMBO J. 30, 4554-4570 (2011)
    • (2011) EMBO J. , vol.30 , pp. 4554-4570
    • Jensen, K.S.1
  • 22
    • 79951472912 scopus 로고    scopus 로고
    • The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis
    • Kress, T. R. et al. The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis. Mol. Cell 41, 445-457 (2011)
    • (2011) Mol. Cell , vol.41 , pp. 445-457
    • Kress, T.R.1
  • 23
    • 84860709659 scopus 로고    scopus 로고
    • FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression
    • Ferber, E. C. et al. FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death Differ. 19, 968-979 (2012)
    • (2012) Cell Death Differ. , vol.19 , pp. 968-979
    • Ferber, E.C.1
  • 24
    • 0035129209 scopus 로고    scopus 로고
    • Analysis of C-MYC function in normal cells via conditional gene-targeted mutation
    • de Alboran, I. M. et al. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity 14, 45-55 (2001)
    • (2001) Immunity , vol.14 , pp. 45-55
    • De Alboran, I.M.1
  • 25
    • 84865114403 scopus 로고    scopus 로고
    • Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis
    • Sander, S. et al. Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell 22, 167-179 (2012)
    • (2012) Cancer Cell , vol.22 , pp. 167-179
    • Sander, S.1
  • 26
    • 0037136563 scopus 로고    scopus 로고
    • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
    • Kops, G. J. et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419, 316-321 (2002)
    • (2002) Nature , vol.419 , pp. 316-321
    • Kops, G.J.1
  • 27
    • 0037192473 scopus 로고    scopus 로고
    • Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    • Nemoto, S. & Finkel, T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 295, 2450-2452 (2002)
    • (2002) Science , vol.295 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 28
    • 33846419112 scopus 로고    scopus 로고
    • FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    • Tothova, Z. et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128, 325-339 (2007)
    • (2007) Cell , vol.128 , pp. 325-339
    • Tothova, Z.1
  • 29
    • 34249882777 scopus 로고    scopus 로고
    • Foxo3a is essential for maintenance of the hematopoietic stem cell pool
    • Miyamoto, K. et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 1, 101-112 (2007)
    • (2007) Cell Stem Cell , vol.1 , pp. 101-112
    • Miyamoto, K.1
  • 30
    • 84885172074 scopus 로고    scopus 로고
    • FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells
    • Yeo, H. et al. FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells. EMBO J. 32, 2589-2602 (2013)
    • (2013) EMBO J. , vol.32 , pp. 2589-2602
    • Yeo, H.1
  • 31
    • 0035911253 scopus 로고    scopus 로고
    • Conditional vascular cell adhesion molecule 1 deletion in mice: Impaired lymphocyte migration to bone marrow
    • Koni, P. A. et al. Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J. Exp. Med. 193, 741-754 (2001)
    • (2001) J. Exp. Med. , vol.193 , pp. 741-754
    • Koni, P.A.1
  • 32
    • 39549098360 scopus 로고    scopus 로고
    • Efficient, inducible Cre-recombinase activation in vascular endothelium
    • Claxton, S. et al. Efficient, inducible Cre-recombinase activation in vascular endothelium. Genesis 46, 74-80 (2008)
    • (2008) Genesis , vol.46 , pp. 74-80
    • Claxton, S.1
  • 33
    • 35548932872 scopus 로고    scopus 로고
    • A global doublefluorescent Cre reporter mouse
    • Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L. & Luo, L. A global doublefluorescent Cre reporter mouse. Genesis 45, 593-605 (2007)
    • (2007) Genesis , vol.45 , pp. 593-605
    • Muzumdar, M.D.1    Tasic, B.2    Miyamichi, K.3    Li, L.4    Luo, L.5
  • 34
    • 84873352792 scopus 로고    scopus 로고
    • The embryonic mouse hindbrain as a qualitative and quantitative model for studying the molecular and cellular mechanisms of angiogenesis
    • Fantin, A., Vieira, J. M., Plein, A., Maden, C. H. & Ruhrberg, C. The embryonic mouse hindbrain as a qualitative and quantitative model for studying the molecular and cellular mechanisms of angiogenesis. Nature Protocols 8, 418-429 (2013)
    • (2013) Nature Protocols , vol.8 , pp. 418-429
    • Fantin, A.1    Vieira, J.M.2    Plein, A.3    Maden, C.H.4    Ruhrberg, C.5
  • 35
    • 77955860340 scopus 로고    scopus 로고
    • Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice
    • Pitulescu, M. E., Schmidt, I., Benedito, R. & Adams, R. H. Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice. Nature Protocols 5, 1518-1534 (2010)
    • (2010) Nature Protocols , vol.5 , pp. 1518-1534
    • Pitulescu, M.E.1    Schmidt, I.2    Benedito, R.3    Adams, R.H.4
  • 36
    • 79955926985 scopus 로고    scopus 로고
    • Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
    • Guarani, V. et al. Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature 473, 234-238 (2011)
    • (2011) Nature , vol.473 , pp. 234-238
    • Guarani, V.1
  • 37
    • 0036651790 scopus 로고    scopus 로고
    • A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR
    • Ramaswamy, S., Nakamura, N., Sansal, I., Bergeron, L. & Sellers, W. R. A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2, 81-91 (2002)
    • (2002) Cancer Cell , vol.2 , pp. 81-91
    • Ramaswamy, S.1    Nakamura, N.2    Sansal, I.3    Bergeron, L.4    Sellers, W.R.5
  • 38
    • 12944281162 scopus 로고    scopus 로고
    • Identification of CDK4 as a target of c-MYC
    • Hermeking, H. et al. Identification of CDK4 as a target of c-MYC. Proc. Natl Acad. Sci. USA 97, 2229-2234 (2000)
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 2229-2234
    • Hermeking, H.1
  • 39
    • 0842278571 scopus 로고    scopus 로고
    • An integrated database of genes responsive to the Myc oncogenic transcription factor: Identification of direct genomic targets
    • Zeller, K. I., Jegga, A. G., Aronow, B. J., ODonnell, K. A. & Dang, C. V. An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol. 4, R69 (2003)
    • (2003) Genome Biol. , vol.4 , pp. R69
    • Zeller, K.I.1    Jegga, A.G.2    Aronow, B.J.3    ODonnell, K.A.4    Dang, C.V.5
  • 40
    • 0037197962 scopus 로고    scopus 로고
    • Characterization of the c-MYC-regulated transcriptome by
    • SAGE: identification and analysis of c-MYC target genes
    • Menssen, A. & Hermeking, H. Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes. Proc. Natl Acad. Sci. USA 99, 6274-6279 (2002)
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 6274-6279
    • Menssen, A.1    Hermeking, H.2
  • 41
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath, I. et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nature Genet. 40, 499-507 (2008)
    • (2008) Nature Genet. , vol.40 , pp. 499-507
    • Ben-Porath, I.1
  • 42
    • 31144459985 scopus 로고    scopus 로고
    • Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    • Bild, A. H. et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439, 353-357 (2006)
    • (2006) Nature , vol.439 , pp. 353-357
    • Bild, A.H.1


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