메뉴 건너뛰기




Volumn 37, Issue , 2017, Pages 51-76

β-Hydroxybutyrate: A Signaling Metabolite

Author keywords

Aging; Epigenetics; Fasting; Ketone bodies; Metabolism

Indexed keywords

3 HYDROXYBUTYRIC ACID;

EID: 85028000671     PISSN: 01999885     EISSN: 15454312     Source Type: Book Series    
DOI: 10.1146/annurev-nutr-071816-064916     Document Type: Review
Times cited : (492)

References (163)
  • 2
    • 84988923392 scopus 로고    scopus 로고
    • Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists
    • Ang ZW, Er JZ, Tan NS, Lu JH, Liou YC, et al. 2016. Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists. Sci. Rep. 6:34145
    • (2016) Sci. Rep. , Issue.6 , pp. 34145
    • Ang, Z.W.1    Er, J.Z.2    Tan, N.S.3    Lu, J.H.4    Liou, Y.C.5
  • 4
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPAR? and is a key mediator of hepatic lipid metabolism in ketotic states
    • Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. 2007. Hepatic fibroblast growth factor 21 is regulated by PPAR? and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 5:426-37
    • (2007) Cell Metab. , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 5
  • 6
    • 84957694352 scopus 로고    scopus 로고
    • How to define the latent reservoir: Tools of the trade
    • Barton KM, Palmer SE. 2016. How to define the latent reservoir: Tools of the trade. Curr. HIV/AIDS Rep. 13:77-84
    • (2016) Curr. HIV/AIDS Rep. , vol.13 , pp. 77-84
    • Barton, K.M.1    Palmer, S.E.2
  • 8
  • 9
    • 84864541097 scopus 로고    scopus 로고
    • G protein-coupled receptors for energy metabolites as new therapeutic targets
    • Blad CC, Tang C, Offermanns S. 2012. G protein-coupled receptors for energy metabolites as new therapeutic targets. Nat. Rev. Drug Discov. 11:603-19
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 603-619
    • Blad, C.C.1    Tang, C.2    Offermanns, S.3
  • 10
    • 79952451443 scopus 로고    scopus 로고
    • Obesity, insulin resistance and free fatty acids
    • Boden G. 2011. Obesity, insulin resistance and free fatty acids. Curr. Opin. Endocrinol. Diabetes Obes. 18:139-43
    • (2011) Curr. Opin. Endocrinol. Diabetes Obes. , vol.18 , pp. 139-143
    • Boden, G.1
  • 11
    • 0038363378 scopus 로고    scopus 로고
    • The orphan G proteincoupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    • Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, et al. 2003. The orphan G proteincoupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J. Biol. Chem. 278:11312-19
    • (2003) J. Biol. Chem. , vol.278 , pp. 11312-11319
    • Brown, A.J.1    Goldsworthy, S.M.2    Barnes, A.A.3    Eilert, M.M.4    Tcheang, L.5
  • 12
    • 33750110683 scopus 로고    scopus 로고
    • Fuel metabolism in starvation
    • Cahill GF Jr. 2006. Fuel metabolism in starvation. Annu. Rev. Nutr. 26:1-22
    • (2006) Annu. Rev. Nutr. , vol.26 , pp. 1-22
    • Cahill, G.F.1
  • 14
    • 84938602184 scopus 로고    scopus 로고
    • Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice
    • Chen YF, Du JF, Zhao YT, Zhang L, Lv GR, et al. 2015. Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice. Cardiovasc. Diabetol. 14:99
    • (2015) Cardiovasc. Diabetol. , vol.14 , pp. 99
    • Chen, Y.F.1    Du, J.F.2    Zhao, Y.T.3    Zhang, L.4    Lv, G.R.5
  • 15
    • 85012150662 scopus 로고    scopus 로고
    • Questions and controversies in innate immune research:What is the physiological role of NLRP3?
    • Coll RC, O'Neill LAJ, Schroder K. 2016. Questions and controversies in innate immune research:What is the physiological role of NLRP3? Cell Death Discov. 2:16019
    • (2016) Cell Death Discov. , vol.2 , pp. 16019
    • Coll, R.C.1    O'Neill, L.A.J.2    Schroder, K.3
  • 16
    • 20744431937 scopus 로고    scopus 로고
    • The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy
    • Dahlin M, Elfving A, Ungerstedt U, Amark P. 2005. The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy. Epilepsy Res. 64:115-25
    • (2005) Epilepsy Res. , vol.64 , pp. 115-125
    • Dahlin, M.1    Elfving, A.2    Ungerstedt, U.3    Amark, P.4
  • 17
    • 84892814749 scopus 로고    scopus 로고
    • Microbiotagenerated metabolites promote metabolic benefits via gut-brain neural circuits
    • De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, et al. 2014. Microbiotagenerated metabolites promote metabolic benefits via gut-brain neural circuits. Cell 156:84-96
    • (2014) Cell , vol.156 , pp. 84-96
    • De Vadder, F.1    Kovatcheva-Datchary, P.2    Goncalves, D.3    Vinera, J.4    Zitoun, C.5
  • 18
    • 84904383437 scopus 로고    scopus 로고
    • Role of ?-hydroxybutyrate, its polymer poly-?-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease
    • Dedkova EN, Blatter LA. 2014. Role of ?-hydroxybutyrate, its polymer poly-?-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease. Front. Physiol. 5:260
    • (2014) Front. Physiol. , vol.5 , pp. 260
    • Dedkova, E.N.1    Blatter, L.A.2
  • 19
    • 0028901560 scopus 로고
    • Metabolism of (R, S)-1, 3-butanediol acetoacetate esters, potential parenteral and enteral nutrients in conscious pigs
    • Desrochers S, Dubreuil P, Brunet J, Jette M, David F, et al. 1995. Metabolism of (R, S)-1, 3-butanediol acetoacetate esters, potential parenteral and enteral nutrients in conscious pigs.Am. J. Physiol. 268:E660-67
    • (1995) Am. J. Physiol. , vol.268 , pp. E660-E667
    • Desrochers, S.1    Dubreuil, P.2    Brunet, J.3    Jette, M.4    David, F.5
  • 20
    • 84925448638 scopus 로고    scopus 로고
    • GSK256073 acutely regulates NEFA levels via HCA2 agonism but does not achieve durable glycaemic control in type 2 diabetes. A randomised trial
    • Dobbins R, Byerly R, Gaddy R, Gao F, Mahar K, et al. 2015. GSK256073 acutely regulates NEFA levels via HCA2 agonism but does not achieve durable glycaemic control in type 2 diabetes. A randomised trial. Eur. J. Pharmacol. 755:95-101
    • (2015) Eur. J. Pharmacol. , vol.755 , pp. 95-101
    • Dobbins, R.1    Byerly, R.2    Gaddy, R.3    Gao, F.4    Mahar, K.5
  • 21
    • 84885313597 scopus 로고    scopus 로고
    • GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus
    • Dobbins RL, Shearn SP, Byerly RL, Gao FF, Mahar KM, et al. 2013. GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus. Diabetes Obes. Metab. 15:1013-21
    • (2013) Diabetes Obes. Metab. , vol.15 , pp. 1013-1021
    • Dobbins, R.L.1    Shearn, S.P.2    Byerly, R.L.3    Gao, F.F.4    Mahar, K.M.5
  • 22
    • 0142136079 scopus 로고    scopus 로고
    • Voltage-dependent block of N-methyl-Daspartate receptors by the novel anticonvulsant dibenzylamine, a bioactive constituent of L-(+)-?-hydroxybutyrate
    • Donevan SD, White HS, Anderson GD, Rho JM. 2003. Voltage-dependent block of N-methyl-Daspartate receptors by the novel anticonvulsant dibenzylamine, a bioactive constituent of L-(+)-?-hydroxybutyrate. Epilepsia 44:1274-79
    • (2003) Epilepsia , vol.44 , pp. 1274-1279
    • Donevan, S.D.1    White, H.S.2    Anderson, G.D.3    Rho, J.M.4
  • 23
    • 77952348698 scopus 로고    scopus 로고
    • Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation
    • Dovey OM, Foster CT, Cowley SM. 2010. Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation. PNAS 107:8242-47
    • (2010) PNAS , vol.107 , pp. 8242-8247
    • Dovey, O.M.1    Foster, C.T.2    Cowley, S.M.3
  • 25
    • 0029833561 scopus 로고    scopus 로고
    • Regulation of GABA level in rat brain synaptosomes: Fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies
    • Erecinska M, Nelson D, Daikhin Y, Yudkoff M. 1996. Regulation of GABA level in rat brain synaptosomes: Fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies. J. Neurochem. 67:2325-34
    • (1996) J. Neurochem. , vol.67 , pp. 2325-2334
    • Erecinska, M.1    Nelson, D.2    Daikhin, Y.3    Yudkoff, M.4
  • 26
    • 0036900873 scopus 로고    scopus 로고
    • The retinoblastoma-histone deacetylase 3 complex inhibits PPAR?and adipocyte differentiation
    • Fajas L, Egler V, Reiter R, Hansen J, Kristiansen K, et al. 2002. The retinoblastoma-histone deacetylase 3 complex inhibits PPAR?and adipocyte differentiation. Dev. Cell 3:903-10
    • (2002) Dev. Cell , vol.3 , pp. 903-910
    • Fajas, L.1    Egler, V.2    Reiter, R.3    Hansen, J.4    Kristiansen, K.5
  • 27
    • 84930836001 scopus 로고    scopus 로고
    • DAMPs as mediators of sterile inflammation in agingrelated pathologies
    • Feldman N, Rotter-Maskowitz A, Okun E. 2015. DAMPs as mediators of sterile inflammation in agingrelated pathologies. Ageing Res. Rev. 24:29-39
    • (2015) Ageing Res. Rev. , vol.24 , pp. 29-39
    • Feldman, N.1    Rotter-Maskowitz, A.2    Okun, E.3
  • 28
    • 34248523169 scopus 로고    scopus 로고
    • Recovery of learning and memory is associated with chromatin remodelling
    • Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH. 2007. Recovery of learning and memory is associated with chromatin remodelling. Nature 447:178-82
    • (2007) Nature , vol.447 , pp. 178-182
    • Fischer, A.1    Sananbenesi, F.2    Wang, X.3    Dobbin, M.4    Tsai, L.H.5
  • 29
    • 84956596401 scopus 로고    scopus 로고
    • The pathogenic role of the inflammasome in neurodegenerative diseases
    • Freeman LC, Ting JPY. 2016. The pathogenic role of the inflammasome in neurodegenerative diseases. J. Neurochem. 136:29-38
    • (2016) J. Neurochem. , vol.136 , pp. 29-38
    • Freeman, L.C.1    Ting, J.P.Y.2
  • 30
    • 84880142494 scopus 로고    scopus 로고
    • Differential tissue and ligand-dependent signaling of GPR109A receptor: Implications for anti-atherosclerotic therapeutic potential
    • Gaidarov I, Chen XH, Anthony T, Maciejewski-Lenoir D, Liaw C, Unett DJ. 2013. Differential tissue and ligand-dependent signaling of GPR109A receptor: Implications for anti-atherosclerotic therapeutic potential. Cell. Signal. 25:2003-16
    • (2013) Cell. Signal. , vol.25 , pp. 2003-2016
    • Gaidarov, I.1    Chen, X.H.2    Anthony, T.3    MacIejewski-Lenoir, D.4    Liaw, C.5    Unett, D.J.6
  • 31
    • 84869106554 scopus 로고    scopus 로고
    • Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue
    • Galmozzi A, Mitro N, Ferrari A, Gers E, Gilardi F, et al. 2013. Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue. Diabetes 62:732-42
    • (2013) Diabetes , vol.62 , pp. 732-742
    • Galmozzi, A.1    Mitro, N.2    Ferrari, A.3    Gers, E.4    Gilardi, F.5
  • 32
    • 67649238355 scopus 로고    scopus 로고
    • Butyrate improves insulin sensitivity and increases energy expenditure in mice
    • Gao Z, Yin J, Zhang J, Ward RE, Martin RJ, et al. 2009. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 58:1509-17
    • (2009) Diabetes , vol.58 , pp. 1509-1517
    • Gao, Z.1    Yin, J.2    Zhang, J.3    Ward, R.E.4    Martin, R.J.5
  • 33
    • 77957086876 scopus 로고    scopus 로고
    • The lifespan-regulator p66Shc in mitochondria: Redox enzyme or redox sensor?
    • Gertz M, Steegborn C. 2010. The lifespan-regulator p66Shc in mitochondria: Redox enzyme or redox sensor? Antioxid. Redox Signal. 13:1417-28
    • (2010) Antioxid. Redox Signal. , vol.13 , pp. 1417-1428
    • Gertz, M.1    Steegborn, C.2
  • 34
    • 28044471827 scopus 로고    scopus 로고
    • Acetylation and deacetylation of non-histone proteins
    • Glozak MA, Sengupta N, Zhang X, Seto E. 2005. Acetylation and deacetylation of non-histone proteins. Gene 363:15-23
    • (2005) Gene , vol.363 , pp. 15-23
    • Glozak, M.A.1    Sengupta, N.2    Zhang, X.3    Seto, E.4
  • 35
    • 84945438257 scopus 로고    scopus 로고
    • Amyloid, microglia, and the inflammasome in Alzheimer's disease
    • Gold M, El Khoury J. 2015. ?-amyloid, microglia, and the inflammasome in Alzheimer's disease. Semin. Immunopathol. 37:607-11
    • (2015) Semin. Immunopathol. , vol.37 , pp. 607-611
    • Gold, M.1    El Khoury, J.2
  • 36
    • 85014089976 scopus 로고    scopus 로고
    • Hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares
    • Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, et al. 2017. ?-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares. Cell Rep. 18:2077-87
    • (2017) Cell Rep. , Issue.18 , pp. 2077-2087
    • Goldberg, E.L.1    Asher, J.L.2    Molony, R.D.3    Shaw, A.C.4    Zeiss, C.J.5
  • 37
    • 84927748959 scopus 로고    scopus 로고
    • Drivers of age-related inflammation and strategies for healthspan extension
    • Goldberg EL, Dixit VD. 2015. Drivers of age-related inflammation and strategies for healthspan extension. Immunol. Rev. 265:63-74
    • (2015) Immunol. Rev. , vol.265 , pp. 63-74
    • Goldberg, E.L.1    Dixit, V.D.2
  • 38
    • 84959518014 scopus 로고    scopus 로고
    • Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2
    • Graff EC, Fang H, Wanders D, Judd RL. 2016. Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2. Metab. Clin. Exp. 65:102-13
    • (2016) Metab. Clin. Exp. , vol.65 , pp. 102-113
    • Graff, E.C.1    Fang, H.2    Wanders, D.3    Judd, R.L.4
  • 39
    • 84862777943 scopus 로고    scopus 로고
    • An epigenetic blockade of cognitive functions in the neurodegenerating brain
    • Graff J, Rei D, Guan JS, Wang WY, Seo J, et al. 2012. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 483:222-26
    • (2012) Nature , vol.483 , pp. 222-226
    • Graff, J.1    Rei, D.2    Guan, J.S.3    Wang, W.Y.4    Seo, J.5
  • 40
    • 84872601036 scopus 로고    scopus 로고
    • Histone acetylation: Molecular mnemonics on the chromatin
    • Graff J, Tsai LH. 2013. Histone acetylation: Molecular mnemonics on the chromatin. Nat. Rev. Neurosci. 14:97-111
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 97-111
    • Graff, J.1    Tsai, L.H.2
  • 41
    • 1842578986 scopus 로고    scopus 로고
    • Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis
    • Gregoretti IV, Lee YM, Goodson HV. 2004. Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis. J. Mol. Biol. 338:17-31
    • (2004) J. Mol. Biol. , vol.338 , pp. 17-31
    • Gregoretti, I.V.1    Lee, Y.M.2    Goodson, H.V.3
  • 43
    • 84886812954 scopus 로고    scopus 로고
    • The nexus of chromatin regulation and intermediary metabolism
    • Gut P, Verdin E. 2013. The nexus of chromatin regulation and intermediary metabolism. Nature 502:489-98
    • (2013) Nature , vol.502 , pp. 489-498
    • Gut, P.1    Verdin, E.2
  • 45
    • 84927779736 scopus 로고    scopus 로고
    • NLRP3 at the interface of metabolism and inflammation
    • Haneklaus M, O'Neill LAJ. 2015. NLRP3 at the interface of metabolism and inflammation. Immunol. Rev. 265:53-62
    • (2015) Immunol. Rev. , vol.265 , pp. 53-62
    • Haneklaus, M.1    O'Neill, L.A.J.2
  • 46
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, et al. 2009. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392-95
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5
  • 49
    • 0033559336 scopus 로고    scopus 로고
    • Mitochondrial 3-hydroxy-3-methylglutaryl-Co A synthase: A control enzyme in ketogenesis
    • Hegardt FG. 1999. Mitochondrial 3-hydroxy-3-methylglutaryl-Co A synthase: A control enzyme in ketogenesis. Biochem. J. 338 (Pt. 3):569-82
    • (1999) Biochem. J. , vol.338 , pp. 569-582
    • Hegardt, F.G.1
  • 50
    • 84873087532 scopus 로고    scopus 로고
    • NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
    • Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, et al. 2013. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493:674-78
    • (2013) Nature , vol.493 , pp. 674-678
    • Heneka, M.T.1    Kummer, M.P.2    Stutz, A.3    Delekate, A.4    Schwartz, S.5
  • 51
    • 77950806433 scopus 로고    scopus 로고
    • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
    • Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, et al. 2010. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 464:121-25
    • (2010) Nature , vol.464 , pp. 121-125
    • Hirschey, M.D.1    Shimazu, T.2    Goetzman, E.3    Jing, E.4    Schwer, B.5
  • 53
    • 84904751060 scopus 로고    scopus 로고
    • NAD+ and sirtuins in aging and disease
    • Imai SI, Guarente L. 2014. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 24:464-71
    • (2014) Trends Cell Biol. , vol.24 , pp. 464-471
    • Imai, S.I.1    Guarente, L.2
  • 54
    • 84925808970 scopus 로고    scopus 로고
    • Sirtuins in epigenetic regulation
    • Jing H, Lin HN. 2015. Sirtuins in epigenetic regulation. Chem. Rev. 115:2350-75
    • (2015) Chem. Rev. , vol.115 , pp. 2350-2375
    • Jing, H.1    Lin, H.N.2
  • 55
    • 84872527628 scopus 로고    scopus 로고
    • M TOR is a key modulator of ageing and age-related disease
    • Johnson SC, Rabinovitch PS, Kaeberlein M. 2013. m TOR is a key modulator of ageing and age-related disease. Nature 493:338-45
    • (2013) Nature , vol.493 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 56
    • 77957307251 scopus 로고    scopus 로고
    • Metabolic control of vesicular glutamate transport and release
    • Juge N, Gray JA, Omote H, Miyaji T, Inoue T, et al. 2010. Metabolic control of vesicular glutamate transport and release. Neuron 68:99-112
    • (2010) Neuron , vol.68 , pp. 99-112
    • Juge, N.1    Gray, J.A.2    Omote, H.3    Miyaji, T.4    Inoue, T.5
  • 57
    • 77950214581 scopus 로고    scopus 로고
    • Lessons on longevity from budding yeast
    • Kaeberlein M. 2010. Lessons on longevity from budding yeast. Nature 464:513-19
    • (2010) Nature , vol.464 , pp. 513-519
    • Kaeberlein, M.1
  • 58
    • 84875253158 scopus 로고    scopus 로고
    • A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease
    • Kashiwaya Y, Bergman C, Lee JH, Wan R, King MT, et al. 2013. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol. Aging 34:1530-39
    • (2013) Neurobiol. Aging , vol.34 , pp. 1530-1539
    • Kashiwaya, Y.1    Bergman, C.2    Lee, J.H.3    Wan, R.4    King, M.T.5
  • 59
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ. 2010. The genetics of ageing. Nature 464:504-12
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 61
    • 0032831936 scopus 로고    scopus 로고
    • Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae
    • Kim S, Benguria A, Lai CY, Jazwinski SM. 1999. Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. Mol. Biol. Cell 10:3125-36
    • (1999) Mol. Biol. Cell , vol.10 , pp. 3125-3136
    • Kim, S.1    Benguria, A.2    Lai, C.Y.3    Jazwinski, S.M.4
  • 62
    • 79956348319 scopus 로고    scopus 로고
    • Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)
    • Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, et al. 2011. Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). PNAS 108:8030-35
    • (2011) PNAS , vol.108 , pp. 8030-8035
    • Kimura, I.1    Inoue, D.2    Maeda, T.3    Hara, T.4    Ichimura, A.5
  • 63
    • 41949120723 scopus 로고    scopus 로고
    • Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks
    • Knutson SK, Chyla BJ, Amann JM, Bhaskara S, Huppert SS, Hiebert SW. 2008. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J. 27:1017-28
    • (2008) EMBO J. , vol.27 , pp. 1017-1028
    • Knutson, S.K.1    Chyla, B.J.2    Amann, J.M.3    Bhaskara, S.4    Huppert, S.S.5    Hiebert, S.W.6
  • 65
    • 0014307410 scopus 로고
    • The redox state of the nicotinamide-adenine dinucleotides in rat liver homogenates
    • Krebs HA, Gascoyne T. 1968. The redox state of the nicotinamide-adenine dinucleotides in rat liver homogenates. Biochem. J. 108:513-20
    • (1968) Biochem. J. , vol.108 , pp. 513-520
    • Krebs, H.A.1    Gascoyne, T.2
  • 66
    • 77953611169 scopus 로고    scopus 로고
    • Role of ?-hydroxybutyric acid in the central regulation of energy balance
    • Laeger T, Metges CC, Kuhla B. 2010. Role of ?-hydroxybutyric acid in the central regulation of energy balance. Appetite 54:450-55
    • (2010) Appetite , vol.54 , pp. 450-455
    • Laeger, T.1    Metges, C.C.2    Kuhla, B.3
  • 69
    • 84865330824 scopus 로고    scopus 로고
    • Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression
    • Lauring B, Taggart AKP, Tata JR, Dunbar R, Caro L, et al. 2012. Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Sci. Transl. Med. 4:148ra115
    • (2012) Sci. Transl. Med. , vol.4 , pp. 115-148
    • Lauring, B.1    Taggart, A.K.P.2    Tata, J.R.3    Dunbar, R.4    Caro, L.5
  • 72
    • 84859529243 scopus 로고    scopus 로고
    • Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3
    • Li H, Gao Z, Zhang J, Ye X, Xu A, et al. 2012. Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. Diabetes 61:797-806
    • (2012) Diabetes , vol.61 , pp. 797-806
    • Li, H.1    Gao, Z.2    Zhang, J.3    Ye, X.4    Xu, A.5
  • 73
    • 84979498569 scopus 로고    scopus 로고
    • SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
    • Li L, Shi L, Yang SD, Yan RR, Zhang D, et al. 2016. SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability. Nat. Commun. 7:12235
    • (2016) Nat. Commun. , vol.7 , pp. 12235
    • Li, L.1    Shi, L.2    Yang, S.D.3    Yan, R.R.4    Zhang, D.5
  • 75
    • 84975526052 scopus 로고    scopus 로고
    • Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan
    • Longo VD, Panda S. 2016. Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan. Cell Metab. 23:1048-59
    • (2016) Cell Metab. , vol.23 , pp. 1048-1059
    • Longo, V.D.1    Panda, S.2
  • 76
    • 84938739658 scopus 로고    scopus 로고
    • The metabolic impact of ?-hydroxybutyrate on neurotransmission: Reduced glycolysis mediates changes in calcium responses and KATP channel receptor sensitivity
    • Lund TM, Ploug KB, Iversen A, Jensen AA, Jansen-Olesen I. 2015. The metabolic impact of ?-hydroxybutyrate on neurotransmission: Reduced glycolysis mediates changes in calcium responses and KATP channel receptor sensitivity. J. Neurochem. 132:520-31
    • (2015) J. Neurochem. , vol.132 , pp. 520-531
    • Lund, T.M.1    Ploug, K.B.2    Iversen, A.3    Jensen, A.A.4    Jansen-Olesen, I.5
  • 77
    • 84914706500 scopus 로고    scopus 로고
    • Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels
    • Lutas A, Birnbaumer L, Yellen G. 2014. Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels. J. Neurosci. 34:16336-47
    • (2014) J. Neurosci. , vol.34 , pp. 16336-16347
    • Lutas, A.1    Birnbaumer, L.2    Yellen, G.3
  • 78
    • 34147189503 scopus 로고    scopus 로고
    • Ketogenic diet metabolites reduce firing in central neurons by opening KATP channels
    • Ma WY, Berg J, Yellen G. 2007. Ketogenic diet metabolites reduce firing in central neurons by opening KATP channels. J. Neurosci. 27:3618-25
    • (2007) J. Neurosci. , vol.27 , pp. 3618-3625
    • Ma, W.Y.1    Berg, J.2    Yellen, G.3
  • 79
    • 84926367699 scopus 로고    scopus 로고
    • Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
    • Macia L, Tan J, Vieira AT, Leach K, Stanley D, et al. 2015. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat. Commun. 6:6734
    • (2015) Nat. Commun. , vol.6 , pp. 6734
    • MacIa, L.1    Tan, J.2    Vieira, A.T.3    Leach, K.4    Stanley, D.5
  • 82
    • 85016907350 scopus 로고    scopus 로고
    • Impact of intermittent fasting on health and disease processes
    • pii:S1568-1637(16)30251-3
    • Mattson MP, Longo V, Harvie M. 2016. Impact of intermittent fasting on health and disease processes. Ageing Res. Rev. pii:S1568-1637(16)30251-3
    • (2016) Ageing Res. Rev.
    • Mattson, M.P.1    Longo, V.2    Harvie, M.3
  • 84
    • 33645852573 scopus 로고    scopus 로고
    • Neuronal-glial interactions in rats fed a ketogenic diet
    • Melo TM, Nehlig A, Sonnewald U. 2006. Neuronal-glial interactions in rats fed a ketogenic diet. Neurochem. Int. 48:498-507
    • (2006) Neurochem. Int. , vol.48 , pp. 498-507
    • Melo, T.M.1    Nehlig, A.2    Sonnewald, U.3
  • 85
    • 84871650811 scopus 로고    scopus 로고
    • Metabolic reprogramming by class I and II histone deacetylases
    • Mihaylova MM, Shaw RJ. 2013. Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol. Metab. 24:48-57
    • (2013) Trends Endocrinol. Metab. , vol.24 , pp. 48-57
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 86
    • 79955815135 scopus 로고    scopus 로고
    • Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
    • Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, et al. 2011. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell 145:607-21
    • (2011) Cell , vol.145 , pp. 607-621
    • Mihaylova, M.M.1    Vasquez, D.S.2    Ravnskjaer, K.3    Denechaud, P.D.4    Yu, R.T.5
  • 87
    • 84905045240 scopus 로고    scopus 로고
    • Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity
    • Milman S, Atzmon G, Huffman DM, Wan JX, Crandall JP, et al. 2014. Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell 13:769-71
    • (2014) Aging Cell , vol.13 , pp. 769-771
    • Milman, S.1    Atzmon, G.2    Huffman, D.M.3    Wan, J.X.4    Crandall, J.P.5
  • 88
    • 84963612261 scopus 로고    scopus 로고
    • Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent m TOR repression
    • Morales CR, Li DL, Pedrozo Z, May HI, Jiang N, et al. 2016. Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent m TOR repression. Sci. Signal. 9:ra34
    • (2016) Sci. Signal. , vol.9 , pp. ra34
    • Morales, C.R.1    Li, D.L.2    Pedrozo, Z.3    May, H.I.4    Jiang, N.5
  • 89
    • 84860476829 scopus 로고    scopus 로고
    • Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility
    • Muoio DM, Noland RC, Kovalik JP, Seiler SE, Davies MN, et al. 2012. Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. Cell Metab. 15:764-77
    • (2012) Cell Metab. , vol.15 , pp. 764-777
    • Muoio, D.M.1    Noland, R.C.2    Kovalik, J.P.3    Seiler, S.E.4    Davies, M.N.5
  • 90
    • 84869869682 scopus 로고    scopus 로고
    • HDAC inhibitor-based therapies: Can we interpret the code?
    • New M, Olzscha H, La Thangue NB. 2012. HDAC inhibitor-based therapies: Can we interpret the code? Mol. Oncol. 6:637-56
    • (2012) Mol. Oncol. , vol.6 , pp. 637-656
    • New, M.1    Olzscha, H.2    La Thangue, N.B.3
  • 94
    • 84922358640 scopus 로고    scopus 로고
    • Expression of the short chain fatty acid receptor Gpr41/Ffar3 in autonomic and somatic sensory ganglia
    • Nohr MK, Egerod KL, Christiansen SH, Gille A, Offermanns S, et al. 2015. Expression of the short chain fatty acid receptor Gpr41/Ffar3 in autonomic and somatic sensory ganglia. Neuroscience 290:126-37
    • (2015) Neuroscience , vol.290 , pp. 126-137
    • Nohr, M.K.1    Egerod, K.L.2    Christiansen, S.H.3    Gille, A.4    Offermanns, S.5
  • 95
    • 79955769365 scopus 로고    scopus 로고
    • International union of basic and clinical pharmacology.LXXXII: Nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B)
    • Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP. 2011. International union of basic and clinical pharmacology. LXXXII: Nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B). Pharmacol. Rev. 63:269-90
    • (2011) Pharmacol. Rev. , vol.63 , pp. 269-290
    • Offermanns, S.1    Colletti, S.L.2    Lovenberg, T.W.3    Semple, G.4    Wise, A.5    Ijzerman, A.P.6
  • 96
    • 84925821034 scopus 로고    scopus 로고
    • Nutritional or pharmacological activation of HCA2 ameliorates neuroinflammation
    • Offermanns S, Schwaninger M. 2015. Nutritional or pharmacological activation of HCA2 ameliorates neuroinflammation. Trends Mol. Med. 21:245-55
    • (2015) Trends Mol. Med. , vol.21 , pp. 245-255
    • Offermanns, S.1    Schwaninger, M.2
  • 97
    • 34249791771 scopus 로고    scopus 로고
    • Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: A circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation
    • Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, et al. 2007. Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: A circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J. Neurosci. 27:5903-14
    • (2007) J. Neurosci. , vol.27 , pp. 5903-5914
    • Ogiwara, I.1    Miyamoto, H.2    Morita, N.3    Atapour, N.4    Mazaki, E.5
  • 98
    • 77952168294 scopus 로고    scopus 로고
    • Altered histone acetylation is associated with age-dependent memory impairment in mice
    • Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, et al. 2010. Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 328:753-56
    • (2010) Science , vol.328 , pp. 753-756
    • Peleg, S.1    Sananbenesi, F.2    Zovoilis, A.3    Burkhardt, S.4    Bahari-Javan, S.5
  • 99
    • 12244262261 scopus 로고    scopus 로고
    • Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain
    • Pellerin L, Bergersen LH, Halestrap AP, Pierre K. 2005. Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain. J. Neurosci. Res. 79:55-64
    • (2005) J. Neurosci. Res. , vol.79 , pp. 55-64
    • Pellerin, L.1    Bergersen, L.H.2    Halestrap, A.P.3    Pierre, K.4
  • 100
    • 84916630473 scopus 로고    scopus 로고
    • Histone deacetylases in memory and cognition
    • Penney J, Tsai LH. 2014. Histone deacetylases in memory and cognition. Sci. Signal. 7:re12
    • (2014) Sci. Signal. , vol.7 , pp. re12
    • Penney, J.1    Tsai, L.H.2
  • 101
    • 0024451319 scopus 로고
    • Treatment of rats with glucagon or mannoheptulose increases mitochondrial 3-hydroxy-3-methylglutaryl-Co A synthase activity and decreases succinyl-Co A content in liver
    • Quant PA, Tubbs PK, Brand MD. 1989. Treatment of rats with glucagon or mannoheptulose increases mitochondrial 3-hydroxy-3-methylglutaryl-Co A synthase activity and decreases succinyl-Co A content in liver. Biochem. J. 262:159-64
    • (1989) Biochem. J. , vol.262 , pp. 159-164
    • Quant, P.A.1    Tubbs, P.K.2    Brand, M.D.3
  • 102
    • 0025060134 scopus 로고
    • Glucagon activates mitochondrial 3-hydroxy-3-methylglutaryl-Co A synthase in vivo by decreasing the extent of succinylation of the enzyme
    • Quant PA, Tubbs PK, Brand MD. 1990. Glucagon activates mitochondrial 3-hydroxy-3-methylglutaryl-Co A synthase in vivo by decreasing the extent of succinylation of the enzyme. Eur. J. Biochem. 187:169-74
    • (1990) Eur. J. Biochem. , vol.187 , pp. 169-174
    • Quant, P.A.1    Tubbs, P.K.2    Brand, M.D.3
  • 103
    • 84901325457 scopus 로고    scopus 로고
    • The?-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages
    • Rahman M, Muhammad S, Khan MA, Chen H, Ridder DA, et al. 2014. The?-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages. Nat. Commun. 5:3944
    • (2014) Nat. Commun. , vol.5 , pp. 3944
    • Rahman, M.1    Muhammad, S.2    Khan, M.A.3    Chen, H.4    Ridder, D.A.5
  • 104
    • 84889636259 scopus 로고    scopus 로고
    • SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks
    • Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, et al. 2013. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab. 18:920-33
    • (2013) Cell Metab. , vol.18 , pp. 920-933
    • Rardin, M.J.1    He, W.2    Nishida, Y.3    Newman, J.C.4    Carrico, C.5
  • 105
    • 84876217035 scopus 로고    scopus 로고
    • Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways
    • Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, et al. 2013. Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PNAS 110:6601-6
    • (2013) PNAS , vol.110 , pp. 6601-6606
    • Rardin, M.J.1    Newman, J.C.2    Held, J.M.3    Cusack, M.P.4    Sorensen, D.J.5
  • 106
    • 84959420280 scopus 로고    scopus 로고
    • Central GPR109A activation mediates glutamate-dependent pressor response in conscious rats
    • Rezq S, Abdel-Rahman AA. 2016. Central GPR109A activation mediates glutamate-dependent pressor response in conscious rats. J. Pharmacol. Exp. Ther. 356:456-65
    • (2016) J. Pharmacol. Exp. Ther. , vol.356 , pp. 456-465
    • Rezq, S.1    Abdel-Rahman, A.A.2
  • 107
    • 84938718749 scopus 로고    scopus 로고
    • How does the ketogenic diet induce anti-seizure effects?
    • Rho JM. 2015. How does the ketogenic diet induce anti-seizure effects? Neurosci. Lett. 637:4-10
    • (2015) Neurosci. Lett. , vol.637 , pp. 4-10
    • Rho, J.M.1
  • 108
    • 0018876377 scopus 로고
    • Physiological roles of ketone bodies as substrates and signals in mammalian tissues
    • Robinson AM, Williamson DH. 1980. Physiological roles of ketone bodies as substrates and signals in mammalian tissues. Physiol. Rev. 60:143-87
    • (1980) Physiol. Rev. , vol.60 , pp. 143-187
    • Robinson, A.M.1    Williamson, D.H.2
  • 109
    • 8644224064 scopus 로고    scopus 로고
    • Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    • Rogina B, Helfand SL. 2004. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. PNAS 101:15998-6003
    • (2004) PNAS , vol.101 , pp. 15998-16003
    • Rogina, B.1    Helfand, S.L.2
  • 110
    • 18744416824 scopus 로고    scopus 로고
    • Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction
    • Rogina B, Helfand SL, Frankel S. 2002. Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. Science 298:1745
    • (2002) Science , vol.298 , pp. 1745
    • Rogina, B.1    Helfand, S.L.2    Frankel, S.3
  • 112
    • 84934444202 scopus 로고    scopus 로고
    • Rapid adaptation of rat brain and liver metabolism to a ketogenic diet: An integrated study using 1H-and 13C-NMR spectroscopy
    • Roy M, Beauvieux MC, Naulin J, El Hamrani D, Gallis JL, et al. 2015. Rapid adaptation of rat brain and liver metabolism to a ketogenic diet: An integrated study using 1H-and 13C-NMR spectroscopy. J. Cereb. Blood Flow Metab. 35:1154-62
    • (2015) J. Cereb. Blood Flow Metab. , vol.35 , pp. 1154-1162
    • Roy, M.1    Beauvieux, M.C.2    Naulin, J.3    El Hamrani, D.4    Gallis, J.L.5
  • 113
    • 84867645474 scopus 로고    scopus 로고
    • Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model
    • Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, et al. 2012. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. PNAS 109:E2895-903
    • (2012) PNAS , vol.109 , pp. E2895-E2903
    • Sanchez, P.E.1    Zhu, L.2    Verret, L.3    Vossel, K.A.4    Orr, A.G.5
  • 114
    • 0029008947 scopus 로고
    • Insulin, ketone bodies, and mitochondrial energy transduction
    • Sato K, Kashiwaya Y, Keon CA, Tsuchiya N, King MT, et al. 1995. Insulin, ketone bodies, and mitochondrial energy transduction. FASEB J. 9:651-58
    • (1995) FASEB J. , vol.9 , pp. 651-658
    • Sato, K.1    Kashiwaya, Y.2    Keon, C.A.3    Tsuchiya, N.4    King, M.T.5
  • 115
    • 38849088190 scopus 로고    scopus 로고
    • Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate
    • Sekhavat A, Sun JM, Davie JR. 2007. Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. Biochem. Cell Biol. 85:751-58
    • (2007) Biochem. Cell Biol. , vol.85 , pp. 751-758
    • Sekhavat, A.1    Sun, J.M.2    Davie, J.R.3
  • 116
    • 78650848337 scopus 로고    scopus 로고
    • M TORC1 controls fasting-induced ketogenesis and its modulation by ageing
    • Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM. 2010. m TORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468:1100-4
    • (2010) Nature , vol.468 , pp. 1100-1104
    • Sengupta, S.1    Peterson, T.R.2    Laplante, M.3    Oh, S.4    Sabatini, D.M.5
  • 117
    • 78649509214 scopus 로고    scopus 로고
    • SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl Co A synthase 2 and regulates ketone body production
    • Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, et al. 2010. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl Co A synthase 2 and regulates ketone body production. Cell Metab. 12:654-61
    • (2010) Cell Metab. , vol.12 , pp. 654-661
    • Shimazu, T.1    Hirschey, M.D.2    Hua, L.3    Dittenhafer-Reed, K.E.4    Schwer, B.5
  • 118
    • 84872166360 scopus 로고    scopus 로고
    • Suppression of oxidative stress by ?-hydroxybutyrate, an endogenous histone deacetylase inhibitor
    • Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, et al. 2013. Suppression of oxidative stress by ?-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339:211-14
    • (2013) Science , vol.339 , pp. 211-214
    • Shimazu, T.1    Hirschey, M.D.2    Newman, J.3    He, W.4    Shirakawa, K.5
  • 119
    • 84959421384 scopus 로고    scopus 로고
    • Concise review: Epigenetic regulation of myogenesis in health and disease
    • Sincennes MC, Brun CE, Rudnicki MA. 2016. Concise review: Epigenetic regulation of myogenesis in health and disease. Stem Cells Transl. Med. 5:282-90
    • (2016) Stem Cells Transl. Med. , Issue.5 , pp. 282-290
    • Sincennes, M.C.1    Brun, C.E.2    Rudnicki, M.A.3
  • 120
    • 84975321438 scopus 로고    scopus 로고
    • Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body ?-hydroxybutyrate
    • pii e15092
    • Sleiman SF, Henry J, Al-Haddad R, El Hayek L, Abou Haidar E, et al. 2016. Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body ?-hydroxybutyrate. e Life pii:e15092
    • (2016) E Life
    • Sleiman, S.F.1    Henry, J.2    Al-Haddad, R.3    El Hayek, L.4    Abou Haidar, E.5
  • 121
    • 78651468722 scopus 로고    scopus 로고
    • Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
    • Someya S, Yu W, Hallows WC, Xu JZ, Vann JM, et al. 2010. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 143:802-12
    • (2010) Cell , vol.143 , pp. 802-812
    • Someya, S.1    Yu, W.2    Hallows, W.C.3    Xu, J.Z.4    Vann, J.M.5
  • 122
    • 3142562372 scopus 로고    scopus 로고
    • Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases
    • Somoza JR, Skene RJ, Katz BA, Mol C, Ho JD, et al. 2004. Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases. Structure 12:1325-34
    • (2004) Structure , vol.12 , pp. 1325-1334
    • Somoza, J.R.1    Skene, R.J.2    Katz, B.A.3    Mol, C.4    Ho, J.D.5
  • 123
    • 84865411082 scopus 로고    scopus 로고
    • The dynamic regulation of NAD metabolism inmitochondria
    • Stein LR, Imai S. 2012. The dynamic regulation of NAD metabolism inmitochondria. Trends Endocrinol. Metab. 23:420-28
    • (2012) Trends Endocrinol. Metab. , vol.23 , pp. 420-428
    • Stein, L.R.1    Imai, S.2
  • 124
    • 22844439234 scopus 로고    scopus 로고
    • (D)-?-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G
    • Taggart AK, Kero J, Gan X, Cai TQ, Cheng K, et al. 2005. (D)-?-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J. Biol. Chem. 280:26649-52
    • (2005) J. Biol. Chem. , vol.280 , pp. 26649-26652
    • Taggart, A.K.1    Kero, J.2    Gan, X.3    Cai, T.Q.4    Cheng, K.5
  • 125
    • 84922620529 scopus 로고    scopus 로고
    • Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes
    • Tang C, Ahmed K, Gille A, Lu S, Grone HJ, et al. 2015. Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes. Nat. Med. 21:85-89
    • (2015) Nat. Med. , vol.21 , pp. 85-89
    • Tang, C.1    Ahmed, K.2    Gille, A.3    Lu, S.4    Grone, H.J.5
  • 126
    • 0343775830 scopus 로고    scopus 로고
    • Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission
    • Thio LL, Wong M, Yamada KA. 2000. Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission. Neurology 54:325-31
    • (2000) Neurology , vol.54 , pp. 325-331
    • Thio, L.L.1    Wong, M.2    Yamada, K.A.3
  • 127
    • 0027161537 scopus 로고
    • Developmental changes in mitochondrial 3-hydroxy-3-methylglutaryl-Co A synthase gene expression in rat liver, intestine and kidney
    • Thumelin S, Forestier M, Girard J, Pegorier JP. 1993. Developmental changes in mitochondrial 3-hydroxy-3-methylglutaryl-Co A synthase gene expression in rat liver, intestine and kidney. Biochem. J. 292(Pt. 2):493-96
    • (1993) Biochem. J. , vol.292 , pp. 493-496
    • Thumelin, S.1    Forestier, M.2    Girard, J.3    Pegorier, J.P.4
  • 128
    • 84893704050 scopus 로고    scopus 로고
    • Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis
    • Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, et al. 2014. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat. Med. 20:159-66
    • (2014) Nat. Med. , vol.20 , pp. 159-166
    • Trompette, A.1    Gollwitzer, E.S.2    Yadava, K.3    Sichelstiel, A.K.4    Sprenger, N.5
  • 129
    • 0037352280 scopus 로고    scopus 로고
    • PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
    • Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, et al. 2003. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat. Med. 9:352-55
    • (2003) Nat. Med. , vol.9 , pp. 352-355
    • Tunaru, S.1    Kero, J.2    Schaub, A.3    Wufka, C.4    Blaukat, A.5
  • 130
    • 6344222799 scopus 로고    scopus 로고
    • Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexedwith a hydroxamic acid inhibitor
    • Vannini A, Volpari C, Filocamo G, Casavola EC, Brunetti M, et al. 2004. Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexedwith a hydroxamic acid inhibitor. PNAS 101:15064-69
    • (2004) PNAS , vol.101 , pp. 15064-15069
    • Vannini, A.1    Volpari, C.2    Filocamo, G.3    Casavola, E.C.4    Brunetti, M.5
  • 131
    • 1042299789 scopus 로고    scopus 로고
    • The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: Ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
    • Veech RL. 2004. The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: Ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot. Essent. Fatty Acids 70:309-19
    • (2004) Prostaglandins Leukot. Essent. Fatty Acids , vol.70 , pp. 309-319
    • Veech, R.L.1
  • 132
    • 84996553637 scopus 로고    scopus 로고
    • GPR41modulates insulin secretion and gene expression in pancreatic ?-cells and modifies metabolic homeostasis in fed and fasting states
    • Veprik A, Laufer D, Weiss S, Rubins N, Walker MD. 2016. GPR41modulates insulin secretion and gene expression in pancreatic ?-cells and modifies metabolic homeostasis in fed and fasting states. FASEB J. 30:3860-69
    • (2016) FASEB J. , vol.30 , pp. 3860-3869
    • Veprik, A.1    Laufer, D.2    Weiss, S.3    Rubins, N.4    Walker, M.D.5
  • 133
    • 84949036094 scopus 로고    scopus 로고
    • NAD+ in aging, metabolism, and neurodegeneration
    • Verdin E. 2015. NAD+ in aging, metabolism, and neurodegeneration. Science 350:1208-13
    • (2015) Science , vol.350 , pp. 1208-1213
    • Verdin, E.1
  • 134
    • 84860334015 scopus 로고    scopus 로고
    • Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model
    • Verret L, Mann EO, Hang GB, Barth AM, Cobos I, et al. 2012. Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell 149:708-21
    • (2012) Cell , vol.149 , pp. 708-721
    • Verret, L.1    Mann, E.O.2    Hang, G.B.3    Barth, A.M.4    Cobos, I.5
  • 135
    • 84875382650 scopus 로고    scopus 로고
    • Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism
    • von Meyenn F, Porstmann T, Gasser E, Selevsek N, Schmidt A, et al. 2013. Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism. Cell Metab. 17:436-47
    • (2013) Cell Metab. , vol.17 , pp. 436-447
    • Von Meyenn, F.1    Porstmann, T.2    Gasser, E.3    Selevsek, N.4    Schmidt, A.5
  • 136
    • 84883759456 scopus 로고    scopus 로고
    • Seizures and epileptiform activity in the early stages of Alzheimer disease
    • Vossel KA, Beagle AJ, Rabinovici GD, Shu HD, Lee SE, et al. 2013. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 70:1158-66
    • (2013) JAMA Neurol. , vol.70 , pp. 1158-1166
    • Vossel, K.A.1    Beagle, A.J.2    Rabinovici, G.D.3    Shu, H.D.4    Lee, S.E.5
  • 137
    • 27444435580 scopus 로고    scopus 로고
    • Toward selective histone deacetylase inhibitor design: Homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases
    • Wang DF, Helquist P, Wiech NL, Wiest O. 2005. Toward selective histone deacetylase inhibitor design: Homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases. J. Med. Chem. 48:6936-47
    • (2005) J. Med. Chem. , vol.48 , pp. 6936-6947
    • Wang, D.F.1    Helquist, P.2    Wiech, N.L.3    Wiest, O.4
  • 138
    • 0017701487 scopus 로고
    • Utilization of L(+)-3-hydroxybutyrate D(-)-3-hydroxybutyrate, acetoacetate, and glucose for respiration and lipid synthesis in the 18-day-old rat
    • Webber RJ, Edmond J. 1977. Utilization of L(+)-3-hydroxybutyrate, D(-)-3-hydroxybutyrate, acetoacetate, and glucose for respiration and lipid synthesis in the 18-day-old rat. J. Biol. Chem. 252:5222-26
    • (1977) J. Biol. Chem. , vol.252 , pp. 5222-5226
    • Webber, R.J.1    Edmond, J.2
  • 139
    • 84883307077 scopus 로고    scopus 로고
    • Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation
    • Weinert BT, Scholz C, Wagner SA, Iesmantavicius V, Su D, et al. 2013. Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep. 4:842-51
    • (2013) Cell Rep. , vol.4 , pp. 842-851
    • Weinert BT, S.1
  • 141
    • 77955425859 scopus 로고    scopus 로고
    • Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis
    • Wilting RH, Yanover E, Heideman MR, Jacobs H, Horner J, et al. 2010. Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. EMBO J. 29:2586-97
    • (2010) EMBO J. , vol.29 , pp. 2586-2597
    • Wilting, R.H.1    Yanover, E.2    Heideman, M.R.3    Jacobs, H.4    Horner, J.5
  • 143
    • 11144244418 scopus 로고    scopus 로고
    • Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
    • Wolfrum C, Asilmaz E, Luca E, Friedman JM, Stoffel M. 2004. Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature 432:1027-32
    • (2004) Nature , vol.432 , pp. 1027-1032
    • Wolfrum, C.1    Asilmaz, E.2    Luca, E.3    Friedman, J.M.4    Stoffel, M.5
  • 144
    • 0141705364 scopus 로고    scopus 로고
    • Insulin regulates the activity of forkhead transcription factor Hnf-3?/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization
    • Wolfrum C, Besser D, Luca E, Stoffel M. 2003. Insulin regulates the activity of forkhead transcription factor Hnf-3?/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization. PNAS 100:11624-29
    • (2003) PNAS , vol.100 , pp. 11624-11629
    • Wolfrum, C.1    Besser, D.2    Luca, E.3    Stoffel, M.4
  • 145
    • 84889078129 scopus 로고    scopus 로고
    • Hydroxybutyrate modulates N-type calcium channels in rat sympathetic neurons by acting as an agonist for the G-protein-coupled receptor FFA3
    • Won YJ, Lu VB, Puhl HL 3rd, Ikeda SR. 2013. ?-Hydroxybutyrate modulates N-type calcium channels in rat sympathetic neurons by acting as an agonist for the G-protein-coupled receptor FFA3. J. Neurosci. 33:19314-25
    • (2013) J. Neurosci. , vol.33 , pp. 19314-19325
    • Won, Y.J.1    Lu, V.B.2    Puhl, H.L.3    Ikeda, S.R.4
  • 147
    • 84963812301 scopus 로고    scopus 로고
    • Metabolic regulation of gene expression by histone lysine ?-hydroxybutyrylation
    • Xie ZY, Zhang D, Chung DJ, Tang ZY, Huang H, et al. 2016. Metabolic regulation of gene expression by histone lysine ?-hydroxybutyrylation. Mol. Cell 62:194-206
    • (2016) Mol. Cell , vol.62 , pp. 194-206
    • Xie, Z.Y.1    Zhang, D.2    Chung, D.J.3    Tang, Z.Y.4    Huang, H.5
  • 148
    • 84866400208 scopus 로고    scopus 로고
    • Differentiating enantioselective actions of GABOB: A possible role for threonine 244 in the binding site of GABAC ?1 receptors
    • Yamamoto I, Absalom N, Carland JE, Doddareddy MR, Gavande N, et al. 2012. Differentiating enantioselective actions of GABOB: A possible role for threonine 244 in the binding site of GABAC ?1 receptors. ACS Chem. Neurosci. 3:665-73
    • (2012) ACS Chem. Neurosci. , vol.3 , pp. 665-673
    • Yamamoto, I.1    Absalom, N.2    Carland, J.E.3    Doddareddy, M.R.4    Gavande, N.5
  • 150
    • 39749127166 scopus 로고    scopus 로고
    • The Rpd3/Hda1 family of lysine deacetylases: From bacteria and yeast to mice and men
    • Yang XJ, Seto E. 2008. The Rpd3/Hda1 family of lysine deacetylases: From bacteria and yeast to mice and men. Nat. Rev. Mol. Cell Biol. 9:206-18
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 206-218
    • Yang, X.J.1    Seto, E.2
  • 151
    • 84860203624 scopus 로고    scopus 로고
    • Function and molecular mechanism of acetylation in autophagy regulation
    • Yi C, Ma M, Ran L, Zheng J, Tong J, et al. 2012. Function and molecular mechanism of acetylation in autophagy regulation. Science 336:474-77
    • (2012) Science , vol.336 , pp. 474-477
    • Yi, C.1    Ma, M.2    Ran, L.3    Zheng, J.4    Tong, J.5
  • 152
    • 80053920774 scopus 로고    scopus 로고
    • Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice
    • Yoshino J, Mills KF, Yoon MJ, Imai S. 2011. Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice. Cell Metab. 14:528-36
    • (2011) Cell Metab. , vol.14 , pp. 528-536
    • Yoshino, J.1    Mills, K.F.2    Yoon, M.J.3    Imai, S.4
  • 153
    • 84924356420 scopus 로고    scopus 로고
    • The ketone metabolite ?-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
    • Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, et al. 2015. The ketone metabolite ?-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat.Med. 21:263-69
    • (2015) Nat.Med. , vol.21 , pp. 263-269
    • Youm, Y.H.1    Nguyen, K.Y.2    Grant, R.W.3    Goldberg, E.L.4    Bodogai, M.5
  • 154
    • 38449086860 scopus 로고    scopus 로고
    • The ketogenic diet and brain metabolism of amino acids: Relationship to the anticonvulsant effect
    • Yudkoff M, Daikhin Y, Melo TM, Nissim I, Sonnewald U, Nissim I. 2007. The ketogenic diet and brain metabolism of amino acids: Relationship to the anticonvulsant effect. Annu. Rev. Nutr. 27:415-30
    • (2007) Annu. Rev. Nutr. , vol.27 , pp. 415-430
    • Yudkoff, M.1    Daikhin, Y.2    Melo, T.M.3    Nissim, I.4    Sonnewald, U.5    Nissim, I.6
  • 157
    • 84887226066 scopus 로고    scopus 로고
    • Three single nucleotide variants of the HDAC gene are associated with type 2 diabetes mellitus in a Chinese population: A community-based case-control study
    • Zeng Z, Liao R, Yao Z, Zhou W, Ye P, et al. 2014. Three single nucleotide variants of the HDAC gene are associated with type 2 diabetes mellitus in a Chinese population: A community-based case-control study. Gene 533:427-33
    • (2014) Gene , vol.533 , pp. 427-433
    • Zeng, Z.1    Liao, R.2    Yao, Z.3    Zhou, W.4    Ye, P.5
  • 158
    • 79251586531 scopus 로고    scopus 로고
    • Proteomics analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes
    • Zhang D, Yang H, Kong X, Wang K, Mao X, et al. 2011. Proteomics analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes. Am. J. Physiol. Endocrinol. Metab. 300:E287-95
    • (2011) Am. J. Physiol. Endocrinol. Metab. , vol.300 , pp. E287-E295
    • Zhang, D.1    Yang, H.2    Kong, X.3    Wang, K.4    Mao, X.5
  • 159
    • 84965034275 scopus 로고    scopus 로고
    • NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
    • Zhang HB, Ryu D, Wu YB, Gariani K, Wang X, et al. 2016. NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science 352:1436-43
    • (2016) Science , vol.352 , pp. 1436-1443
    • Zhang, H.B.1    Ryu, D.2    Wu, Y.B.3    Gariani, K.4    Wang, X.5
  • 160
    • 84863349101 scopus 로고    scopus 로고
    • Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis
    • Zhang L, Qin X, Zhao Y, Fast L, Zhuang SG, et al. 2012. Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis. J. Pharmacol. Exp. Ther. 341:285-93
    • (2012) J. Pharmacol. Exp. Ther. , vol.341 , pp. 285-293
    • Zhang, L.1    Qin, X.2    Zhao, Y.3    Fast, L.4    Zhuang, S.G.5
  • 161
    • 84881508008 scopus 로고    scopus 로고
    • The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
    • Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, et al. 2012. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. e Life 1:e00065
    • (2012) E Life , vol.1 , pp. e00065
    • Zhang, Y.1    Xie, Y.2    Berglund, E.D.3    Coate, K.C.4    He, T.T.5
  • 162
    • 15044356553 scopus 로고    scopus 로고
    • Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors
    • Zhao Y, Sun H, Lu J, Li X, Chen X, et al. 2005. Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors. J. Exp. Biol. 208:697-705
    • (2005) J. Exp. Biol. , vol.208 , pp. 697-705
    • Zhao, Y.1    Sun, H.2    Lu, J.3    Li, X.4    Chen, X.5
  • 163
    • 35148885660 scopus 로고    scopus 로고
    • Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice
    • Zimmermann S, Kiefer F, Prudenziati M, Spiller C, Hansen J, et al. 2007. Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice. Cancer Res. 67:9047-54
    • (2007) Cancer Res. , vol.67 , pp. 9047-9054
    • Zimmermann, S.1    Kiefer, F.2    Prudenziati, M.3    Spiller, C.4    Hansen, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.