-
1
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
-
Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006;127:1109-1122
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
Geny, B.11
Laakso, M.12
Puigserver, P.13
Auwerx, J.14
-
2
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337-342
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
Pistell, P.J.11
Poosala, S.12
Becker, K.G.13
Boss, O.14
Gwinn, D.15
Wang, M.16
Ramaswamy, S.17
Fishbein, K.W.18
Spencer, R.G.19
Lakatta, E.G.20
Le Couteur, D.21
Shaw, R.J.22
Navas, P.23
Puigserver, P.24
Ingram, D.K.25
de Cabo, R.26
Sinclair, D.A.27
more..
-
3
-
-
31444454037
-
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
-
Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006;439:484-489
-
(2006)
Nature
, vol.439
, pp. 484-489
-
-
Watanabe, M.1
Houten, S.M.2
Mataki, C.3
Christoffolete, M.A.4
Kim, B.W.5
Sato, H.6
Messaddeq, N.7
Harney, J.W.8
Ezaki, O.9
Kodama, T.10
Schoonjans, K.11
Bianco, A.C.12
Auwerx, J.13
-
4
-
-
33744548069
-
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets
-
Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA Jr, Lowell BB. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab 2006;3:417-427
-
(2006)
Cell Metab
, vol.3
, pp. 417-427
-
-
Zhang, C.Y.1
Parton, L.E.2
Ye, C.P.3
Krauss, S.4
Shen, R.5
Lin, C.T.6
Porco Jr, J.A.7
Lowell, B.B.8
-
5
-
-
0037126667
-
The microbiology of butyrate formation in the human colon
-
Pryde SE, Duncan SH, Hold GL, Stewart CS, Flint HJ. The microbiology of butyrate formation in the human colon. FEMS Microbiol Lett 2002;217:133-139
-
(2002)
FEMS Microbiol Lett
, vol.217
, pp. 133-139
-
-
Pryde, S.E.1
Duncan, S.H.2
Hold, G.L.3
Stewart, C.S.4
Flint, H.J.5
-
7
-
-
0038676409
-
Inhibition of histone deacetylase activity by butyrate
-
Davie JR: Inhibition of histone deacetylase activity by butyrate. J Nutr 2003;133:2485S-2493S
-
(2003)
J Nutr
, vol.133
-
-
Davie, J.R.1
-
8
-
-
24144463983
-
Metabolic control through the PGC-1 family of transcription coactivators
-
Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 2005;1:361-370
-
(2005)
Cell Metab
, vol.1
, pp. 361-370
-
-
Lin, J.1
Handschin, C.2
Spiegelman, B.M.3
-
9
-
-
0037102256
-
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
-
Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 2002;418:797-801
-
(2002)
Nature
, vol.418
, pp. 797-801
-
-
Lin, J.1
Wu, H.2
Tarr, P.T.3
Zhang, C.Y.4
Wu, Z.5
Boss, O.6
Michael, L.F.7
Puigserver, P.8
Isotani, E.9
Olson, E.N.10
Lowell, B.B.11
Bassel-Duby, R.12
Spiegelman, B.M.13
-
10
-
-
0032549811
-
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
-
Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998;92:829-839
-
(1998)
Cell
, vol.92
, pp. 829-839
-
-
Puigserver, P.1
Wu, Z.2
Park, C.W.3
Graves, R.4
Wright, M.5
Spiegelman, B.M.6
-
11
-
-
2342477730
-
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
-
Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A 2004;101:6570-6575
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 6570-6575
-
-
Mootha, V.K.1
Handschin, C.2
Arlow, D.3
Xie, X.4
St Pierre, J.5
Sihag, S.6
Yang, W.7
Altshuler, D.8
Puigserver, P.9
Patterson, N.10
Willy, P.J.11
Schulman, I.G.12
Heyman, R.A.13
Lander, E.S.14
Spiegelman, B.M.15
-
12
-
-
0038054341
-
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003;34:267-273
-
(2003)
Nat Genet
, vol.34
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
Eriksson, K.F.3
Subramanian, A.4
Sihag, S.5
Lehar, J.6
Puigserver, P.7
Carlsson, E.8
Ridderstrale, M.9
Laurila, E.10
Houstis, N.11
Daly, M.J.12
Patterson, N.13
Mesirov, J.P.14
Golub, T.R.15
Tamayo, P.16
Spiegelman, B.17
Lander, E.S.18
Hirschhorn, J.N.19
Altshuler, D.20
Groop, L.C.21
more..
-
13
-
-
0038025371
-
Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
-
Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003;300:1140-1142
-
(2003)
Science
, vol.300
, pp. 1140-1142
-
-
Petersen, K.F.1
Befroy, D.2
Dufour, S.3
Dziura, J.4
Ariyan, C.5
Rothman, D.L.6
DiPietro, L.7
Cline, G.W.8
Shulman, G.I.9
-
14
-
-
0037477855
-
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
-
Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJ. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A 2003;100:8466-8471
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8466-8471
-
-
Patti, M.E.1
Butte, A.J.2
Crunkhorn, S.3
Cusi, K.4
Berria, R.5
Kashyap, S.6
Miyazaki, Y.7
Kohane, I.8
Costello, M.9
Saccone, R.10
Landaker, E.J.11
Goldfine, A.B.12
Mun, E.13
DeFronzo, R.14
Finlayson, J.15
Kahn, C.R.16
Mandarino, L.J.17
-
15
-
-
33845989841
-
Inactivation of PKC{theta} leads to increased susceptibility to obesity and dietary insulin resistance in mice
-
Gao Z, Wang Z, Zhang X, Butler AA, Zuberi A, Gawronska-Kozak B, Lefevre M, York D, Ravussin E, Berthoud HR, McGuinness O, Cefalu WT, Ye J. Inactivation of PKC{theta} leads to increased susceptibility to obesity and dietary insulin resistance in mice.. Am J Physiol Endocrinol Metab 2007;292:E84-E91
-
(2007)
Am J Physiol Endocrinol Metab
, vol.292
-
-
Gao, Z.1
Wang, Z.2
Zhang, X.3
Butler, A.A.4
Zuberi, A.5
Gawronska-Kozak, B.6
Lefevre, M.7
York, D.8
Ravussin, E.9
Berthoud, H.R.10
McGuinness, O.11
Cefalu, W.T.12
Ye, J.13
-
16
-
-
35148854599
-
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
-
Ye J, Gao Z, Yin J, He H. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 2007;293:E1118-E1128
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
-
-
Ye, J.1
Gao, Z.2
Yin, J.3
He, H.4
-
17
-
-
0029740336
-
The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: Inhibition of AP1 binding and activation of a silencer element
-
Ye J, Cippitelli M, Dorman L, Ortaldo JR, Young HA. The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silencer element. Mol Cell Biol 1996;16:4744-4753
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4744-4753
-
-
Ye, J.1
Cippitelli, M.2
Dorman, L.3
Ortaldo, J.R.4
Young, H.A.5
-
18
-
-
34249848180
-
A direct method for fatty acid methyl ester synthesis: Application to wet meat tissues, oils, and feedstuffs
-
O'Fallon JV, Busboom JR, Nelson ML, Gaskins CT. A direct method for fatty acid methyl ester synthesis: application to wet meat tissues, oils, and feedstuffs. J Anim Sci 2007;85:1511-1521
-
(2007)
J Anim Sci
, vol.85
, pp. 1511-1521
-
-
O'Fallon, J.V.1
Busboom, J.R.2
Nelson, M.L.3
Gaskins, C.T.4
-
19
-
-
0029666290
-
Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase
-
Schwarz M, Lund EG, Setchell KD, Kayden HJ, Zerwekh JE, Bjorkhem I, Herz J, Russell DW. Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase. J Biol Chem 1996;271:18024-18031
-
(1996)
J Biol Chem
, vol.271
, pp. 18024-18031
-
-
Schwarz, M.1
Lund, E.G.2
Setchell, K.D.3
Kayden, H.J.4
Zerwekh, J.E.5
Bjorkhem, I.6
Herz, J.7
Russell, D.W.8
-
20
-
-
0018646453
-
A role for brown adipose tissue in diet-induced thermogenesis
-
Rothwell NJ, Stock MJ. A role for brown adipose tissue in diet-induced thermogenesis. Nature 1979;281:31-35
-
(1979)
Nature
, vol.281
, pp. 31-35
-
-
Rothwell, N.J.1
Stock, M.J.2
-
21
-
-
0018964918
-
Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis
-
Brooks SL, Rothwell NJ, Stock MJ, Goodbody AE, Trayhurn P. Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis. Nature 1980;286:274-276
-
(1980)
Nature
, vol.286
, pp. 274-276
-
-
Brooks, S.L.1
Rothwell, N.J.2
Stock, M.J.3
Goodbody, A.E.4
Trayhurn, P.5
-
22
-
-
0019440913
-
Brown adipose tissue: Thermic response increased by a single low protein, high carbohydrate meal
-
Glick Z, Teague RJ, Bray GA. Brown adipose tissue: thermic response increased by a single low protein, high carbohydrate meal. Science 1981;213:1125-1127
-
(1981)
Science
, vol.213
, pp. 1125-1127
-
-
Glick, Z.1
Teague, R.J.2
Bray, G.A.3
-
23
-
-
0018766103
-
Reduced thermogenesis in obesity
-
Jung RT, Shetty PS, James WP, Barrand MA, Callingham BA. Reduced thermogenesis in obesity. Nature 1979;279:322-323
-
(1979)
Nature
, vol.279
, pp. 322-323
-
-
Jung, R.T.1
Shetty, P.S.2
James, W.P.3
Barrand, M.A.4
Callingham, B.A.5
-
24
-
-
0037326196
-
Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha): Transcriptional coactivator and metabolic regulator
-
Puigserver P, Spiegelman BM. Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 2003;24:78-90
-
(2003)
Endocr Rev
, vol.24
, pp. 78-90
-
-
Puigserver, P.1
Spiegelman, B.M.2
-
25
-
-
33746328957
-
Signaling pathways in skeletal muscle remodeling
-
Bassel-Duby R, Olson EN. Signaling pathways in skeletal muscle remodeling. Annu Rev Biochem 2006;75:19-37
-
(2006)
Annu Rev Biochem
, vol.75
, pp. 19-37
-
-
Bassel-Duby, R.1
Olson, E.N.2
-
26
-
-
34547545892
-
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
-
Jager S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A 2007;104:12017-12022
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 12017-12022
-
-
Jager, S.1
Handschin, C.2
St-Pierre, J.3
Spiegelman, B.M.4
-
27
-
-
0035859836
-
Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor
-
Knutti D, Kressler D, Kralli A. Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor. Proc Natl Acad Sci U S A 2001;98:9713-9718
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 9713-9718
-
-
Knutti, D.1
Kressler, D.2
Kralli, A.3
-
28
-
-
18244399631
-
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
-
Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell 2001;8:971-982
-
(2001)
Mol Cell
, vol.8
, pp. 971-982
-
-
Puigserver, P.1
Rhee, J.2
Lin, J.3
Wu, Z.4
Yoon, J.C.5
Zhang, C.Y.6
Krauss, S.7
Mootha, V.K.8
Lowell, B.B.9
Spiegelman, B.M.10
-
29
-
-
0037453718
-
Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity
-
Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, Evans RM. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 2003;113:159-170
-
(2003)
Cell
, vol.113
, pp. 159-170
-
-
Wang, Y.X.1
Lee, C.H.2
Tiep, S.3
Yu, R.T.4
Ham, J.5
Kang, H.6
Evans, R.M.7
-
30
-
-
61449183682
-
Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates
-
Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, McManus K, Champagne CM, Bishop LM, Laranjo N, Leboff MS, Rood JC, de Jonge L, Greenway FL, Loria CM, Obarzanek E, Williamson DA. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 2009;360:859-873
-
(2009)
N Engl J Med
, vol.360
, pp. 859-873
-
-
Sacks, F.M.1
Bray, G.A.2
Carey, V.J.3
Smith, S.R.4
Ryan, D.H.5
Anton, S.D.6
McManus, K.7
Champagne, C.M.8
Bishop, L.M.9
Laranjo, N.10
Leboff, M.S.11
Rood, J.C.12
de Jonge, L.13
Greenway, F.L.14
Loria, C.M.15
Obarzanek, E.16
Williamson, D.A.17
-
31
-
-
0038587678
-
PPARgamma coactivator-1alpha expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations
-
Irrcher I, Adhihetty PJ, Sheehan T, Joseph AM, Hood DA. PPARgamma coactivator-1alpha expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations. Am J Physiol Cell Physiol 2003;284:C1669-C1677
-
(2003)
Am J Physiol Cell Physiol
, vol.284
-
-
Irrcher, I.1
Adhihetty, P.J.2
Sheehan, T.3
Joseph, A.M.4
Hood, D.A.5
-
32
-
-
0042423598
-
Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles
-
Suwa M, Nakano H, Kumagai S. Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles. J Appl Physiol 2003;95:960-968
-
(2003)
J Appl Physiol
, vol.95
, pp. 960-968
-
-
Suwa, M.1
Nakano, H.2
Kumagai, S.3
-
33
-
-
0036386911
-
Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle
-
Terada S, Goto M, Kato M, Kawanaka K, Shimokawa T, Tabata I. Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle. Biochem Biophys Res Commun 2002;296:350-354
-
(2002)
Biochem Biophys Res Commun
, vol.296
, pp. 350-354
-
-
Terada, S.1
Goto, M.2
Kato, M.3
Kawanaka, K.4
Shimokawa, T.5
Tabata, I.6
-
34
-
-
0037058977
-
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
-
Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ, Shulman GI. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci U S A 2002;99:15983-15987
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 15983-15987
-
-
Zong, H.1
Ren, J.M.2
Young, L.H.3
Pypaert, M.4
Mu, J.5
Birnbaum, M.J.6
Shulman, G.I.7
-
35
-
-
10744222588
-
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: Modulation by p38 MAPK
-
Fan M, Rhee J, St-Pierre J, Handschin C, Puigserver P, Lin J, Jaeger S, Erdjument-Bromage H, Tempst P, Spiegelman BM. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev 2004;18:278-289
-
(2004)
Genes Dev
, vol.18
, pp. 278-289
-
-
Fan, M.1
Rhee, J.2
St-Pierre, J.3
Handschin, C.4
Puigserver, P.5
Lin, J.6
Jaeger, S.7
Erdjument-Bromage, H.8
Tempst, P.9
Spiegelman, B.M.10
-
36
-
-
0035798668
-
Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase
-
Xi X, Han J, Zhang J-Z: Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase. J Biol Chem 2001;276:41029-41034
-
(2001)
J Biol Chem
, vol.276
, pp. 41029-41034
-
-
Xi, X.1
Han, J.2
Zhang, J.-Z.3
-
37
-
-
0034938816
-
Butyrate impairs energy metabolism in isolated perfused liver of fed rats
-
Beauvieux MC, Tissier P, Gin H, Canioni P, Gallis JL. Butyrate impairs energy metabolism in isolated perfused liver of fed rats. J Nutr 2001;131:1986-1992
-
(2001)
J Nutr
, vol.131
, pp. 1986-1992
-
-
Beauvieux, M.C.1
Tissier, P.2
Gin, H.3
Canioni, P.4
Gallis, J.L.5
|