β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares

Cell Reports

Volumn 18, Issue 9, 2017, Pages 2077-2087

  Goldberg, Emily L ^a   Asher, Jennifer L ^a   Molony, Ryan D ^a   Shaw, Albert C ^a   Zeiss, Caroline J ^a   Wang, Chao ^b   Morozova Roche, Ludmilla A ^b   Herzog, Raimund I ^a   Iwasaki, Akiko ^a,c   Dixit, Vishwa Deep ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UMEÅ UNIVERSITY   (Sweden)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

aging; gout; IL 1; inflammation; neutrophil; NLRP3 inflammasome; hydroxybutyrate

Indexed keywords

3 HYDROXYBUTYRIC ACID; CALGRANULIN B; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; URIC ACID;

ADULT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL ISOLATION; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GOUT; HUMAN; HUMAN EXPERIMENT; IMMUNITY; IN VITRO STUDY; KETOGENIC DIET; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; NORMAL HUMAN; PERITONITIS; RAT; STAPHYLOCOCCUS INFECTION; ADOLESCENT; ANIMAL; C57BL MOUSE; DRUG EFFECTS; INFLAMMATION; METABOLISM; MIDDLE AGED; YOUNG ADULT;

3-HYDROXYBUTYRIC ACID; ADOLESCENT; ADULT; AGED; ANIMALS; DIET, KETOGENIC; FEMALE; GOUT; HUMANS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; NEUTROPHILS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; RATS; URIC ACID; YOUNG ADULT;

EID: 85014089976     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.02.004     Document Type: Article

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