메뉴 건너뛰기




Volumn 37, Issue 6, 2015, Pages 607-611

β-amyloid, microglia, and the inflammasome in Alzheimer’s disease

Author keywords

Alzheimer s disease; Macrophage; Microglia; NLRP3 inflammasome; amyloid

Indexed keywords

AMYLOID BETA PROTEIN; CATHEPSIN B; CD36 ANTIGEN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PURINERGIC P2X7 RECEPTOR; CARRIER PROTEIN; CYTOKINE; NLRP3 PROTEIN, HUMAN;

EID: 84945438257     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-015-0518-0     Document Type: Review
Times cited : (156)

References (61)
  • 1
    • 0023633015 scopus 로고
    • Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR
    • COI: 1:STN:280:DyaL1c%2FjvFKrtg%3D%3D, PID: 3670729
    • McGeer PL et al (1987) Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR. Neurosci Lett 79(1-2):195–200
    • (1987) Neurosci Lett , vol.79 , Issue.1-2 , pp. 195-200
    • McGeer, P.L.1
  • 2
    • 0022504686 scopus 로고
    • Role of microglia in plaque formation in senile dementia of the Alzheimer type. An immunohistochemical study
    • COI: 1:STN:280:DyaL283ptFWnsA%3D%3D, PID: 2874657
    • Rozemuller JM, Eikelenboom P, Stam FC (1986) Role of microglia in plaque formation in senile dementia of the Alzheimer type. An immunohistochemical study. Virchows Arch B Cell Pathol Incl Mol Pathol 51(3):247–54
    • (1986) Virchows Arch B Cell Pathol Incl Mol Pathol , vol.51 , Issue.3 , pp. 247-254
    • Rozemuller, J.M.1    Eikelenboom, P.2    Stam, F.C.3
  • 3
    • 0031974406 scopus 로고    scopus 로고
    • Microglial response to amyloid plaques in APPsw transgenic mice
    • COI: 1:CAS:528:DyaK1cXktlylsw%3D%3D, PID: 9422548
    • Frautschy SA et al (1998) Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol 152(1):307–17
    • (1998) Am J Pathol , vol.152 , Issue.1 , pp. 307-317
    • Frautschy, S.A.1
  • 4
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    • COI: 1:CAS:528:DC%2BD1cXhtVaktLnE, PID: 18701698
    • Hickman SE, Allison EK, El Khoury J (2008) Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci 28(33):8354–60
    • (2008) J Neurosci , vol.28 , Issue.33 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 5
    • 78650031168 scopus 로고    scopus 로고
    • Neurodegeneration and the neuroimmune system
    • PID: 21135838
    • El Khoury J (2010) Neurodegeneration and the neuroimmune system. Nat Med 16(12):1369–70
    • (2010) Nat Med , vol.16 , Issue.12 , pp. 1369-1370
    • El Khoury, J.1
  • 6
    • 79955605102 scopus 로고    scopus 로고
    • Physiology of microglia
    • COI: 1:CAS:528:DC%2BC3MXns1Cms78%3D, PID: 21527731
    • Kettenmann H et al (2011) Physiology of microglia. Physiol Rev 91(2):461–553
    • (2011) Physiol Rev , vol.91 , Issue.2 , pp. 461-553
    • Kettenmann, H.1
  • 7
    • 56349166514 scopus 로고    scopus 로고
    • Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications
    • PID: 18835047
    • El Khoury J, Luster AD (2008) Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends Pharmacol Sci 29(12):626–32
    • (2008) Trends Pharmacol Sci , vol.29 , Issue.12 , pp. 626-632
    • El Khoury, J.1    Luster, A.D.2
  • 8
    • 34147115541 scopus 로고    scopus 로고
    • Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
    • PID: 17351623
    • El Khoury J et al (2007) Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med 13(4):432–8
    • (2007) Nat Med , vol.13 , Issue.4 , pp. 432-438
    • El Khoury, J.1
  • 9
    • 0038204838 scopus 로고    scopus 로고
    • CD36 mediates the innate host response to beta-amyloid
    • PID: 12796468
    • El Khoury JB et al (2003) CD36 mediates the innate host response to beta-amyloid. J Exp Med 197(12):1657–66
    • (2003) J Exp Med , vol.197 , Issue.12 , pp. 1657-1666
    • El Khoury, J.B.1
  • 10
    • 84883361779 scopus 로고    scopus 로고
    • Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression
    • PID: 23799536
    • Frenkel D et al (2013) Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression. Nat Commun 4:2030
    • (2013) Nat Commun , vol.4 , pp. 2030
    • Frenkel, D.1
  • 11
    • 75649087741 scopus 로고    scopus 로고
    • CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
    • COI: 1:CAS:528:DC%2BD1MXhs1SktbvE, PID: 20037584
    • Stewart CR et al (2010) CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol 11(2):155–61
    • (2010) Nat Immunol , vol.11 , Issue.2 , pp. 155-161
    • Stewart, C.R.1
  • 12
    • 47849085872 scopus 로고    scopus 로고
    • The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
    • COI: 1:CAS:528:DC%2BD1cXoslCmu74%3D, PID: 18604209
    • Halle A et al (2008) The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 9(8):857–65
    • (2008) Nat Immunol , vol.9 , Issue.8 , pp. 857-865
    • Halle, A.1
  • 13
    • 84873087532 scopus 로고    scopus 로고
    • NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
    • COI: 1:CAS:528:DC%2BC38XhvV2ntLfM, PID: 23254930
    • Heneka MT et al (2013) NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493(7434):674–8
    • (2013) Nature , vol.493 , Issue.7434 , pp. 674-678
    • Heneka, M.T.1
  • 14
    • 84880777411 scopus 로고    scopus 로고
    • CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
    • COI: 1:CAS:528:DC%2BC3sXhtVaku7vE, PID: 23812099
    • Sheedy FJ et al (2013) CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol 14(8):812–20
    • (2013) Nat Immunol , vol.14 , Issue.8 , pp. 812-820
    • Sheedy, F.J.1
  • 15
    • 0025220976 scopus 로고
    • Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
    • COI: 1:STN:280:DyaK3M3htFyiuw%3D%3D, PID: 2089275
    • Lawson LJ et al (1990) Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39(1):151–70
    • (1990) Neuroscience , vol.39 , Issue.1 , pp. 151-170
    • Lawson, L.J.1
  • 16
    • 84888324248 scopus 로고    scopus 로고
    • The microglial sensome revealed by direct RNA sequencing
    • COI: 1:CAS:528:DC%2BC3sXhs1yhsrnE, PID: 24162652
    • Hickman SE et al (2013) The microglial sensome revealed by direct RNA sequencing. Nat Neurosci 16(12):1896–905
    • (2013) Nat Neurosci , vol.16 , Issue.12 , pp. 1896-1905
    • Hickman, S.E.1
  • 17
    • 0035101188 scopus 로고    scopus 로고
    • Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices
    • COI: 1:STN:280:DC%2BD3M3lvFOgsQ%3D%3D, PID: 11241743
    • Stence N, Waite M, Dailey ME (2001) Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 33(3):256–66
    • (2001) Glia , vol.33 , Issue.3 , pp. 256-266
    • Stence, N.1    Waite, M.2    Dailey, M.E.3
  • 18
    • 0028171374 scopus 로고
    • Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from Parkinsonian patients
    • COI: 1:CAS:528:DyaK2cXmvFygtLk%3D, PID: 7700568
    • Mogi M et al (1994) Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from Parkinsonian patients. Neurosci Lett 180(2):147–50
    • (1994) Neurosci Lett , vol.180 , Issue.2 , pp. 147-150
    • Mogi, M.1
  • 19
    • 79959669857 scopus 로고    scopus 로고
    • Expression profiles of cytokines in the brains of Alzheimer's disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology
    • COI: 1:CAS:528:DC%2BC3MXnsVSitro%3D, PID: 21368376
    • Morimoto K et al (2011) Expression profiles of cytokines in the brains of Alzheimer's disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology. J Alzheimers Dis 25(1):59–76
    • (2011) J Alzheimers Dis , vol.25 , Issue.1 , pp. 59-76
    • Morimoto, K.1
  • 20
    • 33244485505 scopus 로고    scopus 로고
    • Pro- and anti-inflammatory cytokines in the CSF of patients with Creutzfeldt-Jakob disease
    • COI: 1:CAS:528:DC%2BD28XhvVWhu7g%3D, PID: 16330103
    • Stoeck K, Bodemer M, Zerr I (2006) Pro- and anti-inflammatory cytokines in the CSF of patients with Creutzfeldt-Jakob disease. J Neuroimmunol 172(1-2):175–81
    • (2006) J Neuroimmunol , vol.172 , Issue.1-2 , pp. 175-181
    • Stoeck, K.1    Bodemer, M.2    Zerr, I.3
  • 21
    • 0036141148 scopus 로고    scopus 로고
    • CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils
    • COI: 1:CAS:528:DC%2BD38XnvFehsw%3D%3D, PID: 11786404
    • Coraci IS et al (2002) CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. Am J Pathol 160(1):101–12
    • (2002) Am J Pathol , vol.160 , Issue.1 , pp. 101-112
    • Coraci, I.S.1
  • 22
    • 84869178487 scopus 로고    scopus 로고
    • Microglia and neurodegeneration: the role of systemic inflammation
    • PID: 22674585
    • Cunningham C (2013) Microglia and neurodegeneration: the role of systemic inflammation. Glia 61(1):71–90
    • (2013) Glia , vol.61 , Issue.1 , pp. 71-90
    • Cunningham, C.1
  • 23
    • 0035068235 scopus 로고    scopus 로고
    • Repression of proinflammatory cytokine and inducible nitric oxide synthase (NOS2) gene expression in activated microglia by N-acetyl-O-methyldopamine: protein kinase A-dependent mechanism
    • COI: 1:STN:280:DC%2BD3M3jsFOluw%3D%3D, PID: 11246231
    • Cho S et al (2001) Repression of proinflammatory cytokine and inducible nitric oxide synthase (NOS2) gene expression in activated microglia by N-acetyl-O-methyldopamine: protein kinase A-dependent mechanism. Glia 33(4):324–33
    • (2001) Glia , vol.33 , Issue.4 , pp. 324-333
    • Cho, S.1
  • 24
    • 0033982028 scopus 로고    scopus 로고
    • Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia
    • COI: 1:CAS:528:DC%2BD3cXhtlChs7k%3D, PID: 10693932
    • Yates SL et al (2000) Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia. J Neurochem 74(3):1017–25
    • (2000) J Neurochem , vol.74 , Issue.3 , pp. 1017-1025
    • Yates, S.L.1
  • 25
    • 0030879929 scopus 로고    scopus 로고
    • Integrin Mac-1 and beta-amyloid in microglial release of nitric oxide
    • COI: 1:CAS:528:DyaK2sXlslelt70%3D, PID: 9369326
    • Goodwin JL, Kehrli ME Jr, Uemura E (1997) Integrin Mac-1 and beta-amyloid in microglial release of nitric oxide. Brain Res 768(1-2):279–86
    • (1997) Brain Res , vol.768 , Issue.1-2 , pp. 279-286
    • Goodwin, J.L.1    Kehrli, M.E.2    Uemura, E.3
  • 26
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • COI: 1:CAS:528:DC%2BD38XmslyrurY%3D, PID: 12191486
    • Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10(2):417–26
    • (2002) Mol Cell , vol.10 , Issue.2 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 27
    • 31744441475 scopus 로고    scopus 로고
    • Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
    • COI: 1:CAS:528:DC%2BD28XotlGksA%3D%3D, PID: 16429160
    • Boyden ED, Dietrich WF (2006) Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 38(2):240–4
    • (2006) Nat Genet , vol.38 , Issue.2 , pp. 240-244
    • Boyden, E.D.1    Dietrich, W.F.2
  • 28
    • 32944470765 scopus 로고    scopus 로고
    • Cryopyrin activates the inflammasome in response to toxins and ATP
    • COI: 1:CAS:528:DC%2BD28XitFGitLs%3D, PID: 16407890
    • Mariathasan S et al (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440(7081):228–32
    • (2006) Nature , vol.440 , Issue.7081 , pp. 228-232
    • Mariathasan, S.1
  • 29
    • 3142654767 scopus 로고    scopus 로고
    • Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    • COI: 1:CAS:528:DC%2BD2cXlsVGjsrk%3D, PID: 15190255
    • Mariathasan S et al (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430(6996):213–8
    • (2004) Nature , vol.430 , Issue.6996 , pp. 213-218
    • Mariathasan, S.1
  • 30
    • 77951269392 scopus 로고    scopus 로고
    • The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
    • COI: 1:CAS:528:DC%2BC3cXjvFartrs%3D, PID: 20351692
    • Rathinam VA et al (2010) The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol 11(5):395–402
    • (2010) Nat Immunol , vol.11 , Issue.5 , pp. 395-402
    • Rathinam, V.A.1
  • 31
    • 67349271142 scopus 로고    scopus 로고
    • Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
    • COI: 1:CAS:528:DC%2BD1MXjvV2ksLs%3D, PID: 19339971
    • Gross O et al (2009) Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 459(7245):433–6
    • (2009) Nature , vol.459 , Issue.7245 , pp. 433-436
    • Gross, O.1
  • 32
    • 84864600268 scopus 로고    scopus 로고
    • TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria
    • COI: 1:CAS:528:DC%2BC38XhtVOltr3E, PID: 22819539
    • Rathinam VA et al (2012) TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell 150(3):606–19
    • (2012) Cell , vol.150 , Issue.3 , pp. 606-619
    • Rathinam, V.A.1
  • 33
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • COI: 1:CAS:528:DC%2BD28XitFGitLg%3D, PID: 16407889
    • Martinon F et al (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440(7081):237–41
    • (2006) Nature , vol.440 , Issue.7081 , pp. 237-241
    • Martinon, F.1
  • 34
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • COI: 1:CAS:528:DC%2BC3cXltl2mu7w%3D, PID: 20428172
    • Duewell P et al (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464(7293):1357–61
    • (2010) Nature , vol.464 , Issue.7293 , pp. 1357-1361
    • Duewell, P.1
  • 35
    • 84890235827 scopus 로고    scopus 로고
    • The interleukin-1 family: back to the future
    • COI: 1:CAS:528:DC%2BC3sXhvFOhtLfE, PID: 24332029
    • Garlanda C, Dinarello CA, Mantovani A (2013) The interleukin-1 family: back to the future. Immunity 39(6):1003–18
    • (2013) Immunity , vol.39 , Issue.6 , pp. 1003-1018
    • Garlanda, C.1    Dinarello, C.A.2    Mantovani, A.3
  • 36
    • 77953483260 scopus 로고    scopus 로고
    • Age-related neuroinflammatory changes negatively impact on neuronal function
    • PID: 20552057
    • Lynch MA (2010) Age-related neuroinflammatory changes negatively impact on neuronal function. Front Aging Neurosci 1:6
    • (2010) Front Aging Neurosci , vol.1 , pp. 6
    • Lynch, M.A.1
  • 37
    • 70249138036 scopus 로고    scopus 로고
    • Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
    • COI: 1:CAS:528:DC%2BD1MXotFWgt78%3D, PID: 19570822
    • Bauernfeind FG et al (2009) Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 183(2):787–91
    • (2009) J Immunol , vol.183 , Issue.2 , pp. 787-791
    • Bauernfeind, F.G.1
  • 38
    • 70249110860 scopus 로고    scopus 로고
    • Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation
    • COI: 1:CAS:528:DC%2BD1MXotFWgt7w%3D, PID: 19542372
    • Franchi L, Eigenbrod T, Nunez G (2009) Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol 183(2):792–6
    • (2009) J Immunol , vol.183 , Issue.2 , pp. 792-796
    • Franchi, L.1    Eigenbrod, T.2    Nunez, G.3
  • 39
    • 0033574415 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
    • COI: 1:CAS:528:DyaK1MXis1Gntbw%3D, PID: 10196138
    • Chow JC et al (1999) Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274(16):10689–92
    • (1999) J Biol Chem , vol.274 , Issue.16 , pp. 10689-10692
    • Chow, J.C.1
  • 40
    • 84867770402 scopus 로고    scopus 로고
    • Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation
    • COI: 1:CAS:528:DC%2BC38XhsFCjsrvN, PID: 22948162
    • Juliana C et al (2012) Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem 287(43):36617–22
    • (2012) J Biol Chem , vol.287 , Issue.43 , pp. 36617-36622
    • Juliana, C.1
  • 41
    • 34249941913 scopus 로고    scopus 로고
    • Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling
    • COI: 1:CAS:528:DC%2BD2sXmtFSnu74%3D, PID: 17483456
    • Duncan JA et al (2007) Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. Proc Natl Acad Sci U S A 104(19):8041–6
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.19 , pp. 8041-8046
    • Duncan, J.A.1
  • 42
    • 0037077283 scopus 로고    scopus 로고
    • The PYRIN-CARD protein ASC is an activating adaptor for caspase-1
    • COI: 1:CAS:528:DC%2BD38Xkslyqsb8%3D, PID: 11967258
    • Srinivasula SM et al (2002) The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem 277(24):21119–22
    • (2002) J Biol Chem , vol.277 , Issue.24 , pp. 21119-21122
    • Srinivasula, S.M.1
  • 43
    • 84904646033 scopus 로고    scopus 로고
    • The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
    • COI: 1:CAS:528:DC%2BC2cXhtVais7zK, PID: 24952504
    • Baroja-Mazo A et al (2014) The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol 15(8):738–48
    • (2014) Nat Immunol , vol.15 , Issue.8 , pp. 738-748
    • Baroja-Mazo, A.1
  • 44
    • 84904692363 scopus 로고    scopus 로고
    • The adaptor ASC has extracellular and ‘prionoid’ activities that propagate inflammation
    • COI: 1:CAS:528:DC%2BC2cXhtVais7zI, PID: 24952505
    • Franklin BS et al (2014) The adaptor ASC has extracellular and ‘prionoid’ activities that propagate inflammation. Nat Immunol 15(8):727–37
    • (2014) Nat Immunol , vol.15 , Issue.8 , pp. 727-737
    • Franklin, B.S.1
  • 45
    • 84920990887 scopus 로고    scopus 로고
    • Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome
    • COI: 1:CAS:528:DC%2BC2MXhtF2lsbc%3D, PID: 25594175
    • Yan Y et al (2015) Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome. Cell 160(1-2):62–73
    • (2015) Cell , vol.160 , Issue.1-2 , pp. 62-73
    • Yan, Y.1
  • 46
    • 77951880839 scopus 로고    scopus 로고
    • The immunoregulatory role of dopamine: an update
    • COI: 1:CAS:528:DC%2BC3cXkvFKlsrg%3D, PID: 19896530
    • Sarkar C et al (2010) The immunoregulatory role of dopamine: an update. Brain Behav Immun 24(4):525–8
    • (2010) Brain Behav Immun , vol.24 , Issue.4 , pp. 525-528
    • Sarkar, C.1
  • 47
    • 84870508924 scopus 로고    scopus 로고
    • The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
    • COI: 1:CAS:528:DC%2BC38Xhs1Ckt7bP, PID: 23143333
    • Lee GS et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492(7427):123–7
    • (2012) Nature , vol.492 , Issue.7427 , pp. 123-127
    • Lee, G.S.1
  • 48
    • 84924415042 scopus 로고    scopus 로고
    • A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
    • COI: 1:CAS:528:DC%2BC2MXivVSit7g%3D, PID: 25686105
    • Coll RC et al (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med 21(3):248–255
    • (2015) Nat Med , vol.21 , Issue.3 , pp. 248-255
    • Coll, R.C.1
  • 49
    • 0001360461 scopus 로고
    • Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
    • COI: 1:STN:280:DyaK3c%2FhslGhug%3D%3D, PID: 2529544
    • Griffin WS et al (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A 86(19):7611–5
    • (1989) Proc Natl Acad Sci U S A , vol.86 , Issue.19 , pp. 7611-7615
    • Griffin, W.S.1
  • 50
    • 84894283121 scopus 로고    scopus 로고
    • Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10
    • COI: 1:CAS:528:DC%2BC3sXhsleksrjP
    • Murphy N, Grehan B, Lynch MA (2014) Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10. Neuromol Med 16(1):205–15
    • (2014) Neuromol Med , vol.16 , Issue.1 , pp. 205-215
    • Murphy, N.1    Grehan, B.2    Lynch, M.A.3
  • 51
    • 1942422683 scopus 로고    scopus 로고
    • Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release
    • COI: 1:CAS:528:DC%2BD2cXkt1emtL4%3D, PID: 15075209
    • Kahlenberg JM, Dubyak GR (2004) Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. Am J Physiol Cell Physiol 286(5):C1100–8
    • (2004) Am J Physiol Cell Physiol , vol.286 , Issue.5 , pp. 1100-1108
    • Kahlenberg, J.M.1    Dubyak, G.R.2
  • 52
    • 33750601018 scopus 로고    scopus 로고
    • Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus
    • COI: 1:CAS:528:DC%2BD28XhtlWmsL3K, PID: 17086106
    • McLarnon JG et al (2006) Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus. J Neuropathol Exp Neurol 65(11):1090–7
    • (2006) J Neuropathol Exp Neurol , vol.65 , Issue.11 , pp. 1090-1097
    • McLarnon, J.G.1
  • 53
    • 28244459680 scopus 로고    scopus 로고
    • Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis
    • COI: 1:CAS:528:DC%2BD2MXht1ent73F, PID: 16301671
    • Kahlenberg JM et al (2005) Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis. J Immunol 175(11):7611–22
    • (2005) J Immunol , vol.175 , Issue.11 , pp. 7611-7622
    • Kahlenberg, J.M.1
  • 54
    • 0038790267 scopus 로고    scopus 로고
    • Origin and turnover of microglial cells in fibrillar plaques of APPsw transgenic mice
    • PID: 12624793
    • Wegiel J et al (2003) Origin and turnover of microglial cells in fibrillar plaques of APPsw transgenic mice. Acta Neuropathol 105(4):393–402
    • (2003) Acta Neuropathol , vol.105 , Issue.4 , pp. 393-402
    • Wegiel, J.1
  • 55
    • 77954851584 scopus 로고    scopus 로고
    • Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice
    • COI: 1:CAS:528:DC%2BC3cXpsl2jur4%3D, PID: 20660248
    • Lebson L et al (2010) Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. J Neurosci 30(29):9651–8
    • (2010) J Neurosci , vol.30 , Issue.29 , pp. 9651-9658
    • Lebson, L.1
  • 56
    • 0347407828 scopus 로고    scopus 로고
    • CCL2 transgene expression in the central nervous system directs diffuse infiltration of CD45(high)CD11b(+) monocytes and enhanced Theiler's murine encephalomyelitis virus-induced demyelinating disease
    • COI: 1:CAS:528:DC%2BD3sXptVOlsro%3D, PID: 14602575
    • Bennett JL et al (2003) CCL2 transgene expression in the central nervous system directs diffuse infiltration of CD45(high)CD11b(+) monocytes and enhanced Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Neurovirol 9(6):623–36
    • (2003) J Neurovirol , vol.9 , Issue.6 , pp. 623-636
    • Bennett, J.L.1
  • 57
    • 0025900245 scopus 로고
    • Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system
    • COI: 1:STN:280:DyaK3MzjsVCrsw%3D%3D, PID: 1651506
    • Sedgwick JD et al (1991) Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system. Proc Natl Acad Sci U S A 88(16):7438–42
    • (1991) Proc Natl Acad Sci U S A , vol.88 , Issue.16 , pp. 7438-7442
    • Sedgwick, J.D.1
  • 58
    • 78149438403 scopus 로고    scopus 로고
    • Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice
    • PID: 21060874
    • Saederup N et al (2010) Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice. PLoS One 5(10):e13693
    • (2010) PLoS One , vol.5 , Issue.10 , pp. 13693
    • Saederup, N.1
  • 59
    • 84860876124 scopus 로고    scopus 로고
    • Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease
    • COI: 1:CAS:528:DC%2BC38XovFektrs%3D, PID: 22160221
    • Naert G, Rivest S (2012) Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. Mol Med 18:297–313
    • (2012) Mol Med , vol.18 , pp. 297-313
    • Naert, G.1    Rivest, S.2
  • 60
    • 84924737031 scopus 로고    scopus 로고
    • TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models
    • COI: 1:CAS:528:DC%2BC2MXmt12ksL8%3D, PID: 25732305
    • Jay TR et al (2015) TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med 212(3):287–295
    • (2015) J Exp Med , vol.212 , Issue.3 , pp. 287-295
    • Jay, T.R.1
  • 61
    • 84939525561 scopus 로고    scopus 로고
    • Therapeutic effects of glatiramer acetate and grafted CD115+ monocytes in a mouse model of Alzheimer's disease
    • PID: 26049087
    • Koronyo Y et al (2015) Therapeutic effects of glatiramer acetate and grafted CD115+ monocytes in a mouse model of Alzheimer's disease. Brain 138(8):2399–2422
    • (2015) Brain , vol.138 , Issue.8 , pp. 2399-2422
    • Koronyo, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.