Insulin regulates the activity of forkhead transcription factor Hnf-3β/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 20, 2003, Pages 11624-11629

  Wolfrum, Christian ^a   Besser, Daniel ^a   Luca, Edlira ^a   Stoffel, Markus ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Foxo 1; Phosphatidylinositol 3 kinase; Phosphoenolpyruvate carboxykinase

Indexed keywords

FOXA 1 PROTEIN; FOXA 2 PROTEIN; FOXA 3 PROTEIN; HEPATOCYTE NUCLEAR FACTOR 3; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 3GAMMA; INSULIN; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN KINASE B; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOL; EMBRYO; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; LIVER; METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; CELL LINE; CELL NUCLEUS; CYTOSOL; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HUMANS; INSULIN; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

HEXAPODA; MAMMALIA;

EID: 0141705364     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1931483100     Document Type: Article

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