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Volumn 300, Issue 2, 2011, Pages

Proteomics analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes

Author keywords

Diabetic nephropathy; Epithelial tomesenchymal transition; Gene expression; Ketone body

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; 3 HYDROXY 3 METHYLGLUTARYL COENZYME A SYNTHASE 2; 3 HYDROXYBUTYRIC ACID; COLLAGEN TYPE 1; ENZYME; KETONE BODY; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

EID: 79251586531     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00308.2010     Document Type: Article
Times cited : (64)

References (50)
  • 1
    • 12144278197 scopus 로고    scopus 로고
    • Use of genetic mouse models in the study of diabetic nephropathy
    • Allen TJ, Cooper ME, Lan HY. Use of genetic mouse models in the study of diabetic nephropathy. Curr Diab Rep 4: 435-440, 2004. (Pubitemid 40104219)
    • (2004) Current Diabetes Reports , vol.4 , Issue.6 , pp. 435-440
    • Allen, T.J.1    Cooper, M.E.2    Lan, H.Y.3
  • 2
    • 35348903240 scopus 로고    scopus 로고
    • Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice
    • Barati MT, Merchant ML, Kain AB, Jevans AW, McLeish KR, Klein JB. Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice. Am J Physiol Renal Physiol 293: F1157-F1165, 2007.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Barati, M.T.1    Merchant, M.L.2    Kain, A.B.3    Jevans, A.W.4    McLeish, K.R.5    Klein, J.B.6
  • 5
    • 34547559826 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor alpha/ gamma dual agonist tesaglitazar attenuates diabetic nephropathy in db/db mice
    • Cha DR, Zhang X, Zhang Y, Wu J, Su D, Han JY, Fang X, Yu B, Breyer MD, Guan Y. Peroxisome proliferator activated receptor alpha/ gamma dual agonist tesaglitazar attenuates diabetic nephropathy in db/db mice. Diabetes 56: 2036-2045, 2007.
    • (2007) Diabetes , vol.56 , pp. 2036-2045
    • Cha, D.R.1    Zhang, X.2    Zhang, Y.3    Wu, J.4    Su, D.5    Han, J.Y.6    Fang, X.7    Yu, B.8    Breyer, M.D.9    Guan, Y.10
  • 6
    • 0038709727 scopus 로고    scopus 로고
    • 1H NMR spectroscopy of blood plasma metabolites
    • 1H NMR spectroscopy of blood plasma metabolites. Anal Chem 75: 2100-2104, 2003.
    • (2003) Anal Chem , vol.75 , pp. 2100-2104
    • De Graaf, R.A.1    Behar, K.L.2
  • 8
    • 0026651527 scopus 로고
    • Transport of β-hydroxybutyrate and acetoacetate along rat nephrons: A micropuncture study
    • Ferrier B, Martin M, Janbon B, Baverel G. Transport of β-hydroxybutyrate and acetoacetate along rat nephrons: a micropuncture study. Am J Physiol Renal Physiol 262: F762-F769, 1992.
    • (1992) Am J Physiol Renal Physiol , vol.262
    • Ferrier, B.1    Martin, M.2    Janbon, B.3    Baverel, G.4
  • 9
    • 0344083505 scopus 로고    scopus 로고
    • Beta-hydroxybutyrate-induced growth inhibition and collagen production in HK-2 cells are dependent on TGF-beta and Smad3
    • Guh JY, Chuang TD, Chen HC, Hung WC, Lai YH, Shin SJ, Chuang LY. Beta-hydroxybutyrate-induced growth inhibition and collagen production in HK-2 cells are dependent on TGF-beta and Smad3. Kidney Int 64: 2041-2051, 2003.
    • (2003) Kidney Int , vol.64 , pp. 2041-2051
    • Guh, J.Y.1    Chuang, T.D.2    Chen, H.C.3    Hung, W.C.4    Lai, Y.H.5    Shin, S.J.6    Chuang, L.Y.7
  • 10
    • 0033559336 scopus 로고    scopus 로고
    • Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: A control enzyme in ketogenesis
    • Hegardt FG. Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis. Biochem J 338: 569-582, 1999.
    • (1999) Biochem J , vol.338 , pp. 569-582
    • Hegardt, F.G.1
  • 11
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112: 1776-1784, 2003.
    • (2003) J Clin Invest , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 12
    • 0029020259 scopus 로고
    • Two-dimensional electrophoresis of proteins: An updated protocol and implications for a functional analysis of the genome
    • Klose J, Kobalz U. Two-dimensional electrophoresis of proteins: an updated protocol and implications for a functional analysis of the genome. Electrophoresis 16: 1034-1059, 1995.
    • (1995) Electrophoresis , vol.16 , pp. 1034-1059
    • Klose, J.1    Kobalz, U.2
  • 14
    • 0033400713 scopus 로고    scopus 로고
    • Ketone bodies: A review of physiology, pathophysiology and application of monitoring to diabetes
    • Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev 15: 412-426, 1999.
    • (1999) Diabetes Metab Res Rev , vol.15 , pp. 412-426
    • Laffel, L.1
  • 15
    • 0030898474 scopus 로고    scopus 로고
    • Investigation of human hepatic mitochondrial 3-hydroxy-3-methylglutaryl- coenzyme a synthase in postmortem or biopsy tissue
    • Lascelles CV, Quant PA. Investigation of human hepatic mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase in postmortem or biopsy tissue. Clin Chim Acta 260: 85-96, 1997.
    • (1997) Clin Chim Acta , vol.260 , pp. 85-96
    • Lascelles, C.V.1    Quant, P.A.2
  • 16
    • 33745600824 scopus 로고    scopus 로고
    • A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide
    • Li N, Guo R, Li W, Shao J, Li S, Zhao K, Chen X, Xu N, Liu S, Lu Y. A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide. Carcinogenesis 27: 1222-1231, 2006.
    • (2006) Carcinogenesis , vol.27 , pp. 1222-1231
    • Li, N.1    Guo, R.2    Li, W.3    Shao, J.4    Li, S.5    Zhao, K.6    Chen, X.7    Xu, N.8    Liu, S.9    Lu, Y.10
  • 17
    • 0028948686 scopus 로고
    • Molecular cloning and tissue expression of human mitochondrial 3-hydroxy-3-methylglutaryl- CoA synthase
    • Mascaro C, Buesa C, Ortiz JA, Haro D, Hegardt FG. Molecular cloning and tissue expression of human mitochondrial 3-hydroxy-3-methylglutaryl- CoA synthase. Arch Biochem Biophys 317: 385-390, 1995.
    • (1995) Arch Biochem Biophys , vol.317 , pp. 385-390
    • Mascaro, C.1    Buesa, C.2    Ortiz, J.A.3    Haro, D.4    Hegardt, F.G.5
  • 18
    • 11944269692 scopus 로고
    • Renal structure and function in insulin-dependent diabetes mellitus and type I membrano-proliferative glomerulonephritis in humans
    • Mauer SM, Lane P, Hattori M, Fioretto P, Steffes MW. Renal structure and function in insulin-dependent diabetes mellitus and type I membrano- proliferative glomerulonephritis in humans. J Am Soc Nephrol 2: S181-S184, 1992.
    • (1992) J Am Soc Nephrol , vol.2
    • Mauer, S.M.1    Lane, P.2    Hattori, M.3    Fioretto, P.4    Steffes, M.W.5
  • 20
    • 0032403084 scopus 로고    scopus 로고
    • A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARalpha
    • Meertens LM, Miyata KS, Cechetto JD, Rachubinski RA, Capone JP. A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARalpha. EMBO J 17: 6972-6978, 1998.
    • (1998) EMBO J , vol.17 , pp. 6972-6978
    • Meertens, L.M.1    Miyata, K.S.2    Cechetto, J.D.3    Rachubinski, R.A.4    Capone, J.P.5
  • 21
    • 29644435760 scopus 로고    scopus 로고
    • Proteomics and diabetic nephropathy
    • Merchant ML, Klein JB. Proteomics and diabetic nephropathy. Curr Diab Rep 5: 464-469, 2005.
    • (2005) Curr Diab Rep , vol.5 , pp. 464-469
    • Merchant, M.L.1    Klein, J.B.2
  • 22
    • 73949138025 scopus 로고    scopus 로고
    • Newly identified cytoskeletal components are associated with dynamic changes of podocyte foot processes
    • Miao J, Fan Q, Cui Q, Zhang H, Chen L, Wang S, Guan N, Guan Y, Ding J. Newly identified cytoskeletal components are associated with dynamic changes of podocyte foot processes. Nephrol Dial Transplant 24: 3297-3305, 2009.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 3297-3305
    • Miao, J.1    Fan, Q.2    Cui, Q.3    Zhang, H.4    Chen, L.5    Wang, S.6    Guan, N.7    Guan, Y.8    Ding, J.9
  • 23
    • 0037103808 scopus 로고    scopus 로고
    • Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: The role of the forkhead transcription factor FKHRL1
    • Nadal A, Marrero PF, Haro D. Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1. Biochem J 366: 289-297, 2002.
    • (2002) Biochem J , vol.366 , pp. 289-297
    • Nadal, A.1    Marrero, P.F.2    Haro, D.3
  • 24
    • 0016711037 scopus 로고
    • High resolution two-dimensional electrophoresis of proteins
    • O'Farrell PH. High resolution two-dimensional electrophoresis of proteins. J Biol Chem 250: 4007-4021, 1975.
    • (1975) J Biol Chem , vol.250 , pp. 4007-4021
    • O'Farrell, P.H.1
  • 25
    • 0027999518 scopus 로고
    • Transfection of the ketogenic mitochondrial 3-hydroxy-3-methylglutaryl- Coenzyme a synthase cDNA into Mev-1 cells corrects their auxotrophy for mevalonate
    • Ortiz JA, Gil-Gomez G, Casaroli-Marano RP, Vilaro S, Hegardt FG, Haro D. Transfection of the ketogenic mitochondrial 3-hydroxy-3-methylglutaryl- coenzyme A synthase cDNA into Mev-1 cells corrects their auxotrophy for mevalonate. J Biol Chem 269: 28523-28526, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 28523-28526
    • Ortiz, J.A.1    Gil-Gomez, G.2    Casaroli-Marano, R.P.3    Vilaro, S.4    Hegardt, F.G.5    Haro, D.6
  • 27
    • 67649654301 scopus 로고    scopus 로고
    • Diabetes complications and the renin-angiotensin system
    • Perkins BA, Aiello LP, Krolewski AS. Diabetes complications and the renin-angiotensin system. N Engl J Med 361: 83-85, 2009.
    • (2009) N Engl J Med , vol.361 , pp. 83-85
    • Perkins, B.A.1    Aiello, L.P.2    Krolewski, A.S.3
  • 28
    • 33750580307 scopus 로고    scopus 로고
    • Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes
    • Proctor G, Jiang T, Iwahashi M, Wang Z, Li J, Levi M. Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes. Diabetes 55: 2502-2509, 2006.
    • (2006) Diabetes , vol.55 , pp. 2502-2509
    • Proctor, G.1    Jiang, T.2    Iwahashi, M.3    Wang, Z.4    Li, J.5    Levi, M.6
  • 29
    • 0026033227 scopus 로고
    • Control of hepatic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase during the foetal/neonatal transition, suckling and weaning in the rat
    • Quant PA, Robin D, Robin P, Ferre P, Brand MD, Girard J. Control of hepatic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase during the foetal/neonatal transition, suckling and weaning in the rat. Eur J Biochem 195: 449-454, 1991.
    • (1991) Eur J Biochem , vol.195 , pp. 449-454
    • Quant, P.A.1    Robin, D.2    Robin, P.3    Ferre, P.4    Brand, M.D.5    Girard, J.6
  • 30
    • 0024451319 scopus 로고
    • Treatment of rats with glucagon or mannoheptulose increases mitochondrial 3-hydroxy-3-methylglutaryl- CoA synthase activity and decreases succinyl-CoA content in liver
    • Quant PA, Tubbs PK, Brand MD. Treatment of rats with glucagon or mannoheptulose increases mitochondrial 3-hydroxy-3-methylglutaryl- CoA synthase activity and decreases succinyl-CoA content in liver. Biochem J 262: 159-164, 1989.
    • (1989) Biochem J , vol.262 , pp. 159-164
    • Quant, P.A.1    Tubbs, P.K.2    Brand, M.D.3
  • 31
    • 0034608937 scopus 로고    scopus 로고
    • Transforming growth factor beta contributes to progressive diabetic nephropathy
    • Reeves WB, Andreoli TE. Transforming growth factor beta contributes to progressive diabetic nephropathy. Proc Natl Acad Sci USA 97: 7667-7669, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7667-7669
    • Reeves, W.B.1    Andreoli, T.E.2
  • 32
    • 20544437490 scopus 로고    scopus 로고
    • Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells
    • Rhyu DY, Yang Y, Ha H, Lee GT, Song JS, Uh ST, Lee HB. Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. J Am Soc Nephrol 16: 667-675, 2005.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 667-675
    • Rhyu, D.Y.1    Yang, Y.2    Ha, H.3    Lee, G.T.4    Song, J.S.5    Uh, S.T.6    Lee, H.B.7
  • 34
    • 33746371464 scopus 로고    scopus 로고
    • Protection of the kidney by thiazolidinediones: An assessment from bench to bedside
    • Sarafidis PA, Bakris GL. Protection of the kidney by thiazolidinediones: an assessment from bench to bedside. Kidney Int 70: 1223-1233, 2006.
    • (2006) Kidney Int , vol.70 , pp. 1223-1233
    • Sarafidis, P.A.1    Bakris, G.L.2
  • 36
    • 0029924637 scopus 로고    scopus 로고
    • Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
    • Sharma K, Jin Y, Guo J, Ziyadeh FN. Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 45: 522-530, 1996.
    • (1996) Diabetes , vol.45 , pp. 522-530
    • Sharma, K.1    Jin, Y.2    Guo, J.3    Ziyadeh, F.N.4
  • 38
    • 34247533369 scopus 로고    scopus 로고
    • Phenotypic transitions and fibrosis in diabetic nephropathy
    • Simonson MS. Phenotypic transitions and fibrosis in diabetic nephropathy. Kidney Int 71: 846-854, 2007.
    • (2007) Kidney Int , vol.71 , pp. 846-854
    • Simonson, M.S.1
  • 39
    • 55249114365 scopus 로고    scopus 로고
    • Diabetic nephropathy: Important pathophysiologic mechanisms
    • Soldatos G, Cooper ME. Diabetic nephropathy: important pathophysiologic mechanisms. Diab Res Clin Pract 82, Suppl 1: S75-S79, 2008.
    • (2008) Diab Res Clin Pract , vol.82 , Issue.SUPPL. 1
    • Soldatos, G.1    Cooper, M.E.2
  • 41
    • 85056024824 scopus 로고    scopus 로고
    • Proteomic identification and immunolocalization of increased renal calbindin- D28k expression in OVE26 diabetic mice
    • Thongboonkerd V, Zheng S, McLeish KR, Epstein PN, Klein JB. Proteomic identification and immunolocalization of increased renal calbindin- D28k expression in OVE26 diabetic mice. Rev Diabet Stud 2: 19-26, 2005.
    • (2005) Rev Diabet Stud , vol.2 , pp. 19-26
    • Thongboonkerd, V.1    Zheng, S.2    McLeish, K.R.3    Epstein, P.N.4    Klein, J.B.5
  • 42
    • 0027161537 scopus 로고
    • Developmental changes in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in rat liver, intestine and kidney
    • Thumelin S, Forestier M, Girard J, Pegorier JP. Developmental changes in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in rat liver, intestine and kidney. Biochem J 292: 493-496, 1993.
    • (1993) Biochem J , vol.292 , pp. 493-496
    • Thumelin, S.1    Forestier, M.2    Girard, J.3    Pegorier, J.P.4
  • 43
    • 34249681985 scopus 로고    scopus 로고
    • Diabetes-induced changes in the renal cortical proteome assessed with two-dimensional gel electrophoresis and mass spectrometry
    • Tilton RG, Haidacher SJ, Lejeune WS, Zhang X, Zhao Y, Kurosky A, Brasier AR, Denner L. Diabetes-induced changes in the renal cortical proteome assessed with two-dimensional gel electrophoresis and mass spectrometry. Proteomics 7: 1729-1742, 2007.
    • (2007) Proteomics , vol.7 , pp. 1729-1742
    • Tilton, R.G.1    Haidacher, S.J.2    Lejeune, W.S.3    Zhang, X.4    Zhao, Y.5    Kurosky, A.6    Brasier, A.R.7    Denner, L.8
  • 44
    • 0028270687 scopus 로고
    • Overexpression of mitochondrial 3-hydroxy-3-methylglutaryl- CoA synthase in transgenic mice causes hepatic hyperketogenesis
    • Valera A, Pelegrin M, Asins G, Fillat C, Sabater J, Pujol A, Hegardt FG, Bosch F. Overexpression of mitochondrial 3-hydroxy-3-methylglutaryl- CoA synthase in transgenic mice causes hepatic hyperketogenesis. J Biol Chem 269: 6267-6270, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 6267-6270
    • Valera, A.1    Pelegrin, M.2    Asins, G.3    Fillat, C.4    Sabater, J.5    Pujol, A.6    Hegardt, F.G.7    Bosch, F.8
  • 45
    • 23644438916 scopus 로고    scopus 로고
    • Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes
    • Wang Z, Jiang T, Li J, Proctor G, McManaman JL, Lucia S, Chua S, Levi M. Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Diabetes 54: 2328-2335, 2005.
    • (2005) Diabetes , vol.54 , pp. 2328-2335
    • Wang, Z.1    Jiang, T.2    Li, J.3    Proctor, G.4    McManaman, J.L.5    Lucia, S.6    Chua, S.7    Levi, M.8
  • 47
    • 33644675373 scopus 로고    scopus 로고
    • Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells
    • Yang J, Robert CE, Burkhardt BR, Young RA, Wu J, Gao Z, Wolf BA. Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells. Diabetes 54: 3217-3228, 2005.
    • (2005) Diabetes , vol.54 , pp. 3217-3228
    • Yang, J.1    Robert, C.E.2    Burkhardt, B.R.3    Young, R.A.4    Wu, J.5    Gao, Z.6    Wolf, B.A.7
  • 49
    • 36248983781 scopus 로고    scopus 로고
    • Thiazolidinediones: A novel class of drugs for the prevention of diabetic nephropathy?
    • Zheng F, Guan Y. Thiazolidinediones: a novel class of drugs for the prevention of diabetic nephropathy? Kidney Int 72: 1301-1303, 2007.
    • (2007) Kidney Int , vol.72 , pp. 1301-1303
    • Zheng, F.1    Guan, Y.2


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