메뉴 건너뛰기




Volumn 36, Issue 3, 2012, Pages 706-716

HIV latency: Experimental systems and molecular models

Author keywords

Chromatin; Heterochromatin; Latency; Primary latency models; Repression; Virus

Indexed keywords

CD69 ANTIGEN; CHEMOKINE RECEPTOR CCR7; HETEROCHROMATIN PROTEIN 1; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HISTONE H2A; HISTONE H2B; HISTONE H3; HISTONE H4; INTERLEUKIN 2 RECEPTOR ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE; TRANSCRIPTION FACTOR YY1;

EID: 84859373016     PISSN: 01686445     EISSN: 15746976     Source Type: Journal    
DOI: 10.1111/j.1574-6976.2012.00335.x     Document Type: Review
Times cited : (63)

References (54)
  • 1
    • 33748159867 scopus 로고    scopus 로고
    • Effect of SWI/SNF chromatin remodeling complex on HIV-1 Tat activated transcription
    • Agbottah E, Deng L, Dannenberg LO, Pumfery A & Kashanchi F (2006) Effect of SWI/SNF chromatin remodeling complex on HIV-1 Tat activated transcription. Retrovirology 3: 48.
    • (2006) Retrovirology , vol.3 , pp. 48
    • Agbottah, E.1    Deng, L.2    Dannenberg, L.O.3    Pumfery, A.4    Kashanchi, F.5
  • 2
    • 35348929372 scopus 로고    scopus 로고
    • HIV-1 integrates into resting CD4+ T cells even at low inoculums as demonstrated with an improved assay for HIV-1 integration
    • Agosto LM, Yu JJ, Dai J, Kaletsky R, Monie D & O'Doherty U (2007) HIV-1 integrates into resting CD4+ T cells even at low inoculums as demonstrated with an improved assay for HIV-1 integration. Virology 368: 60-72.
    • (2007) Virology , vol.368 , pp. 60-72
    • Agosto, L.M.1    Yu, J.J.2    Dai, J.3    Kaletsky, R.4    Monie, D.5    O'Doherty, U.6
  • 3
    • 0032544559 scopus 로고    scopus 로고
    • Activation of integrated provirus requires histone acetyltransferase. p300 and P/CAF are coactivators for HIV-1 Tat
    • Benkirane M, Chun RF, Xiao H, Ogryzko VV, Howard BH, Nakatani Y & Jeang KT (1998) Activation of integrated provirus requires histone acetyltransferase. p300 and P/CAF are coactivators for HIV-1 Tat. J Biol Chem 273: 24898-24905.
    • (1998) J Biol Chem , vol.273 , pp. 24898-24905
    • Benkirane, M.1    Chun, R.F.2    Xiao, H.3    Ogryzko, V.V.4    Howard, B.H.5    Nakatani, Y.6    Jeang, K.T.7
  • 4
    • 70049090006 scopus 로고    scopus 로고
    • CpG methylation controls reactivation of HIV from latency
    • Blazkova J, Trejbalova K, Gondois-Rey F et al. (2009) CpG methylation controls reactivation of HIV from latency. PLoS Pathog 5: e1000554.
    • (2009) PLoS Pathog , vol.5
    • Blazkova, J.1    Trejbalova, K.2    Gondois-Rey, F.3
  • 5
    • 59449101108 scopus 로고    scopus 로고
    • Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
    • Bosque A & Planelles V (2009) Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells. Blood 113: 58-65.
    • (2009) Blood , vol.113 , pp. 58-65
    • Bosque, A.1    Planelles, V.2
  • 6
    • 0242268402 scopus 로고    scopus 로고
    • Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
    • Brooks DG, Arlen PA, Gao L, Kitchen CM & Zack JA (2003) Identification of T cell-signaling pathways that stimulate latent HIV in primary cells. P Natl Acad Sci USA 100: 12955-12960.
    • (2003) P Natl Acad Sci USA , vol.100 , pp. 12955-12960
    • Brooks, D.G.1    Arlen, P.A.2    Gao, L.3    Kitchen, C.M.4    Zack, J.A.5
  • 8
    • 68349139711 scopus 로고    scopus 로고
    • HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    • Chomont N, El-Far M, Ancuta P et al. (2009) HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 15: 893-900.
    • (2009) Nat Med , vol.15 , pp. 893-900
    • Chomont, N.1    El-Far, M.2    Ancuta, P.3
  • 9
    • 0032490570 scopus 로고    scopus 로고
    • Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines
    • Chun TW, Engel D, Mizell SB, Ehler LA & Fauci AS (1998) Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines. J Exp Med 188: 83-91.
    • (1998) J Exp Med , vol.188 , pp. 83-91
    • Chun, T.W.1    Engel, D.2    Mizell, S.B.3    Ehler, L.A.4    Fauci, A.S.5
  • 10
    • 73249136755 scopus 로고    scopus 로고
    • Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies
    • Colin L & Van Lint C (2009) Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies. Retrovirology 6: 111.
    • (2009) Retrovirology , vol.6 , pp. 111
    • Colin, L.1    Van Lint, C.2
  • 11
    • 0033929108 scopus 로고    scopus 로고
    • The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1
    • Coull JJ, Romerio F, Sun JM et al. (2000) The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1. J Virol 74: 6790-6799.
    • (2000) J Virol , vol.74 , pp. 6790-6799
    • Coull, J.J.1    Romerio, F.2    Sun, J.M.3
  • 12
    • 66149118152 scopus 로고    scopus 로고
    • Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells
    • Dai J, Agosto LM, Baytop C, Yu JJ, Pace MJ, Liszewski MK & O'Doherty U (2009) Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells. J Virol 83: 4528-4537.
    • (2009) J Virol , vol.83 , pp. 4528-4537
    • Dai, J.1    Agosto, L.M.2    Baytop, C.3    Yu, J.J.4    Pace, M.J.5    Liszewski, M.K.6    O'Doherty, U.7
  • 13
    • 79954449481 scopus 로고    scopus 로고
    • Simian immunodeficiency virus macaque models of HIV latency
    • Deere JD, Schinazi RF & North TW (2011) Simian immunodeficiency virus macaque models of HIV latency. Curr Opin HIV AIDS 6: 57-61.
    • (2011) Curr Opin HIV AIDS , vol.6 , pp. 57-61
    • Deere, J.D.1    Schinazi, R.F.2    North, T.W.3
  • 14
    • 33846506800 scopus 로고    scopus 로고
    • Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency
    • du Chene I, Basyuk E, Lin YL et al. (2007) Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency. EMBO J 26: 424-435.
    • (2007) EMBO J , vol.26 , pp. 424-435
    • du Chene, I.1    Basyuk, E.2    Lin, Y.L.3
  • 15
    • 77955660383 scopus 로고    scopus 로고
    • Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription
    • Easley R, Carpio L, Dannenberg L et al. (2010) Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription. Virology 405: 322-333.
    • (2010) Virology , vol.405 , pp. 322-333
    • Easley, R.1    Carpio, L.2    Dannenberg, L.3
  • 17
    • 33744952170 scopus 로고    scopus 로고
    • Transcriptional repression of human immunodeficiency virus type 1 by AP-4
    • Imai K & Okamoto T (2006) Transcriptional repression of human immunodeficiency virus type 1 by AP-4. J Biol Chem 281: 12495-12505.
    • (2006) J Biol Chem , vol.281 , pp. 12495-12505
    • Imai, K.1    Okamoto, T.2
  • 18
    • 77952767617 scopus 로고    scopus 로고
    • Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294
    • Imai K, Togami H & Okamoto T (2010) Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294. J Biol Chem 285: 16538-16545.
    • (2010) J Biol Chem , vol.285 , pp. 16538-16545
    • Imai, K.1    Togami, H.2    Okamoto, T.3
  • 19
    • 35148858784 scopus 로고    scopus 로고
    • c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter
    • Jiang G, Espeseth A, Hazuda DJ & Margolis DM (2007) c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. J Virol 81: 10914-10923.
    • (2007) J Virol , vol.81 , pp. 10914-10923
    • Jiang, G.1    Espeseth, A.2    Hazuda, D.J.3    Margolis, D.M.4
  • 20
    • 0037446948 scopus 로고    scopus 로고
    • HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
    • Jordan A, Bisgrove D & Verdin E (2003) HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J 22: 1868-1877.
    • (2003) EMBO J , vol.22 , pp. 1868-1877
    • Jordan, A.1    Bisgrove, D.2    Verdin, E.3
  • 22
    • 65349193781 scopus 로고    scopus 로고
    • A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression
    • Keedy KS, Archin NM, Gates AT, Espeseth A, Hazuda DJ & Margolis DM (2009) A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression. J Virol 83: 4749-4756.
    • (2009) J Virol , vol.83 , pp. 4749-4756
    • Keedy, K.S.1    Archin, N.M.2    Gates, A.T.3    Espeseth, A.4    Hazuda, D.J.5    Margolis, D.M.6
  • 24
    • 21044451712 scopus 로고    scopus 로고
    • Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription
    • Lewinski MK, Bisgrove D, Shinn P et al. (2005) Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription. J Virol 79: 6610-6619.
    • (2005) J Virol , vol.79 , pp. 6610-6619
    • Lewinski, M.K.1    Bisgrove, D.2    Shinn, P.3
  • 25
    • 0347624643 scopus 로고    scopus 로고
    • Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter
    • Lusic M, Marcello A, Cereseto A & Giacca M (2003) Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. EMBO J 22: 6550-6561.
    • (2003) EMBO J , vol.22 , pp. 6550-6561
    • Lusic, M.1    Marcello, A.2    Cereseto, A.3    Giacca, M.4
  • 26
    • 77950482945 scopus 로고    scopus 로고
    • Memory CD4 T cells: generation, reactivation and re-assignment
    • MacLeod MK, Kappler JW & Marrack P (2010) Memory CD4 T cells: generation, reactivation and re-assignment. Immunology 130: 10-15.
    • (2010) Immunology , vol.130 , pp. 10-15
    • MacLeod, M.K.1    Kappler, J.W.2    Marrack, P.3
  • 27
    • 33746021681 scopus 로고    scopus 로고
    • The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter
    • Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M & Verdin E (2006) The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. J Biol Chem 281: 19960-19968.
    • (2006) J Biol Chem , vol.281 , pp. 19960-19968
    • Mahmoudi, T.1    Parra, M.2    Vries, R.G.3    Kauder, S.E.4    Verrijzer, C.P.5    Ott, M.6    Verdin, E.7
  • 28
    • 1842733449 scopus 로고    scopus 로고
    • HP1 and the dynamics of heterochromatin maintenance
    • Maison C & Almouzni G (2004) HP1 and the dynamics of heterochromatin maintenance. Nat Rev Mol Cell Biol 5: 296-304.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 296-304
    • Maison, C.1    Almouzni, G.2
  • 29
    • 20244374692 scopus 로고    scopus 로고
    • COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells
    • Marban C, Redel L, Suzanne S et al. (2005) COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells. Nucleic Acids Res 33: 2318-2331.
    • (2005) Nucleic Acids Res , vol.33 , pp. 2318-2331
    • Marban, C.1    Redel, L.2    Suzanne, S.3
  • 30
    • 33846536395 scopus 로고    scopus 로고
    • Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing
    • Marban C, Suzanne S, Dequiedt F et al. (2007) Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing. EMBO J 26: 412-423.
    • (2007) EMBO J , vol.26 , pp. 412-423
    • Marban, C.1    Suzanne, S.2    Dequiedt, F.3
  • 31
    • 71849085382 scopus 로고    scopus 로고
    • An in vitro system to model the establishment and reactivation of HIV-1 latency
    • Marini A, Harper JM & Romerio F (2008) An in vitro system to model the establishment and reactivation of HIV-1 latency. J Immunol 181: 7713-7720.
    • (2008) J Immunol , vol.181 , pp. 7713-7720
    • Marini, A.1    Harper, J.M.2    Romerio, F.3
  • 32
    • 2542482697 scopus 로고    scopus 로고
    • Control of T cell viability
    • Marrack P & Kappler J (2004) Control of T cell viability. Annu Rev Immunol 22: 765-787.
    • (2004) Annu Rev Immunol , vol.22 , pp. 765-787
    • Marrack, P.1    Kappler, J.2
  • 33
    • 15044348013 scopus 로고    scopus 로고
    • Role of acetylases and deacetylase inhibitors in IRF-1-mediated HIV-1 long terminal repeat transcription
    • Marsili G, Remoli AL, Sgarbanti M & Battistini A (2004) Role of acetylases and deacetylase inhibitors in IRF-1-mediated HIV-1 long terminal repeat transcription. Ann N Y Acad Sci 1030: 636-643.
    • (2004) Ann N Y Acad Sci , vol.1030 , pp. 636-643
    • Marsili, G.1    Remoli, A.L.2    Sgarbanti, M.3    Battistini, A.4
  • 34
  • 35
    • 0037236203 scopus 로고    scopus 로고
    • Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes
    • Messi M, Giacchetto I, Nagata K, Lanzavecchia A, Natoli G & Sallusto F (2003) Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes. Nat Immunol 4: 78-86.
    • (2003) Nat Immunol , vol.4 , pp. 78-86
    • Messi, M.1    Giacchetto, I.2    Nagata, K.3    Lanzavecchia, A.4    Natoli, G.5    Sallusto, F.6
  • 36
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time
    • Perelson AS, Neumann AU, Markowitz M, Leonard JM & Ho DD (1996) HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 271: 1582-1586.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 37
    • 0031301825 scopus 로고    scopus 로고
    • Dynamics of HIV-1 and CD4+ lymphocytes in vivo
    • Perelson AS, Essunger P & Ho DD (1997a) Dynamics of HIV-1 and CD4+ lymphocytes in vivo. AIDS 11(Suppl A): S17-S24.
    • (1997) AIDS , vol.11 , Issue.SUPPL A
    • Perelson, A.S.1    Essunger, P.2    Ho, D.D.3
  • 38
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy
    • Perelson AS, Essunger P, Cao Y et al. (1997b) Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387: 188-191.
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1    Essunger, P.2    Cao, Y.3
  • 39
    • 0036340605 scopus 로고    scopus 로고
    • Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection
    • Pierson TC, Zhou Y, Kieffer TL, Ruff CT, Buck C & Siliciano RF (2002) Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection. J Virol 76: 8518-8531.
    • (2002) J Virol , vol.76 , pp. 8518-8531
    • Pierson, T.C.1    Zhou, Y.2    Kieffer, T.L.3    Ruff, C.T.4    Buck, C.5    Siliciano, R.F.6
  • 40
    • 82455219436 scopus 로고    scopus 로고
    • Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency
    • Rafati H, Parra M, Hakre S, Moshkin Y, Verdin E & Mahmoudi T (2011) Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency. PLoS Biol 9: e1001206.
    • (2011) PLoS Biol , vol.9
    • Rafati, H.1    Parra, M.2    Hakre, S.3    Moshkin, Y.4    Verdin, E.5    Mahmoudi, T.6
  • 41
    • 80054827869 scopus 로고    scopus 로고
    • Transcriptional and epigenetic mechanisms of addiction
    • Robison AJ & Nestler EJ (2011) Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci 12: 623-637.
    • (2011) Nat Rev Neurosci , vol.12 , pp. 623-637
    • Robison, A.J.1    Nestler, E.J.2
  • 42
    • 33750608725 scopus 로고    scopus 로고
    • A novel in vitro system to generate and study latently HIV-infected long-lived normal CD4+ T-lymphocytes
    • Sahu GK, Lee K, Ji J, Braciale V, Baron S & Cloyd MW (2006) A novel in vitro system to generate and study latently HIV-infected long-lived normal CD4+ T-lymphocytes. Virology 355: 127-137.
    • (2006) Virology , vol.355 , pp. 127-137
    • Sahu, G.K.1    Lee, K.2    Ji, J.3    Braciale, V.4    Baron, S.5    Cloyd, M.W.6
  • 43
    • 39649100240 scopus 로고    scopus 로고
    • CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency
    • Saleh S, Solomon A, Wightman F, Xhilaga M, Cameron PU & Lewin SR (2007) CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency. Blood 110: 4161-4164.
    • (2007) Blood , vol.110 , pp. 4161-4164
    • Saleh, S.1    Solomon, A.2    Wightman, F.3    Xhilaga, M.4    Cameron, P.U.5    Lewin, S.R.6
  • 44
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    • Siliciano JD, Kajdas J, Finzi D et al. (2003) Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med 9: 727-728.
    • (2003) Nat Med , vol.9 , pp. 727-728
    • Siliciano, J.D.1    Kajdas, J.2    Finzi, D.3
  • 45
    • 27644599799 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuli
    • Swiggard WJ, Baytop C, Yu JJ et al. (2005) Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuli. J Virol 79: 14179-14188.
    • (2005) J Virol , vol.79 , pp. 14179-14188
    • Swiggard, W.J.1    Baytop, C.2    Yu, J.J.3
  • 46
    • 33646130853 scopus 로고    scopus 로고
    • Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter
    • Treand C, du Chene I, Bres V, Kiernan R, Benarous R, Benkirane M & Emiliani S (2006) Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter. EMBO J 25: 1690-1699.
    • (2006) EMBO J , vol.25 , pp. 1690-1699
    • Treand, C.1    du Chene, I.2    Bres, V.3    Kiernan, R.4    Benarous, R.5    Benkirane, M.6    Emiliani, S.7
  • 47
    • 37149031062 scopus 로고    scopus 로고
    • CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency
    • Tyagi M & Karn J (2007) CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency. EMBO J 26: 4985-4995.
    • (2007) EMBO J , vol.26 , pp. 4985-4995
    • Tyagi, M.1    Karn, J.2
  • 48
    • 77953313393 scopus 로고    scopus 로고
    • Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction
    • Tyagi M, Pearson RJ & Karn J (2010) Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction. J Virol 84: 6425-6437.
    • (2010) J Virol , vol.84 , pp. 6425-6437
    • Tyagi, M.1    Pearson, R.J.2    Karn, J.3
  • 49
    • 0029919356 scopus 로고    scopus 로고
    • Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation
    • Van Lint C, Emiliani S, Ott M & Verdin E (1996) Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J 15: 1112-1120.
    • (1996) EMBO J , vol.15 , pp. 1112-1120
    • Van Lint, C.1    Emiliani, S.2    Ott, M.3    Verdin, E.4
  • 50
    • 13744259064 scopus 로고    scopus 로고
    • IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
    • Wang FX, Xu Y, Sullivan J et al. (2005) IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART. J Clin Invest 115: 128-137.
    • (2005) J Clin Invest , vol.115 , pp. 128-137
    • Wang, F.X.1    Xu, Y.2    Sullivan, J.3
  • 51
    • 30444431914 scopus 로고    scopus 로고
    • NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation
    • Williams SA, Chen LF, Kwon H, Ruiz-Jarabo CM, Verdin E & Greene WC (2006) NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J 25: 139-149.
    • (2006) EMBO J , vol.25 , pp. 139-149
    • Williams, S.A.1    Chen, L.F.2    Kwon, H.3    Ruiz-Jarabo, C.M.4    Verdin, E.5    Greene, W.C.6
  • 52
    • 70449377960 scopus 로고    scopus 로고
    • Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation
    • Yang HC, Xing S, Shan L et al. (2009) Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation. J Clin Invest 119: 3473-3486.
    • (2009) J Clin Invest , vol.119 , pp. 3473-3486
    • Yang, H.C.1    Xing, S.2    Shan, L.3
  • 53
    • 50249107532 scopus 로고    scopus 로고
    • HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells
    • Yoder A, Yu D, Dong L et al. (2008) HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell 134: 782-792.
    • (2008) Cell , vol.134 , pp. 782-792
    • Yoder, A.1    Yu, D.2    Dong, L.3
  • 54
    • 0025342694 scopus 로고
    • HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure
    • Zack JA, Arrigo SJ, Weitsman SR, Go AS, Haislip A & Chen IS (1990) HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61: 213-222.
    • (1990) Cell , vol.61 , pp. 213-222
    • Zack, J.A.1    Arrigo, S.J.2    Weitsman, S.R.3    Go, A.S.4    Haislip, A.5    Chen, I.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.