Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation

Epigenetics

Volumn 4, Issue 6, 2009, Pages 399-403

  Madiraju, Padma ^a,c   Pande, Shri V ^a   Prentki, Marc ^b   Madiraju, S R Murthy ^a,b  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Acetyl CoA; Acetylcarnitine; ATP citrate lyase; Carnitine; Carnitine acetyltransferase; Carnitine acylcarnitine translocase; Histone acetylation; Mitochondria; Primary fibroblasts

Indexed keywords

MAMMALIA;

EID: 73449116731     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.4.6.9767     Document Type: Article

References (19)

1. Gallinari P, Di Marco S, Jones P, Pallaoro M, Steinkuhler C. HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics. Cell Res 2007; 17:195-211.
2. Santoso B, Kadonaga JT. Reconstitution of chromatin transcription with purified components reveals a chromatin-specific repressive activity of p300. Nat Struct Mol Biol 2006; 13:131-9.
3. Takahashi H, McCaffery JM, Irizarry RA, Boeke JD. Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell 2006; 23:207-17.
4. Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 2009; 324:1076-80.
5. Murthy MS, Pande SV. Mechanism of carnitine acylcarnitine translocase-catalyzed import of acylcarnitines into mitochondria. J Biol Chem 1984; 259:9082-9.
6. Stanley CA, Hale DE, Berry GT, Deleeuw S, Boxer J, Bonnefont JP. Brief report: a deficiency of carnitine-acylcarnitine translocase in the inner mitochondrial membrane. N Engl J Med 1992; 327:19-23.
7. Murthy MS, Ramsay RR, Pande SV. Acyl-CoA chain length affects the specificity of various carnitine palmitoyltransferases with respect to carnitine analogues. Possible application in the discrimination of different carnitine palmitoyltransferase activities. Biochem J 1990; 267:273-6.
8. Parvin R, Goswami T, Pande SV. Inhibition of mitochondrial carnitine-acylcarnitine translocase by sulfobetaines. Can J Biochem 1980; 58:822-30.
9. Pande SV, Parvin R. Pyruvate and acetoacetate transport in mitochondria. A reappraisal. J Biol Chem 1978; 253:1565-73.
10. Rubio-Gozalbo ME, Bakker JA, Waterham HR, Wanders RJ. Carnitine-acylcarnitine translocase deficiency, clinical, biochemical and genetic aspects. Mol Aspects Med 2004; 25:521-32.
11. Corti O, DiDonato S, Finocchiaro G. Divergent sequences in the 5′ region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations. Biochem J 1994; 303:37-41.
12. Rathmell JC, Newgard CB. Biochemistry. A glucose-to-gene link. Science 2009; 324:1021-2.
13. Pearson DJ, Tubbs PK. Carnitine and derivatives in rat tissues. Biochem J 1967; 105:953-63.
14. Olnes MI, Kurl RN. Isolation of nuclear extracts from fragile cells: a simplified procedure applied to thymocytes. BioTechniques 1994; 17:828-9.
15. Kutney SN, Hong R, Macfarlan T, Chakravarti D. A signaling role of histone-binding proteins and INHAT subunits pp32 and Set/TAF-Ibeta in integrating chromatin hypoacetylation and transcriptional repression. J Biol Chem 2004; 279:30850-5.
16. Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D. Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. Cell 2001; 104:119-30.
17. Widnell CC, Tata JR. A procedure for the isolation of enzymically active rat-liver nuclei. Biochem J 1964; 92:313-7.
18. Graham JM, Ford T, Rickwood D. Isolation of the major subcellular organelles from mouse liver using Nycodenz gradients without the use of an ultracentrifuge. Anal Biochem 1990; 187:318-23.
19. Parvin R, Pande SV. Microdetermination of (-)carnitine and carnitine acetyltransferase activity. Anal Biochem 1977; 79:190-201.