Differential tissue and ligand-dependent signaling of GPR109A receptor: Implications for anti-atherosclerotic therapeutic potential

Cellular Signalling

Volumn 25, Issue 10, 2013, Pages 2003-2016

  Gaidarov, Ibragim ^a   Chen, Xiaohua ^a   Anthony, Todd ^a   Maciejewski Lenoir, Dominique ^a   Liaw, Chen ^a   Unett, David J ^a  

^a ARENA PHARMACEUTICALS   (United States)

Author keywords

ABCA1; Atherosclerosis; Biased signaling; GPR109A; Macrophage; Niacin

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; ADENYLATE CYCLASE; CALCIUM ION; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GPR109A RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINIC ACID; PROSTANOID; UNCLASSIFIED DRUG;

ADIPOCYTE; ANTIATHEROSCLEROTIC ACTIVITY; ARTICLE; CALCIUM SIGNALING; CELL DIFFERENTIATION; CHOLESTEROL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LANGERHANS CELL; LIGAND BINDING; MACROPHAGE; PRIMARY CELL CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ABCA1; ATHEROSCLEROSIS; BIASED SIGNALING; GPR109A; MACROPHAGE; NIACIN;

ADIPOCYTES; ATHEROSCLEROSIS; ATP BINDING CASSETTE TRANSPORTER 1; ATP-BINDING CASSETTE TRANSPORTERS; CALCIUM SIGNALING; CHOLESTEROL; HUMANS; LANGERHANS CELLS; LIGANDS; MAP KINASE SIGNALING SYSTEM; NIACIN; ORGAN SPECIFICITY; PROSTAGLANDINS; PYRAZOLES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC; SIGNAL TRANSDUCTION; TETRAZOLES;

EID: 84880142494     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.06.008     Document Type: Article

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