Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease

Frontiers in Physiology

Volumn 5 JUL, Issue , 2014, Pages

  Dedkova, Elena N ^a   Blatter, Lothar A ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cardiovascular disease; Heart failure; Inorganic polyphosphate; Mitochondrial permeability transition pore; Poly hydroxybutyrate; Hydroxybutyrate

Indexed keywords

3 HYDROXYBUTYRATE DEHYDROGENASE; 3 HYDROXYBUTYRIC ACID; ACETYL COENZYME A; AMPHOPHILE; CALCIUM ION; INDUCIBLE NITRIC OXIDE SYNTHASE; KETONE BODY; LIPOSOME; POLY(3 HYDROXYBUTYRIC ACID); POLYPHOSPHATE;

APOPTOSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD CLOTTING; BONE DEVELOPMENT; BONE MINERALIZATION; CANCER CELL; CARDIOVASCULAR DISEASE; CELL PROLIFERATION; ENERGY METABOLISM; ENERGY RESOURCE; ENZYME ACTIVITY; FEEDBACK SYSTEM; HEART MUSCLE CELL; HISTOPATHOLOGY; HUMAN; INFLAMMATION; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINE FLORA; ION TRANSPORT; KETOACIDOSIS; LIPID BILAYER; MACROPHAGE; MAMMAL CELL; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PHOSPHATE METABOLISM; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

EID: 84904383437     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2014.00260     Document Type: Article

References (225)

1. Abramov, A.Y., Fraley, C., Diao, C.T., Winkfein, R., Colicos, M.A., Duchen, M.R., French, R.J., and Pavlov, E. (2007). Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death. Proc Natl Acad Sci U S A 104, 18091-18096. doi: 0708959104 [pii] 10.1073/pnas.0708959104
2. Al-Zaid, N.S., Dashti, H.M., Mathew, T.C., and Juggi, J.S. (2007). Low carbohydrate ketogenic diet enhances cardiac tolerance to global ischaemia. Acta Cardiol 62, 381-389
3. Anderson, A.J., and Dawes, E.A. (1990). Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates. Microbiol Rev 54, 450-472
4. Aneja, P., Dziak, R., Cai, G.Q., and Charles, T.C. (2002). Identification of an acetoacetyl coenzyme A synthetase-dependent pathway for utilization of L-(+)-3-hydroxybutyrate in Sinorhizobium meliloti. J Bacteriol 184, 1571-1577
5. Arnlov, J., Carlsson, A.C., Sundstrom, J., Ingelsson, E., Larsson, A., Lind, L., and Larsson, T.E. (2013). Serum FGF23 and risk of cardiovascular events in relation to mineral metabolism and cardiovascular pathology. Clin J Am Soc Nephrol 8, 781-786. doi: CJN.09570912 [pii]10.2215/CJN.09570912
6. Aschar-Sobbi, R., Abramov, A.Y., Diao, C., Kargacin, M.E., Kargacin, G.J., French, R.J., and Pavlov, E. (2008). High sensitivity, quantitative measurements of polyphosphate using a new DAPI-based approach. J Fluoresc 18, 859-866. doi: 10.1007/s10895-008-0315-4
7. Azarashvili, T., Odinokova, I., Bakunts, A., Ternovsky, V., Krestinina, O., Tyynela, J., and Saris, N.E. (2013). Potential role of subunit c of FF-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening. Cell Calcium. doi: S0143-4160(13)00155-3 [pii] 10.1016/j.ceca.2013.12.002
8. Bahnson, B.J. (2004). An atomic-resolution mechanism of 3-hydroxy-3-methylglutaryl-CoA synthase. Proc Natl Acad Sci U S A 101, 16399-16400. doi: 0407418101 [pii] 10.1073/pnas.0407418101
9. Best, T.H., Franz, D.N., Gilbert, D.L., Nelson, D.P., and Epstein, M.R. (2000). Cardiac complications in pediatric patients on the ketogenic diet. Neurology 54, 2328-2330
10. Bondarenko, A.I., Jean-Quartier, C., Malli, R., and Graier, W.F. (2013). Characterization of distinct single-channel properties of Ca(2)(+) inward currents in mitochondria Pflugers Arch 465, 997-1010. doi: 10.1007/s00424-013-1224-1
11. Bonora, M., Bononi, A., De Marchi, E., Giorgi, C., Lebiedzinska, M., Marchi, S., Patergnani, S., Rimessi, A., Suski, J.M., Wojtala, A., Wieckowski, M.R., Kroemer, G., Galluzzi, L., and Pinton, P. (2013). Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition. Cell Cycle 12, 674-683 doi: 23599 [pii] 10.4161/cc.23599
12. Bonting, C.F., Kortstee, G.J., and Zehnder, A.J. (1991). Properties of polyphosphate: AMP phosphotransferase of Acinetobacter strain 210A. J Bacteriol 173, 6484-6488
13. Brown, M.R., and Kornberg, A. (2004). Inorganic polyphosphate in the origin and survival of species. Proc Natl Acad Sci U S A 101, 16085-16087. doi: 0406909101 [pii] 10.1073/pnas.0406909101
14. Brown, M.R., and Kornberg, A. (2008). The long and short of it - polyphosphate, PPK and bacterial survival. Trends Biochem Sci 33, 284-290. doi: S0968-0004(08)00088-1 [pii] 10.1016/j.tibs.2008.04.005
15. Cahill, G.F., Jr. (1970). Starvation in man. N Engl J Med 282, 668-675. doi: 10.1056/NEJM197003192821209
16. Cahill, G.F., Jr. (2006). Fuel metabolism in starvation. Annu Rev Nutr 26, 1-22. doi: 10.1146/annurev.nutr.26.061505.111258
17. Cahill, G.F., Jr., and Veech, R.L. (2003). Ketoacids? Good medicine? Trans Am Clin Climatol Assoc 114, 149-161; discussion 162-143
18. Cao, C., Yudin, Y., Bikard, Y., Chen, W., Liu, T., Li, H., Jendrossek, D., Cohen, A., Pavlov, E., Rohacs, T., and Zakharian, E. (2013). Polyester modification of the mammalian TRPM8 channel protein: implications for structure and function. Cell Rep 4, 302-315. doi: S2211-1247(13)00314-8 [pii] 10.1016/j.celrep.2013.06.022
19. Castuma, C.E., Huang, R., Kornberg, A., and Reusch, R.N. (1995). Inorganic polyphosphates in the acquisition of competence in Escherichia coli. J Biol Chem 270, 12980-12983
20. Chance, B., Schoener, B., Oshino, R., Itshak, F., and Nakase, Y. (1979). Oxidationreduction ratio studies of mitochondria in freeze-trapped samples. NADH and flavoprotein fluorescence signals. J Biol Chem 254, 4764-4771
21. Choi, S.H., Smith, S.A., and Morrissey, J.H. (2011). Polyphosphate is a cofactor for the activation of factor XI by thrombin. Blood 118, 6963-6970. doi: blood-2011-07-368811 [pii] 10.1182/blood-2011-07-368811
22. Chuang, Y.M., Belchis, D.A., and Karakousis, P.C. (2013). The polyphosphate kinase gene ppk2 is required for Mycobacterium tuberculosis inorganic polyphosphate regulation and virulence. MBio 4, e00039-00013. doi: mBio.00039-13 [pii] 10.1128/mBio.00039-13
23. Civitelli, R., and Ziambaras, K. (2011). Calcium and phosphate homeostasis: concerted interplay of new regulators. J Endocrinol Invest 34, 3-7
24. Clarke, K., Tchabanenko, K., Pawlosky, R., Carter, E., Knight, N.S., Murray, A.J., Cochlin, L.E., King, M.T., Wong, A.W., Roberts, A., Robertson, J., and Veech, R.L. (2012a). Oral 28-day and developmental toxicity studies of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate. Regul Toxicol Pharmacol 63, 196-208. doi: S0273-2300(12)00065-7 [pii] 10.1016/j.yrtph.2012.04.001
25. Clarke, K., Tchabanenko, K., Pawlosky, R., Carter, E., Todd King, M., Musa-Veloso, K., Ho, M., Roberts, A., Robertson, J., Vanitallie, T.B., and Veech, R.L. (2012b) Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects. Regul Toxicol Pharmacol 63, 401-408. doi: S0273-2300(12)00080-3 [pii] 10.1016/j.yrtph.2012.04.008
26. Cotter, D.G., Schugar, R.C., and Crawford, P.A. (2013). Ketone body metabolism and cardiovascular disease. Am J Physiol Heart Circ Physiol 304, H1060-1076. doi: ajpheart.00646.2012 [pii]10.1152/ajpheart.00646.2012
27. Cowling, R.T., and Birnboim, H.C. (1994). Incorporation of [32P]orthophosphate into inorganic polyphosphates by human granulocytes and other human cell types. J Biol Chem 269, 9480-9485
28. Crawford, P.A., Crowley, J.R., Sambandam, N., Muegge, B.D., Costello, E.K., Hamady, M., Knight, R., and Gordon, J.I. (2009). Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation. Proc Natl Acad Sci U S A 106, 11276-11281. doi: 0902366106 [pii] 10.1073/pnas.0902366106
29. Crooke, E., Akiyama, M., Rao, N.N., and Kornberg, A. (1994). Genetically altered levels of inorganic polyphosphate in Escherichia coli. J Biol Chem 269, 6290-6295
30. Das, S., Lengweiler, U.D., Seebach, D., and Reusch, R.N. (1997). Proof for a nonproteinaceous calcium-selective channel in Escherichia coli by total synthesis from (R)-3-hydroxybutanoic acid and inorganic polyphosphate. Proc Natl Acad Sci U S A 94, 9075-9079
31. Dashti, H.M., Mathew, T.C., Khadada, M., Al-Mousawi, M., Talib, H., Asfar, S.K., Behbahani, A.I., and Al-Zaid, N.S. (2007). Beneficial effects of ketogenic diet in obese diabetic subjects. Mol Cell Biochem 302, 249-256. doi: 10.1007/s11010-007-9448-z
32. Dawes, E.A., and Senior, P.J. (1973). The role and regulation of energy reserve polymers in micro-organisms. Adv Microb Physiol 10, 135-266
33. Dedkova, E.N., Seidlmayer, L.K., and Blatter, L.A. (2013). Mitochondria-mediated cardioprotection by trimetazidine in rabbit heart failure. J Mol Cell Cardiol 59, 41-54. doi: S0022-2828(13)00054-0 [pii] 10.1016/j.yjmcc.2013.01.016
34. Doepner, B., Thierfelder, S., Hirche, H., and Benndorf, K. (1997). 3-hydroxybutyrate blocks the transient K+ outward current in myocardial mouse cells in a stereoselective fashion. J Physiol 500 (Pt 1), 85-94
35. Doi, K., Kubo, T., Takeshita, R., Kajihara, S., Kato, S., Kawazoe, Y., Shiba, T., and Akagawa, Y. (2014). Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: an animal study. Dent Mater J 33, 179-186. doi: DN/JST.JSTAGE/dmj/2013-275 [pii]
36. Du, Z., Shen, A., Huang, Y., Su, L., Lai, W., Wang, P., Xie, Z., Zeng, Q., Ren, H., and Xu, D. (2014). 1H-NMR-based metabolic analysis of human serum reveals novel markers of myocardial energy expenditure in heart failure patients. PLoS One 9, e88102. doi: 10.1371/journal.pone.0088102 PONE-D-13-44927 [pii]
37. Duan, R.D. (2006). Alkaline sphingomyelinase: an old enzyme with novel implications Biochim Biophys Acta 1761, 281-291. doi: S1388-1981(06)00068-0 [pii]10.1016/j.bbalip.2006.03.007
38. Elustondo, P., Zakharian, E., and Pavlov, E. (2012). Identification of the polyhydroxybutyrate granules in mammalian cultured cells. Chem Biodivers 9, 2597-2604. doi: 10.1002/cbdv.201200294
39. Elustondo, P.A., Angelova, P.R., Kawalec, M., Michalak, M., Kurcok, P., Abramov, A.Y., and Pavlov, E.V. (2013a). Polyhydroxybutyrate targets mammalian mitochondria and increases permeability of plasmalemmal and mitochondrial membranes. PLoS One 8, e75812. doi: 10.1371/journal.pone.0075812 PONE-D-13-06819 [pii]
40. Elustondo, P.A., Cohen, A.M., Kawalec, M., Michalak, M., Dedkova, E.N., Kurchok, P., and Pavlov, E. (2013b). Polyhydroxybutyrate Derivative Induces Cyclosporin a Sensitive Mitochondrial Depolarization in Mammalian Cultured Cells Biophysical Journal 104 660a
41. Fillipovich, S.Y., Afanasieva, T.P., Barchurina, G.P., and Kritskii, M.S. (2000). ATP and polyphosphate-dependent bacterial NAD+-kinases. Appl Biochem Microbiol (Mosc) 36, 117-121
42. Forsey, R.G., Reid, K., and Brosnan, J.T. (1987). Competition between fatty acids and carbohydrate or ketone bodies as metabolic fuels for the isolated perfused heart Can J Physiol Pharmacol 65, 401-406
43. Freedland, S.J., Mavropoulos, J., Wang, A., Darshan, M., Demark-Wahnefried, W., Aronson, W.J., Cohen, P., Hwang, D., Peterson, B., Fields, T., Pizzo, S.V., and Isaacs, W.B. (2008). Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. Prostate 68, 11-19. doi: 10.1002/pros.20683
44. Galizzi, M., Bustamante, J.M., Fang, J., Miranda, K., Soares Medeiros, L.C., Tarleton, R.L., and Docampo, R. (2013). Evidence for the role of vacuolar soluble pyrophosphatase and inorganic polyphosphate in Trypanosoma cruzi persistence Mol Microbiol 90, 699-715. doi: 10.1111/mmi.12392
45. Gan, X.T., Ettinger, G., Huang, C.X., Burton, J.P., Haist, J.V., Rajapurohitam, V., Sidaway, J.E., Martin, G., Gloor, G.B., Swann, J.R., Reid, G., and Karmazyn, M (2014). Probiotic Administration Attenuates Myocardial Hypertrophy and Heart Failure Following Myocardial Infarction in the Rat. Circ Heart Fail. doi: CIRCHEARTFAILURE.113.000978 [pii] 10.1161/CIRCHEARTFAILURE.113.000978
46. Gandhi, S., Wood-Kaczmar, A., Yao, Z., Plun-Favreau, H., Deas, E., Klupsch, K., Downward, J., Latchman, D.S., Tabrizi, S.J., Wood, N.W., Duchen, M.R., and Abramov, A.Y. (2009). PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell 33, 627-638. doi: S1097-2765(09)00129-4 [pii] 10.1016/j.molcel.2009.02.013
47. Gezelius, K., Felter, S., and Stahl, A. (1973). [Polyphosphates during multicellular development of Dictyostelium discoideum]. C R Acad Sci Hebd Seances Acad Sci D 276, 117-119
48. Giorgio, V., Von Stockum, S., Antoniel, M., Fabbro, A., Fogolari, F., Forte, M., Glick, G.D., Petronilli, V., Zoratti, M., Szabo, I., Lippe, G., and Bernardi, P. (2013) Dimers of mitochondrial ATP synthase form the permeability transition pore Proceedings of the National Academy of Sciences of the United States of America 110, 5887-5892. doi: 10.1073/pnas.1217823110
49. Gomez-Garcia, M.R., and Kornberg, A. (2004). Formation of an actin-like filament concurrent with the enzymatic synthesis of inorganic polyphosphate. Proc Natl Acad Sci U S A 101, 15876-15880. doi: 0406923101 [pii] 10.1073/pnas.0406923101
50. Gray, M.J., Wholey, W.Y., Wagner, N.O., Cremers, C.M., Mueller-Schickert, A., Hock, N.T., Krieger, A.G., Smith, E.M., Bender, R.A., Bardwell, J.C., and Jakob, U (2014). Polyphosphate is a primordial chaperone. Mol Cell 53, 689-699. doi: S1097-2765(14)00073-2 [pii] 10.1016/j.molcel.2014.01.012
51. Grynpas, M.D., Pilliar, R.M., Kandel, R.A., Renlund, R., Filiaggi, M., and Dumitriu, M (2002). Porous calcium polyphosphate scaffolds for bone substitute applications in vivo studies. Biomaterials 23, 2063-2070
52. Hacchou, Y., Uematsu, T., Ueda, O., Usui, Y., Uematsu, S., Takahashi, M., Uchihashi, T., Kawazoe, Y., Shiba, T., Kurihara, S., Yamaoka, M., and Furusawa, K. (2007) Inorganic polyphosphate: a possible stimulant of bone formation. J Dent Res 86, 893-897. doi: 86/9/893 [pii]
53. Halestrap, A.P. (2012). The monocarboxylate transporter family--Structure and functional characterization. IUBMB Life 64, 1-9. doi: 10.1002/iub.573
54. Halestrap, A.P., and Wilson, M.C. (2012). The monocarboxylate transporter family--role and regulation. IUBMB Life 64, 109-119. doi: 10.1002/iub.572
55. Han, K.Y., Hong, B.S., Yoon, Y.J., Yoon, C.M., Kim, Y.K., Kwon, Y.G., and Gho, Y.S (2007). Polyphosphate blocks tumour metastasis via anti-angiogenic activity Biochem J 406, 49-55. doi: BJ20061542 [pii] 10.1042/BJ20061542
56. Harada, K., Shiba, T., Doi, K., Morita, K., Kubo, T., Makihara, Y., Piattelli, A., and Akagawa, Y. (2013). Inorganic polyphosphate suppresses lipopolysaccharideinduced inducible nitric oxide synthase (iNOS) expression in macrophages. PLoS One 8, e74650. doi: 10.1371/journal.pone.0074650 PONE-D-12-38712 [pii]
57. Haynes, V., Elfering, S.L., Squires, R.J., Traaseth, N., Solien, J., Ettl, A., and Giulivi, C (2003). Mitochondrial nitric-oxide synthase: role in pathophysiology. IUBMB Life 55, 599-603
58. Hernandez-Ruiz, L., Gonzalez-Garcia, I., Castro, C., Brieva, J.A., and Ruiz, F.A. (2006) Inorganic polyphosphate and specific induction of apoptosis in human plasma cells. Haematologica 91, 1180-1186
59. Holmstrom, K.M., Marina, N., Baev, A.Y., Wood, N.W., Gourine, A.V., and Abramov, A.Y. (2013). Signalling properties of inorganic polyphosphate in the mammalian brain. Nat Commun 4, 1362. doi: ncomms2364 [pii] 10.1038/ncomms2364
60. Hron, W.T., Menahan, L.A., and Lech, J.J. (1978). Inhibition of hormonal stimulation of lipolysis in perfused rat heart by ketone bodies. J Mol Cell Cardiol 10, 161-174 doi: 0022-2828(78)90040-8 [pii]
61. Hsieh, P.C., Shenoy, B.C., Jentoft, J.E., and Phillips, N.F. (1993). Purification of polyphosphate and ATP glucose phosphotransferase from Mycobacterium tuberculosis H37Ra: evidence that poly(P) and ATP glucokinase activities are catalyzed by the same enzyme. Protein Expr Purif 4, 76-84. doi: S1046-5928(83)71012-0 [pii] 10.1006/prep.1993.1012
62. Huang, R., and Reusch, R.N. (1995). Genetic competence in Escherichia coli requires poly-beta-hydroxybutyrate/calcium polyphosphate membrane complexes and certain divalent cations. J Bacteriol 177, 486-490
63. Huang, R., and Reusch, R.N. (1996). Poly(3-hydroxybutyrate) is associated with specific proteins in the cytoplasm and membranes of Escherichia coli. J Biol Chem 271, 22196-22202
64. Hugo, S.E., Cruz-Garcia, L., Karanth, S., Anderson, R.M., Stainier, D.Y., and Schlegel, A. (2012). A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting. Genes Dev 26, 282-293. doi: 26/3/282 [pii] 10.1101/gad.180968.111
65. Huser, J., Rechenmacher, C.E., and Blatter, L.A. (1998). Imaging the permeability pore transition in single mitochondria. Biophys J 74, 2129-2137
66. Ichas, F., Jouaville, L.S., and Mazat, J.P. (1997). Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell 89, 1145-1153
67. Ichas, F., and Mazat, J.P. (1998). From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state. Biochim Biophys Acta 1366, 33-50
68. Janardhan, A., Chen, J., and Crawford, P.A. (2011). Altered systemic ketone body metabolism in advanced heart failure. Tex Heart Inst J 38, 533-538
69. Jean-Quartier, C., Bondarenko, A.I., Alam, M.R., Trenker, M., Waldeck-Weiermair, M., Malli, R., and Graier, W.F. (2012). Studying mitochondrial Ca(2+) uptake - a revisit. Mol Cell Endocrinol 353, 114-127. doi: S0303-7207(11)00650-2 [pii] 10.1016/j.mce.2011.10.033
70. Jendrossek, D. (2009). Polyhydroxyalkanoate granules are complex subcellular organelles (carbonosomes). J Bacteriol 191, 3195-3202. doi: JB.01723-08 [pii] 10.1128/JB.01723-08
71. Jeoung, N.H., Rahimi, Y., Wu, P., Lee, W.N., and Harris, R.A. (2012). Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice Biochem J 443, 829-839. doi: BJ20112197 [pii] 10.1042/BJ20112197
72. Jimenez-Nunez, M.D., Moreno-Sanchez, D., Hernandez-Ruiz, L., Benitez-Rondan, A., Ramos-Amaya, A., Rodriguez-Bayona, B., Medina, F., Brieva, J.A., and Ruiz, F.A. (2012). Myeloma cells contain high inorganic polyphosphate levels that are associated with nucleolar transcription. Haematologica. doi: haematol.2011.051409 [pii] 10.3324/haematol.2011.051409
73. Kane, D.A., and Pavlov, E.V. (2013). Calculation of ion currents across the inner membrane of functionally intact mitochondria. Channels (Austin) 7, 426-431. doi: 26290 [pii] 10.4161/chan.26290
74. Karp, H.J., Kemi, V.E., Lamberg-Allardt, C.J., and Karkkainen, M.U. (2012). Mono- and polyphosphates have similar effects on calcium and phosphorus metabolism in healthy young women. Eur J Nutr 52, 991-996. doi: 10.1007/s00394-012-0406-5
75. Kashiwaya, Y., Sato, K., Tsuchiya, N., Thomas, S., Fell, D.A., Veech, R.L., and Passonneau, J.V. (1994). Control of glucose utilization in working perfused rat heart. The Journal of biological chemistry 269, 25502-25514
76. Kashiwaya, Y., Takeshima, T., Mori, N., Nakashima, K., Clarke, K., and Veech, R.L (2000). D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proc Natl Acad Sci U S A 97, 5440-5444. doi: 97/10/5440 [pii]
77. Kawai, S., Mori, S., Mukai, T., Hashimoto, W., and Murata, K. (2001). Molecular characterization of Escherichia coli NAD kinase. Eur J Biochem 268, 4359-4365 doi: ejb2358 [pii]
78. Kawai, S., Mori, S., Mukai, T., Suzuki, S., Yamada, T., Hashimoto, W., and Murata, K (2000). Inorganic Polyphosphate/ATP-NAD kinase of Micrococcus flavus and Mycobacterium tuberculosis H37Rv. Biochem Biophys Res Commun 276, 57-63 doi: 10.1006/bbrc.2000.3433 S0006-291X(00)93433-8 [pii]
79. Kawai, S., and Murata, K. (2008). Structure and function of NAD kinase and NADP phosphatase: key enzymes that regulate the intracellular balance of NAD(H) and NADP(H). Biosci Biotechnol Biochem 72, 919-930. doi: JST.JSTAGE/bbb/70738 [pii]
80. Kawazoe, Y., Katoh, S., Onodera, Y., Kohgo, T., Shindoh, M., and Shiba, T. (2008) Activation of the FGF signaling pathway and subsequent induction of mesenchymal stem cell differentiation by inorganic polyphosphate. Int J Biol Sci 4, 37-47
81. Kawazoe, Y., Shiba, T., Nakamura, R., Mizuno, A., Tsutsumi, K., Uematsu, T., Yamaoka, M., Shindoh, M., and Kohgo, T. (2004). Induction of calcification in MC3T3-E1 cells by inorganic polyphosphate. J Dent Res 83, 613-618. doi: 83/8/613 [pii]
82. Kersten, S., Desvergne, B., and Wahli, W. (2000). Roles of PPARs in health and disease Nature 405, 421-424. doi: 10.1038/35013000
83. Kim, D., and Cavanaugh, E.J. (2007). Requirement of a soluble intracellular factor for activation of transient receptor potential A1 by pungent chemicals: role of inorganic polyphosphates. J Neurosci 27, 6500-6509. doi: 27/24/6500 [pii] 10.1523/JNEUROSCI.0623-07.2007
84. Kim, Y., Moon, J.S., Lee, K.S., Park, S.Y., Cheong, J., Kang, H.S., Lee, H.Y., and Kim, H.D. (2004). Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates the expression of iNOS through IKK and NF-kappaB activity in LPSstimulated mouse peritoneal macrophages and RAW 264.7 cells. Biochem Biophys Res Commun 314, 695-703. doi: S0006291X03027256 [pii]
85. Kimura, I., Inoue, D., Maeda, T., Hara, T., Ichimura, A., Miyauchi, S., Kobayashi, M., Hirasawa, A., and Tsujimoto, G. (2011). Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc Natl Acad Sci U S A 108, 8030-8035. doi: 1016088108 [pii]10.1073/pnas.1016088108
86. Kinnally, K.W., Zorov, D., Antonenko, Y., and Perini, S. (1991). Calcium modulation of mitochondrial inner membrane channel activity. Biochem Biophys Res Commun 176, 1183-1188
87. Kirichok, Y., Krapivinsky, G., and Clapham, D.E. (2004). The mitochondrial calcium uniporter is a highly selective ion channel. Nature 427, 360-364
88. Kornberg, A. (1995). Inorganic polyphosphate: toward making a forgotten polymer unforgettable. J Bacteriol 177, 491-496
89. Kornberg, A., Rao, N.N., and Ault-Riche, D. (1999). Inorganic polyphosphate: a molecule of many functions. Annu Rev Biochem 68, 89-125. doi: 10.1146/annurev.biochem.68.1.89
90. Krebs, H.A., and Veech, R.L. (1969). Equilibrium relations between pyridine nucleotides and adenine nucleotides and their roles in the regulation of metabolic processes Adv Enzyme Regul 7, 397-413
91. Krebs, P., Fan, W., Chen, Y.H., Tobita, K., Downes, M.R., Wood, M.R., Sun, L., Li, X., Xia, Y., Ding, N., Spaeth, J.M., Moresco, E.M., Boyer, T.G., Lo, C.W., Yen, J., Evans, R.M., and Beutler, B. (2011). Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proc Natl Acad Sci U S A 108, 19678-19682. doi: 1117835108 [pii] 10.1073/pnas.1117835108
92. Kulaev, I., Vagabov, V., and Kulakovskaya, T. (1999a). New aspects of inorganic polyphosphate metabolism and function. J Biosci Bioeng 88, 111-129. doi: S1389-1723(99)80189-3 [pii]
93. Kulaev, I.S. (1979). The Biochemistry of Inorganic Polyphosphates. New York: John Wiley and Sons
94. Kulaev, I.S., Kulakovskaya, T.V., Andreeva, N.A., and Lichko, L.P. (1999b) Metabolism and function of polyphosphates in bacteria and yeast. Prog Mol Subcell Biol 23, 27-43
95. Kulaev, I.S., Vagabov, V., and Kulakovskaya, T. (2004). The Biochemistry of Inorganic Polyphosphates. John Wiley & Sons, Ltd
96. Kulakovskaya, T., and Kulaev, I. (2013). Enzymes of inorganic polyphosphate metabolism. Prog Mol Subcell Biol 54, 39-63. doi: 10.1007/978-3-642-41004-8_3
97. Kumble, K.D., and Kornberg, A. (1995). Inorganic polyphosphate in mammalian cells and tissues. J Biol Chem 270, 5818-5822
98. Kumble, K.D., and Kornberg, A. (1996). Endopolyphosphatases for long chain inorganic polyphosphate in yeast and mammals. J Biol Chem 271, 27146-27151
99. Kunau, W.H., Dommes, V., and Schulz, H. (1995). beta-oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: a century of continued progress. Prog Lipid Res 34, 267-342. doi: 0163782795000119 [pii]
100. Kupari, M., Lommi, J., Ventila, M., and Karjalainen, U. (1995). Breath acetone in congestive heart failure. Am J Cardiol 76, 1076-1078. doi: S000291499980304X [pii]
101. Kurihara, M., Akama, Y., and Kimura, J. (2012). Inhibitory effect of beta-hydroxybutyric acid on L-type Ca(2+) current under beta-adrenergic stimulation in guinea pig cardiac ventricular myocytes. Fukushima J Med Sci 58, 144-150. doi: DN/JST.JSTAGE/fms/58.144 [pii]
102. Laffel, L. (1999). Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev 15, 412-426. doi: 10.1002/(SICI)1520-7560(199911/12)15:6<412::AID-DMRR72>3.0.CO;2-8 [pii]
103. Lam, V., Moulder, J.E., Salzman, N.H., Dubinsky, E.A., Andersen, G.L., and Baker, J.E (2012). Intestinal microbiota as novel biomarkers of prior radiation exposure Radiat Res 177, 573-583. doi: 10.1667/RR2691.1 [pii]
104. Lammerant, J., Huynh-Thu, T., and Kolanowski, J. (1985). Inhibitory effects of the D(-)isomer of 3-hydroxybutyrate on cardiac non-esterified fatty acid uptake and oxygen demand induced by norepinephrine in the intact dog. J Mol Cell Cardiol 17, 421-433. doi: S0022-2828(85)80141-3 [pii]
105. Landis, W.J., Hauschka, B.T., Rogerson, C.A., and Glimcher, M.J. (1977). Electron microscopic observations of bone tissue prepared by ultracryomicrotomy. J Ultrastruct Res 59, 185-206
106. Lebovitz, H.E. (1995). Diabetic ketoacidosis. Lancet 345, 767-772. doi: S0140-6736(95)90645-2 [pii]
107. Lehninger, A.L., Sudduth, H.C., and Wise, J.B. (1960). D-beta-Hydroxybutyric dehydrogenase of muitochondria. J Biol Chem 235, 2450-2455
108. Leyhausen, G., Lorenz, B., Zhu, H., Geurtsen, W., Bohnensack, R., Muller, W.E., and Schroder, H.C. (1998). Inorganic polyphosphate in human osteoblast-like cells. J Bone Miner Res 13, 803-812. doi: 10.1359/jbmr.1998.13.5.803
109. Liedtke, A.J., Nellis, S.H., and Whitesell, L.F. (1982). Effects of regional ischemia on metabolic function in adjacent aerobic myocardium. J Mol Cell Cardiol 14, 195-205. doi: 0022-2828(82)90189-4 [pii]
110. Lommi, J., Koskinen, P., Naveri, H., Harkonen, M., and Kupari, M. (1997). Heart failure ketosis. J Intern Med 242, 231-238
111. Lommi, J., Kupari, M., Koskinen, P., Naveri, H., Leinonen, H., Pulkki, K., and Harkonen, M. (1996). Blood ketone bodies in congestive heart failure. J Am Coll Cardiol 28, 665-672. doi: 0735-1097(96)00214-8 [pii]
112. Lopaschuk, G.D., Belke, D.D., Gamble, J., Itoi, T., and Schonekess, B.O. (1994) Regulation of fatty acid oxidation in the mammalian heart in health and disease Biochim Biophys Acta 1213, 263-276
113. Lopaschuk, G.D., Ussher, J.R., Folmes, C.D., Jaswal, J.S., and Stanley, W.C. (2010) Myocardial fatty acid metabolism in health and disease. Physiol Rev 90, 207-258 doi: 90/1/207 [pii] 10.1152/physrev.00015.2009
114. Lorenz, B., and Schroder, H.C. (2001). Mammalian intestinal alkaline phosphatase acts as highly active exopolyphosphatase. Biochim Biophys Acta 1547, 254-261. doi: S0167483801001935 [pii]
115. Magnusson, I., Schumann, W.C., Bartsch, G.E., Chandramouli, V., Kumaran, K., Wahren, J., and Landau, B.R. (1991). Noninvasive tracing of Krebs cycle metabolism in liver. J Biol Chem 266, 6975-6984
116. Marin-Neto, J.A., Cunha-Neto, E., Maciel, B.C., and Simoes, M.V. (2007). Pathogenesis of chronic Chagas heart disease. Circulation 115, 1109-1123. doi: 115/9/1109 [pii] 10.1161/CIRCULATIONAHA.106.624296
117. Marks, A.R., Mcintyre, J.O., Duncan, T.M., Erdjument-Bromage, H., Tempst, P., and Fleischer, S. (1992). Molecular cloning and characterization of (R)-3-hydroxybutyrate dehydrogenase from human heart. J Biol Chem 267, 15459-15463
118. Mayr, M., Yusuf, S., Weir, G., Chung, Y.L., Mayr, U., Yin, X., Ladroue, C., Madhu, B., Roberts, N., De Souza, A., Fredericks, S., Stubbs, M., Griffiths, J.R., Jahangiri, M., Xu, Q., and Camm, A.J. (2008). Combined metabolomic and proteomic analysis of human atrial fibrillation. J Am Coll Cardiol 51, 585-594. doi: S0735-1097(07)03611-X [pii] 10.1016/j.jacc.2007.09.055
119. Mcdaniel, S.S., Rensing, N.R., Thio, L.L., Yamada, K.A., and Wong, M. (2011). The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway Epilepsia 52, e7-11. doi: 10.1111/j.1528-1167.2011.02981.x
120. Mcgarry, J.D., and Foster, D.W. (1980). Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem 49, 395-420. doi: 10.1146/annurev.bi.49.070180.002143
121. Merritt, M.E., Harrison, C., Sherry, A.D., Malloy, C.R., and Burgess, S.C. (2011). Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance. Proc Natl Acad Sci U S A 108, 19084-19089. doi: 1111247108 [pii] 10.1073/pnas.1111247108
122. Moreno-Sanchez, D., Hernandez-Ruiz, L., Ruiz, F.A., and Docampo, R. (2012) Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes. J Biol Chem 287, 28435-28444. doi: M112.385823 [pii] 10.1074/jbc.M112.385823
123. Morimoto, D., Tomita, T., Kuroda, S., Higuchi, C., Kato, S., Shiba, T., Nakagami, H., Morishita, R., and Yoshikawa, H. (2010). Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells. J Bone Miner Metab 28, 418-423. doi: 10.1007/s00774-010-0157-4
124. Morrissey, J.H. (2012). Polyphosphate: a link between platelets, coagulation and inflammation. Int J Hematol 95, 346-352. doi: 10.1007/s12185-012-1054-5
125. Morrissey, J.H., Choi, S.H., and Smith, S.A. (2012). Polyphosphate: an ancient molecule that links platelets, coagulation and inflammation. Blood. doi: blood-2012-03-306605 [pii] 10.1182/blood-2012-03-306605
126. Muller, F., Mutch, N.J., Schenk, W.A., Smith, S.A., Esterl, L., Spronk, H.M., Schmidbauer, S., Gahl, W.A., Morrissey, J.H., and Renne, T. (2009). Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell 139, 1143-1156. doi: S0092-8674(09)01374-9 [pii] 10.1016/j.cell.2009.11.001
127. Murray, A.J., Anderson, R.E., Watson, G.C., Radda, G.K., and Clarke, K. (2004) Uncoupling proteins in human heart. Lancet 364, 1786-1788
128. Murshed, M., Harmey, D., Millan, J.L., Mckee, M.D., and Karsenty, G. (2005). Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev 19, 1093-1104. doi: gad.1276205 [pii] 10.1101/gad.1276205
129. Mutch, N.J., Engel, R., Uitte De Willige, S., Philippou, H., and Ariens, R.A. (2010a) Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin. Blood 115, 3980-3988. doi: blood-2009-11-254029 [pii] 10.1182/blood-2009-11-254029
130. Mutch, N.J., Myles, T., Leung, L.L., and Morrissey, J.H. (2010b). Polyphosphate binds with high affinity to exosite II of thrombin. J Thromb Haemost 8, 548-555. doi: JTH3723 [pii] 10.1111/j.1538-7836.2009.03723.x
131. Negoda, A., Negoda, E., and Reusch, R.N. (2010). Importance of oligo-R-3-hydroxybutyrates to S. lividans KcsA channel structure and function. Mol Biosyst 6, 2249-2255. doi: 10.1039/c0mb00092b
132. Norris, V., Bresson-Dumont, H., Gardea, E., Reusch, R.N., and Gruber, D. (2009) Hypothesis: poly-(R)-3-hydroxybutyrate is a major factor in intraocular pressure Med Hypotheses 73, 398-401. doi: S0306-9877(09)00237-0 [pii] 10.1016/j.mehy.2008.10.036
133. Nuti, M.P., De Bertoldi, M., and Lepidi, A.A. (1972). Influence of phenylacetic acid on poly-beta-hydroxybutyrate (PHB) polymerization and cell elongation in Azotobacter chroococcum Beij. Can J Microbiol 18, 1257-1261
134. Offermanns, S., Colletti, S.L., Lovenberg, T.W., Semple, G., Wise, A., and Ap, I.J (2011). International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B). Pharmacol Rev 63, 269-290. doi: pr.110.003301 [pii] 10.1124/pr.110.003301
135. Ohashi, K., Kawai, S., and Murata, K. (2012). Identification and characterization of a human mitochondrial NAD kinase. Nat Commun 3, 1248. doi: ncomms2262 [pii] 10.1038/ncomms2262
136. Omelon, S., Georgiou, J., Henneman, Z.J., Wise, L.M., Sukhu, B., Hunt, T., Wynnyckyj, C., Holmyard, D., Bielecki, R., and Grynpas, M.D. (2009). Control of vertebrate skeletal mineralization by polyphosphates. PLoS One 4, e5634. doi: 10.1371/journal.pone.0005634
137. Opie, L.H. (2004). The metabolic vicious cycle in heart failure. Lancet 364, 1733-1734
138. Owen, O.E., Morgan, A.P., Kemp, H.G., Sullivan, J.M., Herrera, M.G., and Cahill, G.F., Jr. (1967). Brain metabolism during fasting. J Clin Invest 46, 1589-1595. doi: 10.1172/JCI105650
139. Palmieri, V., Roman, M.J., Bella, J.N., Liu, J.E., Best, L.G., Lee, E.T., Howard, B.V., and Devereux, R.B. (2008). Prognostic implications of relations of left ventricular systolic dysfunction with body composition and myocardial energy expenditure: the Strong Heart Study. J Am Soc Echocardiogr 21, 66-71. doi: S0894-7317(07)00390-2 [pii] 10.1016/j.echo.2007.05.008
140. Pan, X., Liu, J., Nguyen, T., Liu, C., Sun, J., Teng, Y., Fergusson, M.M., Rovira, Ii, Allen, M., Springer, D.A., Aponte, A.M., Gucek, M., Balaban, R.S., Murphy, E., and Finkel, T. (2013). The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Nat Cell Biol 15, 1464-1472. doi: ncb2868 [pii] 10.1038/ncb2868
141. Pavlov, E., Aschar-Sobbi, R., Campanella, M., Turner, R.J., Gomez-Garcia, M.R., and Abramov, A.Y. (2010). Inorganic polyphosphate and energy metabolism in mammalian cells. J Biol Chem 285, 9420-9428. doi: M109.013011 [pii] 10.1074/jbc.M109.013011
142. Pavlov, E., Grimbly, C., Diao, C.T., and French, R.J. (2005a). A high-conductance mode of a poly-3-hydroxybutyrate/calcium/polyphosphate channel isolated from competent Escherichia coli cells. FEBS Lett 579, 5187-5192. doi: S0014-5793(05)01027-6 [pii] 10.1016/j.febslet.2005.08.032
143. Pavlov, E., Zakharian, E., Bladen, C., Diao, C.T., Grimbly, C., Reusch, R.N., and French, R.J. (2005b). A large, voltage-dependent channel, isolated from mitochondria by water-free chloroform extraction. Biophys J 88, 2614-2625. doi: S0006-3495(05)73316-6 [pii] 10.1529/biophysj.104.057281
144. Persson, B. (1970). Determination of plasma acetoacetate and D-beta-hydroxybutyrate in new-born infants by an enzymatic fluorometric micro-method. Scand J Clin Lab Invest 25, 9-18
145. Phillips, N.F., Horn, P.J., and Wood, H.G. (1993). The polyphosphate- and ATPdependent glucokinase from Propionibacterium shermanii: both activities are catalyzed by the same protein. Arch Biochem Biophys 300, 309-319. doi: S0003-9861(83)71043-X [pii] 10.1006/abbi.1993.1043
146. Pick, U., Bental, M., Chitlaru, E., and Weiss, M. (1990). Polyphosphate-hydrolysis--a protective mechanism against alkaline stress? FEBS Lett 274, 15-18
147. Pilliar, R.M., Kandel, R.A., Grynpas, M.D., Zalzal, P., and Hurtig, M. (2007) Osteochondral defect repair using a novel tissue engineering approach: sheep model study. Technol Health Care 15, 47-56
148. Pisoni, R.L., and Lindley, E.R. (1992). Incorporation of [32P]orthophosphate into long chains of inorganic polyphosphate within lysosomes of human fibroblasts. J Biol Chem 267, 3626-3631
149. Poli, A., Di Donato, P., Abbamondi, G.R., and Nicolaus, B. (2011). Synthesis, production, and biotechnological applications of exopolysaccharides and polyhydroxyalkanoates by archaea. Archaea 2011, 693253. doi: 10.1155/2011/693253
150. Pollak, N., Dolle, C., and Ziegler, M. (2007). The power to reduce: pyridine nucleotides--small molecules with a multitude of functions. Biochem J 402, 205-218. doi: BJ20061638 [pii] 10.1042/BJ20061638
151. Potter, M., and Steinbuchel, A. (2005). Poly(3-hydroxybutyrate) granule-associated proteins: impacts on poly(3-hydroxybutyrate) synthesis and degradation Biomacromolecules 6, 552-560. doi: 10.1021/bm049401n
152. Ramasamy, I. (2013). Recent advances in physiological lipoprotein metabolism. Clin Chem Lab Med, 1-33. doi: 10.1515/cclm-2013-0358/j/cclm.ahead-of-print/cclm-2013-0358/cclm-2013-0358.xml [pii]
153. Reger, M.A., Henderson, S.T., Hale, C., Cholerton, B., Baker, L.D., Watson, G.S., Hyde, K., Chapman, D., and Craft, S. (2004). Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging 25, 311-314. doi: 10.1016/S0197-4580(03)00087-3S0197458003000873 [pii]
154. Rehm, B.H. (2006). Genetics and biochemistry of polyhydroxyalkanoate granule selfassembly: The key role of polyester synthases. Biotechnol Lett 28, 207-213. doi: 10.1007/s10529-005-5521-4
155. Reusch, R.N. (1989). Poly-beta-hydroxybutyrate/calcium polyphosphate complexes in eukaryotic membranes. Proc Soc Exp Biol Med 191, 377-381
156. Reusch, R.N. (1992). Biological complexes of poly-beta-hydroxybutyrate. FEMS Microbiol Rev 9, 119-129
157. Reusch, R.N. (1999). Streptomyces lividans potassium channel contains poly-(R)-3-hydroxybutyrate and inorganic polyphosphate. Biochemistry 38, 15666-15672 doi: bi991782f [pii]
158. Reusch, R.N. (2000). Transmembrane ion transport by polyphosphate/poly-(R)-3-hydroxybutyrate complexes. Biochemistry (Mosc) 65, 280-295. doi: BCM65030335 [pii]
159. Reusch, R.N. (2012). Physiological importance of poly-(R)-3-hydroxybutyrates. Chem Biodivers 9, 2343-2366. doi: 10.1002/cbdv.201200278
160. Reusch, R.N. (2013). The Role of Short-Chain Conjugated Poly-(R)-3-Hydroxybutyrate (cPHB) in Protein Folding. Int J Mol Sci 14, 10727-10748. doi: ijms140610727 [pii] 10.3390/ijms140610727
161. Reusch, R.N., Bryant, E.M., and Henry, D.N. (2003). Increased poly-(R)-3-hydroxybutyrate concentrations in streptozotocin (STZ) diabetic rats. Acta Diabetol 40, 91-94. doi: 10.1007/s005920300011
162. Reusch, R.N., Hiske, T.W., and Sadoff, H.L. (1986). Poly-beta-hydroxybutyrate membrane structure and its relationship to genetic transformability in Escherichia coli. J Bacteriol 168, 553-562
163. Reusch, R.N., Huang, R., and Bramble, L.L. (1995). Poly-3-hydroxybutyrate/polyphosphate complexes form voltage-activated Ca2+ channels in the plasma membranes of Escherichia coli. Biophys J 69, 754-766. doi: S0006-3495(95)79958-1 [pii] 10.1016/S0006-3495(95)79958-1
164. Reusch, R.N., Huang, R., and Kosk-Kosicka, D. (1997). Novel components and enzymatic activities of the human erythrocyte plasma membrane calcium pump FEBS Lett 412, 592-596. doi: S0014-5793(97)00863-6 [pii]
165. Reusch, R.N., and Sadoff, H.L. (1983). D-(-)-poly-beta-hydroxybutyrate in membranes of genetically competent bacteria. J Bacteriol 156, 778-788
166. Reusch, R.N., and Sadoff, H.L. (1988). Putative structure and functions of a poly-betahydroxybutyrate/ calcium polyphosphate channel in bacterial plasma membranes Proc Natl Acad Sci U S A 85, 4176-4180
167. Reusch, R.N., Shabalin, O., Crumbaugh, A., Wagner, R., Schroder, O., and Wurm, R (2002). Posttranslational modification of E. coli histone-like protein H-NS and bovine histones by short-chain poly-(R)-3-hydroxybutyrate (cPHB). FEBS Lett 527, 319-322. doi: S0014579302032362 [pii]
168. Reusch, R.N., Sparrow, A.W., and Gardiner, J. (1992). Transport of poly-betahydroxybutyrate in human plasma. Biochim Biophys Acta 1123, 33-40. doi: 0005-2760(92)90168-U [pii]
169. Robinson, A.M., and Williamson, D.H. (1980). Physiological roles of ketone bodies as substrates and signals in mammalian tissues. Physiol Rev 60, 143-187
170. Ruiz, F.A., Lea, C.R., Oldfield, E., and Docampo, R. (2004). Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. J Biol Chem 279, 44250-44257. doi: 10.1074/jbc.M406261200M406261200 [pii]
171. Rutsch, F., Nitschke, Y., and Terkeltaub, R. (2011). Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel. Circ Res 109, 578-592. doi: 109/5/578 [pii] 10.1161/CIRCRESAHA.111.247965
172. Salles, Ii, Feys, H.B., Iserbyt, B.F., De Meyer, S.F., Vanhoorelbeke, K., and Deckmyn, H. (2008). Inherited traits affecting platelet function. Blood Rev 22, 155-172. doi: S0268-960X(07)00071-9 [pii] 10.1016/j.blre.2007.11.002
173. Sato, K., Kashiwaya, Y., Keon, C.A., Tsuchiya, N., King, M.T., Radda, G.K., Chance, B., Clarke, K., and Veech, R.L. (1995). Insulin, ketone bodies, and mitochondrial energy transduction. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 9, 651-658
174. Scofield, R.F., Brady, P.S., Schumann, W.C., Kumaran, K., Ohgaku, S., Margolis, J.M., and Landau, B.R. (1982). On the lack of formation of L-(+)-3-hydroxybutyrate by liver. Arch Biochem Biophys 214, 268-272. doi: 0003-9861(82)90030-3 [pii]
175. Seebach, D., Brunner, A., Burger, H.M., Schneider, J., and Reusch, R.N. (1994) Isolation and 1H-NMR spectroscopic identification of poly(3-hydroxybutanoate) from prokaryotic and eukaryotic organisms. Determination of the absolute configuration (R) of the monomeric unit 3-hydroxybutanoic acid from Escherichia coli and spinach. Eur J Biochem 224, 317-328
176. Seebach, D., and Fritz, M.G. (1999). Detection, synthesis, structure, and function of oligo(3-hydroxyalkanoates): contributions by synthetic organic chemists. Int J Biol Macromol 25, 217-236. doi: S0141-8130(99)00037-9 [pii]
177. Segawa, S., Fujiya, M., Konishi, H., Ueno, N., Kobayashi, N., Shigyo, T., and Kohgo, Y (2011). Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway. PLoS One 6, e23278. doi: 10.1371/journal.pone.0023278PONE-D-11-10949 [pii]
178. Seidlmayer, L.K., Blatter, L.A., Pavlov, E., and Dedkova, E.N. (2012a). Inorganic polyphosphate-an unusual suspect of the mitochondrial permeability transition mystery. Channels (Austin) 6, 463-467. doi: 21939 [pii] 10.4161/chan.21939
179. Seidlmayer, L.K., Gomez-Garcia, M.R., Blatter, L.A., Pavlov, E., and Dedkova, E.N (2012b). Inorganic polyphosphate is a potent activator of the mitochondrial permeability transition pore in cardiac myocytes. J Gen Physiol 139, 321-331 doi: jgp.201210788 [pii] 10.1085/jgp.201210788
180. Seidlmayer, L.K., Juettner, V.V., Blatter, L.A., and Dedkova, E.N. (2013). Ca2+-dependent ROS generation during ischemia triggers mPTP-dependent cell death during reperfusion. Biophysical Journal 104 216a
181. Sengupta, S., Peterson, T.R., Laplante, M., Oh, S., and Sabatini, D.M. (2010). mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468, 1100-1104. doi: nature09584 [pii] 10.1038/nature09584
182. Senior, B., and Loridan, L. (1968). Direct regulatory effect of ketones on lipolysis and on glucose concentrations in man. Nature 219, 83-84
183. Shanjani, Y., De Croos, J.N., Pilliar, R.M., Kandel, R.A., and Toyserkani, E. (2007) Solid freeform fabrication and characterization of porous calcium polyphosphate structures for tissue engineering purposes. J Biomed Mater Res B Appl Biomater 93, 510-519. doi: 10.1002/jbm.b.31610
184. Shiba, T., Nishimura, D., Kawazoe, Y., Onodera, Y., Tsutsumi, K., Nakamura, R., and Ohshiro, M. (2003). Modulation of mitogenic activity of fibroblast growth factors by inorganic polyphosphate. J Biol Chem 278, 26788-26792. doi: 10.1074/jbc.M303468200M303468200 [pii]
185. Shimazu, T., Hirschey, M.D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C.A., Lim, H., Saunders, L.R., Stevens, R.D., Newgard, C.B., Farese, R.V., Jr., De Cabo, R., Ulrich, S., Akassoglou, K., and Verdin, E. (2013). Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339, 211-214. doi: science.1227166 [pii] 10.1126/science.1227166
186. Smith, S.A., Choi, S.H., Collins, J.N., Travers, R.J., Cooley, B.C., and Morrissey, J.H (2012). Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation. Blood 120, 5103-5110. doi: blood-2012-07-444935 [pii] 10.1182/blood-2012-07-444935
187. Smith, S.A., Choi, S.H., Davis-Harrison, R., Huyck, J., Boettcher, J., Rienstra, C.M., and Morrissey, J.H. (2010). Polyphosphate exerts differential effects on blood clotting, depending on polymer size. Blood 116, 4353-4359. doi: blood-2010-01-266791 [pii] 10.1182/blood-2010-01-266791
188. Smith, S.A., and Morrissey, J.H. (2008a). Polyphosphate as a general procoagulant agent J Thromb Haemost 6, 1750-1756. doi: JTH3104 [pii] 10.1111/j.1538-7836.2008.03104.x
189. Smith, S.A., and Morrissey, J.H. (2008b). Polyphosphate enhances fibrin clot structure Blood 112, 2810-2816. doi: blood-2008-03-145755 [pii] 10.1182/blood-2008-03-145755
190. Smith, S.A., Mutch, N.J., Baskar, D., Rohloff, P., Docampo, R., and Morrissey, J.H (2006). Polyphosphate modulates blood coagulation and fibrinolysis. Proc Natl Acad Sci U S A 103, 903-908. doi: 0507195103 [pii] 10.1073/pnas.0507195103
191. Smithen, M., Elustondo, P.A., Winkfein, R., Zakharian, E., Abramov, A.Y., and Pavlov, E. (2013). Role of polyhydroxybutyrate in mitochondrial calcium uptake. Cell Calcium 54, 86-94. doi: S0143-4160(13)00058-4 [pii] 10.1016/j.ceca.2013.04.006
192. Snorek, M., Hodyc, D., Sedivy, V., Durisova, J., Skoumalova, A., Wilhelm, J., Neckar, J., Kolar, F., and Herget, J. (2012). Short-term fasting reduces the extent of myocardial infarction and incidence of reperfusion arrhythmias in rats. Physiol Res 61, 567-574. doi: 932338 [pii]
193. Spudich, J.A. (2004). Two important polymers cross paths. Proc Natl Acad Sci U S A 101, 15825-15826. doi: 0406932101 [pii] 10.1073/pnas.0406932101
194. Squires, J.E., Sun, J., Caffrey, J.L., Yoshishige, D., and Mallet, R.T. (2003). Acetoacetate augments beta-adrenergic inotropism of stunned myocardium by an antioxidant mechanism. Am J Physiol Heart Circ Physiol 284, H1340-1347. doi: 10.1152/ajpheart.00473.200200473.2002 [pii]
195. Stanley, W.C., Meadows, S.R., Kivilo, K.M., Roth, B.A., and Lopaschuk, G.D. (2003) beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content. Am J Physiol Heart Circ Physiol 285, H1626-1631. doi: 10.1152/ajpheart.00332.2003285/4/H1626 [pii]
196. Sun, N., Zou, H., Yang, L., Morita, K., Gong, P., Shiba, T., Akagawa, Y., and Yuan, Q (2012). Inorganic polyphosphates stimulate FGF23 expression through the FGFR pathway. Biochem Biophys Res Commun 428, 298-302. doi: S0006-291X(12)02005-0 [pii] 10.1016/j.bbrc.2012.10.051
197. Szabo, I., and Zoratti, M. (1991). The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A. J Biol Chem 266, 3376-3379
198. Taggart, A.K., Kero, J., Gan, X., Cai, T.Q., Cheng, K., Ippolito, M., Ren, N., Kaplan, R., Wu, K., Wu, T.J., Jin, L., Liaw, C., Chen, R., Richman, J., Connolly, D., Offermanns, S., Wright, S.D., and Waters, M.G. (2005). (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J Biol Chem 280, 26649-26652. doi: C500213200 [pii] 10.1074/jbc.C500213200
199. Tammenkoski, M., Koivula, K., Cusanelli, E., Zollo, M., Steegborn, C., Baykov, A.A., and Lahti, R. (2008). Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase. Biochemistry 47, 9707-9713. doi: 10.1021/bi8010847
200. Tieu, K., Perier, C., Caspersen, C., Teismann, P., Wu, D.C., Yan, S.D., Naini, A., Vila, M., Jackson-Lewis, V., Ramasamy, R., and Przedborski, S. (2003). D-betahydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. J Clin Invest 112, 892-901. doi: 10.1172/JCI18797112/6/892 [pii]
201. Tsai, Y.C., Chou, Y.C., Wu, A.B., Hu, C.M., Chen, C.Y., Chen, F.A., and Lee, J.A (2006). Stereoselective effects of 3-hydroxybutyrate on glucose utilization of rat cardiomyocytes. Life Sci 78, 1385-1391. doi: S0024-3205(05)00929-X [pii] 10.1016/j.lfs.2005.07.013
202. Tsutsumi, K., Saito, N., Kawazoe, Y., Ooi, H.K., and Shiba, T. (2014). Morphogenetic study on the maturation of osteoblastic cell as induced by inorganic polyphosphate. PLoS One 9, e86834. doi: 10.1371/journal.pone.0086834 PONED-13-34148 [pii]
203. Tunaru, S., Kero, J., Schaub, A., Wufka, C., Blaukat, A., Pfeffer, K., and Offermanns, S (2003). PUMA-G and HM74 are receptors for nicotinic acid and mediate its antilipolytic effect. Nat Med 9, 352-355. doi: 10.1038/nm824nm824 [pii]
204. Usui, Y., Uematsu, T., Uchihashi, T., Takahashi, M., Ishizuka, M., Doto, R., Tanaka, H., Komazaki, Y., Osawa, M., Yamada, K., Yamaoka, M., and Furusawa, K. (2010) Inorganic polyphosphate induces osteoblastic differentiation. J Dent Res 89, 504-509. doi: 0022034510363096 [pii] 10.1177/0022034510363096
205. Van Veen, H.W., Abee, T., Kortstee, G.J., Konings, W.N., and Zehnder, A.J. (1993) Mechanism and energetics of the secondary phosphate transport system of Acinetobacter johnsonii 210A. J Biol Chem 268, 19377-19383
206. Veech, R.L. (2004). The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids 70, 309-319. doi: 10.1016/j.plefa.2003.09.007S0952327803002217 [pii]
207. Veech, R.L. (2013). Ketone esters increase brown fat in mice and overcome insulin resistance in other tissues in the rat. Ann N Y Acad Sci 1302, 42-48. doi: 10.1111/nyas.12222
208. Veech, R.L. (2014). Ketone Ester Effects on Metabolism and Transcription. J Lipid Res doi: jlr.R046292 [pii] 10.1194/jlr.R046292
209. Veech, R.L., Chance, B., Kashiwaya, Y., Lardy, H.A., and Cahill, G.F., Jr. (2001) Ketone bodies, potential therapeutic uses. IUBMB Life 51, 241-247. doi: 10.1080/152165401753311780
210. Wang, L., Fraley, C.D., Faridi, J., Kornberg, A., and Roth, R.A. (2003). Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells. Proc Natl Acad Sci U S A 100, 11249-11254. doi: 10.1073/pnas.15348051001534805100 [pii]
211. Wang, P., Tate, J.M., and Lloyd, S.G. (2008). Low carbohydrate diet decreases myocardial insulin signaling and increases susceptibility to myocardial ischemia Life Sci 83, 836-844. doi: S0024-3205(08)00402-5 [pii] 10.1016/j.lfs.2008.09.024
212. Welty, F.K. (2013). How do elevated triglycerides and low HDL-cholesterol affect inflammation and atherothrombosis? Curr Cardiol Rep 15, 400. doi: 10.1007/s11886-013-0400-4
213. Whitehead, M.P., Eagles, L., Hooley, P., and Brown, M.R. (2014). Most bacteria synthesise polyphosphate by unknown mechanisms. Microbiology. doi: mic.0.075366-0 [pii] 10.1099/mic.0.075366-0
214. Whitehead, M.P., Hooley, P., and Mr, W.B. (2013). Horizontal transfer of bacterial polyphosphate kinases to eukaryotes: implications for the ice age and land colonisation. BMC Res Notes 6, 221. doi: 1756-0500-6-221 [pii]10.1186/1756-0500-6-221
215. Won, Y.J., Lu, V.B., Puhl, H.L., 3rd, and Ikeda, S.R. (2013). beta-Hydroxybutyrate modulates N-type calcium channels in rat sympathetic neurons by acting as an agonist for the G-protein-coupled receptor FFA3. J Neurosci 33, 19314-19325 doi: 33/49/19314 [pii]10.1523/JNEUROSCI.3102-13.2013
216. Wood, H.G., and Clark, J.E. (1988). Biological aspects of inorganic polyphosphates Annu Rev Biochem 57, 235-260. doi: 10.1146/annurev.bi.57.070188.001315
217. Wu, Q., Wang, Y., and Chen, G.Q. (2009). Medical application of microbial biopolyesters polyhydroxyalkanoates. Artif Cells Blood Substit Immobil Biotechnol 37, 1-12. doi: 907476591 [pii] 10.1080/10731190802664429
218. Xian, M., Fuerst, M.M., Shabalin, Y., and Reusch, R.N. (2007). Sorting signal of Escherichia coli OmpA is modified by oligo-(R)-3-hydroxybutyrate. Biochim Biophys Acta 1768, 2660-2666. doi: S0005-2736(07)00235-0 [pii] 10.1016/j.bbamem.2007.06.019
219. Zakharian, E., Cao, C., and Rohacs, T. (2010). Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers. J Neurosci 30, 12526-12534. doi: 30/37/12526 [pii] 10.1523/JNEUROSCI.3189-10.2010
220. Zakharian, E., Thyagarajan, B., French, R.J., Pavlov, E., and Rohacs, T. (2009) Inorganic polyphosphate modulates TRPM8 channels. PLoS One 4, e5404. doi: 10.1371/journal.pone.0005404
221. Zemel, M.B., and Linkswiler, H.M. (1981). Calcium metabolism in the young adult male as affected by level and form of phosphorus intake and level of calcium intake. J Nutr 111, 315-324
222. Zhang, Z., Tan, M., Xie, Z., Dai, L., Chen, Y., and Zhao, Y. (2011). Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol 7, 58-63. doi: nchembio.495 [pii] 10.1038/nchembio.495
223. Zhou, X., Yang, W., and Li, J. (2006). Ca2+- and protein kinase C-dependent signaling pathway for nuclear factor-kappaB activation, inducible nitric-oxide synthase expression, and tumor necrosis factor-alpha production in lipopolysaccharidestimulated rat peritoneal macrophages. J Biol Chem 281, 31337-31347. doi: M602739200 [pii] 10.1074/jbc.M602739200
224. Zhu, Y., Huang, W., Lee, S.S., and Xu, W. (2005). Crystal structure of a polyphosphate kinase and its implications for polyphosphate synthesis. EMBO Rep 6, 681-687 doi: 7400448 [pii]10.1038/sj.embor.7400448
225. Zou, Z., Sasaguri, S., Rajesh, K.G., and Suzuki, R. (2002). dl-3-Hydroxybutyrate administration prevents myocardial damage after coronary occlusion in rat hearts Am J Physiol Heart Circ Physiol 283, H1968-1974. doi: 10.1152/ajpheart.00250.2002