Voltage-Dependent Block of N-Methyl-D-Aspartate Receptors by the Novel Anticonvulsant Dibenzylamine, a Bioactive Constituent of L-(+)-β -Hydroxybutyrate

Epilepsia

Volumn 44, Issue 10, 2003, Pages 1274-1279

  Donevan, Sean D ^a   White, H Steve ^c   Anderson, Gail D ^d   Rho, Jong M ^b,e  

^a PFIZER INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hydroxybutyrate; 3 Hydroxybutanoic acid; 3 Hydroxybutyrate; Dibenzylamine; Epilepsy; Ketogenic diet; NMDA receptor

Indexed keywords

3 HYDROXYBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ACETOACETIC ACID; ACETONE; AMPA RECEPTOR; ANTICONVULSIVE AGENT; DIBENZYLAMINE; ION CHANNEL; IONOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN NERVE CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG MECHANISM; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; ION CURRENT; MOUSE; MOUSE STRAIN; NEOCORTEX; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RECEPTOR BLOCKING; SEIZURE SUSCEPTIBILITY; STEREOISOMERISM; VOLTAGE CLAMP;

3-HYDROXYBUTYRIC ACID; ANIMALS; ANTICONVULSANTS; BENZYLAMINES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FETUS; MICE; NEOCORTEX; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0142136079     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1528-1157.2003.07203.x     Document Type: Article

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