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Volumn 67, Issue 6, 1996, Pages 2325-2334

Regulation of GABA level in rat brain synaptosomes: Fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies

Author keywords

Epilepsy; GABA; GABA transaminase activity; Glutamic acid decarboxylase activity; Ketone bodies; Synaptosomes

Indexed keywords

2 OXOGLUTARIC ACID; 4 AMINOBUTYRATE AMINOTRANSFERASE; CALCIUM; GLUTAMATE DECARBOXYLASE; GLUTAMIC ACID; KETONE BODY;

EID: 0029833561     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.67062325.x     Document Type: Article
Times cited : (155)

References (49)
  • 1
    • 0014739411 scopus 로고
    • The operation of the γ-aminobutyrate bypath of the tricarboxylic acid cycle in brain tissue in vitro
    • Balázs R., Machiyama Y., Hammond B. J., Julian T., and Richter D. (1970) The operation of the γ-aminobutyrate bypath of the tricarboxylic acid cycle in brain tissue in vitro. Biochem. J. 116, 445-467.
    • (1970) Biochem. J. , vol.116 , pp. 445-467
    • Balázs, R.1    Machiyama, Y.2    Hammond, B.J.3    Julian, T.4    Richter, D.5
  • 2
    • 0002775177 scopus 로고
    • Ketogenic diets for treatment of childhood epilepsy
    • (Walser M., Imbembo A. L., Margolis S., and Eifert G., eds), Saunders, Philadelphia
    • Barbosa E., Freeman J., and Eifert G. (1984) Ketogenic diets for treatment of childhood epilepsy, in Nutritional Management: The Johns Hopkins Handbook (Walser M., Imbembo A. L., Margolis S., and Eifert G., eds), pp. 272-292. Saunders, Philadelphia.
    • (1984) Nutritional Management: The Johns Hopkins Handbook , pp. 272-292
    • Barbosa, E.1    Freeman, J.2    Eifert, G.3
  • 3
    • 0025326247 scopus 로고
    • Stimulation of synaptosomal γ-aminobutyric acid synthesis by glutamate and glutamine
    • Battaglioli G. and Martin D. L. (1990) Stimulation of synaptosomal γ-aminobutyric acid synthesis by glutamate and glutamine. J. Neurochem. 54, 1179-1187.
    • (1990) J. Neurochem. , vol.54 , pp. 1179-1187
    • Battaglioli, G.1    Martin, D.L.2
  • 4
    • 0025779184 scopus 로고
    • GABA synthesis in brain slices is dependent on glutamine produced in astrocytes
    • Battaglioli G. and Martin D. L. (1991) GABA synthesis in brain slices is dependent on glutamine produced in astrocytes. Neurochem. Res. 16, 151-156.
    • (1991) Neurochem. Res. , vol.16 , pp. 151-156
    • Battaglioli, G.1    Martin, D.L.2
  • 5
    • 0018070988 scopus 로고
    • A rapid method for the preparation of relatively pure metabolically competent synaptosomes from rat brain
    • Booth R. F. G. and Clark J. B. (1978) A rapid method for the preparation of relatively pure metabolically competent synaptosomes from rat brain. Biochem. J. 176, 365-370.
    • (1978) Biochem. J. , vol.176 , pp. 365-370
    • Booth, R.F.G.1    Clark, J.B.2
  • 6
    • 0020507605 scopus 로고
    • Cortical GABA turnover during bicuculline seizures in rats
    • Chapman A. G. and Evans M. C. (1983) Cortical GABA turnover during bicuculline seizures in rats. J. Neurochem. 41, 886-889.
    • (1983) J. Neurochem. , vol.41 , pp. 886-889
    • Chapman, A.G.1    Evans, M.C.2
  • 7
    • 0021042447 scopus 로고
    • Electrical stimulation of the stratum radiatum increases the release and neosynthesis of aspartate, glutamate and γ-aminobutyric acid in rat hippocampal slices
    • Corradetti R., Moneti G., Moroni F., Pepeu G., and Wieraszko A. (1983) Electrical stimulation of the stratum radiatum increases the release and neosynthesis of aspartate, glutamate and γ-aminobutyric acid in rat hippocampal slices. J. Neurochem. 41, 1518-1525.
    • (1983) J. Neurochem. , vol.41 , pp. 1518-1525
    • Corradetti, R.1    Moneti, G.2    Moroni, F.3    Pepeu, G.4    Wieraszko, A.5
  • 8
    • 0018178607 scopus 로고
    • Calcium-dependent binding of brain glutamate decarboxylase to phospholipid vesicles
    • Covarrubias M. and Tapia R. (1978) Calcium-dependent binding of brain glutamate decarboxylase to phospholipid vesicles. J. Neurochem. 31, 1209-1214.
    • (1978) J. Neurochem. , vol.31 , pp. 1209-1214
    • Covarrubias, M.1    Tapia, R.2
  • 9
    • 0023265045 scopus 로고
    • + gradients, and neurotransmitter amino acid levels in isolated rat brain synaptosomes
    • + gradients, and neurotransmitter amino acid levels in isolated rat brain synaptosomes. J. Neurochem. 49, 1229-1240.
    • (1987) J. Neurochem. , vol.49 , pp. 1229-1240
    • Dagani, F.1    Erecińska, M.2
  • 11
    • 0023841077 scopus 로고
    • Effects of lowering extracellular and cytosolic pH on calcium fluxes, cytosolic calcium levels, and transmitter release in presynaptic nerve terminals isolated from rat brain
    • Drapeau P. and Nachshen D. A. (1988) Effects of lowering extracellular and cytosolic pH on calcium fluxes, cytosolic calcium levels, and transmitter release in presynaptic nerve terminals isolated from rat brain. J. Gen. Physiol. 91, 305-315.
    • (1988) J. Gen. Physiol. , vol.91 , pp. 305-315
    • Drapeau, P.1    Nachshen, D.A.2
  • 12
    • 0015324442 scopus 로고
    • Cerebral carbohydrate metabolism during acute hypoxia and recovery
    • Duffy T. E., Nelson S. R., and Lowry O. H. (1972) Cerebral carbohydrate metabolism during acute hypoxia and recovery. J. Neurochem. 19, 959-977.
    • (1972) J. Neurochem. , vol.19 , pp. 959-977
    • Duffy, T.E.1    Nelson, S.R.2    Lowry, O.H.3
  • 14
    • 0025196959 scopus 로고
    • Metabolism and role of glutamate in mammalian brain
    • Erecińska M. and Silver I. A. (1990) Metabolism and role of glutamate in mammalian brain. Prog. Neurobiol. 35, 245-296.
    • (1990) Prog. Neurobiol. , vol.35 , pp. 245-296
    • Erecińska, M.1    Silver, I.A.2
  • 16
    • 0021763961 scopus 로고
    • Use of t-butyldimethylsilylation in the GC-MS analysis of physiologic compounds found in the plasma using electron-impact ionization
    • Frederick W. S., Berg P. J., Miles A., and Haymond M. W. (1984) Use of t-butyldimethylsilylation in the GC-MS analysis of physiologic compounds found in the plasma using electron-impact ionization. Anal. Biochem. 141, 101-109.
    • (1984) Anal. Biochem. , vol.141 , pp. 101-109
    • Frederick, W.S.1    Berg, P.J.2    Miles, A.3    Haymond, M.W.4
  • 17
    • 0026476423 scopus 로고
    • GABA and epilepsy: Basic concepts from preclinical research
    • Gale K. (1992) GABA and epilepsy: basic concepts from preclinical research. Epilepsia 33 (Suppl. 5), S3-S12.
    • (1992) Epilepsia , vol.33 , Issue.5 SUPPL.
    • Gale, K.1
  • 18
    • 0025153617 scopus 로고
    • Use of traditional ketogenic diet for treatment of intractable epilepsy
    • Gasch A. T. (1990) Use of traditional ketogenic diet for treatment of intractable epilepsy. J. Am. Diet. Assoc. 90, 1433-1434.
    • (1990) J. Am. Diet. Assoc. , vol.90 , pp. 1433-1434
    • Gasch, A.T.1
  • 19
    • 0018372873 scopus 로고
    • Glutamate decarboxylase activity in striatal slices: Characterization of the increase following depolarization
    • Gold B. A. and Roth R. H. (1979) Glutamate decarboxylase activity in striatal slices: characterization of the increase following depolarization. J. Neurochem. 32, 883-888.
    • (1979) J. Neurochem. , vol.32 , pp. 883-888
    • Gold, B.A.1    Roth, R.H.2
  • 20
    • 29744466425 scopus 로고
    • Determination of serum proteins by means of the biuret reaction
    • Gornall A. G., Bardawill C. J., and David M. M. (1949) Determination of serum proteins by means of the biuret reaction. J. Biol. Chem. 177, 751-766.
    • (1949) J. Biol. Chem. , vol.177 , pp. 751-766
    • Gornall, A.G.1    Bardawill, C.J.2    David, M.M.3
  • 21
    • 0021278520 scopus 로고
    • Neurotransmitter amino acids in the CNS. II. Some changes in amino acid levels in rat brain synaptosomes during and after in vitro anoxia and simulated ischemia
    • Hauptmann M., Nelson D., Wilson D. F., and Erecińska M. (1984) Neurotransmitter amino acids in the CNS. II. Some changes in amino acid levels in rat brain synaptosomes during and after in vitro anoxia and simulated ischemia. Brain Res. 304, 23-25.
    • (1984) Brain Res. , vol.304 , pp. 23-25
    • Hauptmann, M.1    Nelson, D.2    Wilson, D.F.3    Erecińska, M.4
  • 22
    • 0023049123 scopus 로고
    • The separation of o-phthalaldehyde derivatives of amino acids by reversed-phase chromatography on octylsilica column
    • Jarrett H. W., Cooksy K. D., Ellis B., and Anderson J. M. (1986) The separation of o-phthalaldehyde derivatives of amino acids by reversed-phase chromatography on octylsilica column. Anal Biochem. 153, 189-198.
    • (1986) Anal Biochem. , vol.153 , pp. 189-198
    • Jarrett, H.W.1    Cooksy, K.D.2    Ellis, B.3    Anderson, J.M.4
  • 23
    • 0026027134 scopus 로고
    • Two forms of the γ-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions
    • Kaufman D. L., Houser C. R., and Tobin A. J. (1991) Two forms of the γ-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J. Neurochem. 56, 720-723.
    • (1991) J. Neurochem. , vol.56 , pp. 720-723
    • Kaufman, D.L.1    Houser, C.R.2    Tobin, A.J.3
  • 24
    • 0028032122 scopus 로고
    • Combination therapy protects ischemic brain in rats: A glutamate antagonist plus a GABA agonist
    • Lyden P. D. and Lonzo L. (1994) Combination therapy protects ischemic brain in rats: a glutamate antagonist plus a GABA agonist. Stroke 25, 189-195.
    • (1994) Stroke , vol.25 , pp. 189-195
    • Lyden, P.D.1    Lonzo, L.2
  • 25
    • 0017835674 scopus 로고
    • Comparison of the structural characteristics of the 4-aminobutyrate:2-oxoglutarate transaminases from rat and human brain, and of their affinities for certain inhibitors
    • Maitre M., Ciesielski L., Cash C., and Mandel P. (1978) Comparison of the structural characteristics of the 4-aminobutyrate:2-oxoglutarate transaminases from rat and human brain, and of their affinities for certain inhibitors. Biochim. Biophys. Acta 522, 385-399.
    • (1978) Biochim. Biophys. Acta , vol.522 , pp. 385-399
    • Maitre, M.1    Ciesielski, L.2    Cash, C.3    Mandel, P.4
  • 26
    • 0027395911 scopus 로고
    • Regulation of γ-aminobutyric acid synthesis in the brain
    • Martin D. L. and Rimvall K. (1993) Regulation of γ-aminobutyric acid synthesis in the brain. J. Neurochem. 60, 395-407.
    • (1993) J. Neurochem. , vol.60 , pp. 395-407
    • Martin, D.L.1    Rimvall, K.2
  • 27
    • 0018583088 scopus 로고
    • Stimulation by phosphate of the activation of glutamate apodecarboxylase by pyridoxal-5′ phosphate and its implications for the control of GABA synthesis
    • Martin S. B. and Martin D. L. (1979) Stimulation by phosphate of the activation of glutamate apodecarboxylase by pyridoxal-5′ phosphate and its implications for the control of GABA synthesis. J. Neurochem. 33, 1275-1283.
    • (1979) J. Neurochem. , vol.33 , pp. 1275-1283
    • Martin, S.B.1    Martin, D.L.2
  • 28
    • 0018286819 scopus 로고
    • Effects of depolarization on cofactor regulation of glutamic acid decarboxylase in substantia nigra synaptosomes
    • Miller L. P. and Walters J. R. (1979) Effects of depolarization on cofactor regulation of glutamic acid decarboxylase in substantia nigra synaptosomes. J. Neurochem. 33, 533-539.
    • (1979) J. Neurochem. , vol.33 , pp. 533-539
    • Miller, L.P.1    Walters, J.R.2
  • 29
  • 30
    • 0026544324 scopus 로고
    • Metabolic compartmentation of glutamate and glutamine: Morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum
    • Ottersen O. P., Walberg F, and Zhang N. (1992) Metabolic compartmentation of glutamate and glutamine: morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum. Neuroscience 46, 519-534.
    • (1992) Neuroscience , vol.46 , pp. 519-534
    • Ottersen, O.P.1    Walberg, F.2    Zhang, N.3
  • 31
    • 0023926944 scopus 로고
    • Regulation of transmitter γ-aminobutyric acid (GABA) synthesis and metabolism illustrated by the effect of γ-vinyl GABA and hypoglycemia
    • Paulsen R. E. and Fonnum F. (1988) Regulation of transmitter γ-aminobutyric acid (GABA) synthesis and metabolism illustrated by the effect of γ-vinyl GABA and hypoglycemia. J. Neurochem. 50, 1151-1157.
    • (1988) J. Neurochem. , vol.50 , pp. 1151-1157
    • Paulsen, R.E.1    Fonnum, F.2
  • 32
    • 0023097586 scopus 로고
    • Rapid inactivation of brain glutamate decarboxylase by aspartate
    • Porter T. G. and Martin D. L. (1987) Rapid inactivation of brain glutamate decarboxylase by aspartate. J. Neurochem. 48, 67-72.
    • (1987) J. Neurochem. , vol.48 , pp. 67-72
    • Porter, T.G.1    Martin, D.L.2
  • 33
    • 0024255896 scopus 로고
    • Stability and activation of glutamate apodecarboxylase from pig brain
    • Porter T. G. and Martin D. L. (1988) Stability and activation of glutamate apodecarboxylase from pig brain. J. Neurochem. 51, 1886-1891.
    • (1988) J. Neurochem. , vol.51 , pp. 1886-1891
    • Porter, T.G.1    Martin, D.L.2
  • 35
    • 0026699650 scopus 로고
    • Stable isotope tracer analysis by GC-MS, including quantification of isotopomer effects
    • Rosenblatt J., Chinkes D., Wolfe M., and Wolfe R. R. (1992) Stable isotope tracer analysis by GC-MS, including quantification of isotopomer effects. Am. J. Physiol. 263, E584-E596.
    • (1992) Am. J. Physiol. , vol.263
    • Rosenblatt, J.1    Chinkes, D.2    Wolfe, M.3    Wolfe, R.R.4
  • 36
    • 0026581322 scopus 로고
    • Pharmacology of vigabatrin
    • Sabers A. and Gram L. (1992) Pharmacology of vigabatrin. Pharmacol. Toxicol. 70, 237-243.
    • (1992) Pharmacol. Toxicol. , vol.70 , pp. 237-243
    • Sabers, A.1    Gram, L.2
  • 37
    • 0001766942 scopus 로고
    • Subcellular distribution of the enzymes of the glutamic acid, glutamine and γ-aminobutyric acid cycles in rat brain
    • Salganicoff L. and De Robertis E. (1965) Subcellular distribution of the enzymes of the glutamic acid, glutamine and γ-aminobutyric acid cycles in rat brain. J. Neurochem. 12, 287-309.
    • (1965) J. Neurochem. , vol.12 , pp. 287-309
    • Salganicoff, L.1    De Robertis, E.2
  • 39
    • 0026670061 scopus 로고
    • Gamma-vinyl GABA prevents hippocampal and substantia nigra reticulata damage in repetitive transient ischemia in gerbils
    • Shuaib A., Ijaz S., Hasan S., and Kalra J. (1992) Gamma-vinyl GABA prevents hippocampal and substantia nigra reticulata damage in repetitive transient ischemia in gerbils. Brain Res. 590, 13-17.
    • (1992) Brain Res. , vol.590 , pp. 13-17
    • Shuaib, A.1    Ijaz, S.2    Hasan, S.3    Kalra, J.4
  • 40
    • 0030019916 scopus 로고    scopus 로고
    • The neuroprotective effects of gamma-vinyl GABA in transient global ischemia: A morphological study with early and delayed evaluations
    • Shuaib A., Murabit M. A., Kantham R., Hewlett W., and Wishart T. (1996) The neuroprotective effects of gamma-vinyl GABA in transient global ischemia: a morphological study with early and delayed evaluations. Neurosci. Lett. 204, 1-4.
    • (1996) Neurosci. Lett. , vol.204 , pp. 1-4
    • Shuaib, A.1    Murabit, M.A.2    Kantham, R.3    Hewlett, W.4    Wishart, T.5
  • 41
    • 0027081175 scopus 로고
    • Ultrastructural immunocytochemical observations on the localization, metabolism and transport of glutamate in normal and ischemic brain tissue
    • (Yu A. C. H., Hertz L., Norenberg M. D., Syková E., and Waxman S. G., eds), Elsevier Science Publishers, Amsterdam
    • Storm-Mathisen J., Danbolt N. C., Rothe F., Torp R. Zhang N., Aas J.-E., Kanner B. I., Langmoen I., and Ottersen O. P. (1992) Ultrastructural immunocytochemical observations on the localization, metabolism and transport of glutamate in normal and ischemic brain tissue, in Progress in Brain Research, Vol. 94 (Yu A. C. H., Hertz L., Norenberg M. D., Syková E., and Waxman S. G., eds), pp. 225-241. Elsevier Science Publishers, Amsterdam.
    • (1992) Progress in Brain Research , vol.94 , pp. 225-241
    • Storm-Mathisen, J.1    Danbolt, N.C.2    Rothe, F.3    Torp, R.4    Zhang, N.5    Aas, J.-E.6    Kanner, B.I.7    Langmoen, I.8    Ottersen, O.P.9
  • 42
    • 0021356335 scopus 로고
    • 14C] glucose in hippocampal slices: Effect of depolarization
    • 14C] glucose in hippocampal slices: effect of depolarization. Brain Res. 293, 293-303.
    • (1984) Brain Res. , vol.293 , pp. 293-303
    • Szerb, J.C.1
  • 43
    • 0014738679 scopus 로고
    • Inhibition of brain glutamate decarboxylase by adenosine triphosphate
    • Tursky T. (1970) Inhibition of brain glutamate decarboxylase by adenosine triphosphate. Eur. J. Biochem. 12, 544-549.
    • (1970) Eur. J. Biochem. , vol.12 , pp. 544-549
    • Tursky, T.1
  • 44
    • 0022220071 scopus 로고
    • Succinic semialdehyde as a substrate for the formation of γ-aminobutyric acid
    • van Bemmelen F. J., Scheuten M. J., Fekkes D. and Bruinvels J. (1985) Succinic semialdehyde as a substrate for the formation of γ-aminobutyric acid. J. Neurochem. 45, 1471-1474.
    • (1985) J. Neurochem. , vol.45 , pp. 1471-1474
    • Van Bemmelen, F.J.1    Scheuten, M.J.2    Fekkes, D.3    Bruinvels, J.4
  • 45
    • 0018774833 scopus 로고
    • Di-n-propylacetate and GABA degradation. Preferential inhibition of succinic semialdehyde dehydrogenase and indirect inhibition of GABA-transaminase
    • van der Laan J. W., de Boer T., and Bruinvels J. (1979) Di-n-propylacetate and GABA degradation. Preferential inhibition of succinic semialdehyde dehydrogenase and indirect inhibition of GABA-transaminase. J. Neurochem. 32, 1769-1780.
    • (1979) J. Neurochem. , vol.32 , pp. 1769-1780
    • Van Der Laan, J.W.1    De Boer, T.2    Bruinvels, J.3
  • 46
    • 0001544644 scopus 로고
    • Effects of ketonuria on the course of epilepsy
    • Wilder R. M. (1921) Effects of ketonuria on the course of epilepsy. Mayo Clin. Bull. 2, 307-310.
    • (1921) Mayo Clin. Bull. , vol.2 , pp. 307-310
    • Wilder, R.M.1
  • 47
    • 0001039779 scopus 로고
    • Epilepsy in childhood. III. Results with the ketogenic diet
    • Wilkins L. (1937) Epilepsy in childhood. III. Results with the ketogenic diet. J. Pediatr. 10, 341-357.
    • (1937) J. Pediatr. , vol.10 , pp. 341-357
    • Wilkins, L.1
  • 48
    • 0016118413 scopus 로고
    • Properties of brain L-glutamate decarboxylase: Inhibition studies
    • Wu J.-Y. and Roberts E. (1974) Properties of brain L-glutamate decarboxylase: inhibition studies. J. Neurochem. 23, 759-767.
    • (1974) J. Neurochem. , vol.23 , pp. 759-767
    • Wu, J.-Y.1    Roberts, E.2
  • 49
    • 0028036798 scopus 로고
    • Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle
    • Yudkoff M., Nelson D., Daikhin Y., and Erecińska M. (1994) Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle. J. Biol. Chem. 269, 27414-27420.
    • (1994) J. Biol. Chem. , vol.269 , pp. 27414-27420
    • Yudkoff, M.1    Nelson, D.2    Daikhin, Y.3    Erecińska, M.4


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