메뉴 건너뛰기




Volumn 6, Issue 8, 2014, Pages 621-644

D-beta-hydroxybutyrate extends lifespan in C. elegans

Author keywords

Aging; Beta hydroxybutyrate; C. elegans; Ketone bodies; Lifespan; Mitochondria

Indexed keywords

3 HYDROXYBUTYRIC ACID; HISTONE DEACETYLASE; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3;

EID: 84907089341     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100683     Document Type: Article
Times cited : (135)

References (102)
  • 3
    • 0033529032 scopus 로고    scopus 로고
    • Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans
    • Braeckman BP, Houthoofd K, De Vreese A and Vanfleteren JR. Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans. Curr Biol. 1999; 9:493-496.
    • (1999) Curr Biol , vol.9 , pp. 493-496
    • Braeckman, B.P.1    Houthoofd, K.2    De Vreese, A.3    Vanfleteren, J.R.4
  • 6
    • 33645472504 scopus 로고    scopus 로고
    • New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen
    • Hansen M, Hsu AL, Dillin A and Kenyon C. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS genetics. 2005; 1:119-128.
    • (2005) PLoS genetics , vol.1 , pp. 119-128
    • Hansen, M.1    Hsu, A.L.2    Dillin, A.3    Kenyon, C.4
  • 7
    • 0030615104 scopus 로고    scopus 로고
    • Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age
    • Hansford RG, Hogue BA and Mildaziene V. Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age. J Bioenerg Biomembr. 1997; 29:89-95.
    • (1997) J Bioenerg Biomembr , vol.29 , pp. 89-95
    • Hansford, R.G.1    Hogue, B.A.2    Mildaziene, V.3
  • 8
    • 0037160091 scopus 로고    scopus 로고
    • Topology of superoxide production from different sites in the mitochondrial electron transport chain
    • St-Pierre J, Buckingham JA, Roebuck SJ and Brand MD. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem. 2002; 277:44784-44790.
    • (2002) J Biol Chem , vol.277 , pp. 44784-44790
    • St-Pierre, J.1    Buckingham, J.A.2    Roebuck, S.J.3    Brand, M.D.4
  • 9
    • 71349087186 scopus 로고    scopus 로고
    • Origin and evolution of the free radical theory of aging: a brief personal history 1954-2009
    • Harman D. Origin and evolution of the free radical theory of aging: a brief personal history, 1954-2009. Biogerontology. 2009; 10:773-781.
    • (2009) Biogerontology , vol.10 , pp. 773-781
    • Harman, D.1
  • 10
    • 63549108476 scopus 로고    scopus 로고
    • Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    • Greer EL and Brunet A. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell. 2009; 8:113-127.
    • (2009) Aging Cell , vol.8 , pp. 113-127
    • Greer, E.L.1    Brunet, A.2
  • 12
    • 0035917440 scopus 로고    scopus 로고
    • A conserved regulatory system for aging
    • Kenyon C. A conserved regulatory system for aging. Cell. 2001; 105:165-168.
    • (2001) Cell , vol.105 , pp. 165-168
    • Kenyon, C.1
  • 13
    • 84890978770 scopus 로고    scopus 로고
    • Ketone bodies as signaling metabolites
    • Newman JC and Verdin E. Ketone bodies as signaling metabolites. Trends Endocrinol Metab. 2014; 25:42-52.
    • (2014) Trends Endocrinol Metab , vol.25 , pp. 42-52
    • Newman, J.C.1    Verdin, E.2
  • 15
    • 84901750107 scopus 로고    scopus 로고
    • Fatty acids in energy metabolism of the central nervous system
    • Panov A, Orynbayeva Z, Vavilin V and Lyakhovich V. Fatty acids in energy metabolism of the central nervous system. Biomed Res Int. 2014; 2014:472459.
    • (2014) Biomed Res Int , vol.2014 , pp. 472459
    • Panov, A.1    Orynbayeva, Z.2    Vavilin, V.3    Lyakhovich, V.4
  • 16
    • 84901797293 scopus 로고    scopus 로고
    • Endogenous siderophore 2 5-dihydroxybenzoic acid deficiency promotes anemia and splenic iron overload in mice
    • Liu Z, Ciocea A and Devireddy L. Endogenous siderophore 2,5-dihydroxybenzoic acid deficiency promotes anemia and splenic iron overload in mice. Mol Cell Biol. 2014; 34:2533-2546.
    • (2014) Mol Cell Biol , vol.34 , pp. 2533-2546
    • Liu, Z.1    Ciocea, A.2    Devireddy, L.3
  • 17
  • 20
    • 77956197971 scopus 로고    scopus 로고
    • Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice
    • Dragicevic N, Mamcarz M, Zhu Y, Buzzeo R, Tan J, Arendash GW and Bradshaw PC. Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice. J Alzheimers Dis. 2010; 20 Suppl 2:S535-550.
    • (2010) J Alzheimers Dis , vol.20 , pp. S535-S550
    • Dragicevic, N.1    Mamcarz, M.2    Zhu, Y.3    Buzzeo, R.4    Tan, J.5    Arendash, G.W.6    Bradshaw, P.C.7
  • 22
    • 27744549328 scopus 로고    scopus 로고
    • A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease
    • Van der Auwera I, Wera S, Van Leuven F and Henderson ST. A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease. Nutr Metab (Lond). 2005; 2:28.
    • (2005) Nutr Metab (Lond) , vol.2 , pp. 28
    • Van der Auwera, I.1    Wera, S.2    Van Leuven, F.3    Henderson, S.T.4
  • 23
    • 84884177253 scopus 로고    scopus 로고
    • Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology
    • Brownlow ML, Benner L, D'Agostino D, Gordon MN and Morgan D. Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology. PLoS One. 2013; 8:e75713.
    • (2013) PLoS One , vol.8 , pp. e75713
    • Brownlow, M.L.1    Benner, L.2    D'Agostino, D.3    Gordon, M.N.4    Morgan, D.5
  • 24
    • 84880508862 scopus 로고    scopus 로고
    • 3-Hydroxybutyrate methyl ester as a potential drug against Alzheimer's disease via mitochondria protection mechanism
    • Zhang J, Cao Q, Li S, Lu X, Zhao Y, Guan JS, Chen JC, Wu Q and Chen GQ. 3-Hydroxybutyrate methyl ester as a potential drug against Alzheimer's disease via mitochondria protection mechanism. Biomaterials. 2013; 34:7552-7562.
    • (2013) Biomaterials , vol.34 , pp. 7552-7562
    • Zhang, J.1    Cao, Q.2    Li, S.3    Lu, X.4    Zhao, Y.5    Guan, J.S.6    Chen, J.C.7    Wu, Q.8    Chen, G.Q.9
  • 26
    • 44749085250 scopus 로고    scopus 로고
    • Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification
    • Cole NB, Dieuliis D, Leo P, Mitchell DC and Nussbaum RL. Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification. Exp Cell Res. 2008; 314:2076-2089.
    • (2008) Exp Cell Res , vol.314 , pp. 2076-2089
    • Cole, N.B.1    Dieuliis, D.2    Leo, P.3    Mitchell, D.C.4    Nussbaum, R.L.5
  • 27
    • 44049099669 scopus 로고    scopus 로고
    • Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
    • Devi L, Raghavendran V, Prabhu BM, Avadhani NG and Anandatheerthavarada HK. Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J Biol Chem. 2008; 283:9089-9100.
    • (2008) J Biol Chem , vol.283 , pp. 9089-9100
    • Devi, L.1    Raghavendran, V.2    Prabhu, B.M.3    Avadhani, N.G.4    Anandatheerthavarada, H.K.5
  • 31
    • 33645008089 scopus 로고    scopus 로고
    • Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study
    • 617 author reply
    • Jabre MG and Bejjani BP. Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study. Neurology. 2006; 66:617; author reply 617.
    • (2006) Neurology , vol.66 , pp. 617
    • Jabre, M.G.1    Bejjani, B.P.2
  • 34
    • 0038676409 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase activity by butyrate
    • Davie JR. Inhibition of histone deacetylase activity by butyrate. J Nutr. 2003; 133:2485S-2493S.
    • (2003) J Nutr , vol.133 , pp. 2485S-2493S
    • Davie, J.R.1
  • 35
    • 0036079767 scopus 로고    scopus 로고
    • Characterization of CeHDA-7, a class II histone deacetylase interacting with MEF-2 in Caenorhabditis elegans
    • Choi KY, Ji YJ, Jee C, Kim DH and Ahnn J. Characterization of CeHDA-7, a class II histone deacetylase interacting with MEF-2 in Caenorhabditis elegans. Biochem Biophys Res Commun. 2002; 293:1295-1300.
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 1295-1300
    • Choi, K.Y.1    Ji, Y.J.2    Jee, C.3    Kim, D.H.4    Ahnn, J.5
  • 37
    • 0031594921 scopus 로고    scopus 로고
    • Evolution of mammalian 11beta- and 17betahydroxysteroid dehydrogenases-type 2 and retinol dehydrogenases from ancestors in Caenorhabditis elegans and evidence for horizontal transfer of a eukaryote dehydrogenase to E. coli
    • Baker ME. Evolution of mammalian 11beta- and 17betahydroxysteroid dehydrogenases-type 2 and retinol dehydrogenases from ancestors in Caenorhabditis elegans and evidence for horizontal transfer of a eukaryote dehydrogenase to E. coli. J Steroid Biochem Mol Biol. 1998; 66:355-363.
    • (1998) J Steroid Biochem Mol Biol , vol.66 , pp. 355-363
    • Baker, M.E.1
  • 38
    • 0035933785 scopus 로고    scopus 로고
    • Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties
    • Chetyrkin SV, Belyaeva OV, Gough WH and Kedishvili NY. Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties. J Biol Chem. 2001; 276:22278-22286.
    • (2001) J Biol Chem , vol.276 , pp. 22278-22286
    • Chetyrkin, S.V.1    Belyaeva, O.V.2    Gough, W.H.3    Kedishvili, N.Y.4
  • 40
    • 84871809827 scopus 로고    scopus 로고
    • A survey of putative secreted and transmembrane proteins encoded in the C. elegans genome
    • Suh J and Hutter H. A survey of putative secreted and transmembrane proteins encoded in the C. elegans genome. BMC Genomics. 2012; 13:333.
    • (2012) BMC Genomics , vol.13 , pp. 333
    • Suh, J.1    Hutter, H.2
  • 41
    • 84884695800 scopus 로고    scopus 로고
    • Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf
    • Glover-Cutter KM, Lin S and Blackwell TK. Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf. PLoS Genet. 2013; 9:e1003701.
    • (2013) PLoS Genet , vol.9 , pp. e1003701
    • Glover-Cutter, K.M.1    Lin, S.2    Blackwell, T.K.3
  • 45
    • 84863790485 scopus 로고    scopus 로고
    • Unique structure and regulation of the nematode detoxification gene regulator SKN-1: implications to understanding and controlling drug resistance.
    • Choe KP, Leung CK and Miyamoto MM. Unique structure and regulation of the nematode detoxification gene regulator, SKN-1: implications to understanding and controlling drug resistance. Drug Metab Rev. 2012; 44:209-223.
    • (2012) Drug Metab Rev. , vol.44 , pp. 209-223
    • Choe, K.P.1    Leung, C.K.2    Miyamoto, M.M.3
  • 46
    • 66349105688 scopus 로고    scopus 로고
    • The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans
    • Choe KP, Przybysz AJ and Strange K. The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Mol Cell Biol. 2009; 29:2704-2715.
    • (2009) Mol Cell Biol , vol.29 , pp. 2704-2715
    • Choe, K.P.1    Przybysz, A.J.2    Strange, K.3
  • 47
    • 68149149835 scopus 로고    scopus 로고
    • The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans
    • Zhang Y, Shao Z, Zhai Z, Shen C and Powell-Coffman JA. The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS One. 2009; 4:e6348.
    • (2009) PLoS One , vol.4 , pp. e6348
    • Zhang, Y.1    Shao, Z.2    Zhai, Z.3    Shen, C.4    Powell-Coffman, J.A.5
  • 48
  • 49
    • 33947520506 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
    • Koivunen P, Hirsila M, Remes AM, Hassinen IE, Kivirikko KI and Myllyharju J. Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J Biol Chem. 2007; 282:4524-4532.
    • (2007) J Biol Chem , vol.282 , pp. 4524-4532
    • Koivunen, P.1    Hirsila, M.2    Remes, A.M.3    Hassinen, I.E.4    Kivirikko, K.I.5    Myllyharju, J.6
  • 51
    • 4944234936 scopus 로고    scopus 로고
    • Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
    • Yoneda T, Benedetti C, Urano F, Clark SG, Harding HP and Ron D. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J Cell Sci. 2004; 117:4055-4066.
    • (2004) J Cell Sci , vol.117 , pp. 4055-4066
    • Yoneda, T.1    Benedetti, C.2    Urano, F.3    Clark, S.G.4    Harding, H.P.5    Ron, D.6
  • 52
    • 0027078293 scopus 로고
    • Temporal and spatial expression patterns of the small heat shock (hsp16) genes in transgenic Caenorhabditis elegans
    • Stringham EG, Dixon DK, Jones D and Candido EP. Temporal and spatial expression patterns of the small heat shock (hsp16) genes in transgenic Caenorhabditis elegans. Mol Biol Cell. 1992; 3:221-233.
    • (1992) Mol Biol Cell , vol.3 , pp. 221-233
    • Stringham, E.G.1    Dixon, D.K.2    Jones, D.3    Candido, E.P.4
  • 53
    • 33846423520 scopus 로고    scopus 로고
    • Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    • Hansen M, Taubert S, Crawford D, Libina N, Lee SJ and Kenyon C. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell. 2007; 6:95-110.
    • (2007) Aging Cell , vol.6 , pp. 95-110
    • Hansen, M.1    Taubert, S.2    Crawford, D.3    Libina, N.4    Lee, S.J.5    Kenyon, C.6
  • 54
    • 84883817838 scopus 로고    scopus 로고
    • The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans
    • Rousakis A, Vlassis A, Vlanti A, Patera S, Thireos G and Syntichaki P. The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans. Aging Cell. 2013; 12:742-751.
    • (2013) Aging Cell , vol.12 , pp. 742-751
    • Rousakis, A.1    Vlassis, A.2    Vlanti, A.3    Patera, S.4    Thireos, G.5    Syntichaki, P.6
  • 55
    • 84870885054 scopus 로고    scopus 로고
    • Amino acid sensing in dietary-restriction-mediated longevity: roles of signaltransducing kinases GCN2 and TOR
    • Gallinetti J, Harputlugil E and Mitchell JR. Amino acid sensing in dietary-restriction-mediated longevity: roles of signaltransducing kinases GCN2 and TOR. Biochem J. 2013; 449:1-10.
    • (2013) Biochem J , vol.449 , pp. 1-10
    • Gallinetti, J.1    Harputlugil, E.2    Mitchell, J.R.3
  • 56
    • 84864065342 scopus 로고    scopus 로고
    • Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2
    • Baker BM, Nargund AM, Sun T and Haynes CM. Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2. PLoS Genet. 2012; 8:e1002760.
    • (2012) PLoS Genet , vol.8 , pp. e1002760
    • Baker, B.M.1    Nargund, A.M.2    Sun, T.3    Haynes, C.M.4
  • 57
    • 84856695667 scopus 로고    scopus 로고
    • S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells
    • Korta DZ, Tuck S and Hubbard EJ. S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells. Development. 2012; 139:859-870.
    • (2012) Development , vol.139 , pp. 859-870
    • Korta, D.Z.1    Tuck, S.2    Hubbard, E.J.3
  • 58
    • 70449711342 scopus 로고    scopus 로고
    • An eIF4E-binding protein regulates katanin protein levels in C. elegans embryos
    • Li W, DeBella LR, Guven-Ozkan T, Lin R and Rose LS. An eIF4E-binding protein regulates katanin protein levels in C. elegans embryos. J Cell Biol. 2009; 187:33-42.
    • (2009) J Cell Biol , vol.187 , pp. 33-42
    • Li, W.1    DeBella, L.R.2    Guven-Ozkan, T.3    Lin, R.4    Rose, L.S.5
  • 59
    • 0034994933 scopus 로고    scopus 로고
    • Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans
    • Hartman PS, Ishii N, Kayser EB, Morgan PG and Sedensky MM. Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans. Mech Ageing Dev. 2001; 122:1187-1201.
    • (2001) Mech Ageing Dev , vol.122 , pp. 1187-1201
    • Hartman, P.S.1    Ishii, N.2    Kayser, E.B.3    Morgan, P.G.4    Sedensky, M.M.5
  • 61
    • 81155134279 scopus 로고    scopus 로고
    • FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity
    • Lublin A, Isoda F, Patel H, Yen K, Nguyen L, Hajje D, Schwartz M and Mobbs C. FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. PLoS One. 2011; 6:e27762.
    • (2011) PLoS One , vol.6 , pp. e27762
    • Lublin, A.1    Isoda, F.2    Patel, H.3    Yen, K.4    Nguyen, L.5    Hajje, D.6    Schwartz, M.7    Mobbs, C.8
  • 62
    • 70350365110 scopus 로고    scopus 로고
    • Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression
    • Lee S-J, Murphy CT and Kenyon C. Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression. Cell Metabolism. 2009; 10:379-391.
    • (2009) Cell Metabolism , vol.10 , pp. 379-391
    • Lee, S.-J.1    Murphy, C.T.2    Kenyon, C.3
  • 64
    • 34748850786 scopus 로고    scopus 로고
    • Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    • Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M and Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 2007; 6:280-293.
    • (2007) Cell Metab , vol.6 , pp. 280-293
    • Schulz, T.J.1    Zarse, K.2    Voigt, A.3    Urban, N.4    Birringer, M.5    Ristow, M.6
  • 65
    • 80055117409 scopus 로고    scopus 로고
    • Assaying beta-amyloid toxicity using a transgenic C. elegans model
    • Dostal V and Link CD. Assaying beta-amyloid toxicity using a transgenic C. elegans model. J Vis Exp. 2010.
    • (2010) J Vis ExP
    • Dostal, V.1    Link, C.D.2
  • 71
    • 60749090581 scopus 로고    scopus 로고
    • The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
    • Maalouf M, Rho JM and Mattson MP. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev. 2009; 59:293-315.
    • (2009) Brain Res Rev , vol.59 , pp. 293-315
    • Maalouf, M.1    Rho, J.M.2    Mattson, M.P.3
  • 74
    • 58149328569 scopus 로고    scopus 로고
    • Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1
    • Piantadosi CA, Carraway MS, Babiker A and Suliman HB. Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res. 2008; 103:1232-1240.
    • (2008) Circ Res , vol.103 , pp. 1232-1240
    • Piantadosi, C.A.1    Carraway, M.S.2    Babiker, A.3    Suliman, H.B.4
  • 77
    • 73449114300 scopus 로고    scopus 로고
    • Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2
    • Hashimoto T, Horikawa M, Nomura T and Sakamoto K. Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16. Biogerontology. 2010; 11:31-43.
    • (2010) 1 and daf-16. Biogerontology. , vol.11 , pp. 31-43
    • Hashimoto, T.1    Horikawa, M.2    Nomura, T.3    Sakamoto, K.4
  • 79
    • 33846852428 scopus 로고    scopus 로고
    • Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation
    • Maalouf M, Sullivan PG, Davis L, Kim DY and Rho JM. Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation. Neuroscience. 2007; 145:256-264.
    • (2007) Neuroscience , vol.145 , pp. 256-264
    • Maalouf, M.1    Sullivan, P.G.2    Davis, L.3    Kim, D.Y.4    Rho, J.M.5
  • 81
    • 74049134984 scopus 로고    scopus 로고
    • Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway
    • Williams DS, Cash A, Hamadani L and Diemer T. Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell. 2009; 8:765-768.
    • (2009) Aging Cell , vol.8 , pp. 765-768
    • Williams, D.S.1    Cash, A.2    Hamadani, L.3    Diemer, T.4
  • 85
    • 73449116731 scopus 로고    scopus 로고
    • Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation
    • Madiraju P, Pande SV, Prentki M and Madiraju SR. Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation. Epigenetics. 2009; 4:399-403.
    • (2009) Epigenetics , vol.4 , pp. 399-403
    • Madiraju, P.1    Pande, S.V.2    Prentki, M.3    Madiraju, S.R.4
  • 86
    • 77956843122 scopus 로고    scopus 로고
    • {beta}-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle
    • Yamada T, Zhang SJ, Westerblad H and Katz A. {beta}-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle. Am J Physiol Endocrinol Metab. 2010; 299:E364-373.
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , pp. E364-373
    • Yamada, T.1    Zhang, S.J.2    Westerblad, H.3    Katz, A.4
  • 92
    • 33748298884 scopus 로고    scopus 로고
    • Neuroprotective and disease-modifying effects of the ketogenic diet
    • Gasior M, Rogawski MA and Hartman AL. Neuroprotective and disease-modifying effects of the ketogenic diet. Behav Pharmacol. 2006; 17:431-439.
    • (2006) Behav Pharmacol , vol.17 , pp. 431-439
    • Gasior, M.1    Rogawski, M.A.2    Hartman, A.L.3
  • 93
    • 46749091229 scopus 로고    scopus 로고
    • Ketone bodies as a therapeutic for Alzheimer's disease
    • Henderson ST. Ketone bodies as a therapeutic for Alzheimer's disease. Neurotherapeutics. 2008; 5:470-480.
    • (2008) Neurotherapeutics , vol.5 , pp. 470-480
    • Henderson, S.T.1
  • 95
    • 33644830913 scopus 로고    scopus 로고
    • Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity
    • Bates EA, Victor M, Jones AK, Shi Y and Hart AC. Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. J Neurosci. 2006; 26:2830-2838.
    • (2006) J Neurosci , vol.26 , pp. 2830-2838
    • Bates, E.A.1    Victor, M.2    Jones, A.K.3    Shi, Y.4    Hart, A.C.5
  • 96
    • 34249888736 scopus 로고    scopus 로고
    • PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
    • Panowski SH, Wolff S, Aguilaniu H, Durieux J and Dillin A. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature. 2007; 447:550-555.
    • (2007) Nature , vol.447 , pp. 550-555
    • Panowski, S.H.1    Wolff, S.2    Aguilaniu, H.3    Durieux, J.4    Dillin, A.5
  • 97
    • 11144244418 scopus 로고    scopus 로고
    • Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
    • Wolfrum C, Asilmaz E, Luca E, Friedman JM and Stoffel M. Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature. 2004; 432:1027-1032.
    • (2004) Nature , vol.432 , pp. 1027-1032
    • Wolfrum, C.1    Asilmaz, E.2    Luca, E.3    Friedman, J.M.4    Stoffel, M.5
  • 98
    • 77953152484 scopus 로고    scopus 로고
    • A transfer-less, multi-well liquid culture feeding system for screening small molecules that affect the longevity of Caenorhabditis elegans
    • Fitzgerald VK, Mensack MM, Wolfe P and Thompson HJ. A transfer-less, multi-well liquid culture feeding system for screening small molecules that affect the longevity of Caenorhabditis elegans. Biotechniques. 2009; 47(4 Suppl.):ix-xv.
    • (2009) Biotechniques , vol.47 , Issue.4 , pp. ix-xv
    • Fitzgerald, V.K.1    Mensack, M.M.2    Wolfe, P.3    Thompson, H.J.4
  • 99
    • 0032578911 scopus 로고    scopus 로고
    • Specific interference by ingested dsRNA
    • Timmons L and Fire A. Specific interference by ingested dsRNA. Nature. 1998; 395:854-854.
    • (1998) Nature , vol.395 , pp. 854-1854
    • Timmons, L.1    Fire, A.2
  • 100
    • 0021362949 scopus 로고
    • Regional enzyme development in rat brain Enzymes associated with glucose utilization.
    • Leong SF and Clark JB. Regional enzyme development in rat brain. Enzymes associated with glucose utilization. Biochem J. 1984; 218:131-138.
    • (1984) Biochem J. , vol.218 , pp. 131-138
    • Leong, S.F.1    Clark, J.B.2
  • 101
    • 77957001185 scopus 로고
    • Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods
    • John ML, ed. Methods in Enzymology: Academic Press
    • Williamson JR and Corkey BE. Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods. In: John ML, ed. Methods in Enzymology: Academic Press. 1969; pp. 434-513.
    • (1969) , pp. 434-513
    • Williamson, J.R.1    Corkey, B.E.2
  • 102
    • 84875041132 scopus 로고    scopus 로고
    • Iridoid compound 10-O-trans-pcoumaroylcatalpol extends longevity and reduces alpha synuclein aggregation in Caenorhabditis elegans
    • Shukla V, Phulara SC, Yadav D, Tiwari S, Kaur S, Gupta MM, Nazir A and Pandey R. Iridoid compound 10-O-trans-pcoumaroylcatalpol extends longevity and reduces alpha synuclein aggregation in Caenorhabditis elegans. CNS Neurol Disord Drug Targets. 2012; 11:984-992.
    • (2012) CNS Neurol Disord Drug Targets , vol.11 , pp. 984-992
    • Shukla, V.1    Phulara, S.C.2    Yadav, D.3    Tiwari, S.4    Kaur, S.5    Gupta, M.M.6    Nazir, A.7    Pandey, R.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.