-
1
-
-
34249275353
-
Phenotypic plasticity and the epigenetics of human disease
-
Feinberg, A. P. Phenotypic plasticity and the epigenetics of human disease. Nature 447, 433-440 (2007).
-
(2007)
Nature
, vol.447
, pp. 433-440
-
-
Feinberg, A.P.1
-
2
-
-
33847070442
-
The role of chromatin during transcription
-
Li, B., Carey, M. & Workman, J. L. The role of chromatin during transcription. Cell 128, 707-719 (2007).
-
(2007)
Cell
, vol.128
, pp. 707-719
-
-
Li, B.1
Carey, M.2
Workman, J.L.3
-
3
-
-
0034610814
-
The language of covalent histone modifications
-
Strahl, B. D. & Allis, C. D. The language of covalent histone modifications. Nature 403, 41-45 (2000).
-
(2000)
Nature
, vol.403
, pp. 41-45
-
-
Strahl, B.D.1
Allis, C.D.2
-
4
-
-
34249299791
-
The complex language of chromatin regulation during transcription
-
Berger, S. L. The complex language of chromatin regulation during transcription. Nature 447, 407-412 (2007).
-
(2007)
Nature
, vol.447
, pp. 407-412
-
-
Berger, S.L.1
-
5
-
-
0035839136
-
Translating the histone code
-
Jenuwein, T. & Allis, C. D. Translating the histone code. Science 293, 1074-1080 (2001).
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
6
-
-
0017331464
-
Structure of chromatin
-
Kornberg, R. D. Structure of chromatin. Annu. Rev. Biochem. 46, 931-954 (1977).
-
(1977)
Annu. Rev. Biochem.
, vol.46
, pp. 931-954
-
-
Kornberg, R.D.1
-
7
-
-
79960563344
-
Determinants and dynamics of genome accessibility
-
Bell, O., Tiwari, V. K., Thomä, N. H. & Schübeler, D. Determinants and dynamics of genome accessibility. Nature Rev. Genet. 12, 554-564 (2011).
-
(2011)
Nature Rev. Genet.
, vol.12
, pp. 554-564
-
-
Bell, O.1
Tiwari, V.K.2
Thomä, N.H.3
Schübeler, D.4
-
8
-
-
84870792079
-
Perceiving the epigenetic landscape through histone readers
-
Musselman, C. A., Lalonde, M.-E., Cote, J. & Kutateladze, T. G. Perceiving the epigenetic landscape through histone readers. Nature Struct. Mol. Biol. 19, 1218-1227 (2012).
-
(2012)
Nature Struct. Mol. Biol.
, vol.19
, pp. 1218-1227
-
-
Musselman, C.A.1
Lalonde, M.-E.2
Cote, J.3
Kutateladze, T.G.4
-
9
-
-
33847076849
-
Chromatin modifications and their function
-
Kouzarides, T. Chromatin modifications and their function. Cell 128, 693-705 (2007).
-
(2007)
Cell
, vol.128
, pp. 693-705
-
-
Kouzarides, T.1
-
10
-
-
84875755814
-
Influence of metabolism on epigenetics and disease
-
Kaelin, W. G. & McKnight, S. L. Influence of metabolism on epigenetics and disease. Cell 153, 56-69 (2013).
-
(2013)
Cell
, vol.153
, pp. 56-69
-
-
Kaelin, W.G.1
McKnight, S.L.2
-
11
-
-
84863534997
-
Metabolic regulation of epigenetics
-
Lu, C. & Thompson, C. B. Metabolic regulation of epigenetics. Cell Metab. 16, 9-17 (2012).
-
(2012)
Cell Metab.
, vol.16
, pp. 9-17
-
-
Lu, C.1
Thompson, C.B.2
-
12
-
-
84858796367
-
A two-way street: Reciprocal regulation of metabolism and signalling
-
Wellen, K. E. & Thompson, C. B. A two-way street: reciprocal regulation of metabolism and signalling. Nature Rev. Mol. Cell Biol. 13, 270-276 (2012).
-
(2012)
Nature Rev. Mol. Cell Biol.
, vol.13
, pp. 270-276
-
-
Wellen, K.E.1
Thompson, C.B.2
-
13
-
-
84856090681
-
Connecting threads: Epigenetics and metabolism
-
Katada, S., Imhof, A. & Sassone-Corsi, P. Connecting threads: epigenetics and metabolism. Cell 148, 24-28 (2012).
-
(2012)
Cell
, vol.148
, pp. 24-28
-
-
Katada, S.1
Imhof, A.2
Sassone-Corsi, P.3
-
14
-
-
77957666255
-
Histone methyl transferases and demethylases; Can they link metabolism and transcription?
-
Teperino, R., Schoonjans, K. & Auwerx, J. Histone methyl transferases and demethylases; can they link metabolism and transcription? Cell Metab. 12, 321-327 (2010).
-
(2010)
Cell Metab.
, vol.12
, pp. 321-327
-
-
Teperino, R.1
Schoonjans, K.2
Auwerx, J.3
-
15
-
-
34249337761
-
Perceptions of epigenetics
-
Bird, A. Perceptions of epigenetics. Nature 447, 396-398 (2007).
-
(2007)
Nature
, vol.447
, pp. 396-398
-
-
Bird, A.1
-
16
-
-
38349100549
-
Epigenetic events in mammalian germ-cell development: Reprogramming and beyond
-
Sasaki, H. & Matsui, Y. Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nature Rev. Genet. 9, 129-140 (2008).
-
(2008)
Nature Rev. Genet.
, vol.9
, pp. 129-140
-
-
Sasaki, H.1
Matsui, Y.2
-
17
-
-
34249279527
-
Stability and flexibility of epigenetic gene regulation in mammalian development
-
Reik, W. Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447, 425-432 (2007).
-
(2007)
Nature
, vol.447
, pp. 425-432
-
-
Reik, W.1
-
18
-
-
77950806433
-
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
-
Hirschey, M. D. et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 464, 121-125 (2010).
-
(2010)
Nature
, vol.464
, pp. 121-125
-
-
Hirschey, M.D.1
-
19
-
-
84871107379
-
Mitochondrial protein acylation and intermediary metabolism: Regulation by sirtuins and implications for metabolic disease
-
Newman, J. C., He, W. & Verdin, E. Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J. Biol. Chem. 287, 42436-42443 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 42436-42443
-
-
Newman, J.C.1
He, W.2
Verdin, E.3
-
20
-
-
84865421953
-
Mitochondrial sirtuins: Regulators of protein acylation and metabolism
-
He, W., Newman, J. C., Wang, M. Z., Ho, L. & Verdin, E. Mitochondrial sirtuins: regulators of protein acylation and metabolism. Trends Endocrinol. Metab. 23, 467-476 (2012).
-
(2012)
Trends Endocrinol. Metab.
, vol.23
, pp. 467-476
-
-
He, W.1
Newman, J.C.2
Wang, M.Z.3
Ho, L.4
Verdin, E.5
-
21
-
-
34249026300
-
High-resolution profiling of histone methylations in the human genome
-
Barski, A. et al. High-resolution profiling of histone methylations in the human genome. Cell 129, 823-837 (2007).
-
(2007)
Cell
, vol.129
, pp. 823-837
-
-
Barski, A.1
-
22
-
-
16344368814
-
Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process
-
Forneris, F., Binda, C., Vanoni, M. A., Mattevi, A. & Battaglioli, E. Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. FEBS Lett. 579, 2203-2207 (2005).
-
(2005)
FEBS Lett.
, vol.579
, pp. 2203-2207
-
-
Forneris, F.1
Binda, C.2
Vanoni, M.A.3
Mattevi, A.4
Battaglioli, E.5
-
23
-
-
39349105090
-
Expanding chemical biology of 2-oxoglutarate oxygenases
-
Loenarz, C. & Schofield, C. J. Expanding chemical biology of 2-oxoglutarate oxygenases. Nature Chem. Biol. 4, 152-156 (2008).
-
(2008)
Nature Chem. Biol.
, vol.4
, pp. 152-156
-
-
Loenarz, C.1
Schofield, C.J.2
-
24
-
-
78650447665
-
β-N-acetylglucosamine (O-GlcNAc) is part of the histone code
-
Sakabe, K., Wang, Z. & Hart, G. W. β-N-acetylglucosamine (O-GlcNAc) is part of the histone code. Proc. Natl Acad. Sci. USA 107, 19915-19920 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 19915-19920
-
-
Sakabe, K.1
Wang, Z.2
Hart, G.W.3
-
25
-
-
34247583996
-
Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins
-
Hart, G. W. G., Housley, M. P. M. & Slawson, C. C. Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins. Nature 446, 1017-1022 (2007).
-
(2007)
Nature
, vol.446
, pp. 1017-1022
-
-
Hart, G.W.G.1
Housley, M.P.M.2
Slawson, C.C.3
-
26
-
-
84860184939
-
Bittersweet memories: Linking metabolism to epigenetics through O-GlcNAcylation
-
Hanover, J. A. J., Krause, M. W. M. & Love, D. C. D. Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nature Rev. Mol. Cell Biol. 13, 312-321 (2012).
-
(2012)
Nature Rev. Mol. Cell Biol.
, vol.13
, pp. 312-321
-
-
Hanover, J.A.J.1
Krause, M.W.M.2
Love, D.C.D.3
-
27
-
-
84859512121
-
β-N-Acetylglucosamine (O-GlcNAc) is a novel regulator of mitosis-specific phosphorylations on histone H3
-
Fong, J. J. et al. β-N-Acetylglucosamine (O-GlcNAc) is a novel regulator of mitosis-specific phosphorylations on histone H3. J. Biol. Chem. 287, 12195-12203 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 12195-12203
-
-
Fong, J.J.1
-
28
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
-
Rodgers, J. T. et al. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature 434, 113-118 (2005).
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
-
29
-
-
0027887302
-
Functions for DNA methylation in vertebrates
-
Bird, A. P. Functions for DNA methylation in vertebrates. Cold Spring Harb. Symp. Quant. Biol. 58, 281-285 (1993).
-
(1993)
Cold Spring Harb. Symp. Quant. Biol.
, vol.58
, pp. 281-285
-
-
Bird, A.P.1
-
30
-
-
84886860116
-
TET enzymes, TDG and the dynamics of DNA demethylation
-
Kohli, R. M. & Zhang, Y. TET enzymes, TDG and the dynamics of DNA demethylation. Nature 502, 472-479 (2013).
-
(2013)
Nature
, vol.502
, pp. 472-479
-
-
Kohli, R.M.1
Zhang, Y.2
-
31
-
-
77957970301
-
Epigenetic modifications and human disease
-
Portela, A. & Esteller, M. Epigenetic modifications and human disease. Nature Biotechnol. 28, 1057-1068 (2010).
-
(2010)
Nature Biotechnol.
, vol.28
, pp. 1057-1068
-
-
Portela, A.1
Esteller, M.2
-
32
-
-
84876784115
-
Epigenetic flexibility in metabolic regulation: Disease cause and prevention?
-
Kirchner, H., Osler, M. E., Krook, A. & Zierath, J. R. Epigenetic flexibility in metabolic regulation: disease cause and prevention? Trends Cell Biol. 23, 203-209 (2013).
-
(2013)
Trends Cell Biol.
, vol.23
, pp. 203-209
-
-
Kirchner, H.1
Osler, M.E.2
Krook, A.3
Zierath, J.R.4
-
33
-
-
69149087790
-
Non-CpG methylation of the PGC-1α promoter through DNMT3B controls mitochondrial density
-
Barrès, R. et al. Non-CpG methylation of the PGC-1α promoter through DNMT3B controls mitochondrial density. Cell Metab. 10, 189-198 (2009).
-
(2009)
Cell Metab.
, vol.10
, pp. 189-198
-
-
Barrès, R.1
-
34
-
-
84876979205
-
Weight loss after gastric bypass surgery in human obesity remodels promoter methylation
-
Barrès, R. et al. Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep. 3, 1020-1027 (2013).
-
(2013)
Cell Rep.
, vol.3
, pp. 1020-1027
-
-
Barrès, R.1
-
35
-
-
84864010293
-
Nutrition and epigenetics: An interplay of dietary methyl donors, one-carbon metabolism and DNA methylation
-
Anderson, O. S., Sant, K. E. & Dolinoy, D. C. Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. J. Nutr. Biochem. 23, 853-859 (2012).
-
(2012)
J. Nutr. Biochem.
, vol.23
, pp. 853-859
-
-
Anderson, O.S.1
Sant, K.E.2
Dolinoy, D.C.3
-
36
-
-
84862632865
-
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
-
Xiao, M. et al. Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 26, 1326-1338 (2012).
-
(2012)
Genes Dev.
, vol.26
, pp. 1326-1338
-
-
Xiao, M.1
-
37
-
-
33749052511
-
Rheostat control of gene expression by metabolites
-
Ladurner, A. G. Rheostat control of gene expression by metabolites. Mol. Cell 24, 1-11 (2006).
-
(2006)
Mol. Cell
, vol.24
, pp. 1-11
-
-
Ladurner, A.G.1
-
38
-
-
4143147468
-
Metabolic enzymes and coenzymes in transcription-a direct link between metabolism and transcription?
-
Shi, Y. & Shi, Y. Metabolic enzymes and coenzymes in transcription-a direct link between metabolism and transcription? Trends Genet. 20, 445-452 (2004).
-
(2004)
Trends Genet.
, vol.20
, pp. 445-452
-
-
Shi, Y.1
Shi, Y.2
-
39
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang, L. et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739-744 (2009).
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
-
40
-
-
78751676934
-
KAT(ching) metabolism by the tail: Insight into the links between lysine acetyltransferases and metabolism
-
Albaugh, B. N., Arnold, K. M. & Denu, J. M. KAT(ching) metabolism by the tail: insight into the links between lysine acetyltransferases and metabolism. Chem Bio Chem 12, 290-298 (2011).
-
(2011)
Chem Bio Chem
, vol.12
, pp. 290-298
-
-
Albaugh, B.N.1
Arnold, K.M.2
Denu, J.M.3
-
41
-
-
84876217035
-
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways
-
Rardin, M. J. et al. Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc. Natl Acad. Sci. USA 110, 6601-6606(2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 6601-6606
-
-
Rardin, M.J.1
-
42
-
-
84872276165
-
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome
-
Hebert, A. S. et al. Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol. Cell 49, 186-199 (2012).
-
(2012)
Mol. Cell
, vol.49
, pp. 186-199
-
-
Hebert, A.S.1
-
43
-
-
33747591416
-
Metabolic cycles as an underlying basis of biological oscillations
-
Tu, B. P. & McKnight, S. L. Metabolic cycles as an underlying basis of biological oscillations. Nature Rev. Mol. Cell Biol. 7, 696-701 (2006).
-
(2006)
Nature Rev. Mol. Cell Biol.
, vol.7
, pp. 696-701
-
-
Tu, B.P.1
McKnight, S.L.2
-
44
-
-
36749067297
-
Cyclic changes in metabolic state during the life of a yeast cell
-
Tu, B. P. et al. Cyclic changes in metabolic state during the life of a yeast cell. Proc. Natl Acad. Sci. USA 104, 16886-16891 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 16886-16891
-
-
Tu, B.P.1
-
45
-
-
57049152851
-
Catalysis and substrate selection by histone/protein lysine acetyltransferases
-
Berndsen, C. E. & Denu, J. M. Catalysis and substrate selection by histone/protein lysine acetyltransferases. Curr. Opin. Struct. Biol. 18, 682-689 (2008).
-
(2008)
Curr. Opin. Struct. Biol.
, vol.18
, pp. 682-689
-
-
Berndsen, C.E.1
Denu, J.M.2
-
46
-
-
79955960768
-
Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes
-
Cai, L., Sutter, B. M., Li, B. & Tu, B. P. Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes. Mol. Cell 42, 426-437 (2011).
-
(2011)
Mol. Cell
, vol.42
, pp. 426-437
-
-
Cai, L.1
Sutter, B.M.2
Li, B.3
Tu, B.P.4
-
47
-
-
33745557847
-
Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription
-
Takahashi, H., McCaffery, J. M., Irizarry, R. A. & Boeke, J. D. Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol. Cell 23, 207-217 (2006).
-
(2006)
Mol. Cell
, vol.23
, pp. 207-217
-
-
Takahashi, H.1
McCaffery, J.M.2
Irizarry, R.A.3
Boeke, J.D.4
-
48
-
-
66249105703
-
ATP-citrate lyase links cellular metabolism to histone acetylation
-
Wellen, K. E. et al. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324, 1076-1080 (2009).
-
(2009)
Science
, vol.324
, pp. 1076-1080
-
-
Wellen, K.E.1
-
49
-
-
33751113602
-
Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction
-
Haigis, M. C. & Guarente, L. P. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev. 20, 2913-2921 (2006).
-
(2006)
Genes Dev.
, vol.20
, pp. 2913-2921
-
-
Haigis, M.C.1
Guarente, L.P.2
-
50
-
-
84858797950
-
Sirtuins as regulators of metabolism and healthspan
-
Houtkooper, R. H., Pirinen, E. & Auwerx, J. Sirtuins as regulators of metabolism and healthspan. Nature Rev. Mol. Cell Biol. 13, 225-238 (2012).
-
(2012)
Nature Rev. Mol. Cell Biol.
, vol.13
, pp. 225-238
-
-
Houtkooper, R.H.1
Pirinen, E.2
Auwerx, J.3
-
51
-
-
84455188711
-
+, a circadian metabolite with an epigenetic twist
-
+, a circadian metabolite with an epigenetic twist. Endocrinology 153, 1-5 (2012).
-
(2012)
Endocrinology
, vol.153
, pp. 1-5
-
-
Sassone-Corsi, P.1
-
53
-
-
47549088250
-
+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
-
+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134, 329-340 (2008).
-
(2008)
Cell
, vol.134
, pp. 329-340
-
-
Nakahata, Y.1
-
54
-
-
43049169926
-
Epigenetic control of rDNA loci in response to intracellular energy status
-
Murayama, A. et al. Epigenetic control of rDNA loci in response to intracellular energy status. Cell 133, 627-639 (2008).
-
(2008)
Cell
, vol.133
, pp. 627-639
-
-
Murayama, A.1
-
55
-
-
41349090663
-
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
-
Michishita, E. et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452, 492-496 (2008).
-
(2008)
Nature
, vol.452
, pp. 492-496
-
-
Michishita, E.1
-
56
-
-
58149090925
-
SIRT6 links histone H3 lysine 9 deacetylation to NF-κB-dependent gene expression and organismal life span
-
Kawahara, T. L. A. et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-κB-dependent gene expression and organismal life span. Cell 136, 62-74 (2009).
-
(2009)
Cell
, vol.136
, pp. 62-74
-
-
Kawahara, T.L.A.1
-
57
-
-
31044445366
-
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
-
Mostoslavsky, R. et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124, 315-329 (2006).
-
(2006)
Cell
, vol.124
, pp. 315-329
-
-
Mostoslavsky, R.1
-
58
-
-
84858000209
-
The sirtuin SIRT6 regulates lifespan in male mice
-
Kanfi, Y. et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature 483, 218-221 (2012).
-
(2012)
Nature
, vol.483
, pp. 218-221
-
-
Kanfi, Y.1
-
59
-
-
0014621744
-
The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver
-
Veech, R. L. R., Eggleston, L. V. L. & Krebs, H. A. H. The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver. Biochem. J. 115, 609-619 (1969).
-
(1969)
Biochem. J.
, vol.115
, pp. 609-619
-
-
Veech, R.L.R.1
Eggleston, L.V.L.2
Krebs, H.A.H.3
-
60
-
-
84255198350
-
The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD
-
Gerhart-Hines, Z. et al. The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD. Mol. Cell 44, 851-863 (2011).
-
(2011)
Mol. Cell
, vol.44
, pp. 851-863
-
-
Gerhart-Hines, Z.1
-
61
-
-
84862022077
-
+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
-
+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 15, 838-847 (2012).
-
(2012)
Cell Metab.
, vol.15
, pp. 838-847
-
-
Cantó, C.1
-
62
-
-
84874721105
-
Evidence for a common mechanism of SIRT1 regulation by allosteric activators
-
Hubbard, B. P. et al. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science 339, 1216-1219 (2013).
-
(2013)
Science
, vol.339
, pp. 1216-1219
-
-
Hubbard, B.P.1
-
63
-
-
84877309874
-
Rejuvenating SIRT1 activators
-
Gut, P. & Verdin, E. Rejuvenating SIRT1 activators. Cell Metab. 17, 635-637 (2013).
-
(2013)
Cell Metab.
, vol.17
, pp. 635-637
-
-
Gut, P.1
Verdin, E.2
-
64
-
-
84858782079
-
AMPK: A nutrient and energy sensor that maintains energy homeostasis
-
Hardie, D. G. D., Ross, F. A. F. & Hawley, S. A. S. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nature Rev. Mol. Cell Biol. 13, 251-262 (2012).
-
(2012)
Nature Rev. Mol. Cell Biol.
, vol.13
, pp. 251-262
-
-
Hardie, D.G.D.1
Ross, F.A.F.2
Hawley, S.A.S.3
-
65
-
-
77956294919
-
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation
-
Bungard, D. et al. Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 329, 1201-1205 (2010).
-
(2010)
Science
, vol.329
, pp. 1201-1205
-
-
Bungard, D.1
-
66
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006).
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
67
-
-
78149487692
-
Pluripotency and cellular reprogramming: Facts, hypotheses, unresolved issues
-
Hanna, J. H., Saha, K. & Jaenisch, R. Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell 143, 508-525 (2010).
-
(2010)
Cell
, vol.143
, pp. 508-525
-
-
Hanna, J.H.1
Saha, K.2
Jaenisch, R.3
-
68
-
-
84886859638
-
Chromatin dynamics during cellular reprogramming
-
Apostolou, E. & Hochedlinger, K. Chromatin dynamics during cellular reprogramming. Nature 502, 462-471 (2013).
-
(2013)
Nature
, vol.502
, pp. 462-471
-
-
Apostolou, E.1
Hochedlinger, K.2
-
69
-
-
67749140110
-
Dependence of mouse embryonic stem cells on threonine catabolism
-
Wang, J. et al. Dependence of mouse embryonic stem cells on threonine catabolism. Science 325, 435-439 (2009).
-
(2009)
Science
, vol.325
, pp. 435-439
-
-
Wang, J.1
-
70
-
-
84872160110
-
Influence of threonine metabolism on S-adenosylmethionine and histone methylation
-
Shyh-Chang, N. et al. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science 339, 222-226 (2013).
-
(2013)
Science
, vol.339
, pp. 222-226
-
-
Shyh-Chang, N.1
-
71
-
-
80053144962
-
A decade of exploring the cancer epigenome-biological and translational implications
-
Baylin, S. B. & Jones, P. A. A decade of exploring the cancer epigenome-biological and translational implications. Nature Rev. Cancer 11, 726-734 (2011).
-
(2011)
Nature Rev. Cancer
, vol.11
, pp. 726-734
-
-
Baylin, S.B.1
Jones, P.A.2
-
72
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033 (2009).
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
73
-
-
77956674635
-
Evidence for an alternative glycolytic pathway in rapidly proliferating cells
-
Vander Heiden, M. G. et al. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science 329, 1492-1499 (2010).
-
(2010)
Science
, vol.329
, pp. 1492-1499
-
-
Vander Heiden, M.G.1
-
74
-
-
84867606428
-
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
-
Sturm, D. et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 22, 425-437 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 425-437
-
-
Sturm, D.1
-
75
-
-
84858796263
-
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
-
Turcan, S. et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483, 479-483 (2012).
-
(2012)
Nature
, vol.483
, pp. 479-483
-
-
Turcan, S.1
-
76
-
-
77956265489
-
IDH mutations in glioma and acute myeloid leukemia
-
Dang, L., Jin, S. & Su, S. M. IDH mutations in glioma and acute myeloid leukemia. Trends Mol. Med. 16, 387-397 (2010).
-
(2010)
Trends Mol. Med.
, vol.16
, pp. 387-397
-
-
Dang, L.1
Jin, S.2
Su, S.M.3
-
77
-
-
48649087037
-
Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon
-
Waldecker, M., Kautenburger, T., Daumann, H., Busch, C. & Schrenk, D. Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon. J. Nutr. Biochem. 19, 587-593 (2008).
-
(2008)
J. Nutr. Biochem.
, vol.19
, pp. 587-593
-
-
Waldecker, M.1
Kautenburger, T.2
Daumann, H.3
Busch, C.4
Schrenk, D.5
-
78
-
-
0019940133
-
Utilization of nutrients by isolated epithelial cells of the rat colon
-
Roediger, W. E. Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 83, 424-429 (1982).
-
(1982)
Gastroenterology
, vol.83
, pp. 424-429
-
-
Roediger, W.E.1
-
79
-
-
35848936502
-
Dietary modulation of colon cancer risk
-
Kim, Y. S. & Milner, J. A. Dietary modulation of colon cancer risk. J. Nutr. 137, 2576S-2579S (2007).
-
(2007)
J. Nutr.
, vol.137
-
-
Kim, Y.S.1
Milner, J.A.2
-
80
-
-
84870389262
-
The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation
-
Donohoe, D. R. et al. The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Mol. Cell 48, 612-626 (2012).
-
(2012)
Mol. Cell
, vol.48
, pp. 612-626
-
-
Donohoe, D.R.1
-
81
-
-
33745301716
-
The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype
-
Comalada, M. et al. The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype. J. Cancer Res. Clin. Oncol. 132, 487-497 (2006).
-
(2006)
J. Cancer Res. Clin. Oncol.
, vol.132
, pp. 487-497
-
-
Comalada, M.1
-
82
-
-
33750110683
-
Fuel metabolism in starvation
-
Cahill, G. F. Fuel metabolism in starvation. Annu. Rev. Nutr. 26, 1-22 (2006).
-
(2006)
Annu. Rev. Nutr.
, vol.26
, pp. 1-22
-
-
Cahill, G.F.1
-
83
-
-
0034624968
-
D-β-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease
-
Kashiwaya, Y. et al. D-β-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proc. Natl Acad. Sci. USA 97, 5440-5444 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 5440-5444
-
-
Kashiwaya, Y.1
-
84
-
-
60749090581
-
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
-
Maalouf, M., Rho, J. M. & Mattson, M. P. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res. Rev. 59, 293-315 (2009).
-
(2009)
Brain Res. Rev.
, vol.59
, pp. 293-315
-
-
Maalouf, M.1
Rho, J.M.2
Mattson, M.P.3
-
85
-
-
84872166360
-
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor
-
Shimazu, T. et al. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339, 211-214 (2013).
-
(2013)
Science
, vol.339
, pp. 211-214
-
-
Shimazu, T.1
-
86
-
-
41349085806
-
Nutritional control of reproductive status in honeybees via DNA methylation
-
Kucharski, R., Maleszka, J., Foret, S. & Maleszka, R. Nutritional control of reproductive status in honeybees via DNA methylation. Science 319, 1827-1830 (2008).
-
(2008)
Science
, vol.319
, pp. 1827-1830
-
-
Kucharski, R.1
Maleszka, J.2
Foret, S.3
Maleszka, R.4
-
87
-
-
23044514669
-
Epigenetic differences arise during the lifetime of monozygotic twins
-
Fraga, M. F. M. et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl Acad. Sci. USA 102, 10604-10609 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 10604-10609
-
-
Fraga, M.F.M.1
-
88
-
-
84855956247
-
Epigenetics and the environment: Emerging patterns and implications
-
Feil, R. & Fraga, M. F. Epigenetics and the environment: emerging patterns and implications. Nature Rev. Genet. 13, 97-109 (2011).
-
(2011)
Nature Rev. Genet.
, vol.13
, pp. 97-109
-
-
Feil, R.1
Fraga, M.F.2
-
89
-
-
29144453326
-
Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
-
Nathan, D. M. et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N. Engl. J. Med. 353, 2643-2653 (2005).
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 2643-2653
-
-
Nathan, D.M.1
-
90
-
-
45149133036
-
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
-
Patel, A. et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N. Engl. J. Med. 358, 2560-2572 (2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 2560-2572
-
-
Patel, A.1
-
92
-
-
80053559849
-
Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells
-
Pirola, L. et al. Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells. Genome Res. 21, 1601-1615 (2011).
-
(2011)
Genome Res.
, vol.21
, pp. 1601-1615
-
-
Pirola, L.1
-
93
-
-
48249127225
-
Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes
-
Villeneuve, L. M. et al. Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc. Natl Acad. Sci. USA 105, 9047-9052 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 9047-9052
-
-
Villeneuve, L.M.1
-
94
-
-
65549170303
-
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail
-
Brasacchio, D. et al. Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. Diabetes 58, 1229-1236 (2009).
-
(2009)
Diabetes
, vol.58
, pp. 1229-1236
-
-
Brasacchio, D.1
-
95
-
-
84876673669
-
Intergenerational programming of metabolic disease: Evidence from human populations and experimental animal models
-
Patti, M.-E. Intergenerational programming of metabolic disease: evidence from human populations and experimental animal models. Cell. Mol. Life Sci. 70, 1597-1608 (2013).
-
(2013)
Cell. Mol. Life Sci.
, vol.70
, pp. 1597-1608
-
-
Patti, M.-E.1
-
96
-
-
33847769732
-
Anthropometric measures in middle age after exposure to famine during gestation: Evidence from the Dutch famine
-
Stein, A. D. et al. Anthropometric measures in middle age after exposure to famine during gestation: evidence from the Dutch famine. Am. J. Clin. Nutr. 85, 869-876 (2007).
-
(2007)
Am. J. Clin. Nutr.
, vol.85
, pp. 869-876
-
-
Stein, A.D.1
-
97
-
-
34250781054
-
Transgenerational response to nutrition, early life circumstances and longevity
-
Kaati, G., Bygren, L. O., Pembrey, M. & Sjöström, M. Transgenerational response to nutrition, early life circumstances and longevity. Eur. J. Hum. Genet. 15, 784-790 (2007).
-
(2007)
Eur. J. Hum. Genet.
, vol.15
, pp. 784-790
-
-
Kaati, G.1
Bygren, L.O.2
Pembrey, M.3
Sjöström, M.4
-
98
-
-
32944469027
-
Preconceptional fasting of fathers alters serum glucose in offspring of mice
-
Anderson, L. M. et al. Preconceptional fasting of fathers alters serum glucose in offspring of mice. Nutrition 22, 327-331 (2006).
-
(2006)
Nutrition
, vol.22
, pp. 327-331
-
-
Anderson, L.M.1
-
99
-
-
78650446334
-
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals
-
Carone, B. R. et al. Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell 143, 1084-1096 (2010).
-
(2010)
Cell
, vol.143
, pp. 1084-1096
-
-
Carone, B.R.1
-
100
-
-
0032699670
-
Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting
-
Kersten, S. et al. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J. Clin. Invest. 103, 1489-1498 (1999).
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 1489-1498
-
-
Kersten, S.1
-
101
-
-
77958596171
-
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
-
Ng, S.-F. et al. Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature 467, 963-966 (2010).
-
(2010)
Nature
, vol.467
, pp. 963-966
-
-
Ng, S.-F.1
-
102
-
-
84865790047
-
An integrated encyclopedia of DNA elements in the human genome
-
ENCODE Project Consortium.
-
ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012).
-
(2012)
Nature
, vol.489
, pp. 57-74
-
-
-
103
-
-
84856090875
-
Aging, rejuvenation, and epigenetic reprogramming: Resetting the aging clock
-
Rando, T. A. & Chang, H. Y. Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell 148, 46-57 (2012).
-
(2012)
Cell
, vol.148
, pp. 46-57
-
-
Rando, T.A.1
Chang, H.Y.2
-
104
-
-
20144363712
-
A potential decline in life expectancy in the United States in the 21st century
-
Olshansky, S. J. et al. A potential decline in life expectancy in the United States in the 21st century. N. Engl. J. Med. 352, 1138-1145 (2005).
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 1138-1145
-
-
Olshansky, S.J.1
-
105
-
-
84860371953
-
Epigenetic protein families: A new frontier for drug discovery
-
Arrowsmith, C. H., Bountra, C., Fish, P. V., Lee, K. & Schapira, M. Epigenetic protein families: a new frontier for drug discovery. Nature Rev. Drug Discov. 11, 384-400 (2012).
-
(2012)
Nature Rev. Drug Discov.
, vol.11
, pp. 384-400
-
-
Arrowsmith, C.H.1
Bountra, C.2
Fish, P.V.3
Lee, K.4
Schapira, M.5
-
106
-
-
84886808679
-
Chromatin proteins and modifications as drug targets
-
Helin, K. & Dhanak, D. Chromatin proteins and modifications as drug targets. Nature 502, 480-488 (2013).
-
(2013)
Nature
, vol.502
, pp. 480-488
-
-
Helin, K.1
Dhanak, D.2
-
107
-
-
0037040581
-
Regulation of corepressor function by nuclear NADH
-
Zhang, Q., Piston, D. W. & Goodman, R. H. Regulation of corepressor function by nuclear NADH. Science 295, 1895-1897 (2002).
-
(2002)
Science
, vol.295
, pp. 1895-1897
-
-
Zhang, Q.1
Piston, D.W.2
Goodman, R.H.3
-
108
-
-
84858030373
-
Fluorescence imaging of cellular metabolites with RNA
-
Paige, J. S., Nguyen-Duc, T., Song, W. & Jaffrey, S. R. Fluorescence imaging of cellular metabolites with RNA. Science 335, 1194 (2012).
-
(2012)
Science
, vol.335
, pp. 1194
-
-
Paige, J.S.1
Nguyen-Duc, T.2
Song, W.3
Jaffrey, S.R.4
-
109
-
-
84868024193
-
A genetically encoded metabolite sensor for malonyl-CoA
-
Ellis, J. M. & Wolfgang, M. J. A genetically encoded metabolite sensor for malonyl-CoA. Chem. Biol. 19, 1333-1339 (2012).
-
(2012)
Chem. Biol.
, vol.19
, pp. 1333-1339
-
-
Ellis, J.M.1
Wolfgang, M.J.2
-
110
-
-
79953732149
-
A fluorescent reporter of AMPK activity and cellular energy stress
-
Tsou, P., Bin, B., Zheng, Hsu, C.-H., Sasaki, A. T. & Cantley, L. C. A fluorescent reporter of AMPK activity and cellular energy stress. Cell Metab. 13, 476-486 (2011).
-
(2011)
Cell Metab.
, vol.13
, pp. 476-486
-
-
Tsou, P.1
Bin, B.2
Zheng Hsu, C.-H.3
Sasaki, A.T.4
Cantley, L.C.5
-
111
-
-
67649255876
-
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
-
Niethammer, P., Grabher, C., Look, A. T. & Mitchison, T. J. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature 459, 996-999 (2009).
-
(2009)
Nature
, vol.459
, pp. 996-999
-
-
Niethammer, P.1
Grabher, C.2
Look, A.T.3
Mitchison, T.J.4
-
112
-
-
77950200010
-
The genetics of ageing
-
Kenyon, C. J. The genetics of ageing. Nature 464, 504-512 (2010).
-
(2010)
Nature
, vol.464
, pp. 504-512
-
-
Kenyon, C.J.1
-
113
-
-
84855321183
-
Histone methylation makes its mark on longevity
-
Han, S. & Brunet, A. Histone methylation makes its mark on longevity. Trends Cell Biol. 22, 42-49 (2012).
-
(2012)
Trends Cell Biol.
, vol.22
, pp. 42-49
-
-
Han, S.1
Brunet, A.2
-
114
-
-
81555214034
-
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
-
Greer, E. L. et al. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature 479, 365-371 (2011).
-
(2011)
Nature
, vol.479
, pp. 365-371
-
-
Greer, E.L.1
-
115
-
-
77951176737
-
Extending healthy life span-from yeast to humans
-
Fontana, L., Partridge, L. & Longo, V. D. Extending healthy life span-from yeast to humans. Science 328, 321-326 (2010).
-
(2010)
Science
, vol.328
, pp. 321-326
-
-
Fontana, L.1
Partridge, L.2
Longo, V.D.3
-
116
-
-
17144429302
-
Calorie restriction, SIRT1 and metabolism: Understanding longevity
-
Bordone, L. & Guarente, L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nature Rev. Mol. Cell Biol. 6, 298-305 (2005).
-
(2005)
Nature Rev. Mol. Cell Biol.
, vol.6
, pp. 298-305
-
-
Bordone, L.1
Guarente, L.2
|