Brain amino acid metabolism and ketosis

Journal of Neuroscience Research

Volumn 66, Issue 2, 2001, Pages 272-281

  Yudkoff, Marc ^a,b   Daikhin, Yevgeny ^a   Nissim, Ilana ^a   Lazarow, Adam ^a   Nissim, Itzhak ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Brain metabolism; Epilepsy; Glutamate; Ketogenic diet

Indexed keywords

4 AMINOBUTYRIC ACID; AMINO ACID; ASPARTATE AMINOTRANSFERASE; ASPARTIC ACID; BUTYRIC ACID DERIVATIVE; CITRIC ACID; COENZYME A; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; LACTIC ACID; LEUCINE;

AMINO ACID BRAIN LEVEL; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; KETOACIDOSIS; KETOGENESIS; LIPID DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSAMINATION;

AMINO ACIDS; ANIMALS; ASPARTIC ACID; BLOOD-BRAIN BARRIER; BODY WEIGHT; BRAIN; COENZYME A; DIETARY FATS; GAMMA-AMINOBUTYRIC ACID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCOSE; GLUTAMIC ACID; KETONE BODIES; KETOSIS; MALE; MICE; NERVE TISSUE PROTEINS; PROSENCEPHALON;

EID: 0035888276     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.1221     Document Type: Article

References (80)

1. Diet-induced ketosis does not cause cerebral acidosis
2. Ketogenic diets for treatment of childhood epilepsy
3. Generation of ketone bodies from leucine by cultured astroglial cells
4. A ketogenic diet increases the resistance to pentylenetetrazol-induced seizures in the rat
5. A ketogenic diet exacerbates kainate-induced seizures in the rat
6. Seizure-related elevations of extracellular amino acids in human focal epilepsy
7. Ketone body enzyme activities in purified neurons, astrocytes and oligodendroglia
8. Influence of the malate-aspartate shuttle on oxidative metabolism in synaptosomes
9. Metabolic significance of transamination
10. Ketone bodies and brain glutamate and GABA metabolism
11. Chronic kerosis and cerebral metabolism
12. The effects of ketone bodies on glucose utilization
13. Release of EAA: Animal studies and epileptic foci studies in humans
14. Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture
15. 15N]glutamate
16. Regulation of GABA level in rat brain synaptosomes: Fluxes through enzymes of the GABA shunt and effects of glutamate, calcium and ketone bodies
17. Use of β-methylene-DL-aspartate to assess the role of aspartate aminotransferase in cerebral oxidative metabolism
18. Enhanced aspartate release from hippocampal slices of epileptic (E1) mice
19. Aspartate and glutamate mediate excitatory synaptic transmission in area CA1 of the hippocampus
20. Use of t-butyldimethylsilylation in the GC-MS analysis of physiologic compounds in the plasma using electron-impact ionization
21. Use of traditional ketogenic diet for treatment of intractable epilepsy
22. Induction processes in blood-brain transfer of ketone bodies during starvation
23. Blood-brain barrier permeability of glucose and ketone bodies during short-term starvation in humans
24. Regional ketone body utilization by rat brain in starvation and diabetes
25. Neuronal-astrocytic interactions in metabolism of transmitter amino acids of the glutamate family
26. Ketogenic diet: Effects on expression of kindled seizures and behavior in adult rats
27. Control of the redox state of the pyridine nucleotides in the rat cerebral cortex: Effect of electroshock-induced seizures
28. Ketonemia and seizures: Metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy
29. o-Phthalaldehyde precolumn derivatization and reversed-phase high performance liquid chromatography of polypeptide hydrolysates and physiologic fluids
30. 15N NMR
31. Aminooxyaceric acid inhibits the malate-aspartate shuttle in isolated nerve terminals and prevents the mitochondria from utilizing glycolytic substrates
32. Determination of short-chain coenzyme A compounds by reverse-phase high-performance liquid chromatography
33. Efficacy of the ketogenic diet for intractable seizure disorders: Review of 58 cases
34. Monocarboxylate transporter expression in mouse brain
35. β-Hydroxybutyrate suppresses pentylenetetrazol (PTZ)-induced seizures in young adult rats
36. Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area
37. Regulation of energy metabolism in synaptic terminals and cultured rat brain astrocytes: Differences revealed using amino-oxyacetate
38. Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes
39. Differential distribution of the enzymes glutamate dehydrogenase and aspartate aminotransferase in cortical synaptic mitochondria contributes to metabolic compartmentation in cortical synaptic terminals
40. The role of glutamate in epilepsy and other CNS disorders
41. The acetoacetyl CoA thiolyses of rat brain and their relative activities during postnatal development
42. Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures
43. Ketogenic diet reduces spontaneous seizures and mossy fiber sprouting in the kainic acid model
44. Fine structural localization of glutamine synthetase in astrocytes of rat brain
45. Brain metabolism during fasting
46. Activities of enzymes of ketone-body utilization in brain and other tissues of suckling rats
47. 31P spectroscopic imaging at 4.1T
48. Potassium-induced stimulation of oxidative metabolism of glucose in cultures of intact cerebellar granule cells but not in corresponding cells with dendritic degeneration
49. Branched-chain amino acids
50. Starvation induced changes in transport of ketone bodies across the blood-brain barrier
51. Rapid inactivation of brain glutamate decarboxylase by aspartate
52. Endogenous aspartate release in the rat hippocampus inhibited by M2 "cardiac" muscarinic receptors
53. Epilepsy and the ketogenic diet
54. Physiological roles of ketone bodies as substrates and signals in mammalian tissues
55. Stable isotope tracer analysis by GC-MS, including quantification of isotopomer effects
56. Insulin, ketone bodies and mitochondrial energy, transduction
57. Pharmacologic and functional characterization of astrocytic GABA transport: A short review
58. Blood-brain barrier glucose transporter: Effects of hypo- and hyperglycemia revisited
59. In vivo conversion of γ-aminobutyric acid and 1,4-butanediol to γ-hydroxybutyric acid in rat brain. Studies using stable isotopes
60. 13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons
61. Mitochondrial heterogeneity in the brain at the cellular level
62. Beta-hydroxybutyrate reverses insulin-induced hypoglycemic coma in suckling-weanling mice despite low blood and brain glucose levels
63. Coenzyme A transferase activity in rat brain
64. 14C]butyrate by dissociated cells from rat brain
65. Transport of L-lactate by cultured rat brain astrocytes
66. Brain metabolite concentrations and redox states in rats fed diets containing 1,3-butanediol or ethanol
67. A multicenter study of the efficacy of the ketogenic diet
68. 13C MR spectroscopy
69. The in vivo utilization of acetoacetate, D-(-)-3-hydroxybutyrate, and glucose for lipid synthesis in brain in the 18-day-old rat
70. Effects of ketonuria on the course of epilepsy
71. Epilepsy in childhood. III. Results with the ketogenic diet
72. 15N glutamine enrichment with tertiary butyldimethylsilyl derivatives
73. Brain metabolism of branched-chain amino acids
74. Astrocyte leucine metabolism: Significance of branched-chain amino acid transamination
75. Neuronal metabolism of branched-chain amino acids: Flux through the aminotransferase pathway in synaptosomes
76. 15N]glutamate by cultured astrocytes
77. Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle
78. Effects of ketone bodies on astrocyte amino acid metabolism