-
1
-
-
84905485425
-
Advances in lupus genetics and epigenetics
-
Deng, Y. & Tsao, B. P. Advances in lupus genetics and epigenetics. Curr. Opin. Rheumatol. 26, 482-492 (2014).
-
(2014)
Curr. Opin. Rheumatol.
, vol.26
, pp. 482-492
-
-
Deng, Y.1
Tsao, B.P.2
-
2
-
-
84942591039
-
Advances in lupus genetics
-
Niewold, T. B. Advances in lupus genetics. Curr. Opin. Rheumatol. 27, 440-447 (2015).
-
(2015)
Curr. Opin. Rheumatol.
, vol.27
, pp. 440-447
-
-
Niewold, T.B.1
-
3
-
-
84961905801
-
The genetics of rheumatoid arthritis: Risk and protection in different stages of the evolution of RA
-
Yarwood, A., Huizinga, T. W. & Worthington, J. The genetics of rheumatoid arthritis: risk and protection in different stages of the evolution of RA. Rheumatology (Oxford) 55, 199-209 (2016).
-
(2016)
Rheumatology (Oxford)
, vol.55
, pp. 199-209
-
-
Yarwood, A.1
Huizinga, T.W.2
Worthington, J.3
-
4
-
-
84882449068
-
Genetic insights into common pathways and complex relationships among immune-mediated diseases
-
Parkes, M., Cortes, A., van Heel, D. A. & Brown, M. A. Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat. Rev. Genet. 14, 661-673 (2013).
-
(2013)
Nat. Rev. Genet.
, vol.14
, pp. 661-673
-
-
Parkes, M.1
Cortes, A.2
Van Heel, D.A.3
Brown, M.A.4
-
5
-
-
64749116743
-
Genetics of type 1A diabetes
-
Concannon, P., Rich, S. S. & Nepom, G. T. Genetics of type 1A diabetes. N. Engl. J. Med. 360, 1646-1654 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1646-1654
-
-
Concannon, P.1
Rich, S.S.2
Nepom, G.T.3
-
6
-
-
84922424028
-
B cells take the front seat: Dysregulated B cell signals orchestrate loss of tolerance and autoantibody production
-
Jackson, S. W., Kolhatkar, N. S. & Rawlings, D. J. B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production. Curr. Opin. Immunol. 33, 70-77 (2015).
-
(2015)
Curr. Opin. Immunol.
, vol.33
, pp. 70-77
-
-
Jackson, S.W.1
Kolhatkar, N.S.2
Rawlings, D.J.3
-
9
-
-
0342711256
-
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
-
Lam, K. P., Kuhn, R. & Rajewsky, K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90, 1073-1083 (1997).
-
(1997)
Cell
, vol.90
, pp. 1073-1083
-
-
Lam, K.P.1
Kuhn, R.2
Rajewsky, K.3
-
10
-
-
70350304558
-
PI3 kinase signals BCR-dependent mature B cell survival
-
Srinivasan, L. et al. PI3 kinase signals BCR-dependent mature B cell survival. Cell 139, 573-586 (2009).
-
(2009)
Cell
, vol.139
, pp. 573-586
-
-
Srinivasan, L.1
-
11
-
-
84942912487
-
The B-cell antigen receptor integrates adaptive and innate immune signals
-
Otipoby, K. L. et al. The B-cell antigen receptor integrates adaptive and innate immune signals. Proc. Natl Acad. Sci. USA 112, 12145-12150 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 12145-12150
-
-
Otipoby, K.L.1
-
12
-
-
0025973190
-
Inducible nuclear expression of NF-κB in primary B cells stimulated through the surface Ig receptor
-
Liu, J. L., Chiles, T. C., Sen, R. J. & Rothstein, T. L. Inducible nuclear expression of NF-κB in primary B cells stimulated through the surface Ig receptor. J. Immunol. 146, 1685-1691 (1991).
-
(1991)
J. Immunol.
, vol.146
, pp. 1685-1691
-
-
Liu, J.L.1
Chiles, T.C.2
Sen, R.J.3
Rothstein, T.L.4
-
13
-
-
0029006329
-
Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis
-
Norvell, A., Mandik, L. & Monroe, J. G. Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis. J. Immunol. 154, 4404-4413 (1995).
-
(1995)
J. Immunol.
, vol.154
, pp. 4404-4413
-
-
Norvell, A.1
Mandik, L.2
Monroe, J.G.3
-
14
-
-
0031726050
-
B cell receptor-induced apoptosis in primary transitional murine B cells: Signaling requirements and modulation by T cell help
-
Sater, R. A., Sandel, P. C. & Monroe, J. G. B cell receptor-induced apoptosis in primary transitional murine B cells: signaling requirements and modulation by T cell help. Int. Immunol. 10, 1673-1682 (1998).
-
(1998)
Int. Immunol.
, vol.10
, pp. 1673-1682
-
-
Sater, R.A.1
Sandel, P.C.2
Monroe, J.G.3
-
15
-
-
38749090153
-
Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation
-
Meyer-Bahlburg, A., Andrews, S. F., Yu, K. O., Porcelli, S. A. & Rawlings, D. J. Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation. J. Exp. Med. 205, 155-168 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 155-168
-
-
Meyer-Bahlburg, A.1
Andrews, S.F.2
Yu, K.O.3
Porcelli, S.A.4
Rawlings, D.J.5
-
16
-
-
0026001494
-
Selection of antigen-specific, idiotype-positive B cells in transgenic mice expressing a rearranged M167-μ heavy chain gene
-
Kenny, J. J., O'Connell, C., Sieckmann, D. G., Fischer, R. T. & Longo, D. L. Selection of antigen-specific, idiotype-positive B cells in transgenic mice expressing a rearranged M167-μ heavy chain gene. J. Exp. Med. 174, 1189-1201 (1991).
-
(1991)
J. Exp. Med.
, vol.174
, pp. 1189-1201
-
-
Kenny, J.J.1
O'Connell, C.2
Sieckmann, D.G.3
Fischer, R.T.4
Longo, D.L.5
-
17
-
-
84865721122
-
Endogenous antigen tunes the responsiveness of naive B cells but not T cells
-
Zikherman, J., Parameswaran, R. & Weiss, A. Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature 489, 160-164 (2012).
-
(2012)
Nature
, vol.489
, pp. 160-164
-
-
Zikherman, J.1
Parameswaran, R.2
Weiss, A.3
-
18
-
-
0033973585
-
Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk
-
Martin, F. & Kearney, J. F. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk. Immunity 12, 39-49 (2000).
-
(2000)
Immunity
, vol.12
, pp. 39-49
-
-
Martin, F.1
Kearney, J.F.2
-
19
-
-
81755179431
-
Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?
-
Burn, G. L., Svensson, L., Sanchez-Blanco, C., Saini, M. & Cope, A. P. Why is PTPN22 a good candidate susceptibility gene for autoimmune disease? FEBS Lett. 585, 3689-3698 (2011).
-
(2011)
FEBS Lett.
, vol.585
, pp. 3689-3698
-
-
Burn, G.L.1
Svensson, L.2
Sanchez-Blanco, C.3
Saini, M.4
Cope, A.P.5
-
20
-
-
84925858831
-
The role of PTPN22 risk variant in the development of autoimmunity: Finding common ground between mouse and human
-
Rawlings, D. J., Dai, X. & Buckner, J. H. The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human. J. Immunol. 194, 2977-2984 (2015).
-
(2015)
J. Immunol.
, vol.194
, pp. 2977-2984
-
-
Rawlings, D.J.1
Dai, X.2
Buckner, J.H.3
-
21
-
-
4143105691
-
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE
-
Kyogoku, C. et al. Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am. J. Hum. Genet. 75, 504-507 (2004).
-
(2004)
Am. J. Hum. Genet.
, vol.75
, pp. 504-507
-
-
Kyogoku, C.1
-
22
-
-
12144291502
-
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
-
Bottini, N. et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat. Genet. 36, 337-338 (2004).
-
(2004)
Nat. Genet.
, vol.36
, pp. 337-338
-
-
Bottini, N.1
-
23
-
-
3242713277
-
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
-
Begovich, A. B. et al. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am. J. Hum. Genet. 75, 330-337 (2004).
-
(2004)
Am. J. Hum. Genet.
, vol.75
, pp. 330-337
-
-
Begovich, A.B.1
-
24
-
-
84855369247
-
Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant
-
Habib, T. et al. Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant. J. Immunol. 188, 487-496 (2012).
-
(2012)
J. Immunol.
, vol.188
, pp. 487-496
-
-
Habib, T.1
-
25
-
-
80052376347
-
The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans
-
Menard, L. et al. The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans. J. Clin. Invest. 121, 3635-3644 (2011).
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 3635-3644
-
-
Menard, L.1
-
26
-
-
40349109578
-
Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes
-
Rieck, M. et al. Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes. J. Immunol. 179, 4704-4710 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 4704-4710
-
-
Rieck, M.1
-
27
-
-
28444469783
-
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
-
Vang, T. et al. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat. Genet. 37, 1317-1319 (2005).
-
(2005)
Nat. Genet.
, vol.37
, pp. 1317-1319
-
-
Vang, T.1
-
28
-
-
84877115482
-
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models
-
Dai, X. et al. A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J. Clin. Invest. 123, 2024-2036 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 2024-2036
-
-
Dai, X.1
-
29
-
-
80052239824
-
The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness
-
Zhang, J. et al. The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nat. Genet. 43, 902-907 (2011).
-
(2011)
Nat. Genet.
, vol.43
, pp. 902-907
-
-
Zhang, J.1
-
31
-
-
56349091862
-
Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling
-
Stadanlick, J. E. et al. Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling. Nat. Immunol. 9, 1379-1387 (2008).
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1379-1387
-
-
Stadanlick, J.E.1
-
32
-
-
0037944169
-
Cutting edge: B cell receptor signals regulate BLyS receptor levels in mature B cells and their immediate progenitors
-
Smith, S. H. & Cancro, M. P. Cutting edge: B cell receptor signals regulate BLyS receptor levels in mature B cells and their immediate progenitors. J. Immunol. 170, 5820-5823 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 5820-5823
-
-
Smith, S.H.1
Cancro, M.P.2
-
33
-
-
84875487434
-
The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway
-
Schweighoffer, E. et al. The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway. Immunity 38, 475-488 (2013).
-
(2013)
Immunity
, vol.38
, pp. 475-488
-
-
Schweighoffer, E.1
-
34
-
-
84888438716
-
Context-specific BAFF-R signaling by the NF-κB and PI3K pathways
-
Jellusova, J. et al. Context-specific BAFF-R signaling by the NF-κB and PI3K pathways. Cell Rep. 5, 1022-1035 (2013).
-
(2013)
Cell Rep.
, vol.5
, pp. 1022-1035
-
-
Jellusova, J.1
-
35
-
-
84926176133
-
CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk
-
Hobeika, E. et al. CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk. EMBO J. 34, 925-939 (2015).
-
(2015)
EMBO J.
, vol.34
, pp. 925-939
-
-
Hobeika, E.1
-
36
-
-
33947239920
-
Generation of peripheral B cells occurs via two spatially and temporally distinct pathways
-
Lindsley, R. C., Thomas, M., Srivastava, B. & Allman, D. Generation of peripheral B cells occurs via two spatially and temporally distinct pathways. Blood 109, 2521-2528 (2007).
-
(2007)
Blood
, vol.109
, pp. 2521-2528
-
-
Lindsley, R.C.1
Thomas, M.2
Srivastava, B.3
Allman, D.4
-
37
-
-
33947280631
-
Naive recirculating B cells mature simultaneously in the spleen and bone marrow
-
Cariappa, A., Chase, C., Liu, H., Russell, P. & Pillai, S. Naive recirculating B cells mature simultaneously in the spleen and bone marrow. Blood 109, 2339-2345 (2007).
-
(2007)
Blood
, vol.109
, pp. 2339-2345
-
-
Cariappa, A.1
Chase, C.2
Liu, H.3
Russell, P.4
Pillai, S.5
-
38
-
-
78049494232
-
BAFF receptor signaling AIDS the differentiation of immature B cells into transitional B cells following tonic BCR signaling
-
Rowland, S. L., Leahy, K. F., Halverson, R., Torres, R. M. & Pelanda, R. BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signaling. J. Immunol. 185, 4570-4581 (2010).
-
(2010)
J. Immunol.
, vol.185
, pp. 4570-4581
-
-
Rowland, S.L.1
Leahy, K.F.2
Halverson, R.3
Torres, R.M.4
Pelanda, R.5
-
39
-
-
0033428703
-
Mice transgenic for Baff develop lymphocytic disorders along with autoimmune manifestations
-
Mackay, F. et al. Mice transgenic for Baff develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 190, 1697-1710 (1999).
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1697-1710
-
-
Mackay, F.1
-
40
-
-
10744224617
-
B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: Longitudinal observations
-
Stohl, W. et al. B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations. Arthritis Rheum. 48, 3475-3486 (2003).
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 3475-3486
-
-
Stohl, W.1
-
41
-
-
79952070370
-
Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: A randomised, placebo-controlled, phase 3 trial
-
Navarra, S. V. et al. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet 377, 721-731 (2011).
-
(2011)
Lancet
, vol.377
, pp. 721-731
-
-
Navarra, S.V.1
-
42
-
-
2942518502
-
Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches
-
Thien, M. et al. Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity 20, 785-798 (2004).
-
(2004)
Immunity
, vol.20
, pp. 785-798
-
-
Thien, M.1
-
43
-
-
1842633887
-
Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF
-
Lesley, R. et al. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity 20, 441-453 (2004).
-
(2004)
Immunity
, vol.20
, pp. 441-453
-
-
Lesley, R.1
-
44
-
-
34047134533
-
The role of BLyS/BLyS receptors in anti-chromatin B cell regulation
-
Hondowicz, B. D. et al. The role of BLyS/BLyS receptors in anti-chromatin B cell regulation. Int. Immunol. 19, 465-475 (2007).
-
(2007)
Int. Immunol.
, vol.19
, pp. 465-475
-
-
Hondowicz, B.D.1
-
45
-
-
84858796247
-
Integration of B cell responses through Toll-like receptors and antigen receptors
-
Rawlings, D. J., Schwartz, M. A., Jackson, S. W. & Meyer-Bahlburg, A. Integration of B cell responses through Toll-like receptors and antigen receptors. Nat. Rev. Immunol. 12, 282-294 (2012).
-
(2012)
Nat. Rev. Immunol.
, vol.12
, pp. 282-294
-
-
Rawlings, D.J.1
Schwartz, M.A.2
Jackson, S.W.3
Meyer-Bahlburg, A.4
-
46
-
-
55349142293
-
IRAK-4-and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans
-
Isnardi, I. et al. IRAK-4-and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Immunity 29, 746-757 (2008).
-
(2008)
Immunity
, vol.29
, pp. 746-757
-
-
Isnardi, I.1
-
47
-
-
85013175325
-
BCR and endosomal TLR signals synergize to increase AID expression and establish central B cell tolerance
-
Kuraoka, M. et al. BCR and endosomal TLR signals synergize to increase AID expression and establish central B cell tolerance. Cell Rep. 18, 1627-1635 (2017).
-
(2017)
Cell Rep.
, vol.18
, pp. 1627-1635
-
-
Kuraoka, M.1
-
48
-
-
84855332531
-
The establishment of early B cell tolerance in humans: Lessons from primary immunodeficiency diseases
-
Meffre, E. The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases. Ann. NY Acad. Sci. 1246, 1-10 (2011).
-
(2011)
Ann. NY Acad. Sci.
, vol.1246
, pp. 1-10
-
-
Meffre, E.1
-
49
-
-
84927628470
-
Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production
-
Mills, R. E. et al. Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production. J. Immunol. 194, 3675-3686 (2015).
-
(2015)
J. Immunol.
, vol.194
, pp. 3675-3686
-
-
Mills, R.E.1
-
50
-
-
80053132181
-
WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity
-
Becker-Herman, S. et al. WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity. J. Exp. Med. 208, 2033-2042 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 2033-2042
-
-
Becker-Herman, S.1
-
51
-
-
84943327950
-
Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients
-
Pala, F. et al. Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients. J. Clin. Invest. 125, 3941-3951 (2015).
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 3941-3951
-
-
Pala, F.1
-
52
-
-
84961197588
-
Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome
-
Kolhatkar, N. S. et al. Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome. J. Exp. Med. 212, 1663-1677 (2015).
-
(2015)
J. Exp. Med.
, vol.212
, pp. 1663-1677
-
-
Kolhatkar, N.S.1
-
53
-
-
0031041694
-
Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40
-
Khan, W. N. et al. Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40. Int. Immunol. 9, 395-405 (1997).
-
(1997)
Int. Immunol.
, vol.9
, pp. 395-405
-
-
Khan, W.N.1
-
54
-
-
33746069706
-
Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival
-
Lesley, R., Kelly, L. M., Xu, Y. & Cyster, J. G. Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival. Proc. Natl Acad. Sci. USA 103, 10717-10722 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 10717-10722
-
-
Lesley, R.1
Kelly, L.M.2
Xu, Y.3
Cyster, J.G.4
-
55
-
-
84907192525
-
CD4+ T cells and CD40 participate in selection and homeostasis of peripheral B cells
-
Schwartz, M. A., Kolhatkar, N. S., Thouvenel, C., Khim, S. & Rawlings, D. J. CD4+ T cells and CD40 participate in selection and homeostasis of peripheral B cells. J. Immunol. 193, 3492-3502 (2014).
-
(2014)
J. Immunol.
, vol.193
, pp. 3492-3502
-
-
Schwartz, M.A.1
Kolhatkar, N.S.2
Thouvenel, C.3
Khim, S.4
Rawlings, D.J.5
-
56
-
-
0027960913
-
CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation
-
Castigli, E. et al. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc. Natl Acad. Sci. USA 91, 12135-12139 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 12135-12139
-
-
Castigli, E.1
-
57
-
-
0030026757
-
CD40 expression and function in murine B cell ontogeny
-
Castigli, E., Young, F., Carossino, A. M., Alt, F. W. & Geha, R. S. CD40 expression and function in murine B cell ontogeny. Int. Immunol. 8, 405-411 (1996).
-
(1996)
Int. Immunol.
, vol.8
, pp. 405-411
-
-
Castigli, E.1
Young, F.2
Carossino, A.M.3
Alt, F.W.4
Geha, R.S.5
-
58
-
-
84876468583
-
Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells
-
Kinnunen, T. et al. Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells. Blood 121, 1595-1603 (2013).
-
(2013)
Blood
, vol.121
, pp. 1595-1603
-
-
Kinnunen, T.1
-
59
-
-
0041689676
-
Predominant autoantibody production by early human B cell precursors
-
Wardemann, H. et al. Predominant autoantibody production by early human B cell precursors. Science 301, 1374-1377 (2003).
-
(2003)
Science
, vol.301
, pp. 1374-1377
-
-
Wardemann, H.1
-
60
-
-
2942635727
-
Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice
-
Hoyer, B. F. et al. Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice. J. Exp. Med. 199, 1577-1584 (2004).
-
(2004)
J. Exp. Med.
, vol.199
, pp. 1577-1584
-
-
Hoyer, B.F.1
-
61
-
-
77949501905
-
Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis
-
Huang, H., Benoist, C. & Mathis, D. Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis. Proc. Natl Acad. Sci. USA 107, 4658-4663 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 4658-4663
-
-
Huang, H.1
Benoist, C.2
Mathis, D.3
-
62
-
-
84892169206
-
Long-lived plasma cells in autoimmunity: Lessons from B-cell depleting therapy
-
Mahevas, M., Michel, M., Weill, J. C. & Reynaud, C. A. Long-lived plasma cells in autoimmunity: lessons from B-cell depleting therapy. Front. Immunol. 4, 494 (2013).
-
(2013)
Front. Immunol.
, vol.4
, pp. 494
-
-
Mahevas, M.1
Michel, M.2
Weill, J.C.3
Reynaud, C.A.4
-
63
-
-
0037144519
-
Evolution of autoantibody responses via somatic hypermutation outside of germinal centers
-
William, J., Euler, C., Christensen, S. & Shlomchik, M. J. Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science 297, 2066-2070 (2002).
-
(2002)
Science
, vol.297
, pp. 2066-2070
-
-
William, J.1
Euler, C.2
Christensen, S.3
Shlomchik, M.J.4
-
64
-
-
34547772125
-
BAFF and MyD88 signals promote a lupuslike disease independent of T cells
-
Groom, J. R. et al. BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J. Exp. Med. 204, 1959-1971 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1959-1971
-
-
Groom, J.R.1
-
65
-
-
0037991063
-
Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus
-
Jacobi, A. M. et al. Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus. Arthritis Rheum. 48, 1332-1342 (2003).
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 1332-1342
-
-
Jacobi, A.M.1
-
66
-
-
84962128086
-
Personalized immunomonitoring uncovers molecular networks that stratify lupus patients
-
Banchereau, R. et al. Personalized immunomonitoring uncovers molecular networks that stratify lupus patients. Cell 165, 551-565 (2016).
-
(2016)
Cell
, vol.165
, pp. 551-565
-
-
Banchereau, R.1
-
67
-
-
84931424223
-
Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus
-
Tipton, C. M. et al. Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus. Nat. Immunol. 16, 755-765 (2015).
-
(2015)
Nat. Immunol.
, vol.16
, pp. 755-765
-
-
Tipton, C.M.1
-
68
-
-
0037061453
-
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
-
Leadbetter, E. A. et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416, 603-607 (2002).
-
(2002)
Nature
, vol.416
, pp. 603-607
-
-
Leadbetter, E.A.1
-
69
-
-
79952745936
-
Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response
-
Hou, B. et al. Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response. Immunity 34, 375-384 (2011).
-
(2011)
Immunity
, vol.34
, pp. 375-384
-
-
Hou, B.1
-
70
-
-
77949903821
-
TLR9 regulates TLR7-and MyD88-dependent autoantibody production and disease in a murine model of lupus
-
Nickerson, K. M. et al. TLR9 regulates TLR7-and MyD88-dependent autoantibody production and disease in a murine model of lupus. J. Immunol. 184, 1840-1848 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 1840-1848
-
-
Nickerson, K.M.1
-
71
-
-
58149279490
-
ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity
-
Odegard, J. M. et al. ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J. Exp. Med. 205, 2873-2886 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2873-2886
-
-
Odegard, J.M.1
-
72
-
-
27744444832
-
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
-
Lau, C. M. et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J. Exp. Med. 202, 1171-1177 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1171-1177
-
-
Lau, C.M.1
-
73
-
-
22944490869
-
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
-
Christensen, S. R. et al. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J. Exp. Med. 202, 321-331 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 321-331
-
-
Christensen, S.R.1
-
74
-
-
33748472865
-
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
-
Christensen, S. R. et al. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25, 417-428 (2006).
-
(2006)
Immunity
, vol.25
, pp. 417-428
-
-
Christensen, S.R.1
-
75
-
-
34249792362
-
Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production
-
Yasuda, K. et al. Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production. J. Immunol. 178, 6876-6885 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 6876-6885
-
-
Yasuda, K.1
-
76
-
-
84875547953
-
Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus
-
Teichmann, L. L., Schenten, D., Medzhitov, R., Kashgarian, M. & Shlomchik, M. J. Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity 38, 528-540 (2013).
-
(2013)
Immunity
, vol.38
, pp. 528-540
-
-
Teichmann, L.L.1
Schenten, D.2
Medzhitov, R.3
Kashgarian, M.4
Shlomchik, M.J.5
-
77
-
-
0035860466
-
BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF
-
Thompson, J. S. et al. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293, 2108-2111 (2001).
-
(2001)
Science
, vol.293
, pp. 2108-2111
-
-
Thompson, J.S.1
-
78
-
-
77955921430
-
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88
-
He, B. et al. The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. Nat. Immunol. 11, 836-845 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 836-845
-
-
He, B.1
-
79
-
-
0035004320
-
Regulation of the T-independent humoral response by TACI
-
von Bulow, G. U., van Deursen, J. M. & Bram, R. J. Regulation of the T-independent humoral response by TACI. Immunity 14, 573-582 (2001).
-
(2001)
Immunity
, vol.14
, pp. 573-582
-
-
Von Bulow, G.U.1
Van Deursen, J.M.2
Bram, R.J.3
-
80
-
-
84937521918
-
Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers
-
Figgett, W. A. et al. Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers. J. Autoimmun. 61, 9-16 (2015).
-
(2015)
J. Autoimmun.
, vol.61
, pp. 9-16
-
-
Figgett, W.A.1
-
81
-
-
84974792665
-
Cutting edge: BAFF promotes autoantibody production via TACI-dependent activation of transitional B cells
-
Jacobs, H. M. et al. Cutting edge: BAFF promotes autoantibody production via TACI-dependent activation of transitional B cells. J. Immunol. 196, 3525-3531 (2016).
-
(2016)
J. Immunol.
, vol.196
, pp. 3525-3531
-
-
Jacobs, H.M.1
-
82
-
-
84885090679
-
Elevated serum BAFF levels are associated with rising anti-double-stranded DNA antibody levels and disease flare following B cell depletion therapy in systemic lupus erythematosus
-
Carter, L. M., Isenberg, D. A. & Ehrenstein, M. R. Elevated serum BAFF levels are associated with rising anti-double-stranded DNA antibody levels and disease flare following B cell depletion therapy in systemic lupus erythematosus. Arthritis Rheum. 65, 2672-2679 (2013).
-
(2013)
Arthritis Rheum.
, vol.65
, pp. 2672-2679
-
-
Carter, L.M.1
Isenberg, D.A.2
Ehrenstein, M.R.3
-
83
-
-
33644914684
-
Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: Relationships with B cell depletion, circulating antibodies, and clinical relapse
-
Cambridge, G. et al. Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: relationships with B cell depletion, circulating antibodies, and clinical relapse. Arthritis Rheum. 54, 723-732 (2006).
-
(2006)
Arthritis Rheum.
, vol.54
, pp. 723-732
-
-
Cambridge, G.1
-
84
-
-
34247121380
-
Autoimmunity following haematopoietic stem-cell transplantation
-
Daikeler, T. & Tyndall, A. Autoimmunity following haematopoietic stem-cell transplantation. Best Pract. Res. Clin. Haematol. 20, 349-360 (2007).
-
(2007)
Best Pract. Res. Clin. Haematol.
, vol.20
, pp. 349-360
-
-
Daikeler, T.1
Tyndall, A.2
-
85
-
-
0036753722
-
Dendritic cells, BAFF, and April: Innate players in adaptive antibody responses
-
MacLennan, I. & Vinuesa, C. Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses. Immunity 17, 235-238 (2002).
-
(2002)
Immunity
, vol.17
, pp. 235-238
-
-
MacLennan, I.1
Vinuesa, C.2
-
86
-
-
72949104221
-
Dysregulation of germinal centres in autoimmune disease
-
Vinuesa, C. G., Sanz, I. & Cook, M. C. Dysregulation of germinal centres in autoimmune disease. Nat. Rev. Immunol. 9, 845-857 (2009).
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 845-857
-
-
Vinuesa, C.G.1
Sanz, I.2
Cook, M.C.3
-
87
-
-
21544463136
-
The evolution of human anti-double-stranded DNA autoantibodies
-
Wellmann, U. et al. The evolution of human anti-double-stranded DNA autoantibodies. Proc. Natl Acad. Sci. USA 102, 9258-9263 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 9258-9263
-
-
Wellmann, U.1
-
88
-
-
84901282428
-
Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation
-
Jackson, S. W. et al. Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation. J. Immunol. 192, 4525-4532 (2014).
-
(2014)
J. Immunol.
, vol.192
, pp. 4525-4532
-
-
Jackson, S.W.1
-
89
-
-
84893364183
-
Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice
-
Hua, Z. et al. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J. Immunol. 192, 875-885 (2014).
-
(2014)
J. Immunol.
, vol.192
, pp. 875-885
-
-
Hua, Z.1
-
90
-
-
84969245659
-
B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6
-
Jackson, S. W. et al. B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. J. Exp. Med. 213, 733-750 (2016).
-
(2016)
J. Exp. Med.
, vol.213
, pp. 733-750
-
-
Jackson, S.W.1
-
91
-
-
33344475672
-
Lymphoid neogenesis in chronic inflammatory diseases
-
Aloisi, F. & Pujol-Borrell, R. Lymphoid neogenesis in chronic inflammatory diseases. Nat. Rev. Immunol. 6, 205-217 (2006).
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 205-217
-
-
Aloisi, F.1
Pujol-Borrell, R.2
-
92
-
-
0028116532
-
A multiinstitutional survey of the Wiskott-Aldrich syndrome
-
Sullivan, K. E., Mullen, C. A., Blaese, R. M. & Winkelstein, J. A. A multiinstitutional survey of the Wiskott-Aldrich syndrome. J. Pediatr. 125, 876-885 (1994).
-
(1994)
J. Pediatr.
, vol.125
, pp. 876-885
-
-
Sullivan, K.E.1
Mullen, C.A.2
Blaese, R.M.3
Winkelstein, J.A.4
-
93
-
-
84956581018
-
Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia
-
e3
-
Crestani, E. et al. Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia. J. Allergy Clin. Immunol. 136, 1401-1404.e3 (2015).
-
(2015)
J. Allergy Clin. Immunol.
, vol.136
, pp. 1401-1404
-
-
Crestani, E.1
-
94
-
-
84858836089
-
B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice
-
Recher, M. et al. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood 119, 2819-2828 (2012).
-
(2012)
Blood
, vol.119
, pp. 2819-2828
-
-
Recher, M.1
-
95
-
-
84893392428
-
B cell-specific loss of Lyn kinase leads to autoimmunity
-
Lamagna, C., Hu, Y., DeFranco, A. L. & Lowell, C. A. B cell-specific loss of Lyn kinase leads to autoimmunity. J. Immunol. 192, 919-928 (2014).
-
(2014)
J. Immunol.
, vol.192
, pp. 919-928
-
-
Lamagna, C.1
Hu, Y.2
DeFranco, A.L.3
Lowell, C.A.4
-
96
-
-
12444331082
-
Lyn tyrosine kinase: Accentuating the positive and the negative
-
Xu, Y., Harder, K. W., Huntington, N. D., Hibbs, M. L. & Tarlinton, D. M. Lyn tyrosine kinase: accentuating the positive and the negative. Immunity 22, 9-18 (2005).
-
(2005)
Immunity
, vol.22
, pp. 9-18
-
-
Xu, Y.1
Harder, K.W.2
Huntington, N.D.3
Hibbs, M.L.4
Tarlinton, D.M.5
-
97
-
-
38649125210
-
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
-
Harley, J. B. et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat. Genet. 40, 204-210 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 204-210
-
-
Harley, J.B.1
-
98
-
-
40049108936
-
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
-
Hom, G. et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N. Engl. J. Med. 358, 900-909 (2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 900-909
-
-
Hom, G.1
-
99
-
-
67849097322
-
Genetic associations of LYN with systemic lupus erythematosus
-
Lu, R. et al. Genetic associations of LYN with systemic lupus erythematosus. Genes Immun. 10, 397-403 (2009).
-
(2009)
Genes Immun.
, vol.10
, pp. 397-403
-
-
Lu, R.1
-
100
-
-
77954543178
-
Functionally defective germline variants of sialic acid acetylesterase in autoimmunity
-
Surolia, I. et al. Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature 466, 243-247 (2010).
-
(2010)
Nature
, vol.466
, pp. 243-247
-
-
Surolia, I.1
-
101
-
-
84940898187
-
Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity
-
Soni, C. et al. Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity. J. Autoimmun. 63, 31-46 (2015).
-
(2015)
J. Autoimmun.
, vol.63
, pp. 31-46
-
-
Soni, C.1
-
102
-
-
19344369383
-
Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice
-
Bygrave, A. E. et al. Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice. PLoS Biol. 2, E243 (2004).
-
(2004)
PLoS Biol.
, vol.2
, pp. E243
-
-
Bygrave, A.E.1
-
103
-
-
84975231564
-
Enhanced expression of Bruton's tyrosine kinase in B cells drives systemic autoimmunity by disrupting T cell homeostasis
-
Corneth, O. B. et al. Enhanced expression of Bruton's tyrosine kinase in B cells drives systemic autoimmunity by disrupting T cell homeostasis. J. Immunol. 197, 58-67 (2016).
-
(2016)
J. Immunol.
, vol.197
, pp. 58-67
-
-
Corneth, O.B.1
-
104
-
-
2942537697
-
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
-
Edwards, J. C. et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N. Engl. J. Med. 350, 2572-2581 (2004).
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2572-2581
-
-
Edwards, J.C.1
-
105
-
-
77954651554
-
Rituximab versus cyclophosphamide for ANCA-associated vasculitis
-
Stone, J. H. et al. Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N. Engl. J. Med. 363, 221-232 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 221-232
-
-
Stone, J.H.1
-
106
-
-
70449480577
-
Rituximab, B-lymphocyte depletion, and preservation of β-cell function
-
Pescovitz, M. D. et al. Rituximab, B-lymphocyte depletion, and preservation of β-cell function. N. Engl. J. Med. 361, 2143-2152 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 2143-2152
-
-
Pescovitz, M.D.1
-
107
-
-
85021849895
-
Rituximab for severe membranous nephropathy: A 6-month trial with extended follow-up
-
Dahan, K. et al. Rituximab for severe membranous nephropathy: a 6-month trial with extended follow-up. J. Am. Soc. Nephrol. 28, 348-358 (2016).
-
(2016)
J. Am. Soc. Nephrol.
, vol.28
, pp. 348-358
-
-
Dahan, K.1
-
108
-
-
33750291236
-
Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin
-
Ahmed, A. R., Spigelman, Z., Cavacini, L. A. & Posner, M. R. Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin. N. Engl. J. Med. 355, 1772-1779 (2006).
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 1772-1779
-
-
Ahmed, A.R.1
Spigelman, Z.2
Cavacini, L.A.3
Posner, M.R.4
-
109
-
-
39049142995
-
B-Cell depletion with rituximab in relapsing-remitting multiple sclerosis
-
Hauser, S. L. et al. B-Cell depletion with rituximab in relapsing-remitting multiple sclerosis. N. Engl. J. Med. 358, 676-688 (2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 676-688
-
-
Hauser, S.L.1
-
110
-
-
79960948754
-
Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy
-
Beck, L. H. Jr et al. Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy. J. Am. Soc. Nephrol. 22, 1543-1550 (2011).
-
(2011)
J. Am. Soc. Nephrol.
, vol.22
, pp. 1543-1550
-
-
Beck, L.H.1
-
111
-
-
84922286333
-
Long-term maintenance therapy using rituximab-induced continuous B-cell depletion in patients with ANCA vasculitis
-
Pendergraft, W. F. et al. Long-term maintenance therapy using rituximab-induced continuous B-cell depletion in patients with ANCA vasculitis. Clin. J. Am. Soc. Nephrol. 9, 736-744 (2014).
-
(2014)
Clin. J. Am. Soc. Nephrol.
, vol.9
, pp. 736-744
-
-
Pendergraft, W.F.1
-
112
-
-
67349186964
-
Critical analysis of rituximab-induced serological changes in connective tissue diseases
-
Cornec, D., Avouac, J., Youinou, P. & Saraux, A. Critical analysis of rituximab-induced serological changes in connective tissue diseases. Autoimmun. Rev. 8, 515-519 (2009).
-
(2009)
Autoimmun. Rev.
, vol.8
, pp. 515-519
-
-
Cornec, D.1
Avouac, J.2
Youinou, P.3
Saraux, A.4
-
113
-
-
0033577903
-
A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
-
Chan, O. T., Hannum, L. G., Haberman, A. M., Madaio, M. P. & Shlomchik, M. J. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J. Exp. Med. 189, 1639-1648 (1999).
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1639-1648
-
-
Chan, O.T.1
Hannum, L.G.2
Haberman, A.M.3
Madaio, M.P.4
Shlomchik, M.J.5
-
114
-
-
0031882091
-
A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice
-
Chan, O. & Shlomchik, M. J. A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice. J. Immunol. 160, 51-59 (1998).
-
(1998)
J. Immunol.
, vol.160
, pp. 51-59
-
-
Chan, O.1
Shlomchik, M.J.2
-
115
-
-
4644225746
-
Investigation of the role of B-cells in type 1 diabetes in the NOD mouse
-
Wong, F. S. et al. Investigation of the role of B-cells in type 1 diabetes in the NOD mouse. Diabetes 53, 2581-2587 (2004).
-
(2004)
Diabetes
, vol.53
, pp. 2581-2587
-
-
Wong, F.S.1
-
116
-
-
0033564970
-
I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet β cells of nonobese diabetic mice
-
Noorchashm, H. et al. I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet β cells of nonobese diabetic mice. J. Immunol. 163, 743-750 (1999).
-
(1999)
J. Immunol.
, vol.163
, pp. 743-750
-
-
Noorchashm, H.1
-
117
-
-
84890819172
-
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies
-
Molnarfi, N. et al. MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J. Exp. Med. 210, 2921-2937 (2013).
-
(2013)
J. Exp. Med.
, vol.210
, pp. 2921-2937
-
-
Molnarfi, N.1
-
118
-
-
84941773482
-
B cell-specific MHC class II deletion reveals multiple nonredundant roles for B cell antigen presentation in murine lupus
-
Giles, J. R., Kashgarian, M., Koni, P. A. & Shlomchik, M. J. B cell-specific MHC class II deletion reveals multiple nonredundant roles for B cell antigen presentation in murine lupus. J. Immunol. 195, 2571-2579 (2015).
-
(2015)
J. Immunol.
, vol.195
, pp. 2571-2579
-
-
Giles, J.R.1
Kashgarian, M.2
Koni, P.A.3
Shlomchik, M.J.4
-
119
-
-
84971570695
-
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites
-
Wan, X., Thomas, J. W. & Unanue, E. R. Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites. J. Exp. Med. 213, 967-978 (2016).
-
(2016)
J. Exp. Med.
, vol.213
, pp. 967-978
-
-
Wan, X.1
Thomas, J.W.2
Unanue, E.R.3
-
120
-
-
33645076274
-
TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE
-
Ehlers, M., Fukuyama, H., McGaha, T. L., Aderem, A. & Ravetch, J. V. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J. Exp. Med. 203, 553-561 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 553-561
-
-
Ehlers, M.1
Fukuyama, H.2
McGaha, T.L.3
Aderem, A.4
Ravetch, J.V.5
-
121
-
-
84908146646
-
B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers
-
Soni, C. et al. B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers. J. Immunol. 193, 4400-4414 (2014).
-
(2014)
J. Immunol.
, vol.193
, pp. 4400-4414
-
-
Soni, C.1
-
122
-
-
84867033893
-
Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity
-
Walsh, E. R. et al. Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity. Proc. Natl Acad. Sci. USA 109, 16276-16281 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 16276-16281
-
-
Walsh, E.R.1
-
123
-
-
77957673544
-
Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
-
Shen, N. et al. Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc. Natl Acad. Sci. USA 107, 15838-15843 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 15838-15843
-
-
Shen, N.1
-
124
-
-
77957282676
-
Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population
-
Garcia-Ortiz, H. et al. Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population. Ann. Rheum. Dis. 69, 1861-1865 (2010).
-
(2010)
Ann. Rheum. Dis.
, vol.69
, pp. 1861-1865
-
-
Garcia-Ortiz, H.1
-
125
-
-
79952461669
-
TLR7 single-nucleotide polymorphisms in the 3′ untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: A case-control association study
-
Kawasaki, A. et al. TLR7 single-nucleotide polymorphisms in the 3′ untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study. Arthritis Res. Ther. 13, R41 (2011).
-
(2011)
Arthritis Res. Ther.
, vol.13
, pp. R41
-
-
Kawasaki, A.1
-
126
-
-
84873557459
-
TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation
-
Nickerson, K. M. et al. TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation. J. Immunol. 190, 1447-1456 (2013).
-
(2013)
J. Immunol.
, vol.190
, pp. 1447-1456
-
-
Nickerson, K.M.1
-
127
-
-
70350629871
-
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
-
Han, J. W. et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat. Genet. 41, 1234-1237 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 1234-1237
-
-
Han, J.W.1
-
128
-
-
70350650472
-
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
-
Gateva, V. et al. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat. Genet. 41, 1228-1233 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 1228-1233
-
-
Gateva, V.1
-
129
-
-
46749115446
-
A fundamental role for interleukin-21 in the generation of T follicular helper cells
-
Vogelzang, A. et al. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29, 127-137 (2008).
-
(2008)
Immunity
, vol.29
, pp. 127-137
-
-
Vogelzang, A.1
-
130
-
-
77149122105
-
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
-
Linterman, M. A. et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J. Exp. Med. 207, 353-363 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 353-363
-
-
Linterman, M.A.1
-
131
-
-
46749151286
-
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
-
Nurieva, R. I. et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29, 138-149 (2008).
-
(2008)
Immunity
, vol.29
, pp. 138-149
-
-
Nurieva, R.I.1
-
132
-
-
60849107595
-
A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice
-
Bubier, J. A. et al. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc. Natl Acad. Sci. USA 106, 1518-1523 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 1518-1523
-
-
Bubier, J.A.1
-
133
-
-
6344269331
-
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
-
Ozaki, K. et al. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J. Immunol. 173, 5361-5371 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 5361-5371
-
-
Ozaki, K.1
-
134
-
-
21144438325
-
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
-
Vinuesa, C. G. et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435, 452-458 (2005).
-
(2005)
Nature
, vol.435
, pp. 452-458
-
-
Vinuesa, C.G.1
-
135
-
-
80053173155
-
Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus
-
Dolff, S. et al. Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus. Arthritis Res. Ther. 13, R157 (2011).
-
(2011)
Arthritis Res. Ther.
, vol.13
, pp. R157
-
-
Dolff, S.1
-
136
-
-
84856880967
-
IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Faslpr/lpr/J mice
-
Rankin, A. L. et al. IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Faslpr/lpr/J mice. J. Immunol. 188, 1656-1667 (2012).
-
(2012)
J. Immunol.
, vol.188
, pp. 1656-1667
-
-
Rankin, A.L.1
-
137
-
-
35748930247
-
Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus
-
Bubier, J. A. et al. Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus. Ann. NY Acad. Sci. 1110, 590-601 (2007).
-
(2007)
Ann. NY Acad. Sci.
, vol.1110
, pp. 590-601
-
-
Bubier, J.A.1
-
138
-
-
84886049045
-
IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice
-
McPhee, C. G. et al. IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice. J. Immunol. 191, 4581-4588 (2013).
-
(2013)
J. Immunol.
, vol.191
, pp. 4581-4588
-
-
McPhee, C.G.1
-
139
-
-
0032538991
-
Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component
-
Kopf, M., Herren, S., Wiles, M. V., Pepys, M. B. & Kosco-Vilbois, M. H. Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component. J. Exp. Med. 188, 1895-1906 (1998).
-
(1998)
J. Exp. Med.
, vol.188
, pp. 1895-1906
-
-
Kopf, M.1
Herren, S.2
Wiles, M.V.3
Pepys, M.B.4
Kosco-Vilbois, M.H.5
-
140
-
-
84870283741
-
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1
-
Karnowski, A. et al. B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1. J. Exp. Med. 209, 2049-2064 (2012).
-
(2012)
J. Exp. Med.
, vol.209
, pp. 2049-2064
-
-
Karnowski, A.1
-
141
-
-
77956207524
-
In vivo regulation of Bcl6 and T follicular helper cell development
-
Poholek, A. C. et al. In vivo regulation of Bcl6 and T follicular helper cell development. J. Immunol. 185, 313-326 (2010).
-
(2010)
J. Immunol.
, vol.185
, pp. 313-326
-
-
Poholek, A.C.1
-
142
-
-
69249101229
-
Bcl6 mediates the development of T follicular helper cells
-
Nurieva, R. I. et al. Bcl6 mediates the development of T follicular helper cells. Science 325, 1001-1005 (2009).
-
(2009)
Science
, vol.325
, pp. 1001-1005
-
-
Nurieva, R.I.1
-
143
-
-
0025990288
-
Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis
-
Linker-Israeli, M. et al. Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. J. Immunol. 147, 117-123 (1991).
-
(1991)
J. Immunol.
, vol.147
, pp. 117-123
-
-
Linker-Israeli, M.1
-
144
-
-
84962911289
-
Interleukin 6 accelerates mortality by promoting the progression of the systemic lupus erythematosus-like disease of BXSB.Yaa mice
-
Jain, S. et al. Interleukin 6 accelerates mortality by promoting the progression of the systemic lupus erythematosus-like disease of BXSB.Yaa mice. PLoS ONE 11, e0153059 (2016).
-
(2016)
PLoS ONE
, vol.11
, pp. e0153059
-
-
Jain, S.1
-
145
-
-
75749113331
-
Tocilizumab in systemic lupus erythematosus: Data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study
-
Illei, G. G. et al. Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study. Arthritis Rheum. 62, 542-552 (2010).
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 542-552
-
-
Illei, G.G.1
-
146
-
-
42249098748
-
TLR7 and CD40 cooperate in IL-6 production via enhanced JNK and AP-1 activation
-
Vanden Bush, T. J. & Bishop, G. A. TLR7 and CD40 cooperate in IL-6 production via enhanced JNK and AP-1 activation. Eur. J. Immunol. 38, 400-409 (2008).
-
(2008)
Eur. J. Immunol.
, vol.38
, pp. 400-409
-
-
Vanden Bush, T.J.1
Bishop, G.A.2
-
147
-
-
85015622116
-
NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells
-
de Valle, E. et al. NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells. J. Exp. Med. 213, 621-641 (2016).
-
(2016)
J. Exp. Med.
, vol.213
, pp. 621-641
-
-
De Valle, E.1
-
148
-
-
84892546134
-
Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation
-
Goenka, R. et al. Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation. J. Exp. Med. 211, 45-56 (2014).
-
(2014)
J. Exp. Med.
, vol.211
, pp. 45-56
-
-
Goenka, R.1
-
149
-
-
84992389878
-
Antigen-affinity controls pre-germinal center B cell selection by promoting Mcl-1 induction through BAFF receptor signaling
-
Wensveen, F. M., Slinger, E., van Attekum, M. H., Brink, R. & Eldering, E. Antigen-affinity controls pre-germinal center B cell selection by promoting Mcl-1 induction through BAFF receptor signaling. Sci. Rep. 6, 35673 (2016).
-
(2016)
Sci. Rep.
, vol.6
, pp. 35673
-
-
Wensveen, F.M.1
Slinger, E.2
Van Attekum, M.H.3
Brink, R.4
Eldering, E.5
-
150
-
-
0344492212
-
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
-
Baechler, E. C. et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc. Natl Acad. Sci. USA 100, 2610-2615 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 2610-2615
-
-
Baechler, E.C.1
-
151
-
-
0037451167
-
Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
-
Bennett, L. et al. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J. Exp. Med. 197, 711-723 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 711-723
-
-
Bennett, L.1
-
152
-
-
18644384042
-
Activation of the interferon-α pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease
-
Kirou, K. A. et al. Activation of the interferon-α pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease. Arthritis Rheum. 52, 1491-1503 (2005).
-
(2005)
Arthritis Rheum.
, vol.52
, pp. 1491-1503
-
-
Kirou, K.A.1
-
153
-
-
78649830454
-
Genetic susceptibility to systemic lupus erythematosus in the genomic era
-
Deng, Y. & Tsao, B. P. Genetic susceptibility to systemic lupus erythematosus in the genomic era. Nat. Rev. Rheumatol. 6, 683-692 (2010).
-
(2010)
Nat. Rev. Rheumatol.
, vol.6
, pp. 683-692
-
-
Deng, Y.1
Tsao, B.P.2
-
154
-
-
84861665596
-
Role of type I interferons in the activation of autoreactive B cells
-
Kiefer, K., Oropallo, M. A., Cancro, M. P. & Marshak-Rothstein, A. Role of type I interferons in the activation of autoreactive B cells. Immunol. Cell Biol. 90, 498-504 (2012).
-
(2012)
Immunol. Cell Biol.
, vol.90
, pp. 498-504
-
-
Kiefer, K.1
Oropallo, M.A.2
Cancro, M.P.3
Marshak-Rothstein, A.4
-
155
-
-
0031155269
-
IFN-γ is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice
-
Haas, C., Ryffel, B. & Le Hir, M. IFN-γ is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice. J. Immunol. 158, 5484-5491 (1997).
-
(1997)
J. Immunol.
, vol.158
, pp. 5484-5491
-
-
Haas, C.1
Ryffel, B.2
Le Hir, M.3
-
156
-
-
0031831859
-
IFN-γ receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Faslpr mice
-
Schwarting, A., Wada, T., Kinoshita, K., Tesch, G. & Kelley, V. R. IFN-γ receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Faslpr mice. J. Immunol. 161, 494-503 (1998).
-
(1998)
J. Immunol.
, vol.161
, pp. 494-503
-
-
Schwarting, A.1
Wada, T.2
Kinoshita, K.3
Tesch, G.4
Kelley, V.R.5
-
157
-
-
84869213212
-
Interferon-γ excess leads to pathogenic accumulation of follicular helper T cells and germinal centers
-
Lee, S. K. et al. Interferon-γ excess leads to pathogenic accumulation of follicular helper T cells and germinal centers. Immunity 37, 880-892 (2012).
-
(2012)
Immunity
, vol.37
, pp. 880-892
-
-
Lee, S.K.1
-
158
-
-
84969132610
-
IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity
-
Domeier, P. P. et al. IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J. Exp. Med. 213, 715-732 (2016).
-
(2016)
J. Exp. Med.
, vol.213
, pp. 715-732
-
-
Domeier, P.P.1
-
159
-
-
84962191041
-
Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification
-
Munroe, M. E. et al. Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification. Ann. Rheum. Dis. 75, 2014-2021 (2016).
-
(2016)
Ann. Rheum. Dis.
, vol.75
, pp. 2014-2021
-
-
Munroe, M.E.1
-
160
-
-
0142009533
-
Development of autoantibodies before the clinical onset of systemic lupus erythematosus
-
Arbuckle, M. R. et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N. Engl. J. Med. 349, 1526-1533 (2003).
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 1526-1533
-
-
Arbuckle, M.R.1
-
161
-
-
33644750399
-
Autoantibodies in diabetes
-
Pihoker, C., Gilliam, L. K., Hampe, C. S. & Lernmark, A. Autoantibodies in diabetes. Diabetes 54 (Suppl. 2), S52-S61 (2005).
-
(2005)
Diabetes
, vol.54
, pp. S52-S61
-
-
Pihoker, C.1
Gilliam, L.K.2
Hampe, C.S.3
Lernmark, A.4
-
162
-
-
77953306816
-
Preclinical rheumatoid arthritis: Identification, evaluation, and future directions for investigation
-
Deane, K. D., Norris, J. M. & Holers, V. M. Preclinical rheumatoid arthritis: identification, evaluation, and future directions for investigation. Rheum. Dis. Clin. North Am. 36, 213-241 (2010).
-
(2010)
Rheum. Dis. Clin. North Am.
, vol.36
, pp. 213-241
-
-
Deane, K.D.1
Norris, J.M.2
Holers, V.M.3
-
163
-
-
84861465962
-
Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis
-
Sokolove, J. et al. Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis. PLoS ONE 7, e35296 (2012).
-
(2012)
PLoS ONE
, vol.7
, pp. e35296
-
-
Sokolove, J.1
-
164
-
-
85017940817
-
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02603146 (2017).
-
(2017)
US National Library of Medicine
-
-
-
165
-
-
84984848116
-
T follicular helper cells in space-time
-
Qi, H. T follicular helper cells in space-time. Nat. Rev. Immunol. 16, 612-625 (2016).
-
(2016)
Nat. Rev. Immunol.
, vol.16
, pp. 612-625
-
-
Qi, H.1
-
166
-
-
84861694711
-
Follicular helper T cells in immunity and systemic autoimmunity
-
Craft, J. E. Follicular helper T cells in immunity and systemic autoimmunity. Nat. Rev. Rheumatol. 8, 337-347 (2012).
-
(2012)
Nat. Rev. Rheumatol.
, vol.8
, pp. 337-347
-
-
Craft, J.E.1
-
167
-
-
84875952705
-
Common risk alleles for inflammatory diseases are targets of recent positive selection
-
Raj, T. et al. Common risk alleles for inflammatory diseases are targets of recent positive selection. Am. J. Hum. Genet. 92, 517-529 (2013).
-
(2013)
Am. J. Hum. Genet.
, vol.92
, pp. 517-529
-
-
Raj, T.1
-
168
-
-
84942545494
-
Genetics of autoimmune diseases: Insights from population genetics
-
Ramos, P. S., Shedlock, A. M. & Langefeld, C. D. Genetics of autoimmune diseases: insights from population genetics. J. Hum. Genet. 60, 657-664 (2015).
-
(2015)
J. Hum. Genet.
, vol.60
, pp. 657-664
-
-
Ramos, P.S.1
Shedlock, A.M.2
Langefeld, C.D.3
-
169
-
-
33745652977
-
Genetic influence of PTPN22 R620W polymorphism in tuberculosis
-
Gomez, L. M., Anaya, J. M. & Martin, J. Genetic influence of PTPN22 R620W polymorphism in tuberculosis. Hum. Immunol. 66, 1242-1247 (2005).
-
(2005)
Hum. Immunol.
, vol.66
, pp. 1242-1247
-
-
Gomez, L.M.1
Anaya, J.M.2
Martin, J.3
-
170
-
-
34249736602
-
Systemic lupus erythematosus-associated defects in the inhibitory receptor FcγRIIb reduce susceptibility to malaria
-
Clatworthy, M. R. et al. Systemic lupus erythematosus-associated defects in the inhibitory receptor FcγRIIb reduce susceptibility to malaria. Proc. Natl Acad. Sci. USA 104, 7169-7174 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 7169-7174
-
-
Clatworthy, M.R.1
-
171
-
-
0025948793
-
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
-
Hartley, S. B. et al. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 353, 765-769 (1991).
-
(1991)
Nature
, vol.353
, pp. 765-769
-
-
Hartley, S.B.1
-
172
-
-
33748992038
-
Receptor editing in lymphocyte development and central tolerance
-
Nemazee, D. Receptor editing in lymphocyte development and central tolerance. Nat. Rev. Immunol. 6, 728-740 (2006).
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 728-740
-
-
Nemazee, D.1
-
173
-
-
34547193611
-
B-Cell anergy: From transgenic models to naturally occurring anergic B cells?
-
Cambier, J. C., Gauld, S. B., Merrell, K. T. & Vilen, B. J. B-Cell anergy: from transgenic models to naturally occurring anergic B cells? Nat. Rev. Immunol. 7, 633-643 (2007).
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 633-643
-
-
Cambier, J.C.1
Gauld, S.B.2
Merrell, K.T.3
Vilen, B.J.4
-
174
-
-
1642292521
-
Positive selection of B cells expressing low densities of self-reactive BCRs
-
Gaudin, E. et al. Positive selection of B cells expressing low densities of self-reactive BCRs. J. Exp. Med. 199, 843-853 (2004).
-
(2004)
J. Exp. Med.
, vol.199
, pp. 843-853
-
-
Gaudin, E.1
-
175
-
-
0030023652
-
Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45
-
Cyster, J. G. et al. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature 381, 325-328 (1996).
-
(1996)
Nature
, vol.381
, pp. 325-328
-
-
Cyster, J.G.1
-
176
-
-
0037108513
-
B cell positive selection by soluble self-antigen
-
Julien, S., Soulas, P., Garaud, J. C., Martin, T. & Pasquali, J. L. B cell positive selection by soluble self-antigen. J. Immunol. 169, 4198-4204 (2002).
-
(2002)
J. Immunol.
, vol.169
, pp. 4198-4204
-
-
Julien, S.1
Soulas, P.2
Garaud, J.C.3
Martin, T.4
Pasquali, J.L.5
-
177
-
-
0025828377
-
Most peripheral B cells in mice are ligand selected
-
Gu, H., Tarlinton, D., Muller, W., Rajewsky, K. & Forster, I. Most peripheral B cells in mice are ligand selected. J. Exp. Med. 173, 1357-1371 (1991).
-
(1991)
J. Exp. Med.
, vol.173
, pp. 1357-1371
-
-
Gu, H.1
Tarlinton, D.2
Muller, W.3
Rajewsky, K.4
Forster, I.5
-
178
-
-
0034646356
-
A B-cell receptor-specific selection step governs immature to mature B cell differentiation
-
Levine, M. H. et al. A B-cell receptor-specific selection step governs immature to mature B cell differentiation. Proc. Natl Acad. Sci. USA 97, 2743-2748 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 2743-2748
-
-
Levine, M.H.1
-
179
-
-
0035860559
-
AN essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
-
Schiemann, B. et al. AN essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293, 2111-2114 (2001).
-
(2001)
Science
, vol.293
, pp. 2111-2114
-
-
Schiemann, B.1
-
180
-
-
84887480836
-
Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus
-
Richardson, C. et al. Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus. J. Immunol. 191, 4926-4939 (2013).
-
(2013)
J. Immunol.
, vol.191
, pp. 4926-4939
-
-
Richardson, C.1
-
181
-
-
84887438320
-
9G4+ autoantibodies are an important source of apoptotic cell reactivity associated with high levels of disease activity in systemic lupus erythematosus
-
Jenks, S. A. et al. 9G4+ autoantibodies are an important source of apoptotic cell reactivity associated with high levels of disease activity in systemic lupus erythematosus. Arthritis Rheum. 65, 3165-3175 (2013).
-
(2013)
Arthritis Rheum.
, vol.65
, pp. 3165-3175
-
-
Jenks, S.A.1
-
182
-
-
0026052848
-
Nucleotide sequence analysis of the V regions of two IgM cold agglutinins.Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype
-
Pascual, V. et al. Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype. J. Immunol. 146, 4385-4391 (1991).
-
(1991)
J. Immunol.
, vol.146
, pp. 4385-4391
-
-
Pascual, V.1
-
183
-
-
0025871514
-
Human monoclonal antibodies against blood group antigens preferentially express a VH4-21 variable region gene-associated epitope
-
Thompson, K. M. et al. Human monoclonal antibodies against blood group antigens preferentially express a VH4-21 variable region gene-associated epitope. Scand. J. Immunol. 34, 509-518 (1991).
-
(1991)
Scand. J. Immunol.
, vol.34
, pp. 509-518
-
-
Thompson, K.M.1
-
184
-
-
0034789991
-
Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance
-
Pugh-Bernard, A. E. et al. Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J. Clin. Invest. 108, 1061-1070 (2001).
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1061-1070
-
-
Pugh-Bernard, A.E.1
-
185
-
-
27644452293
-
Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus
-
Cappione, A. et al. Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus. J. Clin. Invest. 115, 3205-3216 (2005).
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 3205-3216
-
-
Cappione, A.1
-
186
-
-
0027485751
-
Identification of the 9G4 idiotope in systemic lupus erythematosus
-
Isenberg, D., Spellerberg, M., Williams, W., Griffiths, M. & Stevenson, F. Identification of the 9G4 idiotope in systemic lupus erythematosus. Br. J. Rheumatol. 32, 876-882 (1993).
-
(1993)
Br. J. Rheumatol.
, vol.32
, pp. 876-882
-
-
Isenberg, D.1
Spellerberg, M.2
Williams, W.3
Griffiths, M.4
Stevenson, F.5
-
187
-
-
0027787933
-
Utilization of the VH4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus
-
Stevenson, F. K. et al. Utilization of the VH4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus. J. Autoimmun. 6, 809-825 (1993).
-
(1993)
J. Autoimmun.
, vol.6
, pp. 809-825
-
-
Stevenson, F.K.1
-
188
-
-
0032812236
-
VH4-34 encoded antibodies in systemic lupus erythematosus: A specific diagnostic marker that correlates with clinical disease characteristics
-
van Vollenhoven, R. F. et al. VH4-34 encoded antibodies in systemic lupus erythematosus: a specific diagnostic marker that correlates with clinical disease characteristics. J. Rheumatol. 26, 1727-1733 (1999).
-
(1999)
J. Rheumatol.
, vol.26
, pp. 1727-1733
-
-
Van Vollenhoven, R.F.1
|