-
1
-
-
40049108936
-
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
-
Hom G, Graham RR, Modrek B, et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 2008; 358:900-909.
-
(2008)
N Engl J Med
, vol.358
, pp. 900-909
-
-
Hom, G.1
Graham, R.R.2
Modrek, B.3
-
2
-
-
38649138296
-
Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
-
Kozyrev SV, Abelson AK, Wojcik J, et al. Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus. Nat Genet 2008; 40:211-216.
-
(2008)
Nat Genet
, vol.40
, pp. 211-216
-
-
Kozyrev, S.V.1
Abelson, A.K.2
Wojcik, J.3
-
3
-
-
38649125210
-
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
-
Harley JB, Alarcon-Riquelme ME, Criswell LA, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008; 40:204-210.
-
(2008)
Nat Genet
, vol.40
, pp. 204-210
-
-
Harley, J.B.1
Alarcon-Riquelme, M.E.2
Criswell, L.A.3
-
4
-
-
50449111452
-
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
-
Graham RR, Cotsapas C, Davies L, et al. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet 2008; 40:1059-1061.
-
(2008)
Nat Genet
, vol.40
, pp. 1059-1061
-
-
Graham, R.R.1
Cotsapas, C.2
Davies, L.3
-
5
-
-
70350629871
-
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
-
Han JW, Zheng HF, Cui Y, et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet 2009; 41:1234-1237.
-
(2009)
Nat Genet
, vol.41
, pp. 1234-1237
-
-
Han, J.W.1
Zheng, H.F.2
Cui, Y.3
-
6
-
-
77649206245
-
Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus
-
Yang W, Shen N, Ye DQ, et al. Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet 2010; 6:e1000841.
-
(2010)
PLoS Genet
, vol.6
-
-
Yang, W.1
Shen, N.2
Ye, D.Q.3
-
7
-
-
84857487791
-
A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese
-
Okada Y, Shimane K, Kochi Y, et al. A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese. PLoS Genet 2012; 8:e1002455.
-
(2012)
PLoS Genet
, vol.8
-
-
Okada, Y.1
Shimane, K.2
Kochi, Y.3
-
8
-
-
84899969998
-
Ethnic specificity of lupus-associated loci identified in a genome-wide association study in Korean women
-
Lee HS, Kim T, Bang SY, et al. Ethnic specificity of lupus-associated loci identified in a genome-wide association study in Korean women. Ann Rheum Dis 2014; 73:1240-1245.
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 1240-1245
-
-
Lee, H.S.1
Kim, T.2
Bang, S.Y.3
-
9
-
-
79955550445
-
A user's guide to the encyclopedia of DNA elements (ENCODE)
-
ENCODE Project Consortium
-
ENCODE Project Consortium. A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol 2011; 9:e1001046.
-
(2011)
PLoS Biol
, vol.9
-
-
-
10
-
-
84892589392
-
Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes
-
Dozmorov MG, Wren JD, Alarcon-Riquelme ME. Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes. Epigenetics 2014; 9:276-285.
-
(2014)
Epigenetics
, vol.9
, pp. 276-285
-
-
Dozmorov, M.G.1
Wren, J.D.2
Alarcon-Riquelme, M.E.3
-
11
-
-
84874774951
-
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production
-
Molineros JE, Maiti AK, Sun C, et al. Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet 2013; 9:e1003222.
-
(2013)
PLoS Genet
, vol.9
-
-
Molineros, J.E.1
Maiti, A.K.2
Sun, C.3
-
12
-
-
80055080962
-
Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus
-
Cunninghame Graham DS, Morris DL, Bhangale TR, et al. Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus. PLoS Genet 2011; 7:e1002341.
-
(2011)
PLoS Genet
, vol.7
-
-
Cunninghame Graham, D.S.1
Morris, D.L.2
Bhangale, T.R.3
-
13
-
-
65249157054
-
High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups
-
Namjou B, Sestak AL, Armstrong DL, et al. High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups. Arthritis Rheum 2009; 60:1085-1095.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1085-1095
-
-
Namjou, B.1
Sestak, A.L.2
Armstrong, D.L.3
-
14
-
-
80155130254
-
Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study
-
Sanchez E, Comeau ME, Freedman BI, et al. Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis Rheum 2011; 63:3493-3501.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 3493-3501
-
-
Sanchez, E.1
Comeau, M.E.2
Freedman, B.I.3
-
15
-
-
79959836816
-
A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus
-
Luo X, Yang W, Ye DQ, et al. A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus. PLoS Genet 2011; 7:e1002128.
-
(2011)
PLoS Genet
, vol.7
-
-
Luo, X.1
Yang, W.2
Ye, D.Q.3
-
16
-
-
33646368404
-
A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus
-
Graham RR, Kozyrev SV, Baechler EC, et al. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet 2006; 38:550-555.
-
(2006)
Nat Genet
, vol.38
, pp. 550-555
-
-
Graham, R.R.1
Kozyrev, S.V.2
Baechler, E.C.3
-
17
-
-
34249860408
-
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus
-
Graham RR, Kyogoku C, Sigurdsson S, et al. Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proc Natl Acad Sci U S A 2007; 104:6758-6763.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 6758-6763
-
-
Graham, R.R.1
Kyogoku, C.2
Sigurdsson, S.3
-
18
-
-
40649121122
-
Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus
-
Sigurdsson S, Goring HH, Kristjansdottir G, et al. Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus. Hum Mol Genet 2008; 17:872-881.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 872-881
-
-
Sigurdsson, S.1
Goring, H.H.2
Kristjansdottir, G.3
-
19
-
-
77949732090
-
Promoter insertion/deletion in the IRF5 gene is highly associated with susceptibility to systemic lupus erythematosus in distinct populations, but exerts a modest effect on gene expression in peripheral blood mononuclear cells
-
Lofgren SE, Yin H, Delgado-Vega AM, et al. Promoter insertion/deletion in the IRF5 gene is highly associated with susceptibility to systemic lupus erythematosus in distinct populations, but exerts a modest effect on gene expression in peripheral blood mononuclear cells. J Rheumatol 2010; 37:574-578.
-
(2010)
J Rheumatol
, vol.37
, pp. 574-578
-
-
Lofgren, S.E.1
Yin, H.2
Delgado-Vega, A.M.3
-
20
-
-
70350650472
-
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
-
Gateva V, Sandling JK, Hom G, et al. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet 2009; 41:1228-1233.
-
(2009)
Nat Genet
, vol.41
, pp. 1228-1233
-
-
Gateva, V.1
Sandling, J.K.2
Hom, G.3
-
21
-
-
84863115400
-
IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus
-
Niewold TB, Kelly JA, Kariuki SN, et al. IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus. Ann Rheum Dis 2012; 71:463-468.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 463-468
-
-
Niewold, T.B.1
Kelly, J.A.2
Kariuki, S.N.3
-
22
-
-
79953707345
-
Association of a functional IRF7 variant with systemic lupus erythematosus
-
Fu Q, Zhao J, Qian X, et al. Association of a functional IRF7 variant with systemic lupus erythematosus. Arthritis Rheum 2011; 63:749-754.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 749-754
-
-
Fu, Q.1
Zhao, J.2
Qian, X.3
-
23
-
-
84874229894
-
Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus
-
Baccala R, Gonzalez-Quintial R, Blasius AL, et al. Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci U S A 2013; 110:2940-2945.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 2940-2945
-
-
Baccala, R.1
Gonzalez-Quintial, R.2
Blasius, A.L.3
-
24
-
-
84859491100
-
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study
-
Lessard CJ, Adrianto I, Ice JA, et al. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am J Hum Genet 2012; 90:648-660.
-
(2012)
Am J Hum Genet
, vol.90
, pp. 648-660
-
-
Lessard, C.J.1
Adrianto, I.2
Ice, J.A.3
-
25
-
-
77957673544
-
Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
-
Shen N, Fu Q, Deng Y, et al. Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc Natl Acad Sci U S A 2010; 107:15838-15843.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 15838-15843
-
-
Shen, N.1
Fu, Q.2
Deng, Y.3
-
26
-
-
84874782774
-
MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus
-
Deng Y, Zhao J, Sakurai D, et al. MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genet 2013; 9:e1003336.
-
(2013)
PLoS Genet
, vol.9
-
-
Deng, Y.1
Zhao, J.2
Sakurai, D.3
-
27
-
-
84884692054
-
An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression
-
Wang S, Wen F, Wiley GB, et al. An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression. PLoS Genet 2013; 9:e1003750.
-
(2013)
PLoS Genet
, vol.9
-
-
Wang, S.1
Wen, F.2
Wiley, G.B.3
-
28
-
-
84873744778
-
Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups
-
Kaufman KM, Zhao J, Kelly JA, et al. Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Ann Rheum Dis 2013; 72:437-444.
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 437-444
-
-
Kaufman, K.M.1
Zhao, J.2
Kelly, J.A.3
-
29
-
-
84875946223
-
Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse
-
Koelsch KA, Webb R, Jeffries M, et al. Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse. J Autoimmun 2013; 41:168-174.
-
(2013)
J Autoimmun
, vol.41
, pp. 168-174
-
-
Koelsch, K.A.1
Webb, R.2
Jeffries, M.3
-
30
-
-
28444469783
-
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
-
Vang T, Congia M, Macis MD, et al. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 2005; 37:1317-1319.
-
(2005)
Nat Genet
, vol.37
, pp. 1317-1319
-
-
Vang, T.1
Congia, M.2
Macis, M.D.3
-
31
-
-
65449176044
-
Cutting edge: The PTPN22 allelic variant associated with autoimmunity impairs B cell signaling
-
Arechiga AF, Habib T, He Y, et al. Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. J Immunol 2009; 182:3343-3347.
-
(2009)
J Immunol
, vol.182
, pp. 3343-3347
-
-
Arechiga, A.F.1
Habib, T.2
He, Y.3
-
32
-
-
80052239824
-
The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness
-
Zhang J, Zahir N, Jiang Q, et al. The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nat Genet 2011; 43:902-907.
-
(2011)
Nat Genet
, vol.43
, pp. 902-907
-
-
Zhang, J.1
Zahir, N.2
Jiang, Q.3
-
33
-
-
80052376347
-
The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans
-
Menard L, Saadoun D, Isnardi I, et al. The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans. J Clin Invest 2011; 121:3635-3644.
-
(2011)
J Clin Invest
, vol.121
, pp. 3635-3644
-
-
Menard, L.1
Saadoun, D.2
Isnardi, I.3
-
34
-
-
84877115482
-
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models
-
Dai X, James RG, Habib T, et al. A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest 2013; 123:2024-2036.
-
(2013)
J Clin Invest
, vol.123
, pp. 2024-2036
-
-
Dai, X.1
James, R.G.2
Habib, T.3
-
35
-
-
84880772196
-
Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4
-
Manku H, Langefeld CD, Guerra SG, et al. Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4. PLoS Genet 2013; 9:e1003554.
-
(2013)
PLoS Genet
, vol.9
-
-
Manku, H.1
Langefeld, C.D.2
Guerra, S.G.3
-
36
-
-
84887310358
-
Preferential binding to Elk-1 bySLE-associated risk allele upregulates expression
-
Sakurai D, Zhao J,Deng Y, et al. Preferential binding to Elk-1 bySLE-associated risk allele upregulates expression. PLoS Genet 2013; 9:e1003870.
-
(2013)
PLoS Genet
, vol.9
-
-
Sakurai, D.1
Zhao, J.2
Deng, Y.3
-
37
-
-
84882453048
-
Genes identified in Asian SLEGWASs are also associated with SLE in Caucasian populations
-
Wang C, Ahlford A, Jarvinen TM, et al. Genes identified in Asian SLEGWASs are also associated with SLE in Caucasian populations. Eur J Hum Genet 2013; 21:994-999.
-
(2013)
Eur J Hum Genet
, vol.21
, pp. 994-999
-
-
Wang, C.1
Ahlford, A.2
Jarvinen, T.M.3
-
38
-
-
84872328824
-
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians
-
Yang W, Tang H, Zhang Y, et al. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Am J Hum Genet 2013; 92:41-51.
-
(2013)
Am J Hum Genet
, vol.92
, pp. 41-51
-
-
Yang, W.1
Tang, H.2
Zhang, Y.3
-
39
-
-
79958044361
-
Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21
-
Hughes T, Kim-Howard X, Kelly JA, et al. Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21. Arthritis Rheum 2011; 63:1689-1697.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 1689-1697
-
-
Hughes, T.1
Kim-Howard, X.2
Kelly, J.A.3
-
40
-
-
84885018609
-
Systematic identification of trans eQTLs as putative drivers of known disease associations
-
Westra HJ, Peters MJ, Esko T, et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet 2013; 45:1238-1243.
-
(2013)
Nat Genet
, vol.45
, pp. 1238-1243
-
-
Westra, H.J.1
Peters, M.J.2
Esko, T.3
-
41
-
-
84898759184
-
Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription
-
Guthridge JM, Lu R, Sun H, et al. Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription. Am J Hum Genet 2014; 94:586-598.
-
(2014)
Am J Hum Genet
, vol.94
, pp. 586-598
-
-
Guthridge, J.M.1
Lu, R.2
Sun, H.3
-
42
-
-
78650862201
-
Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
-
Lessard CJ, Adrianto I, Kelly JA, et al. Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study. Am J Hum Genet 2011; 88:83-91.
-
(2011)
Am J Hum Genet
, vol.88
, pp. 83-91
-
-
Lessard, C.J.1
Adrianto, I.2
Kelly, J.A.3
-
43
-
-
78651086505
-
ELF1 is associated with systemic lupus erythematosus in Asian populations
-
Yang J, Yang W, Hirankarn N, et al. ELF1 is associated with systemic lupus erythematosus in Asian populations. Hum Mol Genet 2011; 20:601-607.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 601-607
-
-
Yang, J.1
Yang, W.2
Hirankarn, N.3
-
44
-
-
84868208900
-
CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences Bcell signaling and activation
-
Manjarrez-Orduno N, Marasco E, Chung SA, et al. CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences Bcell signaling and activation. Nat Genet 2012; 44:1227-1230.
-
(2012)
Nat Genet
, vol.44
, pp. 1227-1230
-
-
Manjarrez-Orduno, N.1
Marasco, E.2
Chung, S.A.3
-
45
-
-
79952787492
-
Follow-up study identifies two novel susceptibility loci PRKCB and 8p11.21 for systemic lupus erythematosus
-
Sheng YJ, Gao JP, Li J, et al. Follow-up study identifies two novel susceptibility loci PRKCB and 8p11.21 for systemic lupus erythematosus. Rheumatology (Oxford) 2011; 50:682-688.
-
(2011)
Rheumatology (Oxford)
, vol.50
, pp. 682-688
-
-
Sheng, Y.J.1
Gao, J.P.2
Li, J.3
-
46
-
-
84867402906
-
Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries
-
Kim K, Brown EE, Choi CB, et al. Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Ann Rheum Dis 2012; 71:1809-1814.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 1809-1814
-
-
Kim, K.1
Brown, E.E.2
Choi, C.B.3
-
47
-
-
78649830454
-
Genetic susceptibility to systemic lupus erythematosus in the genomic era
-
Deng Y, Tsao BP. Genetic susceptibility to systemic lupus erythematosus in the genomic era. Nat Rev Rheumatol 2010; 6:683-692.
-
(2010)
Nat Rev Rheumatol
, vol.6
, pp. 683-692
-
-
Deng, Y.1
Tsao, B.P.2
-
48
-
-
84868495399
-
The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes
-
Rhodes B, FurnrohrBG, Roberts AL, et al. The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes. Ann Rheum Dis 2012; 71:2028-2034.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 2028-2034
-
-
Rhodes, B.1
Furnrohr, B.G.2
Roberts, A.L.3
-
49
-
-
84874290850
-
Phagocytosis is the main CR3- mediated function affected by the lupus-associated variant of CD11b in human myeloid cells
-
Fossati-Jimack L, Ling GS, Cortini A, et al. Phagocytosis is the main CR3- mediated function affected by the lupus-associated variant of CD11b in human myeloid cells. PLoS One 2013; 8:e57082.
-
(2013)
PLoS One
, vol.8
-
-
Fossati-Jimack, L.1
Ling, G.S.2
Cortini, A.3
-
50
-
-
84886793012
-
Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils
-
Zhou Y, Wu J, Kucik DF, et al. Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils. Arthritis Rheum 2013; 65:2907-2916.
-
(2013)
Arthritis Rheum
, vol.65
, pp. 2907-2916
-
-
Zhou, Y.1
Wu, J.2
Kucik, D.F.3
-
51
-
-
84862959180
-
Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase
-
Jacob CO, Eisenstein M, Dinauer MC, et al. Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. Proc Natl Acad Sci U S A 2012; 109:E59-E67.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
-
-
Jacob, C.O.1
Eisenstein, M.2
Dinauer, M.C.3
-
52
-
-
84894384556
-
Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations
-
Kim-Howard X, Sun C, Molineros JE, et al. Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations. Hum Mol Genet 2014; 23:1656-1668.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 1656-1668
-
-
Kim-Howard, X.1
Sun, C.2
Molineros, J.E.3
-
53
-
-
79955464760
-
Two missense variants in UHRF1BP1 are independently associated with systemic lupus erythematosus in Hong Kong Chinese
-
Zhang Y, Yang W, Mok CC, et al. Two missense variants in UHRF1BP1 are independently associated with systemic lupus erythematosus in Hong Kong Chinese. Genes Immun 2011; 12:231-234.
-
(2011)
Genes Immun
, vol.12
, pp. 231-234
-
-
Zhang, Y.1
Yang, W.2
Mok, C.C.3
-
54
-
-
78751689465
-
Polymorphisms at 16p13 are associated with systemic lupus erythematosus in the Chinese population
-
Zhang Z, Cheng Y, Zhou X, et al. Polymorphisms at 16p13 are associated with systemic lupus erythematosus in the Chinese population. J Med Genet 2011; 48:69-72.
-
(2011)
J Med Genet
, vol.48
, pp. 69-72
-
-
Zhang, Z.1
Cheng, Y.2
Zhou, X.3
-
55
-
-
84867745567
-
The genetics of type i interferon in systemic lupus erythematosus
-
Bronson PG, Chaivorapol C, Ortmann W, et al. The genetics of type I interferon in systemic lupus erythematosus. Curr Opin Immunol 2012; 24:530-537.
-
(2012)
Curr Opin Immunol
, vol.24
, pp. 530-537
-
-
Bronson, P.G.1
Chaivorapol, C.2
Ortmann, W.3
-
56
-
-
54149096930
-
Developments in the scientific understanding of lupus
-
Ardoin SP, Pisetsky DS. Developments in the scientific understanding of lupus. Arthritis Res Ther 2008; 10:218.
-
(2008)
Arthritis Res Ther
, vol.10
, pp. 218
-
-
Ardoin, S.P.1
Pisetsky, D.S.2
-
57
-
-
36048962438
-
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
-
Deane JA, Pisitkun P, Barrett RS, et al. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 2007; 27:801-810.
-
(2007)
Immunity
, vol.27
, pp. 801-810
-
-
Deane, J.A.1
Pisitkun, P.2
Barrett, R.S.3
-
58
-
-
33748472865
-
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and opposing inflammatory and regulatory roles in a murine model of lupus
-
Christensen SR, Shupe J, Nickerson K, et al. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 2006; 25:417-428.
-
(2006)
Immunity
, vol.25
, pp. 417-428
-
-
Christensen, S.R.1
Shupe, J.2
Nickerson, K.3
-
59
-
-
37549066665
-
Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
-
Barrat FJ, Meeker T, Chan JH, et al. Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. Eur J Immunol 2007; 37:3582-3586.
-
(2007)
Eur J Immunol
, vol.37
, pp. 3582-3586
-
-
Barrat, F.J.1
Meeker, T.2
Chan, J.H.3
-
60
-
-
75749110600
-
Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients
-
Salloum R, Franek BS, Kariuki SN, et al. Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients. Arthritis Rheum 2010; 62:553-561.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 553-561
-
-
Salloum, R.1
Franek, B.S.2
Kariuki, S.N.3
-
61
-
-
84896759364
-
Common genetic variants modulate pathogensensing responses in human dendritic cells
-
Lee MN, Ye C, Villani AC, et al. Common genetic variants modulate pathogensensing responses in human dendritic cells. Science 2014; 343:1246980.
-
(2014)
Science
, vol.343
, pp. 1246980
-
-
Lee, M.N.1
Ye, C.2
Villani, A.C.3
-
62
-
-
35748940628
-
Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity
-
Liu G, Tsuruta Y, Gao Z, et al. Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity. J Immunol 2007; 179:4125-4134.
-
(2007)
J Immunol
, vol.179
, pp. 4125-4134
-
-
Liu, G.1
Tsuruta, Y.2
Gao, Z.3
-
63
-
-
65549124475
-
Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus
-
Jacob CO, Zhu J, Armstrong DL, et al. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A 2009; 106:6256-6261.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 6256-6261
-
-
Jacob, C.O.1
Zhu, J.2
Armstrong, D.L.3
-
64
-
-
84880733694
-
The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity
-
Wang Y, Shaked I, Stanford SM, et al. The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity 2013; 39:111-122.
-
(2013)
Immunity
, vol.39
, pp. 111-122
-
-
Wang, Y.1
Shaked, I.2
Stanford, S.M.3
-
65
-
-
84940367331
-
The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals
-
[Epub ahead of print]
-
Bayley R, Kite KA, McGettrick HM, et al. The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals. Ann Rheum Dis 2014. [Epub ahead of print]
-
(2014)
Ann Rheum Dis
-
-
Bayley, R.1
Kite, K.A.2
McGettrick, H.M.3
-
66
-
-
80053896562
-
Integrating autoimmune risk loci with geneexpression data identifies specific pathogenic immune cell subsets
-
Hu X, Kim H, Stahl E, et al. Integrating autoimmune risk loci with geneexpression data identifies specific pathogenic immune cell subsets. Am J Hum Genet 2011; 89:496-506.
-
(2011)
Am J Hum Genet
, vol.89
, pp. 496-506
-
-
Hu, X.1
Kim, H.2
Stahl, E.3
-
67
-
-
2342659126
-
Interleukin-10 and related cytokines and receptors
-
Pestka S, Krause CD, Sarkar D, et al. Interleukin-10 and related cytokines and receptors. Annu Rev Immunol 2004; 22:929-979.
-
(2004)
Annu Rev Immunol
, vol.22
, pp. 929-979
-
-
Pestka, S.1
Krause, C.D.2
Sarkar, D.3
-
68
-
-
34249718532
-
Expression of a non-DNA-binding Ikaros isoform exclusively in B cells leads to autoimmunity but not leukemogenesis
-
Wojcik H, Griffiths E, Staggs S, et al. Expression of a non-DNA-binding Ikaros isoform exclusively in B cells leads to autoimmunity but not leukemogenesis. Eur J Immunol 2007; 37:1022-1032.
-
(2007)
Eur J Immunol
, vol.37
, pp. 1022-1032
-
-
Wojcik, H.1
Griffiths, E.2
Staggs, S.3
-
69
-
-
84904003200
-
Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM
-
[Epub ahead of print]
-
Maiti AK, Kim-Howard X, Motghare P, et al. Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM. Hum Mol Genet 2014. [Epub ahead of print]
-
(2014)
Hum Mol Genet
-
-
Maiti, A.K.1
Kim-Howard, X.2
Motghare, P.3
-
71
-
-
84899129832
-
Oxidative stress and its biomarkers in systemic lupus erythematosus
-
Shah D, Mahajan N, Sah S, et al. Oxidative stress and its biomarkers in systemic lupus erythematosus. J Biomed Sci 2014; 21:23.
-
(2014)
J Biomed Sci
, vol.21
, pp. 23
-
-
Shah, D.1
Mahajan, N.2
Sah, S.3
-
73
-
-
50949107996
-
Autoimmune thyroiditis and ROS
-
Burek CL, Rose NR. Autoimmune thyroiditis and ROS. Autoimmun Rev 2008; 7:530-537.
-
(2008)
Autoimmun Rev
, vol.7
, pp. 530-537
-
-
Burek, C.L.1
Rose, N.R.2
-
75
-
-
0037224772
-
Positional identification of Ncf1 as a gene that regulates arthritis severity in rats
-
Olofsson P, Holmberg J, Tordsson J, et al. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet 2003; 33:25-32.
-
(2003)
Nat Genet
, vol.33
, pp. 25-32
-
-
Olofsson, P.1
Holmberg, J.2
Tordsson, J.3
-
76
-
-
4344591766
-
Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene
-
Hultqvist M, Olofsson P, Holmberg J, et al. Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci U S A 2004; 101:12646-12651.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 12646-12651
-
-
Hultqvist, M.1
Olofsson, P.2
Holmberg, J.3
-
78
-
-
79953743757
-
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production
-
Chung SA, Taylor KE, Graham RR, et al. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. PLoS Genet 2011; 7:e1001323.
-
(2011)
PLoS Genet
, vol.7
-
-
Chung, S.A.1
Taylor, K.E.2
Graham, R.R.3
-
79
-
-
80052461085
-
Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus
-
Sanchez E, Nadig A, Richardson BC, et al. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Ann Rheum Dis 2011; 70:1752-1757.
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 1752-1757
-
-
Sanchez, E.1
Nadig, A.2
Richardson, B.C.3
-
80
-
-
84887052296
-
ABIN1 dysfunction as a genetic basis for lupus nephritis
-
Caster DJ, Korte EA, Nanda SK, et al. ABIN1 dysfunction as a genetic basis for lupus nephritis. J Am Soc Nephrol 2013; 24:1743-1754.
-
(2013)
J Am Soc Nephrol
, vol.24
, pp. 1743-1754
-
-
Caster, D.J.1
Korte, E.A.2
Nanda, S.K.3
-
81
-
-
84893680312
-
End-stage renal disease in African Americans with lupus nephritis is associated with APOL1
-
Freedman BI, Langefeld CD, Andringa KK, et al. End-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis Rheumatol 2014; 66:390-396.
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 390-396
-
-
Freedman, B.I.1
Langefeld, C.D.2
Andringa, K.K.3
-
82
-
-
79952261842
-
Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes
-
Taylor KE, Chung SA, Graham RR, et al. Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes. PLoS Genet 2011; 7:e1001311.
-
(2011)
PLoS Genet
, vol.7
-
-
Taylor, K.E.1
Chung, S.A.2
Graham, R.R.3
-
83
-
-
84855961987
-
Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases
-
Hedrich CM, Tsokos GC. Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases. Trends Mol Med 2011; 17:714-724.
-
(2011)
Trends Mol Med
, vol.17
, pp. 714-724
-
-
Hedrich, C.M.1
Tsokos, G.C.2
-
84
-
-
79958260145
-
A new epigenetic challenge: Systemic lupus erythematosus
-
Javierre BM, Richardson B. A new epigenetic challenge: systemic lupus erythematosus. Adv Exp Med Biol 2011; 711:117-136.
-
(2011)
Adv Exp Med Biol
, vol.711
, pp. 117-136
-
-
Javierre, B.M.1
Richardson, B.2
-
85
-
-
84884634092
-
Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations
-
Absher DM, Li X, Waite LL, et al. Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations. PLoS Genet 2013; 9:e1003678.
-
(2013)
PLoS Genet
, vol.9
-
-
Absher, D.M.1
Li, X.2
Waite, L.L.3
-
86
-
-
84878361920
-
Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferonregulated genes in naive CD4+ T cells from lupus patients
-
Coit P, Jeffries M, Altorok N, et al. Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferonregulated genes in naive CD4+ T cells from lupus patients. J Autoimmun 2013; 43:78-84.
-
(2013)
J Autoimmun
, vol.43
, pp. 78-84
-
-
Coit, P.1
Jeffries, M.2
Altorok, N.3
-
87
-
-
84875961571
-
Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus
-
Zhang Y, Zhao M, Sawalha AH, et al. Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus. J Autoimmun 2013; 41:92-99.
-
(2013)
J Autoimmun
, vol.41
, pp. 92-99
-
-
Zhang, Y.1
Zhao, M.2
Sawalha, A.H.3
-
88
-
-
33947315736
-
Cancer epigenomics: DNA methylomes and histone-modification maps
-
Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 2007; 8:286-298.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 286-298
-
-
Esteller, M.1
-
89
-
-
79955623575
-
Epigenetic alterations in autoimmune rheumatic diseases
-
Ballestar E. Epigenetic alterations in autoimmune rheumatic diseases. Nat Rev Rheumatol 2011; 7:263-271.
-
(2011)
Nat Rev Rheumatol
, vol.7
, pp. 263-271
-
-
Ballestar, E.1
-
90
-
-
77649340053
-
Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes
-
Zhang Z, Song L, Maurer K, et al. Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes. Genes Immun 2010; 11:124-133.
-
(2010)
Genes Immun
, vol.11
, pp. 124-133
-
-
Zhang, Z.1
Song, L.2
Maurer, K.3
-
91
-
-
84873086126
-
Chromatin marks identify critical cell types for fine mapping complex trait variants
-
Trynka G, Sandor C, Han B, et al. Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat Genet 2013; 45:124-130.
-
(2013)
Nat Genet
, vol.45
, pp. 124-130
-
-
Trynka, G.1
Sandor, C.2
Han, B.3
-
92
-
-
0347444723
-
MicroRNAs: Genomics, biogenesis, mechanism, and function
-
Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
93
-
-
58149085504
-
MicroRNA control in the immune system: Basic principles
-
Xiao C, Rajewsky K. MicroRNA control in the immune system: basic principles. Cell 2009; 136:26-36.
-
(2009)
Cell
, vol.136
, pp. 26-36
-
-
Xiao, C.1
Rajewsky, K.2
-
94
-
-
84870684707
-
MicroRNAs: Novel regulators of systemic lupus erythematosus pathogenesis
-
Shen N, Liang D, Tang Y, et al. MicroRNAs: novel regulators of systemic lupus erythematosus pathogenesis. Nat Rev Rheumatol 2012; 8:701-709.
-
(2012)
Nat Rev Rheumatol
, vol.8
, pp. 701-709
-
-
Shen, N.1
Liang, D.2
Tang, Y.3
-
95
-
-
84876554579
-
Circulating microRNA expression profiles associated with systemic lupus erythematosus
-
Carlsen AL, Schetter AJ, Nielsen CT, et al. Circulating microRNA expression profiles associated with systemic lupus erythematosus. Arthritis Rheum 2013; 65:1324-1334.
-
(2013)
Arthritis Rheum
, vol.65
, pp. 1324-1334
-
-
Carlsen, A.L.1
Schetter, A.J.2
Nielsen, C.T.3
-
96
-
-
65249138193
-
MicroRNA-146A contributes to abnormal activation of the type i interferon pathway in human lupus by targeting the key signaling proteins
-
Tang Y, Luo X, Cui H, et al. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum 2009; 60:1065-1075.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1065-1075
-
-
Tang, Y.1
Luo, X.2
Cui, H.3
-
97
-
-
78149358596
-
MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus
-
Zhao X, Tang Y, Qu B, et al. MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus. Arthritis Rheum 2010; 62:3425-3435.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 3425-3435
-
-
Zhao, X.1
Tang, Y.2
Qu, B.3
-
98
-
-
84863686039
-
The microRNA miR-23b suppresses IL-17- associated autoimmune inflammation by targeting TAB2, TAB3 and IKKalpha
-
Zhu S, Pan W, Song X, et al. The microRNA miR-23b suppresses IL-17- associated autoimmune inflammation by targeting TAB2, TAB3 and IKKalpha. Nat Med 2012; 18:1077-1086.
-
(2012)
Nat Med
, vol.18
, pp. 1077-1086
-
-
Zhu, S.1
Pan, W.2
Song, X.3
-
99
-
-
79959784552
-
Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: MiR-21 regulates aberrant T cell responses through regulation of PDCD4 expression
-
Stagakis E, Bertsias G, Verginis P, et al. Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression. Ann Rheum Dis 2011; 70:1496-1506.
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 1496-1506
-
-
Stagakis, E.1
Bertsias, G.2
Verginis, P.3
-
100
-
-
84864865406
-
Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus
-
Fan W, Liang D, Tang Y, et al. Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus. Arthritis Rheum 2012; 64:3715-3725.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 3715-3725
-
-
Fan, W.1
Liang, D.2
Tang, Y.3
-
101
-
-
79955569628
-
MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1
-
Zhao S, Wang Y, Liang Y, et al. MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1. Arthritis Rheum 2011; 63:1376-1386.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 1376-1386
-
-
Zhao, S.1
Wang, Y.2
Liang, Y.3
-
102
-
-
77953624215
-
MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1
-
Pan W, Zhu S, Yuan M, et al. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 2010; 184:6773-6781.
-
(2010)
J Immunol
, vol.184
, pp. 6773-6781
-
-
Pan, W.1
Zhu, S.2
Yuan, M.3
-
103
-
-
84894288992
-
Genetics of rheumatoid arthritis contributes to biology and drug discovery
-
Okada Y, Wu D, Trynka G, et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 2014; 506:376-381.
-
(2014)
Nature
, vol.506
, pp. 376-381
-
-
Okada, Y.1
Wu, D.2
Trynka, G.3
|