메뉴 건너뛰기




Volumn 33, Issue , 2015, Pages 70-77

B cells take the front seat: Dysregulated B cell signals orchestrate loss of tolerance and autoantibody production

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; B LYMPHOCYTE ANTIGEN; BANK1 PROTEIN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; CYTOKINE;

EID: 84922424028     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2015.01.018     Document Type: Review
Times cited : (50)

References (66)
  • 5
    • 79952070370 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
    • Navarra S.V., Guzman R.M., Gallacher A.E., Hall S., Levy R.A., Jimenez R.E., Li E.K., Thomas M., Kim H.Y., Leon M.G., et al. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet 2011, 377:721-731.
    • (2011) Lancet , vol.377 , pp. 721-731
    • Navarra, S.V.1    Guzman, R.M.2    Gallacher, A.E.3    Hall, S.4    Levy, R.A.5    Jimenez, R.E.6    Li, E.K.7    Thomas, M.8    Kim, H.Y.9    Leon, M.G.10
  • 8
    • 77951610700 scopus 로고    scopus 로고
    • FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications
    • Smith K.G., Clatworthy M.R. FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications. Nat Rev Immunol 2010, 10:328-343.
    • (2010) Nat Rev Immunol , vol.10 , pp. 328-343
    • Smith, K.G.1    Clatworthy, M.R.2
  • 11
    • 0037144519 scopus 로고    scopus 로고
    • Evolution of autoantibody responses via somatic hypermutation outside of germinal centers
    • William J., Euler C., Christensen S., Shlomchik M.J. Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science 2002, 297:2066-2070.
    • (2002) Science , vol.297 , pp. 2066-2070
    • William, J.1    Euler, C.2    Christensen, S.3    Shlomchik, M.J.4
  • 12
    • 72949104221 scopus 로고    scopus 로고
    • Dysregulation of germinal centres in autoimmune disease
    • Vinuesa C.G., Sanz I., Cook M.C. Dysregulation of germinal centres in autoimmune disease. Nat Rev Immunol 2009, 9:845-857.
    • (2009) Nat Rev Immunol , vol.9 , pp. 845-857
    • Vinuesa, C.G.1    Sanz, I.2    Cook, M.C.3
  • 13
    • 33344475672 scopus 로고    scopus 로고
    • Lymphoid neogenesis in chronic inflammatory diseases
    • Aloisi F., Pujol-Borrell R. Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol 2006, 6:205-217.
    • (2006) Nat Rev Immunol , vol.6 , pp. 205-217
    • Aloisi, F.1    Pujol-Borrell, R.2
  • 14
    • 84858796247 scopus 로고    scopus 로고
    • Integration of B cell responses through Toll-like receptors and antigen receptors
    • Rawlings D.J., Schwartz M.A., Jackson S.W., Meyer-Bahlburg A. Integration of B cell responses through Toll-like receptors and antigen receptors. Nat Rev Immunol 2012, 12:282-294.
    • (2012) Nat Rev Immunol , vol.12 , pp. 282-294
    • Rawlings, D.J.1    Schwartz, M.A.2    Jackson, S.W.3    Meyer-Bahlburg, A.4
  • 15
    • 79952745936 scopus 로고    scopus 로고
    • Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response
    • Hou B., Saudan P., Ott G., Wheeler M.L., Ji M., Kuzmich L., Lee L.M., Coffman R.L., Bachmann M.F., DeFranco A.L. Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response. Immunity 2011, 34:375-384.
    • (2011) Immunity , vol.34 , pp. 375-384
    • Hou, B.1    Saudan, P.2    Ott, G.3    Wheeler, M.L.4    Ji, M.5    Kuzmich, L.6    Lee, L.M.7    Coffman, R.L.8    Bachmann, M.F.9    DeFranco, A.L.10
  • 16
    • 70449464779 scopus 로고    scopus 로고
    • Activating systemic autoimmunity: B's, T's, and tolls
    • Shlomchik M.J. Activating systemic autoimmunity: B's, T's, and tolls. Curr Opin Immunol 2009, 21:626-633.
    • (2009) Curr Opin Immunol , vol.21 , pp. 626-633
    • Shlomchik, M.J.1
  • 17
    • 79953162780 scopus 로고    scopus 로고
    • Toll-like receptor driven B cell activation in the induction of systemic autoimmunity
    • Green N.M., Marshak-Rothstein A. Toll-like receptor driven B cell activation in the induction of systemic autoimmunity. Semin Immunol 2011, 23:106-112.
    • (2011) Semin Immunol , vol.23 , pp. 106-112
    • Green, N.M.1    Marshak-Rothstein, A.2
  • 21
    • 33645076274 scopus 로고    scopus 로고
    • TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE
    • Ehlers M., Fukuyama H., McGaha T.L., Aderem A., Ravetch J.V. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med 2006, 203:553-561.
    • (2006) J Exp Med , vol.203 , pp. 553-561
    • Ehlers, M.1    Fukuyama, H.2    McGaha, T.L.3    Aderem, A.4    Ravetch, J.V.5
  • 22
    • 84875547953 scopus 로고    scopus 로고
    • Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus
    • Teichmann L.L., Schenten D., Medzhitov R., Kashgarian M., Shlomchik M.J. Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity 2013, 38:528-540.
    • (2013) Immunity , vol.38 , pp. 528-540
    • Teichmann, L.L.1    Schenten, D.2    Medzhitov, R.3    Kashgarian, M.4    Shlomchik, M.J.5
  • 23
    • 84893364183 scopus 로고    scopus 로고
    • Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice
    • Hua Z., Gross A.J., Lamagna C., Ramos-Hernandez N., Scapini P., Ji M., Shao H., Lowell C.A., Hou B., DeFranco A.L. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol 2014, 192:875-885.
    • (2014) J Immunol , vol.192 , pp. 875-885
    • Hua, Z.1    Gross, A.J.2    Lamagna, C.3    Ramos-Hernandez, N.4    Scapini, P.5    Ji, M.6    Shao, H.7    Lowell, C.A.8    Hou, B.9    DeFranco, A.L.10
  • 26
    • 33748472865 scopus 로고    scopus 로고
    • Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    • Christensen S.R., Shupe J., Nickerson K., Kashgarian M., Flavell R.A., Shlomchik M.J. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 2006, 25:417-428.
    • (2006) Immunity , vol.25 , pp. 417-428
    • Christensen, S.R.1    Shupe, J.2    Nickerson, K.3    Kashgarian, M.4    Flavell, R.A.5    Shlomchik, M.J.6
  • 27
  • 29
    • 36048962438 scopus 로고    scopus 로고
    • Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
    • Deane J.A., Pisitkun P., Barrett R.S., Feigenbaum L., Town T., Ward J.M., Flavell R.A., Bolland S. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 2007, 27:801-810.
    • (2007) Immunity , vol.27 , pp. 801-810
    • Deane, J.A.1    Pisitkun, P.2    Barrett, R.S.3    Feigenbaum, L.4    Town, T.5    Ward, J.M.6    Flavell, R.A.7    Bolland, S.8
  • 30
    • 84867033893 scopus 로고    scopus 로고
    • Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity
    • Walsh E.R., Pisitkun P., Voynova E., Deane J.A., Scott B.L., Caspi R.R., Bolland S. Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity. Proc Natl Acad Sci USA 2012, 109:16276-16281.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 16276-16281
    • Walsh, E.R.1    Pisitkun, P.2    Voynova, E.3    Deane, J.A.4    Scott, B.L.5    Caspi, R.R.6    Bolland, S.7
  • 31
    • 84908146646 scopus 로고    scopus 로고
    • B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers
    • Soni C., Wong E.B., Domeier P.P., Khan T.N., Satoh T., Akira S., Rahman Z.S. B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers. J Immunol 2014, 193:4400-4414.
    • (2014) J Immunol , vol.193 , pp. 4400-4414
    • Soni, C.1    Wong, E.B.2    Domeier, P.P.3    Khan, T.N.4    Satoh, T.5    Akira, S.6    Rahman, Z.S.7
  • 34
    • 77957282676 scopus 로고    scopus 로고
    • Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population
    • Garcia-Ortiz H., Velazquez-Cruz R., Espinosa-Rosales F., Jimenez-Morales S., Baca V., Orozco L. Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population. Ann Rheum Dis 2010, 69:1861-1865.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1861-1865
    • Garcia-Ortiz, H.1    Velazquez-Cruz, R.2    Espinosa-Rosales, F.3    Jimenez-Morales, S.4    Baca, V.5    Orozco, L.6
  • 35
    • 79952461669 scopus 로고    scopus 로고
    • TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study
    • Kawasaki A., Furukawa H., Kondo Y., Ito S., Hayashi T., Kusaoi M., Matsumoto I., Tohma S., Takasaki Y., Hashimoto H., et al. TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study. Arthritis Res Ther 2011, 13:R41.
    • (2011) Arthritis Res Ther , vol.13 , pp. R41
    • Kawasaki, A.1    Furukawa, H.2    Kondo, Y.3    Ito, S.4    Hayashi, T.5    Kusaoi, M.6    Matsumoto, I.7    Tohma, S.8    Takasaki, Y.9    Hashimoto, H.10
  • 36
    • 70350629871 scopus 로고    scopus 로고
    • Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
    • Han J.W., Zheng H.F., Cui Y., Sun L.D., Ye D.Q., Hu Z., Xu J.H., Cai Z.M., Huang W., Zhao G.P., et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet 2009, 41:1234-1237.
    • (2009) Nat Genet , vol.41 , pp. 1234-1237
    • Han, J.W.1    Zheng, H.F.2    Cui, Y.3    Sun, L.D.4    Ye, D.Q.5    Hu, Z.6    Xu, J.H.7    Cai, Z.M.8    Huang, W.9    Zhao, G.P.10
  • 37
    • 70350650472 scopus 로고    scopus 로고
    • A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
    • Gateva V., Sandling J.K., Hom G., Taylor K.E., Chung S.A., Sun X., Ortmann W., Kosoy R., Ferreira R.C., Nordmark G., et al. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet 2009, 41:1228-1233.
    • (2009) Nat Genet , vol.41 , pp. 1228-1233
    • Gateva, V.1    Sandling, J.K.2    Hom, G.3    Taylor, K.E.4    Chung, S.A.5    Sun, X.6    Ortmann, W.7    Kosoy, R.8    Ferreira, R.C.9    Nordmark, G.10
  • 41
    • 84893392428 scopus 로고    scopus 로고
    • B cell-specific loss of Lyn kinase leads to autoimmunity
    • Lamagna C., Hu Y., DeFranco A.L., Lowell C.A. B cell-specific loss of Lyn kinase leads to autoimmunity. J Immunol 2014, 192:919-928.
    • (2014) J Immunol , vol.192 , pp. 919-928
    • Lamagna, C.1    Hu, Y.2    DeFranco, A.L.3    Lowell, C.A.4
  • 48
    • 80052239824 scopus 로고    scopus 로고
    • The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness
    • Zhang J., Zahir N., Jiang Q., Miliotis H., Heyraud S., Meng X., Dong B., Xie G., Qiu F., Hao Z., et al. The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nat Genet 2011, 43:902-907.
    • (2011) Nat Genet , vol.43 , pp. 902-907
    • Zhang, J.1    Zahir, N.2    Jiang, Q.3    Miliotis, H.4    Heyraud, S.5    Meng, X.6    Dong, B.7    Xie, G.8    Qiu, F.9    Hao, Z.10
  • 49
    • 0037080952 scopus 로고    scopus 로고
    • BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor
    • Yokoyama K., Su Ih I.H., Tezuka T., Yasuda T., Mikoshiba K., Tarakhovsky A., Yamamoto T. BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor. EMBO J 2002, 21:83-92.
    • (2002) EMBO J , vol.21 , pp. 83-92
    • Yokoyama, K.1    Su Ih, I.H.2    Tezuka, T.3    Yasuda, T.4    Mikoshiba, K.5    Tarakhovsky, A.6    Yamamoto, T.7
  • 53
  • 54
    • 0035889964 scopus 로고    scopus 로고
    • B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice
    • Hulbert C., Riseili B., Rojas M., Thomas J.W. B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice. J Immunol 2001, 167:5535-5538.
    • (2001) J Immunol , vol.167 , pp. 5535-5538
    • Hulbert, C.1    Riseili, B.2    Rojas, M.3    Thomas, J.W.4
  • 56
    • 45449099469 scopus 로고    scopus 로고
    • Cytokine-producing B lymphocytes-key regulators of immunity
    • Lund F.E. Cytokine-producing B lymphocytes-key regulators of immunity. Curr Opin Immunol 2008, 20:332-338.
    • (2008) Curr Opin Immunol , vol.20 , pp. 332-338
    • Lund, F.E.1
  • 59
    • 84896041306 scopus 로고    scopus 로고
    • From the regulatory functions of B cells to the identification of cytokine-producing plasma cell subsets
    • Dang V.D., Hilgenberg E., Ries S., Shen P., Fillatreau S. From the regulatory functions of B cells to the identification of cytokine-producing plasma cell subsets. Curr Opin Immunol 2014, 28:77-83.
    • (2014) Curr Opin Immunol , vol.28 , pp. 77-83
    • Dang, V.D.1    Hilgenberg, E.2    Ries, S.3    Shen, P.4    Fillatreau, S.5
  • 60
    • 84869870503 scopus 로고    scopus 로고
    • Developing connections amongst key cytokines and dysregulated germinal centers in autoimmunity
    • Sweet R.A., Lee S.K., Vinuesa C.G. Developing connections amongst key cytokines and dysregulated germinal centers in autoimmunity. Curr Opin Immunol 2012, 24:658-664.
    • (2012) Curr Opin Immunol , vol.24 , pp. 658-664
    • Sweet, R.A.1    Lee, S.K.2    Vinuesa, C.G.3
  • 61
    • 84869213212 scopus 로고    scopus 로고
    • Interferon-gamma excess leads to pathogenic accumulation of follicular helper T cells and germinal centers
    • Lee S.K., Silva D.G., Martin J.L., Pratama A., Hu X., Chang P.P., Walters G., Vinuesa C.G. Interferon-gamma excess leads to pathogenic accumulation of follicular helper T cells and germinal centers. Immunity 2012, 37:880-892.
    • (2012) Immunity , vol.37 , pp. 880-892
    • Lee, S.K.1    Silva, D.G.2    Martin, J.L.3    Pratama, A.4    Hu, X.5    Chang, P.P.6    Walters, G.7    Vinuesa, C.G.8
  • 62
    • 74849131972 scopus 로고    scopus 로고
    • Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial
    • Merrill J.T., Neuwelt C.M., Wallace D.J., Shanahan J.C., Latinis K.M., Oates J.C., Utset T.O., Gordon C., Isenberg D.A., Hsieh H.J., et al. Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial. Arthritis Rheum 2010, 62:222-233.
    • (2010) Arthritis Rheum , vol.62 , pp. 222-233
    • Merrill, J.T.1    Neuwelt, C.M.2    Wallace, D.J.3    Shanahan, J.C.4    Latinis, K.M.5    Oates, J.C.6    Utset, T.O.7    Gordon, C.8    Isenberg, D.A.9    Hsieh, H.J.10
  • 65
    • 77955625479 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
    • Honigberg L.A., Smith A.M., Sirisawad M., Verner E., Loury D., Chang B., Li S., Pan Z., Thamm D.H., Miller R.A., et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci USA 2010, 107:13075-13080.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 13075-13080
    • Honigberg, L.A.1    Smith, A.M.2    Sirisawad, M.3    Verner, E.4    Loury, D.5    Chang, B.6    Li, S.7    Pan, Z.8    Thamm, D.H.9    Miller, R.A.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.