Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches

Immunity

Volumn 20, Issue 6, 2004, Pages 785-798

  Thien, Marilyn ^a   Phan, Tri Giang ^a   Gardam, Sandra ^a   Amesbury, Michelle ^a   Basten, Antony ^a   MacKay, Fabienne ^b   Brink, Robert ^a  

^a CENTENARY INSTITUTE   (Australia)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN;

ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; BONE MARROW; CELL MATURATION; CELL MIGRATION; CELL POPULATION; IMMUNOLOGICAL TOLERANCE; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; SPLEEN CELL;

ANIMALS; B-CELL ACTIVATING FACTOR; B-LYMPHOCYTES; CELL DIFFERENTIATION; CLONAL ANERGY; CLONAL DELETION; FLOW CYTOMETRY; GENE EXPRESSION; MEMBRANE PROTEINS; MICE; SPLEEN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 2942518502     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2004.05.010     Document Type: Article

References (33)

1. Allman D., Lindsley R.C., DeMuth W., Rudd K., Shinton S.A., Hardy R.R. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J. Immunol. 167:2001;6834-6840
2. Attanavanich K., Kearney J.F. Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells. J. Immunol. 172:2004;803-811
3. Batten M., Groom J., Cachero T.G., Qian F., Schneider P., Tschopp J., Browning J.L., Mackay F. BAFF mediates survival of peripheral immature B lymphocytes. J. Exp. Med. 192:2000;1453-1466
4. Cook M.C., Basten A., Fazekas de St Groth B. Outer periarteriolar lymphoid sheath arrest and subsequent differentiation of both naive and tolerant immunoglobulin transgenic B cells is determined by B cell receptor occupancy. J. Exp. Med. 186:1997;631-643
5. Cooke M.P., Heath A.W., Shokat K.M., Zeng Y., Finkelman F.D., Linsley P.S., Howard M., Goodnow C.C. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J. Exp. Med. 179:1994;425-438
6. Cyster J.G. B cells on the front line. Nat. Immunol. 1:2000;9-10
7. Cyster J.G., Goodnow C.C. Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate. Immunity. 3:1995;691-701
8. Cyster J.G., Hartley S.B., Goodnow C.C. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature. 371:1994;389-395
9. Do R.K., Hatada E., Lee H., Tourigny M.R., Hilbert D., Chen-Kiang S. Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response. J. Exp. Med. 192:2000;953-964
10. Forster I., Rajewsky K. The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow. Proc. Natl. Acad. Sci. USA. 87:1990;4781-4784
11. Goodnow C.C., Crosbie J., Adelstein S., Lavoie T.B., Smith-Gill S.J., Brink R.A., Pritchard-Briscoe H., Wotherspoon J.S., Loblay R.H., Raphael K. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature. 334:1988;676-682
12. Goodnow C.C., Crosbie J., Jorgensen H., Brink R.A., Basten A. Induction of self-tolerance in mature peripheral B lymphocytes. Nature. 342:1989;385-391
13. Goodnow C.C., Adelstein S., Basten A. The need for central and peripheral tolerance in the B cell repertoire. Science. 248:1990;1373-1379
14. Groom J., Kalled S.L., Cutler A.H., Olson C., Woodcock S.A., Schneider P., Tschopp J., Cachero T.G., Batten M., Wheway J., et al. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogren's syndrome. J. Clin. Invest. 109:2002;59-68
15. Gross J.A., Dillon S.R., Mudri S., Johnston J., Littau A., Roque R., Rixon M., Schou O., Foley K.P., Haugen H., et al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. Impaired B cell maturation in mice lacking BLyS. Immunity. 15:2001;289-302
16. Hartley S.B., Goodnow C.C. Censoring of self-reactive B cells with a range of receptor affinities in transgenic mice expressing heavy chains for a lysozyme-specific antibody. Int. Immunol. 6:1994;1417-1425
17. Hartley S.B., Crosbie J., Brink R., Kantor A.B., Basten A., Goodnow C.C. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature. 353:1991;765-769
18. Hartley S.B., Cooke M.P., Fulcher D.A., Harris A.W., Cory S., Basten A., Goodnow C.C. Elimination of self-reactive B lymphocytes proceeds in two stages. arrested development and cell death Cell. 72:1993;325-335
19. Healy J.I., Dolmetsch R.E., Timmerman L.A., Cyster J.G., Thomas M.L., Crabtree G.R., Lewis R.S., Goodnow C.C. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity. 6:1997;419-428
20. Hsu B.L., Harless S.M., Lindsley R.C., Hilbert D.M., Cancro M.P. Cutting edge. BLyS enables survival of transitional and mature B cells through distinct mediators J. Immunol. 168:2002;5993-5996
21. Khare S.D., Sarosi I., Xia X.Z., McCabe S., Miner K., Solovyev I., Hawkins N., Kelley M., Chang D., Van G., et al. Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice. Proc. Natl. Acad. Sci. USA. 97:2000;3370-3375
22. Lewandoski M., Wassarman K.M., Martin G.R. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr. Biol. 7:1997;148-151
23. Mackay F., Woodcock S.A., Lawton P., Ambrose C., Baetscher M., Schneider P., Tschopp J., Browning J.L. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 190:1999;1697-1710
24. Mackay F., Schneider P., Rennert P., Browning J. Baff and april. a tutorial on b cell survival Annu. Rev. Immunol. 21:2003;231-264
25. Mason D.Y., Jones M., Goodnow C.C. Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice. Int. Immunol. 4:1992;163-175
26. Nemazee D., Buerki K. Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras. Proc. Natl. Acad. Sci. USA. 86:1989;8039-8043
27. Oliver A.M., Martin F., Gartland G.L., Carter R.H., Kearney J.F. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur. J. Immunol. 27:1997;2366-2374
28. Oliver A.M., Martin F., Kearney J.F. IgMhighCD21high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells. J. Immunol. 162:1999;7198-7207
29. Phan T.G., Amesbury M., Gardam S., Crosbie J., Hasbold J., Hodgkin P.D., Basten A., Brink R. B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells. J. Exp. Med. 197:2003;845-860
30. Rathmell J.C., Fournier S., Weintraub B.C., Allison J.P., Goodnow C.C. Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cells. J. Exp. Med. 188:1998;651-659
31. Rolink A.G., Tschopp J., Schneider P., Melchers F. BAFF is a survival and maturation factor for mouse B cells. Eur. J. Immunol. 32:2002;2004-2010
32. Schiemann B., Gommerman J.L., Vora K., Cachero T.G., Shulga-Morskaya S., Dobles M., Frew E., Scott M.L. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science. 293:2001;2111-2114
33. Thompson J.S., Bixler S.A., Qian F., Vora K., Scott M.L., Cachero T.G., Hession C., Schneider P., Sizing I.D., Mullen C., et al. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science. 293:2001;2108-2111