Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome

Journal of Experimental Medicine

Volumn 212, Issue 10, 2015, Pages 1663-1667

  Kolhatkar, Nikita S ^a   Brahmandam, Archana ^a,b   Thouvene, Christopher D ^a,b   Becker Herman, Shirly ^a,b   Jacobs, Holly M ^a,b   Schwartz, Marc A ^a   Allenspach, Eric J ^a   Khim, Socheath ^a,b   Panigrahi, Anil K ^c   Prak, Eline T Luning ^c   Thrasher, Adrian J ^d   Notarangelo, Luigi D ^e   Candotti, Fabio ^f   Torgerson, Troy R ^a,b   Sanz, Ignacio ^g,h   Rawlings, David J ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^g EMORY UNIVERSITY   (United States)

^h EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; B CELL ACTIVATING FACTOR; LYMPHOCYTE ANTIGEN RECEPTOR; MYD88 PROTEIN, MOUSE; TNFSF13B PROTEIN, MOUSE; WAS PROTEIN, MOUSE; WISKOTT ALDRICH SYNDROME PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; BINDING AFFINITY; CELL CLONING; CELL POPULATION; CELL PROLIFERATION; CELL SELECTION; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; HEAVY CHAIN; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WISKOTT ALDRICH SYNDROME; ADOLESCENT; ADULT; ANIMAL; B LYMPHOCYTE; BLOOD; C57BL MOUSE; CASE CONTROL STUDY; CELL PROTECTION; CHILD; GENETICS; IMMUNOLOGY; INFANT; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PRESCHOOL CHILD; TRANSGENIC MOUSE; YOUNG ADULT;

ADOLESCENT; ADULT; ANIMALS; B-CELL ACTIVATING FACTOR; B-LYMPHOCYTES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CYTOPROTECTION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INFANT; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, ANTIGEN, B-CELL; TOLL-LIKE RECEPTORS; WISKOTT-ALDRICH SYNDROME; WISKOTT-ALDRICH SYNDROME PROTEIN; YOUNG ADULT;

EID: 84961197588     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20150585     Document Type: Article

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