메뉴 건너뛰기




Volumn 194, Issue 8, 2015, Pages 3675-3686

Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; CD45 ANTIGEN; TOLL LIKE RECEPTOR 9; PTPRC PROTEIN, MOUSE; TLR9 PROTEIN, MOUSE;

EID: 84927628470     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1500026     Document Type: Article
Times cited : (6)

References (46)
  • 1
    • 82555196095 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Tsokos, G. C. 2011. Systemic lupus erythematosus. N. Engl. J. Med. 365:2110-2121.
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2110-2121
    • Tsokos, G.C.1
  • 2
    • 67849126802 scopus 로고    scopus 로고
    • Three checkpoints in lupus development: Central tolerance in adaptive immunity, peripheral amplification by innate immunity and end-organ inflammation
    • Kanta, H., and C. Mohan. 2009. Three checkpoints in lupus development: central tolerance in adaptive immunity, peripheral amplification by innate immunity and end-organ inflammation. Genes Immun. 10:390-396.
    • (2009) Genes Immun. , vol.10 , pp. 390-396
    • Kanta, H.1    Mohan, C.2
  • 3
    • 84876282977 scopus 로고    scopus 로고
    • Recent insights into the genetic basis of systemic lupus erythematosus
    • Rullo, O. J., and B. P. Tsao. 2013. Recent insights into the genetic basis of systemic lupus erythematosus. Ann. Rheum. Dis. 72(Suppl. 2):ii56-ii61.
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. ii56-ii61
    • Rullo, O.J.1    Tsao, B.P.2
  • 5
    • 60749095446 scopus 로고    scopus 로고
    • Antigen receptor signaling in the rheumatic diseases
    • Zikherman, J., and A. Weiss. 2009. Antigen receptor signaling in the rheumatic diseases. Arthritis Res. Ther. 11:202.
    • (2009) Arthritis Res. Ther. , vol.11 , pp. 202
    • Zikherman, J.1    Weiss, A.2
  • 6
    • 61849136595 scopus 로고    scopus 로고
    • CD45, CD148, and Lyp/Pep: Critical phosphatases regulating Src family kinase signaling networks in immune cells
    • Hermiston, M. L., J. Zikherman, and J. W. Zhu. 2009. CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells. Immunol. Rev. 228:288-311.
    • (2009) Immunol. Rev. , vol.228 , pp. 288-311
    • Hermiston, M.L.1    Zikherman, J.2    Zhu, J.W.3
  • 7
    • 0034704180 scopus 로고    scopus 로고
    • An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity
    • Majeti, R., Z. Xu, T. G. Parslow, J. L. Olson, D. I. Daikh, N. Killeen, and A. Weiss. 2000. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell 103:1059-1070.
    • (2000) Cell , vol.103 , pp. 1059-1070
    • Majeti, R.1    Xu, Z.2    Parslow, T.G.3    Olson, J.L.4    Daikh, D.I.5    Killeen, N.6    Weiss, A.7
  • 8
    • 28844498739 scopus 로고    scopus 로고
    • The juxtamembrane wedge negatively regulates CD45 function in B cells
    • Hermiston, M. L., A. L. Tan, V. A. Gupta, R. Majeti, and A. Weiss. 2005. The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity 23:635-647.
    • (2005) Immunity , vol.23 , pp. 635-647
    • Hermiston, M.L.1    Tan, A.L.2    Gupta, V.A.3    Majeti, R.4    Weiss, A.5
  • 9
    • 58149296185 scopus 로고    scopus 로고
    • B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency
    • Gupta, V. A., M. L. Hermiston, G. Cassafer, D. I. Daikh, and A. Weiss. 2008. B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency. J. Exp. Med. 205:2755-2761.
    • (2008) J. Exp. Med. , vol.205 , pp. 2755-2761
    • Gupta, V.A.1    Hermiston, M.L.2    Cassafer, G.3    Daikh, D.I.4    Weiss, A.5
  • 10
    • 64249119896 scopus 로고    scopus 로고
    • PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background
    • Zikherman, J., M. Hermiston, D. Steiner, K. Hasegawa, A. Chan, and A. Weiss. 2009. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J. Immunol. 182:4093-4106.
    • (2009) J. Immunol. , vol.182 , pp. 4093-4106
    • Zikherman, J.1    Hermiston, M.2    Steiner, D.3    Hasegawa, K.4    Chan, A.5    Weiss, A.6
  • 12
    • 84874859983 scopus 로고    scopus 로고
    • The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity
    • Zikherman, J., R. Parameswaran, M. Hermiston, and A. Weiss. 2013. The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity. J. Immunol. 190:2527-2535.
    • (2013) J. Immunol. , vol.190 , pp. 2527-2535
    • Zikherman, J.1    Parameswaran, R.2    Hermiston, M.3    Weiss, A.4
  • 15
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander, E., and L. Kruglyak. 1995. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11:241-247.
    • (1995) Nature Genet. , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 16
    • 0034816964 scopus 로고    scopus 로고
    • Delineating the genetic basis of systemic lupus erythematosus
    • Wakeland, E. K., K. Liu, R. R. Graham, and T. W. Behrens. 2001. Delineating the genetic basis of systemic lupus erythematosus. Immunity 15:397-408.
    • (2001) Immunity , vol.15 , pp. 397-408
    • Wakeland, E.K.1    Liu, K.2    Graham, R.R.3    Behrens, T.W.4
  • 18
    • 34250650116 scopus 로고    scopus 로고
    • TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: Results from a genome-wide scan
    • Anderson, A. E., M. L. Worku, W. Khamri, K. B. Bamford, M. M. Walker, and M. R. Thursz. 2007. TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: results from a genome-wide scan. Eur. J. Immunol. 37:1548-1561.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 1548-1561
    • Anderson, A.E.1    Worku, M.L.2    Khamri, W.3    Bamford, K.B.4    Walker, M.M.5    Thursz, M.R.6
  • 19
    • 68849085894 scopus 로고    scopus 로고
    • A cell biological view of Toll-like receptor function: Regulation through compartmentalization
    • Barton, G. M., and J. C. Kagan. 2009. A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat. Rev. Immunol. 9:535-542.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 535-542
    • Barton, G.M.1    Kagan, J.C.2
  • 21
    • 79953162780 scopus 로고    scopus 로고
    • Toll-like receptor driven B cell activation in the induction of systemic autoimmunity
    • Green, N. M., and A. Marshak-Rothstein. 2011. Toll-like receptor driven B cell activation in the induction of systemic autoimmunity. Semin. Immunol. 23:106-112.
    • (2011) Semin. Immunol. , vol.23 , pp. 106-112
    • Green, N.M.1    Marshak-Rothstein, A.2
  • 22
    • 33748472865 scopus 로고    scopus 로고
    • Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    • Christensen, S. R., J. Shupe, K. Nickerson, M. Kashgarian, R. A. Flavell, and M. J. Shlomchik. 2006. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25:417-428.
    • (2006) Immunity , vol.25 , pp. 417-428
    • Christensen, S.R.1    Shupe, J.2    Nickerson, K.3    Kashgarian, M.4    Flavell, R.A.5    Shlomchik, M.J.6
  • 23
    • 77949903821 scopus 로고    scopus 로고
    • TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus
    • Nickerson, K. M., S. R. Christensen, J. Shupe, M. Kashgarian, D. Kim, K. Elkon, and M. J. Shlomchik. 2010. TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. J. Immunol. 184:1840-1848.
    • (2010) J. Immunol. , vol.184 , pp. 1840-1848
    • Nickerson, K.M.1    Christensen, S.R.2    Shupe, J.3    Kashgarian, M.4    Kim, D.5    Elkon, K.6    Shlomchik, M.J.7
  • 25
    • 78649848107 scopus 로고    scopus 로고
    • TAM receptor signaling and autoimmune disease
    • Rothlin, C. V., and G. Lemke. 2010. TAM receptor signaling and autoimmune disease. Curr. Opin. Immunol. 22:740-746.
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 740-746
    • Rothlin, C.V.1    Lemke, G.2
  • 26
    • 77955343903 scopus 로고    scopus 로고
    • Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice
    • Scapini, P., Y. Hu, C. L. Chu, T. S. Migone, A. L. Defranco, M. A. Cassatella, and C. A. Lowell. 2010. Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J. Exp. Med. 207:1757-1773.
    • (2010) J. Exp. Med. , vol.207 , pp. 1757-1773
    • Scapini, P.1    Hu, Y.2    Chu, C.L.3    Migone, T.S.4    Defranco, A.L.5    Cassatella, M.A.6    Lowell, C.A.7
  • 27
    • 78149298238 scopus 로고    scopus 로고
    • Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis
    • Summers, S. A., O. M. Steinmetz, J. D. Ooi, P. Y. Gan, K. M. O'Sullivan, K. Visvanathan, S. Akira, A. R. Kitching, and S. R. Holdsworth. 2010. Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis. Am. J. Pathol. 177:2234-2244.
    • (2010) Am. J. Pathol. , vol.177 , pp. 2234-2244
    • Summers, S.A.1    Steinmetz, O.M.2    Ooi, J.D.3    Gan, P.Y.4    O'Sullivan, K.M.5    Visvanathan, K.6    Akira, S.7    Kitching, A.R.8    Holdsworth, S.R.9
  • 28
    • 84870250088 scopus 로고    scopus 로고
    • Toll-like receptor 9 and vascular endothelial growth factor levels in human kidneys from lupus nephritis patients
    • Frieri, M., M. A. Samih, M. Dzhindzhikhashvili, H. Liu, L. Balsam, and S. Rubinstein. 2012. Toll-like receptor 9 and vascular endothelial growth factor levels in human kidneys from lupus nephritis patients. J. Nephrol. 25:1041-1046.
    • (2012) J. Nephrol. , vol.25 , pp. 1041-1046
    • Frieri, M.1    Samih, M.A.2    Dzhindzhikhashvili, M.3    Liu, H.4    Balsam, L.5    Rubinstein, S.6
  • 29
    • 74049110516 scopus 로고    scopus 로고
    • Checkpoints in lymphocyte development and autoimmune disease
    • Von Boehmer, H., and F. Melchers. 2010. Checkpoints in lymphocyte development and autoimmune disease. Nat. Immunol. 11:14-20.
    • (2010) Nat. Immunol. , vol.11 , pp. 14-20
    • Von Boehmer, H.1    Melchers, F.2
  • 31
    • 31044440025 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling protects against murine lupus
    • Wu, X., and S. L. Peng. 2006. Toll-like receptor 9 signaling protects against murine lupus. Arthritis Rheum. 54:336-342.
    • (2006) Arthritis Rheum. , vol.54 , pp. 336-342
    • Wu, X.1    Peng, S.L.2
  • 36
    • 84873557459 scopus 로고    scopus 로고
    • TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation
    • Nickerson, K. M., S. R. Christensen, J. L. Cullen, W. Meng, E. T. Luning Prak, and M. J. Shlomchik. 2013. TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation. J. Immunol. 190:1447-1456.
    • (2013) J. Immunol. , vol.190 , pp. 1447-1456
    • Nickerson, K.M.1    Christensen, S.R.2    Cullen, J.L.3    Meng, W.4    Luning Prak, E.T.5    Shlomchik, M.J.6
  • 38
    • 52649097448 scopus 로고    scopus 로고
    • The Immunological Genome Project: Networks of gene expression in immune cells
    • Heng, T. S., and M. W. Painter; Immunological Genome Project Consortium. 2008. The Immunological Genome Project: networks of gene expression in immune cells. Nat. Immunol. 9:1091-1094.
    • (2008) Nat. Immunol. , vol.9 , pp. 1091-1094
    • Immunological Genome Project Consortium1    Heng, T.S.2    Painter, M.W.3
  • 39
    • 84863760911 scopus 로고    scopus 로고
    • Associations between TLR polymorphisms and systemic lupus erythematosus: A systematic review and meta-analysis
    • Lee, Y. H., H. S. Lee, S. J. Choi, J. D. Ji, and G. G. Song. 2012. Associations between TLR polymorphisms and systemic lupus erythematosus: a systematic review and meta-analysis. Clin. Exp. Rheumatol. 30:262-265.
    • (2012) Clin. Exp. Rheumatol. , vol.30 , pp. 262-265
    • Lee, Y.H.1    Lee, H.S.2    Choi, S.J.3    Ji, J.D.4    Song, G.G.5
  • 40
    • 84865389006 scopus 로고    scopus 로고
    • Lack of association of Toll-like receptor 9 polymorphisms with susceptibility to systemic lupus erythematosus in an Asian population: A meta-analysis
    • Li, J., J. H. Tao, W. Gao, Y. Fan, M. M. Lu, R. Li, X. P. Li, and D. Q. Ye. 2012. Lack of association of Toll-like receptor 9 polymorphisms with susceptibility to systemic lupus erythematosus in an Asian population: a meta-analysis. Mod. Rheumatol. 22:550-556.
    • (2012) Mod. Rheumatol. , vol.22 , pp. 550-556
    • Li, J.1    Tao, J.H.2    Gao, W.3    Fan, Y.4    Lu, M.M.5    Li, R.6    Li, X.P.7    Ye, D.Q.8
  • 41
    • 84855444149 scopus 로고    scopus 로고
    • TLR9 polymorphisms and systemic lupus erythematosus risk in Asians: A meta-analysis study
    • Yang, Z., Y. Liang, B. Qin, C. Li, and R. Zhong. 2012. TLR9 polymorphisms and systemic lupus erythematosus risk in Asians: a meta-analysis study. Cytokine 57:282-289.
    • (2012) Cytokine , vol.57 , pp. 282-289
    • Yang, Z.1    Liang, Y.2    Qin, B.3    Li, C.4    Zhong, R.5
  • 42
    • 84875282770 scopus 로고    scopus 로고
    • Hydroxychloroquine in lupus: Emerging evidence supporting multiple beneficial effects
    • Tang, C., T. Godfrey, R. Stawell, and M. Nikpour. 2012. Hydroxychloroquine in lupus: emerging evidence supporting multiple beneficial effects. Intern. Med. J. 42:968-978.
    • (2012) Intern. Med. J. , vol.42 , pp. 968-978
    • Tang, C.1    Godfrey, T.2    Stawell, R.3    Nikpour, M.4
  • 44
    • 37549066665 scopus 로고    scopus 로고
    • Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
    • Barrat, F. J., T. Meeker, J. H. Chan, C. Guiducci, and R. L. Coffman. 2007. Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. Eur. J. Immunol. 37:3582-3586.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 3582-3586
    • Barrat, F.J.1    Meeker, T.2    Chan, J.H.3    Guiducci, C.4    Coffman, R.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.