Development of autoantibodies before the clinical onset of systemic lupus erythematosus

New England Journal of Medicine

Volumn 349, Issue 16, 2003, Pages 1526-1533

  Arbuckle, Melissa R ^a,d   McClain, Micah T ^a,b   Rubertone, Mark V ^f   Hal Scofield, R ^a,b,c   Dennis, Gregory J ^d,e   James, Judith A ^a,b   Harley, John B ^a,b,c  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c DEPARTMENT OF VETERANS AFFAIRS   (United States)

^d WALTER REED ARMY MEDICAL CENTER   (United States)

^e NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^f US Army Center for Health Promotion and Preventive Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; DNA ANTIBODY; LEUKOCYTE ANTIBODY; PHOSPHOLIPID ANTIBODY; RHESUS ANTIBODY; RIBONUCLEOPROTEIN ANTIBODY; SMOOTH MUSCLE ANTIBODY; AUTOANTIGEN; DNA; RIBONUCLEOPROTEIN; SM NUCLEAR ANTIGENS; SMALL NUCLEAR RIBONUCLEOPROTEIN; SS A ANTIBODIES; SS B ANTIGEN; SS-A ANTIBODIES; SS-B ANTIGEN;

ADULT; ANTIBODY PRODUCTION; ARMY; ARTICLE; DISEASE COURSE; FEMALE; HUMAN; IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SYSTEMIC LUPUS ERYTHEMATOSUS; UNITED STATES; BLOOD; EVALUATION; IMMUNOLOGY; PHYSIOLOGY; SOLDIER; TIME;

ANTIBODIES, ANTINUCLEAR; AUTOANTIBODIES; AUTOANTIGENS; DNA; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MILITARY PERSONNEL; PROSPECTIVE STUDIES; RIBONUCLEOPROTEINS; RIBONUCLEOPROTEINS, SMALL NUCLEAR; TIME FACTORS;

EID: 0142009533     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa021933     Document Type: Article

References (32)

1. Reichlin M,Harley JB. Antibodies to Ro/SSA and La/SSB. In: Wallace DJ, Hahn BH, eds. Dubois' lupus erythematosus. 6th ed. Philadelphia: Lippincott Williams & Wilkins, 2002:467-80.
2. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725.
3. Gharavi AE, Harris EN, Asherson RA, Hughes GR. Anticardiolipin antibodies: isotype distribution and phospholipid specificity. Ann Rheum Dis 1987;46:1-6.
4. McClain MT, Ramsland PA, Kaufman KM, James JA. Anti-Sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens. J Immunol 2002;168:2054-62.
5. Aarden A, de Groot ER, Feltkamp TEW. Immunology of DNA. III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immunofluorescence technique. Ann N Y Acad Sci 1975;254: 505-15.
6. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
7. Lee ET. Statistical methods for survival data analysis. 2nd ed. New York: John Wiley, 1992.
8. Gehan EA. A generalized Wilcoxon test for comparing arbitrarily singly-censored samples. Biometrika 1965;52:203-23.
9. Idem, A generalized two-sample Wilcoxon test for doubly censored data. Biometrika 1965;52:650-3.
10. Isenberg DA, Dudeney C, Williams W, et al. Measurement of anti-DNA antibodies: a reappraisal using five different methods. Ann Rheum Dis 1987;6:448-56.
11. Avina-Zubieta JA, Galindo-Rodriguez G, Kwan-Yeung L, Davis P, Russell AS. Clinical evaluation of various selected ELISA kits for the detection of anti-DNA antibodies. Lupus 1995;4:370-4.
12. Azizah MR, Azila MN, Zulkifli MN, Norita TY. The prevalence of antinuclear anti-dsDNA, anti-Sm and anti-RNP antibodies in a group of healthy blood donors. Asian Pac J Allergy Immunol 1996;14:125-8.
13. Gaither KK, Fox OF, Yamagata H, Mamula MJ, Reichlin M, Harley JB. Implications of anti-Ro/Sjogren's syndrome A antigen autoantibody in normal sera for autoimmunity. J Clin Invest 1987;79:841-6.
14. Vlachoyiannopoulos PG, Tzavara V, Dafni U, Spanos E, Moutsopoulos HM. Clinical features and evolution of antinuclear antibody positive individuals in a rheumatology outpatient clinic. J Rheumatol 1998; 25:886-91.
15. Mosca M, Tavoni A, Neri P, Bencivelli W, Bombardieri S. Undifferentiated connective tissue diseases: the clinical and serological profiles of 91 patients followed for at least 1 year. Lupus 1998;7:95-100.
16. Press J, Uziel Y, Laxer R, Luy L, Hamilton RM, Silverman ED. Long-term outcome of mothers of children with complete congenital heart block. Am J Med 1996;100:328-32.
17. Julkunen H, Kurki P, Kaaja R, et al. Isolated congenital heart block: long-term outcome of mothers and characterization of the immune response to SS-A/Ro and SS-B/La. Arthritis Rheum 1993;36:1588-98.
18. Simmons-O'Brien E, Chen S, Watson R, et al. One hundred anti-Ro (SS-A) antibody positive patients: a 10-year follow-up. Medicine (Baltimore) 1995;74:109-30.
19. Satoh M, Yamagata H, Watanabe F, et al. Development of anti-Sm and anti-DNA antibodies followed by clinical manifestation of systemic lupus erythematosus in an elderly woman with long-standing Sjogren's syndrome. Lupus 1995;4:63-5.
20. Spronk PE, Limburg PC, Kallenberg CGM. Serologic markers of disease activity in systemic lupus erythematosus. Lupus 1995;4:86-94.
21. Elkon KB. Autoantibodies in SLE. In: Klippel JH, Dieppe PA, eds. Rheumatology. 2nd ed. Vol. 2. Section 7. London: Mosby, 1998:5.1-5.10.
22. Zarmbinksi MA, Messner RP, Mandel JS. Anti-dsDNA antibodies in laboratory workers handling blood from patients with systemic lupus erythematosus. J Rheumatol 1992;19:1380-4.
23. Harvey AM, Schulman LE, Tumulty PA, Conley CL, Schoenrich EH. Systemic lupus erythematosus: review of the literature and clinical analysis of 38 cases. Medicine (Baltimore) 1954;33:291-437.
24. Dubois EL. Results of steroid therapy in systemic lupus erythematosus. In: Dubois EL, ed. Lupus erythematosus: a review of the current status of discoid and systemic lupus erythematosus and their variants. 2nd ed. Los Angeles: University of Southern California Press, 1974:613-32.
25. Ruiz-Irastorza G, Khamashta MA, Castellino G, Hughes GRV. Systemic lupus erythematosus. Lancet 2001;357:1027-32.
26. Julkunen H, Eronen M. Long-term outcome of mothers of children with isolated heart block in Finland. Arthritis Rheum 2001;44:647-52.
27. Aho K, Heliövaara M, Maatela J, Tuomi T, Palosuo T. Rheumatoid factors antedating clinical rheumatoid arthritis. J Rheumatol 1991;18:1282-4.
28. Batstra MR, Aanstoot HJ, Herbrink P. Prediction and diagnosis of type 1 diabetes using beta-cell autoantibodies. Clin Lab 2001;47:497-507.
29. Aho K, Koskela P, Makitalo R, Heliovaara M, Palosuo T. Antinuclear antibodies heralding the onset of systemic lupus erythematosus. J Rheumatol 1992;19:1377-9.
30. Arbuckle MR, James JA, Kohlhase KF, Rubertone MV, Dennis GJ, Harley JB. Development of anti-dsDNA autoantibodies prior to clinical diagnosis of systemic lupus erythematosus. Scand J Immunol 2001;54:211-9.
31. James JA, Gross T, Scofield RH, Harley JB. Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B'-derived PPPGMRPP and PPPGIKGP induce spliceosome autoimmunity. J Exp Med 1995;181:453-61.
32. Arbuckle MP, Rechlin M, Harley JB, James JA. Shared early autoantibody recognition events in the development of anti-Sm B/B' in human lupus. Scand J Immunol 1999;50:447-55.