Positive Selection of B Cells Expressing Low Densities of Self-reactive BCRs

Journal of Experimental Medicine

Volumn 199, Issue 6, 2004, Pages 843-853

  Gaudin, Emmanuelle ^a   Hao, Yi ^a   Rosado, Maria Manuela ^a,c   Chaby, Richard ^b   Girard, Robert ^a   Freitas, António A ^a  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

^c BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

Avidity; B lymphocytes; Selection; Self antigen; Self reactivity

Indexed keywords

AUTOANTIGEN; B LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE DIFFERENTIATION; CELL FATE; CELL SELECTION; CHIMERA; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY;

ANIMALS; AUTOANTIGENS; AUTOIMMUNITY; B-LYMPHOCYTES; BROMODEOXYURIDINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNE TOLERANCE; IODINE RADIOISOTOPES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MURAMIDASE; RECEPTORS, ANTIGEN, B-CELL;

EID: 1642292521     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030955     Document Type: Article

References (46)

1. Goodnow, C.C., J.G. Cyster, S.B. Hartley, S.E. Bell, M.P. Cooke, J.I. Healy, S. Akkaraju, J.C. Rathmell, S.L. Pogue, and K.P. Shokat. 1995. Self-tolerance checkpoints in B lymphocyte development. Adv. Immunol. 59:279-368.
2. Goodnow, C.C., J. Crosbie, S. Adelstein, T.B. Lavoie, S.J. Smith-Gill, R.A. Brink, H. Pritchard-Briscoe, J.S. Wotherspoon, R.H. Loblay, K. Raphael, et al. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature. 334:676-682.
3. Hartley, S.B., J. Crosbie, R. Brink, A.B. Kantor, A. Basten, and C.C. Goodnow. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature. 353:765-769.
4. Nemazee, D.A., and K. Burki. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature. 337:562-566.
5. Nemazee, D., and K. Buerki. 1989. Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras. Proc. Natl. Acad. Sci. USA. 86:8039-8043.
6. Sandel, P.C., and J.G. Monroe. 1999. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter. Immunity. 10:289-299.
7. von Boehmer, H. 1990. Developmental biology of T cells in T-cell receptor transgenic mice. Annu. Rev. Immunol. 8:531-556.
8. Hayakawa, K., M. Asano, S.A. Shinton, M. Gui, D. Allman, C.L. Stewart, J. Silver, and R.R. Hardy. 1999. Positive selection of natural autoreactive B cells. Science. 285:113-116.
9. Lam, K.-P., R. Kuhn, and K. Rajewsky. 1997. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell. 90:1073-1083.
10. Freitas, A.A., and B. Rocha. 2000. Population biology of lymphocytes: the flight for survival. Annu. Rev. Immunol. 18: 83-111.
11. Freitas, A.A., M.P. Lembezat, and A. Coutinho. 1989. Expression of antibody V-regions is genetically and developmentally controlled and modulated by the B lymphocyte environment. Int. Immunol. 1:342-354.
12. Gu, H., D. Tarlinton, W. Muller, K. Rajewsky, and I. Forster. 1991. Most peripheral B cells are ligand selected. J. Exp. Med. 173:1357-1371.
13. Levine, M.H., A.M. Haberman, D.B. Sant'Angelo, L.G. Hannum, M.P. Cancro, C.A. Janeway, Jr., and M.J. Shlomchik. 2000. A B-cell receptor-specific selection step governs immature to mature B cell differentiation. Proc. Natl. Acad. Sci. USA. 97:2743-2748.
14. Heltemes, L.M., and T. Manser. 2002. Level of B cell antigen receptor surface expression influences both positive and negative selection of B cells during primary development. J. Immunol. 169:1283-1292.
15. Morris, S.C., M. Moroldo, E.H. Giannini, T. Orekhova, and F.D. Finkelman. 2000. In vivo survival of autoreactive B cells: characterization of long-lived B cells. J. Immunol. 164: 3035-3046.
16. Li, Y., H. Li, and M. Weigert. 2002. Autoreactive B cells in the marginal zone that express dual receptors. J. Exp. Med. 195:181-188.
17. Adelstein, S., H. Pritchard-Briscoe, T.A. Anderson, J. Crosbie, G. Gammon, R.H. Loblay, A. Basten, and C.C. Goodnow. 1991. Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen. Science. 251:1223-1225.
18. Shinkai, Y., G. Rathbun, K.P. Lam, E.M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A.M. Stall, et al. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68: 855-867.
19. Rusconi, S., and G. Kohler. 1985. Transmission and expression of a specific pair of rearranged immunoglobulin mu and kappa genes in a transgenic mouse line. Nature. 314:330-334.
20. Rosado, M.M., and A.A. Freitas. 2000. B cell positive selection by self antigens and counter-selection of dual B cell receptor cells in the peripheral B cell pools. Eur. J. Immunol. 30: 2181-2190.
21. Akkaraju, S., W.Y. Ho, D. Leong, K. Canaan, M.M. Davis, and C.C. Goodnow. 1997. A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity. 7:255-271.
22. Penit, C., and F. Vasseur. 1993. Phenotype analysis of cycling and postcycling thymocytes: evaluation of detection methods for BrdUrd and surface proteins. Cytometry. 14:757-763.
23. Hunter, R. 1970. Standardization of the chloramine-T method of protein iodination. Proc. Soc. Exp. Biol. Med. 133: 989-992.
24. Agenes, F., M.M. Rosado, and A.A. Freitas. 1997. Independent homeostatic regulation of B cell compartments. Eur. J. Immunol. 27:1801-1807.
25. Freitas, A.A., M.M. Rosado, A.C. Viale, and A. Grandien. 1995. The role of cellular competition in B cell survival and selection of B cell repertoires. Eur. J. Immunol. 25:1729-1738.
26. Wang, H., and M.J. Shlomchik. 1998. Maternal Ig mediates neonatal tolerance in rheumatoid factor transgenic mice but tolerance breaks down in adult mice. J. Immunol. 160:2263-2271.
27. Rolink, A.G., J. Andersson, and F. Melchers. 1998. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity. Eur. J. Immunol. 28:3738-3748.
28. Loder, F., B. Mutschler, R.J. Ray, C.J. Paige, P. Sideras, R. Torres, M.C. Lamers, and R. Carsetti. 1999. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 190:75-89.
29. Oliver, A.M., F. Martin, G.L. Gartland, R.H. Carter, and J.F. Kearney. 1997. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur. J. Immunol. 27:2366-2374.
30. Huesmann, M., B. Scott, P. Kisielow, and H. von Boehmer. 1991. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell. 66: 533-540.
31. Hartley, S.B., and C.C. Goodnow. 1994. Censoring of self-reactive B cells with a range of receptor affinities in transgenic mice expressing heavy chains for a lysozyme-specific antibody. Int. Immunol. 6:1417-1425.
32. Lang, J., M. Jackson, L. Teyton, A. Brunmark, K. Kane, and D. Nemazee. 1996. B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen. J. Exp. Med. 184:1685-1697.
33. Kouskoff, V., S. Famiglietti, G. Lacaud, P. Lang, J.E. Rider, B.K. Kay, J.C. Cambier, and D. Nemazee. 1998. Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses. J. Exp. Med. 188:1453-1464.
34. Fagarasan, S., and T. Honjo. 2000. T-independent immune response: new aspects of B cell biology. Science. 290:89-92.
35. Holmberg, D., G. Wennerstrom, L. Andrade, and A. Coutinho. 1986. The high idiotypic connectivity of "natural" newborn antibodies is not found in adult mitogen-reactive B cell repertoires. Eur. J. Immunol. 16:82-87.
36. Freitas, A.A., L. Andrade, M.P. Lembezat, and A. Coutinho. 1990. Selection of VH gene repertoires: differentiating B cells of adult bone marrow mimic fetal development. Int. Immunol. 2:15-23.
37. Wardemann, H., S. Yurasov, A. Schaefer, J.W. Young, E. Meffre, and M.C. Nussenzweig. 2003. Predominant autoantibody production by early human B cell precursors. Science. 301:1374-1377.
38. Fulcher, D.A., A.B. Lyons, S.L. Korn, M.C. Cook, C. Koleda, C. Parish, B. Fazekas de St Groth, and A. Basten. 1996. The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help. J. Exp. Med. 183:2313-2328.
39. Cyster, J.G., J.I. Healy, K. Kishihara, T.W. Mak, M.L. Thomas, and C.C. Goodnow. 1996. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature. 381:325-328.
40. Okamoto, M., M. Murakami, A. Shimizu, S. Ozaki, T. Tsubata, S. Kumagai, and T. Honjo. 1992. A transgenic model of autoimmune hemolytic anemia. J. Exp. Med. 175:71-79.
41. Andersson, J., F. Melchers, and A. Rolink. 1995. Stimulation by T cell independent antigens can relieve the arrest of differentiation of immature auto-reactive B cells in the bone marrow. Scand. J. Immunol. 42:21-33.
42. Tiegs, S.L., D.M. Russell, and D. Nemazee. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177:1009-1020.
43. Gay, D., T. Saunders, S. Camper, and M. Weigert. 1993. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177:999-1008.
44. Prak, E.L., and M. Weigert. 1995. Light chain replacement: a new model for antibody gene rearrangement. J. Exp. Med. 182:541-548.
45. Pelanda, R., S. Schwers, E. Sonoda, R.M. Torres, D. Nemazee, and K. Rajewsky. 1997. Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity. 7:765-775.
46. Kouskoff, V., G. Lacaud, K. Pape, M. Retter, and D. Nemazee. 2000. B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection. Proc. Natl. Acad. Sci. USA. 97:7435-7439.