Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation

Journal of Experimental Medicine

Volumn 211, Issue 1, 2014, Pages 45-56

  Goenka, Radhika ^a   Matthews, Andrew H ^a   Zhang, Bochao ^b   O'Neill, Patrick J ^a   Scholz, Jean L ^a   Migone, Thi Sau ^c   Leonard, Warren J ^d   Stohl, William ^e   Hershberg, Uri ^b   Cancro, Michael P ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DREXEL UNIVERSITY   (United States)

^c GLAXOSMITHKLINE   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR; B CELL ACTIVATING FACTOR RECEPTOR; B CELL MATURATION ANTIGEN; INTERLEUKIN 21; INTERLEUKIN 4; INTERLEUKIN 6; PROTEIN BCL 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CELL CLONE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GERMINAL CENTER; HELPER CELL; IMMUNOHISTOCHEMISTRY; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SOMATIC HYPERMUTATION; SOMATIC MUTATION; SPLEEN CELL; STEADY STATE; T LYMPHOCYTE;

ANIMALS; ANTIBODY AFFINITY; ANTIBODY FORMATION; B-CELL ACTIVATING FACTOR; B-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GERMINAL CENTER; IMMUNOHISTOCHEMISTRY; MICE; T-LYMPHOCYTES, HELPER-INDUCER; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN;

EID: 84892546134     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20130505     Document Type: Article

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