Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus

Journal of Immunology

Volumn 191, Issue 10, 2013, Pages 4926-4939

  Richardson, Christopher ^a   Chida, Asiya Seema ^a,b   Adlowitz, Diana ^a   Silver, Lin ^a   Fox, Erin ^a   Jenks, Scott A ^a,b   Palmer, Elise ^a   Wang, Youliang ^b   Heimburg Molinaro, Jamie ^c   Li, Quan Zhen ^d   Mohan, Chandra ^d   Cummings, Richard ^c   Tipton, Christopher ^a,b   Sanz, Ignacio ^a,b  

^a UNIVERSITY OF ROCHESTER   (United States)

^b EMORY UNIVERSITY   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9G4 B LYMPHOCYTE ANTIBODY; ANTINUCLEAR ANTIBODY; AUTOANTIGEN; B LYMPHOCYTE ANTIBODY; CARDIOLIPIN; DNA; IDIOTYPIC ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN IDIOTYPE; RECOMBINANT ANTIBODY; UNCLASSIFIED DRUG; CHROMATIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN VARIABLE REGION;

ANTIGEN DETECTION; ANTIGENICITY; APOPTOSIS; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CASE REPORT; CELL POPULATION; CHROMATIN; CONTROLLED STUDY; DNA BINDING; EMBRYO; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MEMORY CELL; MUTAGENESIS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SYSTEMIC LUPUS ERYTHEMATOSUS; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; MOLECULAR GENETICS;

ANTIBODIES, ANTINUCLEAR; APOPTOSIS; AUTOANTIGENS; B-LYMPHOCYTES; CARDIOLIPINS; CHROMATIN; DNA; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN IDIOTYPES; IMMUNOGLOBULIN VARIABLE REGION; LUPUS ERYTHEMATOSUS, SYSTEMIC; MOLECULAR SEQUENCE DATA;

EID: 84887480836     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202263     Document Type: Article

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60. Urbonaviciute, V., B. G. Fürnrohr, S. Meister, L. Munoz, P. Heyder, F. DeMarchis, M. E. Bianchi, C. Kirschning, H. Wagner, A. A. Manfredi, et al. 2008. Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J. Exp. Med. 205:3007-3018.
61. Tiller, T., E. Meffre, S. Yurasov, M. Tsuiji, M. C. Nussenzweig, and H. Wardemann. 2008. Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning. J. Immunol. Methods. 329:112-124.
62. Quách, T. D., N. Manjarrez-Orduño, D. G. Adlowitz, L. Silver, H. Yang, C. Wei, E. C. B. Milner, and I. Sanz. 2011. Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM. J. Immunol. 186:4640-4648.
63. Culton, D. A., B. P. O'Conner, K. L. Conway, R. Diz, J. Rutan, B. J. Vilen, and S. H. Clarke. 2006. Early preplasma cells define a tolerance checkpoint for autoreactive B cells. J. Immunol. 176:790-802.
64. Shlomchik, M. J. 2008. Sites and stages of autoreactive B cell activation and regulation. Immunity. 28:18-28.
65. Watanabe, N., H. M. Fisher, and W. V. Epstein. 1969. Specificity and reactivity of cytoplasmic and nucleolar antibody in SLE sera. Arthritis Rheum. 12:173-180.
66. Sawalha, A. H., B. Namjou, S. K. Nath, J. Kilpatrick, A. Germundson, J. A. Kelly, D. Hutchings, J. James, and J. Harley. 2002. Genetic linkage of systemic lupus erythematosus with chromosome 11q14 (SLEH1) in African-American families stratified by a nucleolar antinuclear antibody pattern. Genes Immun. 3(Suppl 1):S31-S34.
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69. Mockridge, C. I., C. J. Chapman, M. B. Spellerberg, D. A. Isenberg, and F. K. Stevenson. 1996. Use of phage surface expression to analyze regions of human V4-34 (VH4-21)-encoded IgG autoantibody required for recognition of DNA: no involvement of the 9G4 idiotope. J. Immunol. 157:2449-2454.
70. Li, Y., M. B. Spellerberg, F. K. Stevenson, J. D. Capra, and K. N. Potter. 1996. The I binding specificity of human VH 4-34 (VH 4-21) encoded antibodies is determined by both VH framework region 1 and complementarity determining region 3. J. Mol. Biol. 256:577-589.
71. Chapman, C. J., M. B. Spellerberg, G. A. Smith, S. J. Carter, T. J. Hamblin, and F. K. Stevenson. 1993. Autoanti-red cell antibodies synthesized by patients with infectious mononucleosis utilize the VH4-21 gene segment. J. Immunol. 151:1051-1061.
72. Potter, K. N., Y. Li, V. Pascual, R. C. Williams, Jr., L. C. Byres, M. Spellerberg, F. K. Stevenson, and J. D. Capra. 1993. Molecular characterization of a crossreactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment. J. Exp. Med. 178:1419-1428.
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74. Muñoz, L. E., K. Lauber, M. Schiller, A. A. Manfredi, and M. Herrmann. 2010. The role of defective clearance of apoptotic cells in systemic autoimmunity. Nat Rev Rheumatol. 6:280-289.
75. Hall, J. C., L. Casciola-Rosen, and A. Rosen. 2004. Altered structure of autoantigens during apoptosis. Rheum. Dis. Clin. North Am. 30:455-471, vii.
76. Båve, U., M. Magnusson, M. L. Eloranta, A. Perers, G. V. Alm, and L. Rönnblom. 2003. Fc g RIIa is expressed on natural IFN-A-producing cells (plasmacytoid dendritic cells) and is required for the IFN-A production induced by apoptotic cells combined with lupus IgG. J. Immunol. 171:3296-3302.
77. Wardemann, H., J. Hammersen, and M. C. Nussenzweig. 2004. Human autoantibody silencing by immunoglobulin light chains. J. Exp. Med. 200:191-199.
78. Urbonaviciute, V., B. G. Fürnrohr, S. Meister, L. Munoz, P. Heyder, F. DeMarchis, M. E. Bianchi, C. Kirschning, H. Wagner, A. A. Manfredi, et al. 2008. Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J. Exp. Med. 205:3007-3018.
79. Tiller, T., E. Meffre, S. Yurasov, M. Tsuiji, M. C. Nussenzweig, and H. Wardemann. 2008. Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning. J. Immunol. Methods. 329:112-124.
80. Quách, T. D., N. Manjarrez-Orduño, D. G. Adlowitz, L. Silver, H. Yang, C. Wei, E. C. B. Milner, and I. Sanz. 2011. Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM. J. Immunol. 186:4640-4648.
81. Culton, D. A., B. P. O'Conner, K. L. Conway, R. Diz, J. Rutan, B. J. Vilen, and S. H. Clarke. 2006. Early preplasma cells define a tolerance checkpoint for autoreactive B cells. J. Immunol. 176:790-802.
82. Shlomchik, M. J. 2008. Sites and stages of autoreactive B cell activation and regulation. Immunity. 28:18-28.
83. Watanabe, N., H. M. Fisher, and W. V. Epstein. 1969. Specificity and reactivity of cytoplasmic and nucleolar antibody in SLE sera. Arthritis Rheum. 12:173-180.
84. Sawalha, A. H., B. Namjou, S. K. Nath, J. Kilpatrick, A. Germundson, J. A. Kelly, D. Hutchings, J. James, and J. Harley. 2002. Genetic linkage of systemic lupus erythematosus with chromosome 11q14 (SLEH1) in African-American families stratified by a nucleolar antinuclear antibody pattern. Genes Immun. 3(Suppl 1):S31-S34.
85. Li, Q. Z., C. Xie, T. Wu, M. Mackay, C. Aranow, C. Putterman, and C. Mohan. 2005. Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays. J. Clin. Invest. 115:3428-3439.
86. Kalaaji, M., E. Mortensen, L. Jørgensen, R. Olsen, and O. P. Rekvig. 2006. Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cells. Am. J. Pathol. 168:1779-1792.
87. Mockridge, C. I., C. J. Chapman, M. B. Spellerberg, D. A. Isenberg, and F. K. Stevenson. 1996. Use of phage surface expression to analyze regions of human V4-34 (VH4-21)-encoded IgG autoantibody required for recognition of DNA: no involvement of the 9G4 idiotope. J. Immunol. 157:2449-2454.
88. Li, Y., M. B. Spellerberg, F. K. Stevenson, J. D. Capra, and K. N. Potter. 1996. The I binding specificity of human VH 4-34 (VH 4-21) encoded antibodies is determined by both VH framework region 1 and complementarity determining region 3. J. Mol. Biol. 256:577-589.
89. Chapman, C. J., M. B. Spellerberg, G. A. Smith, S. J. Carter, T. J. Hamblin, and F. K. Stevenson. 1993. Autoanti-red cell antibodies synthesized by patients with infectious mononucleosis utilize the VH4-21 gene segment. J. Immunol. 151:1051-1061.
90. Potter, K. N., Y. Li, V. Pascual, R. C. Williams, Jr., L. C. Byres, M. Spellerberg, F. K. Stevenson, and J. D. Capra. 1993. Molecular characterization of a crossreactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment. J. Exp. Med. 178:1419-1428.
91. Spellerberg, M. B., C. J. Chapman, C. I. Mockridge, D. A. Isenberg, and F. K. Stevenson. 1995. Dual recognition of lipid A and DNA by human antibodies encoded by the VH4-21 gene: a possible link between infection and lupus. Hum. Antibodies Hybridomas. 6:52-56.
92. Muñoz, L. E., K. Lauber, M. Schiller, A. A. Manfredi, and M. Herrmann. 2010. The role of defective clearance of apoptotic cells in systemic autoimmunity. Nat Rev Rheumatol. 6:280-289.
93. Hall, J. C., L. Casciola-Rosen, and A. Rosen. 2004. Altered structure of autoantigens during apoptosis. Rheum. Dis. Clin. North Am. 30:455-471, vii.
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