BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance

Cell Reports

Volumn 18, Issue 7, 2017, Pages 1627-1635

  Kuraoka, Masayuki ^a   Snowden, Pilar B ^a   Nojima, Takuya ^a   Verkoczy, Laurent ^a   Haynes, Barton F ^a   Kitamura, Daisuke ^b   Kelsoe, Garnett ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

activation induced cytidine deaminase; B cell receptor signaling; B cell tolerance; intracellular acidification; myeloid primary response gene (88); Toll like receptor signaling

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; B CELL ANTIGEN RECEPTOR; B LYMPHOCYTE ANTIGEN; CHLOROQUINE; LYMPHOCYTE RECEPTOR; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHOLIPASE D; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; CYTIDINE DEAMINASE; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVATION; FEMALE; HETEROZYGOTE; IMMUNOLOGICAL TOLERANCE; LIGAND BINDING; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; ANIMAL; C57BL MOUSE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PRE B LYMPHOCYTE; SIGNAL TRANSDUCTION;

ANIMALS; B-LYMPHOCYTES; CYTIDINE DEAMINASE; ENDOSOMES; FEMALE; IMMUNE TOLERANCE; LIGANDS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHOLIPASE D; PRECURSOR CELLS, B-LYMPHOID; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 85013175325     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.01.050     Document Type: Article

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