-
1
-
-
0026537198
-
A revised estimate of twin concordance in systemic lupus erythematosus
-
Deapen D, Escalante A, Weinrib L, et al. A revised estimate of twin concordance in systemic lupus erythematosus. Arthritis Rheum 1992; 35:311-318.
-
(1992)
Arthritis Rheum
, vol.35
, pp. 311-318
-
-
Deapen, D.1
Escalante, A.2
Weinrib, L.3
-
2
-
-
0016724949
-
Studies of twins with systemic lupus erythematosus. A review of the literatur e and presentation of 12 additional sets
-
Block SR, Winfield JB, Lockshin MD, et al. Studies of twins with systemic lupus erythematosus. A review of the literatur e and presentation of 12 additional sets. Am J Med 1975; 59:533-552.
-
(1975)
Am J Med
, vol.59
, pp. 533-552
-
-
Block, S.R.1
Winfield, J.B.2
Lockshin, M.D.3
-
3
-
-
17244373451
-
Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the gladel cohort
-
Alarcon-Segovia D, Alarcon-Riquelme ME, Cardiel MH, et al. Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort. Arthritis Rheum 2005; 52:1138-1147.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 1138-1147
-
-
Alarcon-Segovia, D.1
Alarcon-Riquelme, M.E.2
Cardiel, M.H.3
-
4
-
-
38649125210
-
Genome-wide as sociation scan in women with systemic lupus erythematosus identifies susceptibility variants in itgam, pxk, kiaa1542 and other loci
-
Harley JB, Alarcon-Riquelme ME, Criswell LA, et al. Genome-wide as sociation scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008; 40:204-210.
-
(2008)
Nat Genet
, vol.40
, pp. 204-210
-
-
Harley, J.B.1
Alarcon-Riquelme, M.E.2
Criswell, L.A.3
-
5
-
-
70350650472
-
A large-scale replication study identifies tnip1, prdm1, jazf1, uhrf1bp1 and il10 as risk loci for systemic lupus erythematosus
-
Gateva V, Sandling JK, Hom G, et al. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet 2009; 41:1228-1233.
-
(2009)
Nat Genet
, vol.41
, pp. 1228-1233
-
-
Gateva, V.1
Sandling, J.K.2
Hom, G.3
-
6
-
-
84881329854
-
Ptpn22 association in systemic lupus erythematosus (sle) with respect to individual ancestry and clinical subphenotypes
-
Namjou B, Kim-Howard X, Sun C, e t al. PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical subphenotypes. PLoS One 2013; 8:e69404.
-
(2013)
PLoS One
, vol.8
, pp. e69404
-
-
Namjou, B.1
Kim-Howard, X.2
Sun, C.3
-
8
-
-
33646368404
-
A common haplotype of interferon regulatory factor 5 (irf5) regulates splic ing and expression and is associated with increased risk of systemic lupus erythematosus
-
Graham RR, Kozyrev SV, Baechler EC, et al. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splic ing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet 2006; 38:550-555.
-
(2006)
Nat Genet
, vol.38
, pp. 550-555
-
-
Graham, R.R.1
Kozyrev, S.V.2
Baechler, E.C.3
-
9
-
-
34249860408
-
Three functional variants of if n regulatory factor 5 (irf5) define risk and protective haplotypes for human lupus
-
Graham RR, Kyogoku C, Sigurdsson S, et al. Three functional variants of IF N regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proc Natl Acad Sci U S A 2007; 104:6758-6763.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 6758-6763
-
-
Graham, R.R.1
Kyogoku, C.2
Sigurdsson, S.3
-
10
-
-
84863115400
-
Irf5 haplotypes demo nstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus
-
Niewold TB, Kelly JA, Kariuki SN, et al. IRF5 haplotypes demo nstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus. Ann Rheum Dis 2012; 71:463-468.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 463-468
-
-
Niewold, T.B.1
Kelly, J.A.2
Kariuki, S.N.3
-
11
-
-
84869044634
-
Brief report: Irf5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of chil dren with neonatal lupus
-
Cherian TS, Kariuki SN, Franek BS, et al. Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of chil dren with neonatal lupus. Arthritis Rheum 2012; 64:3383-3387.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 3383-3387
-
-
Cherian, T.S.1
Kariuki, S.N.2
Franek, B.S.3
-
12
-
-
49449104525
-
Association of the irf5 risk haplotype with high serum interferon-Alpha activity in syst emic lupus erythematosus patients
-
Niewold TB, Kelly JA, Flesch MH, et al. Association of the IRF5 risk haplotype with high serum interferon-Alpha activity in syst emic lupus erythematosus patients. Arthritis Rheum 2008; 58:2481-2487.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2481-2487
-
-
Niewold, T.B.1
Kelly, J.A.2
Flesch, M.H.3
-
13
-
-
84897025665
-
The genomic landscape of neanderthal ancestry in present-day humans
-
Sankararaman S, Mallick S, Dannemann M, et al. The genomic landscape of Neanderthal ancestry in present-day humans. Nature 2014; 507:354-357.
-
(2014)
Nature
, vol.507
, pp. 354-357
-
-
Sankararaman, S.1
Mallick, S.2
Dannemann, M.3
-
14
-
-
70350629871
-
Genome-wide association study in a Chinese han population identifies nine new susceptibility loci for systemic lupus erythematosus
-
Han JW, Zheng HF, Cui Y, et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet 2009; 41:1234-1237.
-
(2009)
Nat Genet
, vol.41
, pp. 1234-1237
-
-
Han, J.W.1
Zheng, H.F.2
Cui, Y.3
-
15
-
-
84872328824
-
Meta-Analysis followed by replication identifies loci in or near cdkn1b, tet3, cd80, dram1, and arid5b as associated with systemic lu pus erythematosus in asians
-
Yang W,Tang H,Zhang Y,et al. Meta-Analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lu pus erythematosus in Asians Am J Hum Genet 2013 92, 41-51.
-
(2013)
Am J Hum Genet
, vol.92
, pp. 41-51
-
-
Yang, W.1
Tang, H.2
Zhang, Y.3
-
16
-
-
80155130254
-
Identification of novel genetic susceptibility loci in african American lupus patients i n a candidate gene association study
-
Sanchez E, Comeau ME, Freedman BI, et al. Identification of novel genetic susceptibility loci in African American lupus patients i n a candidate gene association study. Arthritis Rheum 2011; 63:3493-3501.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 3493-3501
-
-
Sanchez, E.1
Comeau, M.E.2
Freedman, B.I.3
-
17
-
-
38649108122
-
A nonsynonymous functional variant in integrin-Alpha(m) (encoded by itgam) is associated with systemic lupus erythematosus
-
Nath SK, Han S, Kim-Howard X, et al. A nonsynonymous functional variant in integrin-Alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet 2008; 40:152-154. 18.
-
(2008)
Nat Genet
, vol.40
, pp. 152-154
-
-
Nath, S.K.1
Han, S.2
Kim-Howard, X.3
-
18
-
-
84893680312
-
End-stage renal disease in african americans with lupus nephritis is associate d with apol1
-
This study demonstrates that APOL1 alleles that are more common in African American populations are strongly associated with developing end-stage renal disease in African American S LE patients. This study explains a proportion of the increased risk of end-stage renal disease in African American SLE patients.
-
Freedman B.I.,Langefeld C.D.,Andringa K.K.,et al. End-stage renal disease in african americans with lupus nephritis is associate d with apol1 Arthritis Rheumatol 2014 66 390-396 This study demonstrates that APOL1 alleles that are more common in African American populations are strongly associated with developing end-stage renal disease in African American S LE patients. This study explains a proportion of the increased risk of end-stage renal disease in African American SLE patients.
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 390-396
-
-
Freedman, B.I.1
Langefeld, C.D.2
Andringa, K.K.3
-
19
-
-
77953639241
-
African-derived genetic polymorphisms in tnfaip3 mediate risk for autoimmunity
-
Lodolce JP, Kolodziej LE, Rhee L, et al. African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity. J Immunol 2010; 184:7001-7009.
-
(2010)
J Immunol
, vol.184
, pp. 7001-7009
-
-
Lodolce, J.P.1
Kolodziej, L.E.2
Rhee, L.3
-
20
-
-
79952094197
-
A loss-of-function variant of the antiviral molecule mavs is associated with a subset of systemic lupus patients
-
Pothlichet J, Niewold TB, Vitour D, et al. A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients. EMBO Mol Med 2011; 3:142-152.
-
(2011)
EMBO Mol Med
, vol.3
, pp. 142-152
-
-
Pothlichet, J.1
Niewold, T.B.2
Vitour, D.3
-
21
-
-
83455169554
-
Interferon alpha as a primary pathogenic factor in human lupus
-
Niewold TB. Interferon alpha as a primary pathogenic factor in human lupus. J Interferon Cytokine Res 2011; 31:887-892.
-
(2011)
J Interferon Cytokine Res
, vol.31
, pp. 887-892
-
-
Niewold, T.B.1
-
22
-
-
17544373868
-
Systemic lupus erythematosus arising during interferon-Alpha therapy for cryoglobulinemic vasculitis associated with hepatitis c
-
Niewold TB, Swedler WI. Systemic lupus erythematosus arising during interferon-Alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C. Clin Rheumatol 2005; 24:178-181.
-
(2005)
Clin Rheumatol
, vol.24
, pp. 178-181
-
-
Niewold, T.B.1
Swedler, W.I.2
-
23
-
-
84896991922
-
Genetics of the type i interferon pathway in systemic lupus erythematosus
-
Ghodke-Puranik Y, Niewold TB. Genetics of the type I interferon pathway in systemic lupus erythematosus. Int J Clin Rheumatol 2013; 8:657-669.
-
(2013)
Int J Clin Rheumatol
, vol.8
, pp. 657-669
-
-
Ghodke-Puranik, Y.1
Niewold, T.B.2
-
24
-
-
34548438559
-
High serum ifn-Alpha activity is a heritable risk factor for systemic lupus erythematosus
-
Niewold TB, Hua J, Lehman T J, et al. High serum IFN-Alpha activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun 2007; 8:492-502.
-
(2007)
Genes Immun
, vol.8
, pp. 492-502
-
-
Niewold, T.B.1
Hua, J.2
Lehman, T.J.3
-
25
-
-
47249111689
-
Age-And sex-related patterns of serum interferon-Alpha activity in lupus families
-
Niewold TB, Adler JE, Glenn SB, et al. Age-And sex-related patterns of serum interferon-Alpha activity in lupus families. Arthritis Rheum 2008; 58:2113-2119.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2113-2119
-
-
Niewold, T.B.1
Adler, J.E.2
Glenn, S.B.3
-
26
-
-
79955518024
-
Familial aggregation of autoimmune disease in juvenile dermatomyositis
-
Niewold TB, Wu SC, Smith M, et al. Familial aggregation of autoimmune disease in juvenile dermatomyositis. Pediatrics 2011; 127:e1239-e1246.
-
(2011)
Pediatrics
, vol.127
, pp. e1239-e1246
-
-
Niewold, T.B.1
Wu, S.C.2
Smith, M.3
-
27
-
-
79953677484
-
Netw ork analysis of associations between serum interferon-Alpha activity, autoantibodies, and clinical features in systemic lupus erythematosus
-
Weckerle CE, Franek BS, Kelly JA, et al. Netw ork analysis of associations between serum interferon-Alpha activity, autoantibodies, and clinical features in systemic lupus erythematosus. Arthritis Rheum 2011; 63:1044-1053.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 1044-1053
-
-
Weckerle, C.E.1
Franek, B.S.2
Kelly, J.A.3
-
28
-
-
84861796332
-
Genetic ancestry, serum interferon-Alpha activity, and autoantibodies in systemic lupus erythematosus
-
Ko K, Franek BS, Mario n M, et al. Genetic ancestry, serum interferon-Alpha activity, and autoantibodies in systemic lupus erythematosus. J Rheumatol 2012; 39:1238-1240.
-
(2012)
J Rheumatol
, vol.39
, pp. 1238-1240
-
-
Ko, K.1
Franek, B.S.2
Mario, N.M.3
-
29
-
-
84931009595
-
Widely divergent transcriptional patterns between sle patients of different ancestral backgrounds in sorted immune cell populations
-
Sharma S, Jin Z, Rosenzweig E, et al. Widely divergent transcriptional patterns between SLE patients of different ancestral backgrounds in sorted immune cell populations. J Autoimmun 2015; 60:51-58.
-
(2015)
J Autoimmun
, vol.60
, pp. 51-58
-
-
Sharma, S.1
Jin, Z.2
Rosenzweig, E.3
-
30
-
-
84885411616
-
Activation of the interferon pathway is dependent upon autoantibodies in african-American sle patients, but not in european-American sle patients
-
Ko K, Koldobskaya Y, Rosenzweig E, Niewold TB. Activation of the interferon pathway is dependent upon autoantibodies in African-American SLE patients, but not in European-American SLE patients. Front Immunol 2013; 4:309.
-
(2013)
Front Immunol
, vol.4
, pp. 309
-
-
Ko, K.1
Koldobskaya, Y.2
Rosenzweig, E.3
Niewold, T.B.4
-
31
-
-
0344002697
-
Increased number of interleukin-10-producing cells in systemic lupus erythematosus patients and their first-degree relatives and spouses in icelandic multicase families
-
Grondal G, Kristjansdottir H, Gunnlaugsdottir B, et al. Increased number of interleukin-10-producing cells in systemic lupus erythematosus patients and their first-degree relatives and spouses in Icelandic multicase families. Arthritis Rheum 1999; 42:1649-1654.
-
(1999)
Arthritis Rheum
, vol.42
, pp. 1649-1654
-
-
Grondal, G.1
Kristjansdottir, H.2
Gunnlaugsdottir, B.3
-
32
-
-
84885646537
-
Familial aggregation of high tumor necrosis factor alpha levels in systemic lupus erythematosus
-
Mangale D, Kariuki SN, Chrabot BS, et al. Familial aggregation of high tumor necrosis factor alpha levels in systemic lupus erythematosus. Clin Dev Immunol 2013; 2013:267430.
-
(2013)
Clin Dev Immunol
, vol.2013
, pp. 267430
-
-
Mangale, D.1
Kariuki, S.N.2
Chrabot, B.S.3
-
33
-
-
67849083066
-
Age-And gender-specific modulation of serum osteopontin and interferon-Alpha by osteopontin genotype in systemic lupus erythematosus
-
Kariuki SN, Moore JG, Kirou KA, et al. Age-And gender-specific modulation of serum osteopontin and interferon-Alpha by osteopontin genotype in systemic lupus erythematosus. Genes Immun 2009; 10:487-494.
-
(2009)
Genes Immun
, vol.10
, pp. 487-494
-
-
Kariuki, S.N.1
Moore, J.G.2
Kirou, K.A.3
-
34
-
-
75749110600
-
Genetic variation at the irf7/phrf1 locus is associated with autoantibody profile and serum interferon-Alpha activity in lupus patients
-
Salloum R, Franek BS, Kariuki SN, et al. Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-Alpha activity in lupus patients. Arthritis Rheum 2010; 62:553-561.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 553-561
-
-
Salloum, R.1
Franek, B.S.2
Kariuki, S.N.3
-
35
-
-
80051619284
-
Autoimmune disease risk variant of ifih1 is associated with increased sensitivity to ifn-Alpha and serologic autoimmunity in lupus patients
-
Robinson T, Kariuki SN, Franek BS, et al. Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-Alpha and serologic autoimmunity in lupus patients. J Immunol 2011; 187:1298-1303.
-
(2011)
J Immunol
, vol.187
, pp. 1298-1303
-
-
Robinson, T.1
Kariuki, S.N.2
Franek, B.S.3
-
36
-
-
59849096879
-
Cutting edge: Autoimmune disease risk variant of stat4 confers increased sensitivity to ifn-Alpha in lupus patients in vivo
-
Kariuki SN, Kirou KA, MacDermott EJ, et al. Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-Alpha in lupus patients in vivo. J Immunol 2009; 182:34-38.
-
(2009)
J Immunol
, vol.182
, pp. 34-38
-
-
Kariuki, S.N.1
Kirou, K.A.2
MacDermott, E.J.3
-
37
-
-
84889657421
-
Genetic variation near irf8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple scler osis
-
Chrabot BS, Kariuki SN, Zervou MI, et al. Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple scler osis. Genes Immun 2013; 14:471-478.
-
(2013)
Genes Immun
, vol.14
, pp. 471-478
-
-
Chrabot, B.S.1
Kariuki, S.N.2
Zervou, M.I.3
-
38
-
-
77954877255
-
Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic an d cytokine phenotypes in systemic lupus erythematosus
-
Kariuki SN,Franek BS,Kumar AA,et al. Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic an d cytokine phenotypes in systemic lupus erythematosus Arthritis Res Ther 2010, 12, R151.
-
(2010)
Arthritis Res Ther
, vol.12
, pp. R151
-
-
Kariuki, S.N.1
Franek, B.S.2
Kumar, A.A.3
-
39
-
-
84866985812
-
Gene-expression-guided selection of candidate loci and molecular phenotype analyses enhance genetic discovery in systemic lupus erythematosus
-
Koldobskaya Y, Ko K, Kumar AA, et al. Gene-expression-guided selection of candidate loci and molecular phenotype analyses enhance genetic discovery in systemic lupus erythematosus. Clin Dev Immunol 2012; 2012: 682018.
-
(2012)
Clin Dev Immunol
, vol.2012
, pp. 682018
-
-
Koldobskaya, Y.1
Ko, K.2
Kumar, A.A.3
-
40
-
-
84921605360
-
Genetic analysis of the pathogenic molecular sub-phenotype interferon-Alpha identifies multiple novel loci involved in systemic lupus erythe matosus
-
Kariuki SN, Ghodke-Puranik Y, Dorschner JM, et al. Genetic analysis of the pathogenic molecular sub-phenotype interferon-Alpha identifies multiple novel loci involved in systemic lupus erythe matosus. Genes Immun 2015; 16:15-23.
-
(2015)
Genes Immun
, vol.16
, pp. 15-23
-
-
Kariuki, S.N.1
Ghodke-Puranik, Y.2
Dorschner, J.M.3
-
41
-
-
44949149145
-
Specificity of the stat4 genetic association for severe disease manifestations of systemic lupus erythematosus
-
Taylor KE, Remmers EF, Lee AT, et al. Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus. PLoS Genet 2008; 4:e1000084.
-
(2008)
PLoS Genet
, vol.4
, pp. e1000084
-
-
Taylor, K.E.1
Remmers, E.F.2
Lee, A.T.3
-
42
-
-
84859913345
-
Role of myh9 and apol1 in african and non-African populations with lupus nephritis
-
Lin CP, Adrianto I, Lessard CJ, et al. Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. Genes Immun 2012; 13:232-238.
-
(2012)
Genes Immun
, vol.13
, pp. 232-238
-
-
Lin, C.P.1
Adrianto, I.2
Lessard, C.J.3
-
43
-
-
84855398687
-
The autoimmune disease risk allele of ube2l3 in african American patients with systemic lupus erythematosus: A recessive effect upon subphenotypes
-
Agik S, Franek BS, Kumar AA, et al. The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes. J Rheumatol 2012; 39:73-78.
-
(2012)
J Rheumatol
, vol.39
, pp. 73-78
-
-
Agik, S.1
Franek, B.S.2
Kumar, A.A.3
-
44
-
-
85019407334
-
Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA
-
Zhao J, Giles BM, Taylor RL, et al. Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Ann Rheum Dis 2014.
-
(2014)
Ann Rheum Dis
-
-
Zhao, J.1
Giles, B.M.2
Taylor, R.L.3
-
45
-
-
34547182875
-
Specific combinations of HLA-dr2 and dr3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human sle
-
Graham RR, Ortmann W, Rodine P, et al. Specific combinations of HLA-DR2 and DR3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human SLE. Eur J Hum Genet 2007; 15:823-830.
-
(2007)
Eur J Hum Genet
, vol.15
, pp. 823-830
-
-
Graham, R.R.1
Ortmann, W.2
Rodine, P.3
-
46
-
-
0031778836
-
Homozygous c1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
-
Botto M, Dell'Agnola C, Bygrave AE, et al. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet 1998; 19:56-59.
-
(1998)
Nat Genet
, vol.19
, pp. 56-59
-
-
Botto, M.1
Dell'Agnola, C.2
Bygrave, A.E.3
-
47
-
-
82255192363
-
Loss-of-function variant in dnase1l3 causes a familial form of systemic lupus erythematosus
-
Al-Mayouf SM, Sunker A, Abdwani R, et al. Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus. Nat Genet 2011; 43:1186-1188.
-
(2011)
Nat Genet
, vol.43
, pp. 1186-1188
-
-
Al-Mayouf, S.M.1
Sunker, A.2
Abdwani, R.3
-
48
-
-
79958015275
-
Evaluation of the trex1 gene in a large multiancestral lupus cohort
-
Namj ou B, Kothari PH, Kelly JA, et al. Evaluation of the TREX1 gene in a large multiancestral lupus cohort. Genes Immun 2011; 12:270-279.
-
(2011)
Genes Immun
, vol.12
, pp. 270-279
-
-
Namj ou, B.1
Kothari, P.H.2
Kelly, J.A.3
-
49
-
-
34147185679
-
Heterozygous mutations in trex1 cause familial chilblain lupus and dominant aicardi-goutieres syndrome
-
Rice G, Newman WG, Dean J, et al. Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome. Am J Hum Genet 2007; 80:811-815.
-
(2007)
Am J Hum Genet
, vol.80
, pp. 811-815
-
-
Rice, G.1
Newman, W.G.2
Dean, J.3
-
50
-
-
84925501444
-
Human disease phenotypes associated with mutations in trex1
-
Rice GI, Rodero MP, Crow YJ. Human disease phenotypes associated with mutations in TREX1. J Clin Immunol 2015; 35:235-243.
-
(2015)
J Clin Immunol
, vol.35
, pp. 235-243
-
-
Rice, G.I.1
Rodero, M.P.2
Crow, Y.J.3
-
51
-
-
84908680759
-
Type i interferonopathies: Mendelian type i interferon up-regulation
-
Crow YJ. Type I interferonopathies: mendelian type I interferon up-regulation. Curr Opin Immunol 2015; 32:7-12.
-
(2015)
Curr Opin Immunol
, vol.32
, pp. 7-12
-
-
Crow, Y.J.1
-
52
-
-
84874774951
-
Admixture mapping in lupus identifies multiple functional variants within ifih1 associated with apoptosis, inflammation, and autoantibody production
-
Molineros JE, Maiti AK, Sun C, et al. Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet 2013; 9:e1003222.
-
(2013)
PLoS Genet
, vol.9
, pp. e1003222
-
-
Molineros, J.E.1
Maiti, A.K.2
Sun, C.3
-
53
-
-
84905825645
-
Activated sting in a vascular and pulmonary syndrome
-
Liu Y, Jesus AA, Marrero B, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med 2014; 371:507-518.
-
(2014)
N Engl J Med
, vol.371
, pp. 507-518
-
-
Liu, Y.1
Jesus, A.A.2
Marrero, B.3
-
54
-
-
77951439152
-
Trait-Associated snps are more likely to be eqtls: Annotation to enhance discovery from gwas
-
Nicolae DL, Gamazon E, Zhang W, et al. Trait-Associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet 2010; 6:e1000888.
-
(2010)
PLoS Genet
, vol.6
, pp. e1000888
-
-
Nicolae, D.L.1
Gamazon, E.2
Zhang, W.3
-
55
-
-
84864131309
-
A functional haplotype of ube2l3 confers risk for systemic lupus erythematosus
-
Wang S, Adrianto I, Wiley GB, et al. A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus. Genes Immun 2012; 13:380-387.
-
(2012)
Genes Immun
, vol.13
, pp. 380-387
-
-
Wang, S.1
Adrianto, I.2
Wiley, G.B.3
-
56
-
-
84925144681
-
Ube2l3 polymorphism amplifies nf-kappab activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases
-
This study documents important biological effects rela ted to the SLE-Associated UBE2L3 allele, including impacts on NF-kappaB activation in vitro and circulating plasma cells and plasmablasts in SLE patients in vivo
-
Lewis MJ, Vyse S, Shields AM, et al. UBE2L3 polymorphism amplifies NF-kappaB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases. Am J Hum Genet 2015; 96:221-234. This study documents important biological effects rela ted to the SLE-Associated UBE2L3 allele, including impacts on NF-kappaB activation in vitro and circulating plasma cells and plasmablasts in SLE patients in vivo.
-
(2015)
Am J Hum Genet
, vol.96
, pp. 221-234
-
-
Lewis, M.J.1
Vyse, S.2
Shields, A.M.3
-
57
-
-
79952192654
-
Association of a functional variant downstream of tnfaip3 with systemic lupus erythematosus
-
Adrianto I, Wen F, Templeton A, et al. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet 2011; 43:253-258.
-
(2011)
Nat Genet
, vol.43
, pp. 253-258
-
-
Adrianto, I.1
Wen, F.2
Templeton, A.3
-
58
-
-
84884692054
-
An enhancer element harboring variants associa ted with systemic lupus erythematosus engages the tnfaip3 promoter to influence a20 expression
-
Wang S, Wen F, Wiley GB, et al. An enhancer element harboring variants associa ted with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression. PLoS Genet 2013; 9:e1003750.
-
(2013)
PLoS Genet
, vol.9
, pp. e1003750
-
-
Wang, S.1
Wen, F.2
Wiley, G.B.3
-
59
-
-
36549003138
-
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
-
Plenge RM, Cotsapas C, Davies L, et al. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet 2007; 39: 1477-1482.
-
(2007)
Nat Genet
, vol.39
, pp. 1477-1482
-
-
Plenge, R.M.1
Cotsapas, C.2
Davies, L.3
-
60
-
-
52949111858
-
Common variants at cd40 and other loci confer risk of rheumatoid arthritis
-
Raychaudhuri S,Remmers EF,Lee AT,et al. Common variants at CD40 and other loci confer risk of rheumatoid arthritis Nat Genet 2008 40 1216-1223.
-
(2008)
Nat Genet
, vol.40
, pp. 1216-1223
-
-
Raychaudhuri, S.1
Remmers, E.F.2
Lee, A.T.3
-
61
-
-
84934763491
-
Meta-Analysis of the tnfaip3 region in psoriasis reveals a risk haplotype that is distinct from other autoimmune di seases
-
Nititham J, Taylor KE, Gupta R, et al. Meta-Analysis of the TNFAIP3 region in psoriasis reveals a risk haplotype that is distinct from other autoimmune di seases. Genes Immun 2015; 16:120-126.
-
(2015)
Genes Immun
, vol.16
, pp. 120-126
-
-
Nititham, J.1
Taylor, K.E.2
Gupta, R.3
-
62
-
-
84887310358
-
Preferential binding to elk-1 by sleassociated il10 risk allele upregulates il10 expression
-
Sakurai D, Zhao J, Deng Y, et al. Preferential binding to Elk-1 by SLEassociated IL10 risk allele upregulates IL10 expression. PLoS Genet 2013; 9:e1003870
-
(2013)
PLoS Genet
, vol.9
, pp. e1003870
-
-
Sakurai, D.1
Zhao, J.2
Deng, Y.3
-
63
-
-
84929276935
-
Lupus risk variant increases pstat1 binding and decreases ets1 expression
-
This study demonstrates important functio nal consequences of the polymorphism near ETS1 that has been associated with SLE in Asian populations, and documents a fascinating ancestry-specific functional genetic element
-
Lu X, Zoller EE, Weirauch MT, et al. Lupus risk variant increases pSTAT1 binding and decreases ETS1 expression. Am J Hum Genet 2015; 96:731-739. This study demonstrates important functio nal consequences of the polymorphism near ETS1 that has been associated with SLE in Asian populations, and documents a fascinating ancestry-specific functional genetic element.
-
(2015)
Am J Hum Genet
, vol.96
, pp. 731-739
-
-
Lu, X.1
Zoller, E.E.2
Weirauch, M.T.3
-
64
-
-
84882453048
-
Genes identified in asian sle gwass are also associated with sle in caucasian populations
-
Wang C, Ahlford A, Jarvinen TM, et al. Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations. Eur J Hum Genet 2013; 21:994-999.
-
(2013)
Eur J Hum Genet
, vol.21
, pp. 994-999
-
-
Wang, C.1
Ahlford, A.2
Jarvinen, T.M.3
-
65
-
-
80052376347
-
The ptpn22 allele enco ding an r620w variant interferes with the removal of developing autoreactive b cells in humans
-
Menard L, Saadoun D, Isnardi I, et al. The PTPN22 allele enco ding an R620W variant interferes with the removal of developing autoreactive B cells in humans. J Clin Invest 2011; 121:3635-3644.
-
(2011)
J Clin Invest
, vol.121
, pp. 3635-3644
-
-
Menard, L.1
Saadoun, D.2
Isnardi, I.3
-
66
-
-
51849117301
-
The ptpn22 c1858t polymorphism is associated with skewing of cytokine profiles toward high interferon-Alpha activity and low tumor necrosis factor alpha levels in patients with lupus
-
Kariuki SN, Crow MK, Niewold TB. The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-Alpha activity and low tumor necrosis factor alpha levels in patients with lupus. Arthritis Rheum 2008; 58:2818-2823.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2818-2823
-
-
Kariuki, S.N.1
Crow, M.K.2
Niewold, T.B.3
-
67
-
-
84880733694
-
The autoimmunity-Associated gene ptpn22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity
-
Wang Y, Shaked I, Stanford SM, et al. The autoimmunity-Associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity 2013; 39:111-122.
-
(2013)
Immunity
, vol.39
, pp. 111-122
-
-
Wang, Y.1
Shaked, I.2
Stanford, S.M.3
-
68
-
-
28444469783
-
Autoimmune-Associated lymphoid tyrosine phosphatase is a gain-of-function variant
-
Vang T, Congia M, Macis MD, et al. Autoimmune-Associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 2005; 37: 1317-1319.
-
(2005)
Nat Genet
, vol.37
, pp. 1317-1319
-
-
Vang, T.1
Congia, M.2
Macis, M.D.3
-
69
-
-
84862081040
-
Ptpn22 alters the development of regulatory t cells in the thymus
-
Maine CJ, Hamilton-William s EE, Cheung J, et al. PTPN22 alters the development of regulatory T cells in the thymus. J Immunol 2012; 188:5267-5275.
-
(2012)
J Immunol
, vol.188
, pp. 5267-5275
-
-
Maine, C.J.1
Hamilton-William, S.E.E.2
Cheung, J.3
-
70
-
-
84874431366
-
Functional gen etic polymorphisms in ilt3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients
-
Jensen MA, Patterson KC, Kumar AA, et al. Functional gen etic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients. Ann Rheum Dis 2013; 72:596-601.
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 596-601
-
-
Jensen, M.A.1
Patterson, K.C.2
Kumar, A.A.3
-
71
-
-
84885395758
-
Nucleic acid sensors and type i interferon production in systemic lupus erythematosus
-
Shrivastav M, Niewold TB. Nucleic acid sensors and type I interferon production in systemic lupus erythematosus. Front Immunol 2013; 4:319.
-
(2013)
Front Immunol
, vol.4
, pp. 319
-
-
Shrivastav, M.1
Niewold, T.B.2
-
72
-
-
79959836816
-
A functional variant in microrna-146a promo ter modulates its expression and confers disease risk for systemic lupus erythematosus
-
Luo X, Yang W, Ye DQ, et al. A functional variant in microRNA-146a promo ter modulates its expression and confers disease risk for systemic lupus erythematosus. PLoS Genet 2011; 7:e1002128.
-
(2011)
PLoS Genet
, vol.7
, pp. e1002128
-
-
Luo, X.1
Yang, W.2
Ye, D.Q.3
-
73
-
-
84859910035
-
Genetic association of mirna-146a with systemic lupus erythematosus in europeans through decreased expression of the gene
-
Lofgren SE, Frostegard J, Truedsson L, et al. Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene. Genes Immun 2012; 13:268-274.
-
(2012)
Genes Immun
, vol.13
, pp. 268-274
-
-
Lofgren, S.E.1
Frostegard, J.2
Truedsson, L.3
-
74
-
-
84921334545
-
Interferon regulatory factors: Critical mediators of human lupus
-
Jensen MA, Niewold TB. Interferon regulatory factors: critical mediators of human lupus. Transl Res 2015; 165:283-295.
-
(2015)
Transl Res
, vol.165
, pp. 283-295
-
-
Jensen, M.A.1
Niewold, T.B.2
-
75
-
-
77957673544
-
Sex-specific associati on of x-linked toll-like receptor 7 (tlr7) with male systemic lupus erythematosus
-
Shen N, Fu Q, Deng Y, et al. Sex-specific associati on of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc Natl Acad Sci U S A 2010; 107:15838-15843.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 15838-15843
-
-
Shen, N.1
Fu, Q.2
Deng, Y.3
-
76
-
-
84874782774
-
Microrna-3148 modulates a llelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus
-
Deng Y, Zhao J, Sakurai D, et al. MicroRNA-3148 modulates a llelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genet 2013; 9:e1003336.
-
(2013)
PLoS Genet
, vol.9
, pp. e1003336
-
-
Deng, Y.1
Zhao, J.2
Sakurai, D.3
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