메뉴 건너뛰기




Volumn 192, Issue 3, 2014, Pages 875-885

Requirement for myd88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in lyn-deficient mice

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; IMMUNOGLOBULIN G ANTIBODY; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE LYN;

EID: 84893364183     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1300683     Document Type: Article
Times cited : (83)

References (56)
  • 1
    • 40049093765 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Rahman, A., and D. A. Isenberg. 2008. Systemic lupus erythematosus. N. Engl. J. Med. 358: 929-939.
    • (2008) N. Engl. J. Med , vol.358 , pp. 929-939
    • Rahman, A.1    Isenberg, D.A.2
  • 2
    • 80053607514 scopus 로고    scopus 로고
    • Cellular and molecular pathogenesis of systemic lupus erythematosus: Lessons from animal models
    • Pathak, S., and C. Mohan. 2011. Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models. Arthritis Res. Ther. 13: 241.
    • (2011) Arthritis Res. Ther , Issue.13 , pp. 241
    • Pathak, S.1    Mohan, C.2
  • 4
  • 5
    • 61849152775 scopus 로고    scopus 로고
    • Multiple roles of lyn kinase in myeloid cell signaling and function
    • Scapini, P., S. Pereira, H. Zhang, and C. A. Lowell. 2009. Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol. Rev. 228: 23-40.
    • (2009) Immunol. Rev , vol.228 , pp. 23-40
    • Scapini, P.1    Pereira, S.2    Zhang, H.3    Lowell, C.A.4
  • 7
    • 0032492994 scopus 로고    scopus 로고
    • Defective negative regulation of antigen receptor signaling in lyn-deficient b lymphocytes
    • Chan, V. W., C. A. Lowell, and A. L. DeFranco. 1998. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr. Biol. 8: 545-553.
    • (1998) Curr. Biol , vol.8 , pp. 545-553
    • Chan, V.W.1    Lowell, C.A.2    DeFranco, A.L.3
  • 8
    • 77955343903 scopus 로고    scopus 로고
    • Myeloid cells, baff, and ifn-gamma establish an inflammatory loop that exacerbates autoimmunity in lyn-deficient mice
    • Scapini, P., Y. Hu, C. L. Chu, T. S. Migone, A. L. Defranco, M. A. Cassatella, and C. A. Lowell. 2010. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J. Exp. Med. 207: 1757-1773.
    • (2010) J. Exp. Med , vol.207 , pp. 1757-1773
    • Scapini, P.1    Hu, Y.2    Chu, C.L.3    Migone, T.S.4    Defranco, A.L.5    Cassatella, M.A.6    Lowell, C.A.7
  • 11
    • 84883338848 scopus 로고    scopus 로고
    • Hyperactivated myd88 signaling in dendritic cells, through specific deletion of lyn kinase, causes severe autoimmunity and inflammation
    • Lamagna, C., P. Scapini, J. A. van Ziffle, A. L. DeFranco, and C. A. Lowell. 2013. Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc. Natl. Acad. Sci. USA 110: E3311-E3320.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110
    • Lamagna, C.1    Scapini, P.2    Van Ziffle, J.A.3    DeFranco, A.L.4    Lowell, C.A.5
  • 14
    • 84864806973 scopus 로고    scopus 로고
    • Genetic interdependence of lyn and negative regulators of b cell receptor signaling in autoimmune disease development
    • Tsantikos, E., M. J. Maxwell, N. Kountouri, K. W. Harder, D. M. Tarlinton, and M. L. Hibbs. 2012. Genetic interdependence of Lyn and negative regulators of B cell receptor signaling in autoimmune disease development. J. Immunol. 189: 1726-1736.
    • (2012) J. Immunol , Issue.189 , pp. 1726-1736
    • Tsantikos, E.1    Maxwell, M.J.2    Kountouri, N.3    Harder, K.W.4    Tarlinton, D.M.5    Hibbs, M.L.6
  • 15
    • 79953162780 scopus 로고    scopus 로고
    • Toll-like receptor driven b cell activation in the induction of systemic autoimmunity
    • Green, N. M., and A. Marshak-Rothstein. 2011. Toll-like receptor driven B cell activation in the induction of systemic autoimmunity. Semin. Immunol. 23: 106-112.
    • (2011) Semin. Immunol , Issue.23 , pp. 106-112
    • Green, N.M.1    Woodward-Davis, A.2
  • 16
    • 77949903821 scopus 로고    scopus 로고
    • Tlr9 regulates tlr7-And myd88-dependent autoantibody production and disease in a murine model of lupus
    • Nickerson, K. M., S. R. Christensen, J. Shupe, M. Kashgarian, D. Kim, K. Elkon, and M. J. Shlomchik. 2010. TLR9 regulates TLR7-And MyD88-dependent autoantibody production and disease in a murine model of lupus. J. Immunol. 184: 1840-1848.
    • (2010) J. Immunol , vol.184 , pp. 1840-1848
    • Nickerson, K.M.1    Christensen, S.R.2    Shupe, J.3    Kashgarian, M.4    Kim, D.5    Elkon, K.6    Shlomchik, M.J.7
  • 20
    • 33645076274 scopus 로고    scopus 로고
    • Tlr9/myd88 signaling is required for class switching to pathogenic igg2a and 2b autoantibodies in sle
    • Ehlers, M., H. Fukuyama, T. L. McGaha, A. Aderem, and J. V. Ravetch. 2006. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J. Exp. Med. 203: 553-561.
    • (2006) J. Exp. Med , vol.203 , pp. 553-561
    • Ehlers, M.1    Fukuyama, H.2    McGaha, T.L.3    Aderem, A.4    Ravetch, J.V.5
  • 21
    • 48749085121 scopus 로고    scopus 로고
    • T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive b cells
    • Herlands, R. A., S. R. Christensen, R. A. Sweet, U. Hershberg, and M. J. Shlomchik. 2008. T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells. Immunity 29: 249-260.
    • (2008) Immunity , vol.29 , pp. 249-260
    • Herlands, R.A.1    Christensen, S.R.2    Sweet, R.A.3    Hershberg, U.4    Shlomchik, M.J.5
  • 22
    • 48749085127 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases
    • Gilliet, M., W. Cao, and Y. J. Liu. 2008. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 8: 594-606.
    • (2008) Nat. Rev. Immunol , vol.8 , pp. 594-606
    • Gilliet, M.1    Cao, W.2    Liu, Y.J.3
  • 23
    • 33748447541 scopus 로고    scopus 로고
    • Type i interferon in systemic lupus erythematosus and other autoimmune diseases
    • Banchereau, J., and V. Pascual. 2006. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 25: 383-392.
    • (2006) Immunity , vol.25 , pp. 383-392
    • Banchereau, J.1    Pascual, V.2
  • 24
    • 79952745936 scopus 로고    scopus 로고
    • Selective utilization of toll-like receptor and myd88 signaling in b cells for enhancement of the antiviral germinal center response
    • Hou, B., P. Saudan, G. Ott, M. L. Wheeler, M. Ji, L. Kuzmich, L. M. Lee, R. L. Coffman, M. F. Bachmann, and A. L. DeFranco. 2011. Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response. Immunity 34: 375-384.
    • (2011) Immunity , vol.34 , pp. 375-384
    • Hou, B.1    Saudan, P.2    Ott, G.3    Wheeler, M.L.4    Ji, M.5    Kuzmich, L.6    Lee, L.M.7    Coffman, R.L.8    Bachmann, M.F.9    DeFranco, A.L.10
  • 25
    • 48749132777 scopus 로고    scopus 로고
    • Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms
    • Hou, B., B. Reizis, and A. L. DeFranco. 2008. Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms. Immunity 29: 272-282.
    • (2008) Immunity , vol.29 , pp. 272-282
    • Hou, B.1    Reizis, B.2    DeFranco, A.L.3
  • 26
    • 34447275920 scopus 로고    scopus 로고
    • Notch-rbp-j signaling controls the homeostasis of cd82 dendritic cells in the spleen
    • Caton, M. L., M. R. Smith-Raska, and B. Reizis. 2007. Notch-RBP-J signaling controls the homeostasis of CD82 dendritic cells in the spleen. J. Exp. Med. 204: 1653-1664.
    • (2007) J. Exp. Med , vol.204 , pp. 1653-1664
    • Caton, M.L.1    Smith-Raska, M.R.2    Reizis, B.3
  • 29
    • 0027474344 scopus 로고
    • T cell receptor delta gene mutant mice: Independent generation of alpha beta t cells and programmed rearrangements of gamma delta tcr genes
    • Itohara, S., P. Mombaerts, J. Lafaille, J. Iacomini, A. Nelson, A. R. Clarke, M. L. Hooper, A. Farr, and S. Tonegawa. 1993. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes. Cell 72: 337-348.
    • (1993) Cell , vol.72 , pp. 337-348
    • Itohara, S.1    Mombaerts, P.2    Lafaille, J.3    Iacomini, J.4    Nelson, A.5    Clarke, A.R.6    Hooper, M.L.7    Farr, A.8    Tonegawa, S.9
  • 30
    • 0026317875 scopus 로고
    • Creation of a large genomic deletion at the t-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting
    • Mombaerts, P., A. R. Clarke, M. L. Hooper, and S. Tonegawa. 1991. Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting. Proc. Natl. Acad. Sci. USA 88: 3084-3087.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3084-3087
    • Mombaerts, P.1    Clarke, A.R.2    Hooper, M.L.3    Tonegawa, S.4
  • 31
    • 0035182146 scopus 로고    scopus 로고
    • Lupus-like kidney disease in mice deficient in the src family tyrosine kinases lyn and fyn
    • Yu, C. C., T. S. Yen, C. A. Lowell, and A. L. DeFranco. 2001. Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr. Biol. 11: 34-38.
    • (2001) Curr. Biol , vol.11 , pp. 34-38
    • Yu, C.C.1    Yen, T.S.2    Lowell, C.A.3    DeFranco, A.L.4
  • 32
    • 0028292951 scopus 로고
    • Genetic and structural evidence for antigen selection of anti-dna antibodies
    • Radic, M. Z., and M. Weigert. 1994. Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu. Rev. Immunol. 12: 487-520.
    • (1994) Annu. Rev. Immunol , vol.12 , pp. 487-520
    • Radic, M.Z.1    Weigert, M.2
  • 33
    • 0037144519 scopus 로고    scopus 로고
    • Evolution of autoantibody responses via somatic hypermutation outside of germinal centers
    • William, J., C. Euler, S. R. Christensen, and M. J. Shlomchik. 2002. Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science 297: 2066-2070.
    • (2002) Science , vol.297 , pp. 2066-2070
    • William, J.1    Euler, C.2    Christensen, S.R.3    Shlomchik, M.J.4
  • 35
    • 0037448564 scopus 로고    scopus 로고
    • Sap is required for generating long-term humoral immunity
    • Crotty, S., E. N. Kersh, J. Cannons, P. L. Schwartzberg, and R. Ahmed. 2003. SAP is required for generating long-term humoral immunity. Nature 421: 282-287.
    • (2003) Nature , vol.421 , pp. 282-287
    • Crotty, S.1    Kersh, E.N.2    Cannons, J.3    Schwartzberg, P.L.4    Ahmed, R.5
  • 37
    • 70149103642 scopus 로고    scopus 로고
    • Perturbation of the cd4 t cell compartment and expansion of regulatory t cells in autoimmune-prone lyn-deficient mice
    • Tsantikos, E., C. Quilici, K. W. Harder, B. Wang, H. J. Zhu, G. P. Anderson, D. M. Tarlinton, and M. L. Hibbs. 2009. Perturbation of the CD4 T cell compartment and expansion of regulatory T cells in autoimmune-prone Lyn-deficient mice. J. Immunol. 183: 2484-2494.
    • (2009) J. Immunol , vol.183 , pp. 2484-2494
    • Tsantikos, E.1    Quilici, C.2    Harder, K.W.3    Wang, B.4    Zhu, H.J.5    Anderson, G.P.6    Tarlinton, D.M.7    Hibbs, M.L.8
  • 39
    • 77958498224 scopus 로고    scopus 로고
    • Vaccine adjuvants: Putting innate immunity to work
    • Coffman, R. L., A. Sher, and R. A. Seder. 2010. Vaccine adjuvants: putting innate immunity to work. Immunity 33: 492-503.
    • (2010) Immunity , vol.33 , pp. 492-503
    • Coffman, R.L.1    Sher, A.2    Seder, R.A.3
  • 40
    • 77949322552 scopus 로고    scopus 로고
    • Autoimmune disease in lyn-deficient mice is dependent on an inflammatory environment established by il-6
    • Tsantikos, E., S. A. Oracki, C. Quilici, G. P. Anderson, D. M. Tarlinton, and M. L. Hibbs. 2010. Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6. J. Immunol. 184: 1348-1360.
    • (2010) J. Immunol , Issue.184 , pp. 1348-1360
    • Tsantikos, E.1    Oracki, S.A.2    Quilici, C.3    Anderson, G.P.4    Tarlinton, D.M.5    Hibbs, M.L.6
  • 41
    • 82255186830 scopus 로고    scopus 로고
    • Elevated bcr signaling and decreased survival of lyn-deficient transitional and follicular b cells
    • Gross, A. J., I. Proekt, and A. L. DeFranco. 2011. Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells. Eur. J. Immunol. 41: 3645-3655.
    • (2011) Eur J. Immunol , Issue.41 , pp. 3645-3655
    • Gross, A.J.1    Proekt, I.2    DeFranco, A.L.3
  • 43
    • 0036232606 scopus 로고    scopus 로고
    • The tyrosine kinase lyn is required for b cell development beyond the t1 stage in the spleen: Rescue by overexpression of bcl-2
    • Meade, J., C. Fernandez, and M. Turner. 2002. The tyrosine kinase Lyn is required for B cell development beyond the T1 stage in the spleen: rescue by overexpression of Bcl-2. Eur. J. Immunol. 32: 1029-1034.
    • (2002) Eur J. Immunol , vol.32 , pp. 1029-1034
    • Meade, J.1    Fernandez, C.2    Turner, M.3
  • 46
    • 84867033893 scopus 로고    scopus 로고
    • Dual signaling by innate and adaptive immune receptors is required for tlr7-induced b-cell-mediated autoimmunity
    • Walsh, E. R., P. Pisitkun, E. Voynova, J. A. Deane, B. L. Scott, R. R. Caspi, and S. Bolland. 2012. Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity. Proc. Natl. Acad. Sci. USA 109: 16276-16281.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 16276-16281
    • Walsh, E.R.1    Pisitkun, P.2    Voynova, E.3    Deane, J.A.4    Scott, B.L.5    Caspi, R.R.6    Bolland, S.7
  • 47
    • 84858796247 scopus 로고    scopus 로고
    • Integration of b cell responses through toll-like receptors and antigen receptors
    • Rawlings, D. J., M. A. Schwartz, S. W. Jackson, and A. Meyer-Bahlburg. 2012. Integration of B cell responses through Toll-like receptors and antigen receptors. Nat. Rev. Immunol. 12: 282-294.
    • (2012) Nat. Rev. Immunol , vol.12 , pp. 282-294
    • Rawlings, D.J.1    Schwartz, M.A.2    Jackson, S.W.3    Woodward-Davis, A.4
  • 49
    • 0027343886 scopus 로고
    • Treatment of murine lupus with anti-cd4 monoclonal antibodies
    • Wofsy, D. 1993. Treatment of murine lupus with anti-CD4 monoclonal antibodies. Immunol. Ser. 59: 221-236.
    • (1993) Immunol. Ser , vol.59 , pp. 221-236
    • Wofsy, D.1
  • 50
    • 70449464779 scopus 로고    scopus 로고
    • Activating systemic autoimmunity: B's, t's, and tolls
    • Shlomchik, M. J. 2009. Activating systemic autoimmunity: B's, T's, and tolls. Curr. Opin. Immunol. 21: 626-633
    • (2009) Curr. Opin. Immunol , vol.21 , pp. 626-633
    • Shlomchik, M.J.1
  • 51
    • 2342517413 scopus 로고    scopus 로고
    • Murine lupus autoantibodies identify distinct subsets of apoptotic bodies
    • Cline, A. M., and M. Z. Radic. 2004. Murine lupus autoantibodies identify distinct subsets of apoptotic bodies. Autoimmunity 37: 85-93.
    • (2004) Autoimmunity , vol.37 , pp. 85-93
    • Cline, A.M.1    Radic, M.Z.2
  • 52
    • 34447624878 scopus 로고    scopus 로고
    • B cell-specific deletion of protein-tyrosine phosphatase shp1 promotes b-1a cell development and causes systemic autoimmunity
    • Pao, L. I., K. P. Lam, J. M. Henderson, J. L. Kutok, M. Alimzhanov, L. Nitschke, M. L. Thomas, B. G. Neel, and K. Rajewsky. 2007. B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity 27: 35-48.
    • (2007) Immunity , vol.27 , pp. 35-48
    • Pao, L.I.1    Lam, K.P.2    Henderson, J.M.3    Kutok, J.L.4    Alimzhanov, M.5    Nitschke, L.6    Thomas, M.L.7    Neel, B.G.8    Rajewsky, K.9
  • 53
    • 77951627428 scopus 로고    scopus 로고
    • Cd22 x siglec-g double-deficient mice have massively increased b1 cell numbers and develop systemic autoimmunity
    • Jellusova, J., U. Wellmann, K. Amann, T. H. Winkler, and L. Nitschke. 2010. CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity. J. Immunol. 184: 3618-3627.
    • (2010) J. Immunol , vol.184 , pp. 3618-3627
    • Jellusova, J.1    Wellmann, U.2    Amann, K.3    Winkler, T.H.4    Nitschke, L.5
  • 54
    • 28844498739 scopus 로고    scopus 로고
    • The juxtamembrane wedge negatively regulates cd45 function in b cells
    • Hermiston, M. L., A. L. Tan, V. A. Gupta, R. Majeti, and A. Weiss. 2005. The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity 23: 635-647.
    • (2005) Immunity , vol.23 , pp. 635-647
    • Hermiston, M.L.1    Tan, A.L.2    Gupta, V.A.3    Majeti, R.4    Weiss, A.5
  • 55
    • 84874859983 scopus 로고    scopus 로고
    • The structural wedge domain of the receptor-like tyrosine phosphatase cd45 enforces b cell tolerance by regulating substrate specificity
    • Zikherman, J., R. Parameswaran, M. Hermiston, and A.Weiss. 2013. The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity. J. Immunol. 190: 2527-2535.
    • (2013) J. Immunol , Issue.190 , pp. 2527-2535
    • Zikherman, J.1    Parameswaran, R.2    Hermiston, M.3    Weiss, A.4
  • 56
    • 66949130737 scopus 로고    scopus 로고
    • Developmental acquisition of the lyn-cd22-shp-1 inhibitory pathway promotes b cell tolerance
    • Gross, A. J., J. R. Lyandres, A. K. Panigrahi, E. T. Prak, and A. L. DeFranco. 2009. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J. Immunol. 182: 5382-5392.
    • (2009) J. Immunol , vol.182 , pp. 5382-5392
    • Gross, A.J.1    Lyandres, J.R.2    Panigrahi, A.K.3    Prak, E.T.4    DeFranco, A.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.