Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation

Journal of Immunology

Volumn 192, Issue 10, 2014, Pages 4525-4532

  Jackson, Shaun W ^a,b   Scharping, Nicole E ^b   Kolhatkar, Nikita S ^a,b   Khim, Socheath ^b   Schwartz, Marc A ^a,b   Li, Quan Zhen ^c   Hudkins, Kelly L ^a   Alpers, Charles E ^a   Liggitt, Denny ^a   Rawlings, David J ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; DNA ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G2C; IMMUNOGLOBULIN G2C ANTIBODY; RNA ANTIBODY; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE ACTIVATION; CHIMERA; CONTROLLED STUDY; GENE DELETION; GENE REARRANGEMENT; HUMORAL IMMUNITY; IMMUNE COMPLEX NEPHRITIS; IMMUNE DYSREGULATION; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; IMMUNOSTIMULATION; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; TLR7 GENE; TLR9 GENE;

ANIMALS; ANTIBODIES, ANTINUCLEAR; B-LYMPHOCYTES; DISEASE MODELS, ANIMAL; INFLAMMATION; LUPUS ERYTHEMATOSUS, SYSTEMIC; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; RNA; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 9;

EID: 84901282428     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400098     Document Type: Article

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