Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Sokolove, Jeremy ^a,b   Bromberg, Reuven ^a,b   Deane, Kevin D ^c   Lahey, Lauren J ^a   Derber, Lezlie A ^c   Chandra, Piyanka E ^a   Edison, Jess D ^d   Gilliland, William R ^d   Tibshirani, Robert J ^a   Norris, Jill M ^e   Holers, V Michael ^c   Robinson, William H ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d WALTER REED ARMY MEDICAL CENTER   (United States)

^e Department of Civil and Environmental Engineering at Colorado State University and the Department of Environmental and Occupational Health at the Colorado School of Public Health   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BIGLYCAN; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; EPITOPE; FIBRINOGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HISTONE; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; LYMPHOTOXIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ADULT; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; AUTOIMMUNITY; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; RHEUMATOID ARTHRITIS;

ADULT; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOANTIGENS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CYTOKINES; DISEASE PROGRESSION; EPITOPES; FEMALE; HUMANS; MALE; MIDDLE AGED; PEPTIDES, CYCLIC; PROGNOSIS; YOUNG ADULT;

EID: 84861465962     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035296     Document Type: Article

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