Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit

Current Biology

Volumn 11, Issue 12, 2001, Pages 962-966

  Ranganathan, Velvizhi ^a,b   Heine, Walter F ^a,b   Ciccone, David N ^a,b   Rudolph, Karl L ^b,c   Wu, Xiaohua ^b,c   Chang, Sandy ^b,c   Hai, Hua ^a,b   Ahearn, Ian M ^a,b   Livingston, David M ^b,c   Resnick, Igor ^d   Rosen, Fred ^a   Seemanova, Eva ^e   Jarolim, Petr ^f,g   DePinho, Ronald A ^b,c   Weaver, David T ^a,b  

^a CENTER FOR BLOOD RESEARCH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d Research Institute of Pediatric Hematology   (Russian Federation)

^e CHARLES UNIVERSITY   (Czech Republic)

^f INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION   (Czech Republic)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035954284     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00267-6     Document Type: Article

References (39)

1. A new chromosomal instability disorder: The Nijmegen breakage syndrome
2. Familial microcephaly with normal intelligence, immunodeficiency, and risk for lymphoreticular malignancies: A new autosomal recessive disorder
3. The hMre11/Rad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
4. The many interfaces of Mre11
5. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
6. Cell-cycle regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
7. NBS1 and TRF colocalize at promyelocytic leukemia bodies during later S/G2 phases in immortalized telomerase negative cells: Implications of NBS1 in alternative lengthening of telomeres
8. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
9. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
10. Rapid telomere shortening in children
11. Telomeres shorten during aging of human fibroblasts
12. Influence of Atm function on telomere metabolism
13. Telomerase prevents the accelerated cell aging of Werner syndrome fibroblasts
14. Nijmegen breakage syndrome
15. Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia
16. ATM phosphorylates p95/Nbs1 in an S-phase checkpoint pathway
17. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
18. Independence of R/M/N focus formation and the presence of intact BRCA1
19. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
20. Telomere length predicts replicative capacity of human fibroblasts
21. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
22. Telomere maintenance is dependent on activities required for end-repair of double strand breaks
23. Telomeres: Moonlighting by DNA repair proteins
24. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
25. Ku is associated with the telomere in mammals
26. Control of telomere length by the human telomeric protein TRF1
27. TRF2 protects human telomeres from end-to-end fusions
28. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
29. Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae
30. Ataxia-telangiectasia and the Nijmegen breakage syndrome-related disorders but genes apart
31. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
32. Enhanced phosphorylation of p53 by ATM in response to DNA damage
33. Accelerated telomere shortening in ataxia telangiectasia
34. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
35. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae
36. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
37. Longevity, stress response, and cancer in aging telomerase-deficient mice
38. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells
39. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes