PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin

DNA Repair

Volumn 8, Issue 11, 2009, Pages 1311-1320

  Di Virgilio, Michela ^a   Ying, Carol Y ^a   Gautier, Jean ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

Checkpoint recovery; DNA damage; Mre11 phosphorylation; MRN complex; PIKK

Indexed keywords

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ATM PROTEIN; DNA; DOUBLE STRANDED DNA; MRE11 PROTEIN; NIBRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE RELATED KINASE; RAD50 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; BINDING AFFINITY; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; EMBRYO; ENZYME ACTIVATION; HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL LINE; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE ALIGNMENT; TUMOR SUPPRESSOR PROTEINS; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 70349850935     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2009.07.006     Document Type: Article

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