메뉴 건너뛰기




Volumn 43, Issue 17, 2015, Pages 8352-8367

ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1

(15)  Kijas, Amanda W a   Lim, Yi Chieh b   Bolderson, Emma c   Cerosaletti, Karen d   Gatei, Magtouf a   Jakob, Burkhard e   Tobias, Frank e   Taucher Scholz, Gisela e   Gueven, Nuri f   Oakley, Greg g   Concannon, Patrick h   Wolvetang, Ernst i   Khanna, Kum Kum b   Wiesmüller, Lisa j   Lavin, Martin F a  


Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; EXONUCLEASE; EXONUCLEASE 1; MRE11 PROTEIN; NIBRIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; EXODEOXYRIBONUCLEASE; EXODEOXYRIBONUCLEASE I;

EID: 84949032464     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkv754     Document Type: Article
Times cited : (54)

References (66)
  • 1
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: Making it safe to play with knives
    • Ciccia, A. and Elledge, S.J. (2010) The DNA damage response: making it safe to play with knives. Mol. Cell, 40, 179-204.
    • (2010) Mol. Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 2
    • 84880615973 scopus 로고    scopus 로고
    • Detection and repair of ionizing radiation-induced DNA double strand breaks: New developments in nonhomologous end joining
    • Wang, C. and Lees-Miller, S.P. (2013) Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining. Int. J. Radiat. Oncol. Biol. Phys., 86, 440-449.
    • (2013) Int. J. Radiat. Oncol. Biol. Phys , vol.86 , pp. 440-449
    • Wang, C.1    Lees-Miller, S.P.2
  • 3
    • 84891396638 scopus 로고    scopus 로고
    • DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM)
    • Zhou, Y. and Paull, T.T. (2013) DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). J. Biol. Chem., 288, 37112-37125.
    • (2013) J. Biol. Chem , vol.288 , pp. 37112-37125
    • Zhou, Y.1    Paull, T.T.2
  • 4
    • 79956004104 scopus 로고    scopus 로고
    • HSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity
    • Richard, D.J., Cubeddu, L., Urquhart, A.J., Bain, A., Bolderson, E., Menon, D., White, M.F. and Khanna, K.K. (2011) hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity. Nucleic Acids Res., 39, 3643-3651.
    • (2011) Nucleic Acids Res , vol.39 , pp. 3643-3651
    • Richard, D.J.1    Cubeddu, L.2    Urquhart, A.J.3    Bain, A.4    Bolderson, E.5    Menon, D.6    White, M.F.7    Khanna, K.K.8
  • 6
    • 84861843272 scopus 로고    scopus 로고
    • CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination
    • Falck, J., Forment, J.V., Coates, J., Mistrik, M., Lukas, J., Bartek, J. and Jackson, S.P. (2012) CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination. EMBO Rep., 13, 561-568.
    • (2012) EMBO Rep , vol.13 , pp. 561-568
    • Falck, J.1    Forment, J.V.2    Coates, J.3    Mistrik, M.4    Lukas, J.5    Bartek, J.6    Jackson, S.P.7
  • 7
    • 80755187806 scopus 로고    scopus 로고
    • Double-strand break end resection and repair pathway choice
    • Symington, L.S. and Gautier, J. (2011) Double-strand break end resection and repair pathway choice. Annu. Rev. Genet., 45, 247-271.
    • (2011) Annu. Rev. Genet , vol.45 , pp. 247-271
    • Symington, L.S.1    Gautier, J.2
  • 9
    • 80855144827 scopus 로고    scopus 로고
    • Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1
    • Garcia, V., Phelps, S.E., Gray, S. and Neale, M.J. (2011) Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1. Nature, 479, 241-244.
    • (2011) Nature , vol.479 , pp. 241-244
    • Garcia, V.1    Phelps, S.E.2    Gray, S.3    Neale, M.J.4
  • 10
    • 84859004905 scopus 로고    scopus 로고
    • Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions
    • Tomimatsu, N., Mukherjee, B., Deland, K., Kurimasa, A., Bolderson, E., Khanna, K.K. and Burma, S. (2012) Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair (Amst)., 11, 441-448.
    • (2012) DNA Repair (Amst) , vol.11 , pp. 441-448
    • Tomimatsu, N.1    Mukherjee, B.2    Deland, K.3    Kurimasa, A.4    Bolderson, E.5    Khanna, K.K.6    Burma, S.7
  • 11
    • 84877321963 scopus 로고    scopus 로고
    • Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells
    • Truong, L.N., Li, Y., Shi, L.Z., Hwang, P.Y., He, J., Wang, H., Razavian, N., Berns, M.W. and Wu, X. (2013) Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc. Natl. Acad. Sci. U.S.A., 110, 7720-7725.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 7720-7725
    • Truong, L.N.1    Li, Y.2    Shi, L.Z.3    Hwang, P.Y.4    He, J.5    Wang, H.6    Razavian, N.7    Berns, M.W.8    Wu, X.9
  • 14
    • 84894353718 scopus 로고    scopus 로고
    • DNA damage response: Three levels of DNA repair regulation
    • Sirbu, B.M. and Cortez, D. (2013) DNA damage response: three levels of DNA repair regulation. Cold Spring Harb. Perspect. Biol., 5, 1-16.
    • (2013) Cold Spring Harb. Perspect. Biol , vol.5 , pp. 1-16
    • Sirbu, B.M.1    Cortez, D.2
  • 16
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
    • Carney, J.P., Maser, R.S., Olivares, H., Davis, E.M., Le Beau, M., Yates, J.R. 3rd, Hays, L., Morgan, W.F. and Petrini, J.H. (1998) The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell, 93, 477-486.
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1    Maser, R.S.2    Olivares, H.3    Davis, E.M.4    Le Beau, M.5    Yates, J.R.6    Hays, L.7    Morgan, W.F.8    Petrini, J.H.9
  • 18
    • 0037226818 scopus 로고    scopus 로고
    • DNA replication-dependent nuclear dynamics of the Mre11 complex
    • Mirzoeva, O.K. and Petrini, J.H. (2003) DNA replication-dependent nuclear dynamics of the Mre11 complex. Mol. Cancer Res., 1, 207-218.
    • (2003) Mol. Cancer Res , vol.1 , pp. 207-218
    • Mirzoeva, O.K.1    Petrini, J.H.2
  • 19
    • 4544339736 scopus 로고    scopus 로고
    • Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks
    • Robison, J.G., Elliott, J., Dixon, K. and Oakley, G.G. (2004) Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks. J. Biol. Chem., 279, 34802-34810.
    • (2004) J. Biol. Chem , vol.279 , pp. 34802-34810
    • Robison, J.G.1    Elliott, J.2    Dixon, K.3    Oakley, G.G.4
  • 22
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist, C.J. and Kastan, M.B. (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature, 421, 499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 23
    • 33747614605 scopus 로고    scopus 로고
    • Involvement of novel autophosphorylation sites in ATM activation
    • Kozlov, S.V., Graham, M.E., Peng, C., Chen, P., Robinson, P.J. and Lavin, M.F. (2006) Involvement of novel autophosphorylation sites in ATM activation. EMBO J., 25, 3504-3514.
    • (2006) EMBO J , vol.25 , pp. 3504-3514
    • Kozlov, S.V.1    Graham, M.E.2    Peng, C.3    Chen, P.4    Robinson, P.J.5    Lavin, M.F.6
  • 24
    • 24944516931 scopus 로고    scopus 로고
    • A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
    • Sun, Y., Jiang, X., Chen, S., Fernandes, N. and Price, B.D. (2005) A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc. Natl. Acad. Sci. U.S.A., 102, 13182-13187.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 13182-13187
    • Sun, Y.1    Jiang, X.2    Chen, S.3    Fernandes, N.4    Price, B.D.5
  • 25
    • 79957547966 scopus 로고    scopus 로고
    • Beyond ATM: The protein kinase landscape of the DNA damage response
    • Bensimon, A., Aebersold, R. and Shiloh, Y. (2011) Beyond ATM: the protein kinase landscape of the DNA damage response. FEBS Lett., 585, 1625-1639.
    • (2011) FEBS Lett , vol.585 , pp. 1625-1639
    • Bensimon, A.1    Aebersold, R.2    Shiloh, Y.3
  • 28
    • 0036500690 scopus 로고    scopus 로고
    • SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
    • Yazdi, P.T., Wang, Y., Zhao, S., Patel, N., Lee, E.Y. and Qin, J. (2002) SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev., 16, 571-582.
    • (2002) Genes Dev , vol.16 , pp. 571-582
    • Yazdi, P.T.1    Wang, Y.2    Zhao, S.3    Patel, N.4    Lee, E.Y.5    Qin, J.6
  • 29
    • 84884204148 scopus 로고    scopus 로고
    • NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks
    • Wen, J., Cerosaletti, K., Schultz, K.J., Wright, J.A. and Concannon, P. (2013) NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks. Oncogene, 32, 4448-4456.
    • (2013) Oncogene , vol.32 , pp. 4448-4456
    • Wen, J.1    Cerosaletti, K.2    Schultz, K.J.3    Wright, J.A.4    Concannon, P.5
  • 35
    • 84861801547 scopus 로고    scopus 로고
    • PhosphoSiteAnalyzer: A bioinformatic platform for deciphering phospho proteomes using kinase predictions retrieved from NetworKIN
    • Bennetzen, M.V., Cox, J., Mann, M. and Andersen, J.S. (2012) PhosphoSiteAnalyzer: a bioinformatic platform for deciphering phospho proteomes using kinase predictions retrieved from NetworKIN. J. Proteome Res., 11, 3480-3486.
    • (2012) J. Proteome Res , vol.11 , pp. 3480-3486
    • Bennetzen, M.V.1    Cox, J.2    Mann, M.3    Andersen, J.S.4
  • 36
    • 0035449349 scopus 로고    scopus 로고
    • The yeast Xrs2 complex functions in S phase checkpoint regulation
    • D'Amours, D. and Jackson, S.P. (2001) The yeast Xrs2 complex functions in S phase checkpoint regulation. Genes Dev., 15, 2238-2249.
    • (2001) Genes Dev , vol.15 , pp. 2238-2249
    • D'Amours, D.1    Jackson, S.P.2
  • 37
    • 0034964498 scopus 로고    scopus 로고
    • A DNA damage response pathway controlled by Tel1 and the Mre11 complex
    • Usui, T., Ogawa, H. and Petrini, J.H. (2001) A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol. Cell, 7, 1255-1266.
    • (2001) Mol. Cell , vol.7 , pp. 1255-1266
    • Usui, T.1    Ogawa, H.2    Petrini, J.H.3
  • 38
    • 0033538496 scopus 로고    scopus 로고
    • The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage
    • Dong, Z., Zhong, Q. and Chen, P.L. (1999) The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage. J. Biol. Chem., 274, 19513-19516.
    • (1999) J. Biol. Chem , vol.274 , pp. 19513-19516
    • Dong, Z.1    Zhong, Q.2    Chen, P.L.3
  • 39
    • 0037102708 scopus 로고    scopus 로고
    • Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism
    • Yuan, S.S., Chang, H.L., Hou, M.F., Chan, T.F., Kao, Y.H., Wu, Y.C. and Su, J.H. (2002) Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism. Toxicology, 177, 123-130.
    • (2002) Toxicology , vol.177 , pp. 123-130
    • Yuan, S.S.1    Chang, H.L.2    Hou, M.F.3    Chan, T.F.4    Kao, Y.H.5    Wu, Y.C.6    Su, J.H.7
  • 40
    • 70349850935 scopus 로고    scopus 로고
    • PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin
    • Di Virgilio, M., Ying, C.Y. and Gautier, J. (2009) PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair (Amst)., 8, 1311-1320.
    • (2009) DNA Repair (Amst) , vol.8 , pp. 1311-1320
    • Di Virgilio, M.1    Ying, C.Y.2    Gautier, J.3
  • 41
    • 0034997651 scopus 로고    scopus 로고
    • Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization
    • Desai-Mehta, A., Cerosaletti, K.M. and Concannon, P. (2001) Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization. Mol. Cell. Biol., 21, 2184-2191.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 2184-2191
    • Desai-Mehta, A.1    Cerosaletti, K.M.2    Concannon, P.3
  • 42
    • 38149057387 scopus 로고    scopus 로고
    • PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites
    • Haince, J.F., McDonald, D., Rodrigue, A., Dery, U., Masson, J.Y., Hendzel, M.J. and Poirier, G.G. (2008) PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J. Biol. Chem., 283, 1197-1208.
    • (2008) J. Biol. Chem , vol.283 , pp. 1197-1208
    • Haince, J.F.1    McDonald, D.2    Rodrigue, A.3    Dery, U.4    Masson, J.Y.5    Hendzel, M.J.6    Poirier, G.G.7
  • 43
    • 0038301384 scopus 로고    scopus 로고
    • Biological imaging of heavy charged-particle tracks
    • Jakob, B., Scholz, M. and Taucher-Scholz, G. (2003) Biological imaging of heavy charged-particle tracks. Radiat. Res., 159, 676-684.
    • (2003) Radiat. Res , vol.159 , pp. 676-684
    • Jakob, B.1    Scholz, M.2    Taucher-Scholz, G.3
  • 44
    • 62549097982 scopus 로고    scopus 로고
    • Positional stability of damaged chromatin domains along radiation tracks in mammalian cells
    • Jakob, B., Splinter, J. and Taucher-Scholz, G. (2009) Positional stability of damaged chromatin domains along radiation tracks in mammalian cells. Radiat. Res., 171, 405-418.
    • (2009) Radiat. Res , vol.171 , pp. 405-418
    • Jakob, B.1    Splinter, J.2    Taucher-Scholz, G.3
  • 48
    • 84863205849 scopus 로고    scopus 로고
    • NIH Image to ImageJ: 25 years of image analysis
    • Schneider, C.A., Rasband, W.S. and Eliceiri, K.W. (2012) NIH Image to ImageJ: 25 years of image analysis. Nat. Methods, 9, 671-675.
    • (2012) Nat. Methods , vol.9 , pp. 671-675
    • Schneider, C.A.1    Rasband, W.S.2    Eliceiri, K.W.3
  • 51
    • 0034655991 scopus 로고    scopus 로고
    • BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    • Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S.J. and Qin, J. (2000) BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev., 14, 927-939.
    • (2000) Genes Dev , vol.14 , pp. 927-939
    • Wang, Y.1    Cortez, D.2    Yazdi, P.3    Neff, N.4    Elledge, S.J.5    Qin, J.6
  • 52
    • 2942687831 scopus 로고    scopus 로고
    • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
    • Kitagawa, R., Bakkenist, C.J., McKinnon, P.J. and Kastan, M.B. (2004) Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev., 18, 1423-1438.
    • (2004) Genes Dev , vol.18 , pp. 1423-1438
    • Kitagawa, R.1    Bakkenist, C.J.2    McKinnon, P.J.3    Kastan, M.B.4
  • 53
    • 0142136826 scopus 로고    scopus 로고
    • Requirement of the MRN complex for ATM activation by DNA damage
    • Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L. and Shiloh, Y. (2003) Requirement of the MRN complex for ATM activation by DNA damage. EMBO J., 22, 5612-5621.
    • (2003) EMBO J , vol.22 , pp. 5612-5621
    • Uziel, T.1    Lerenthal, Y.2    Moyal, L.3    Andegeko, Y.4    Mittelman, L.5    Shiloh, Y.6
  • 54
    • 0025306692 scopus 로고
    • Enhanced chromatid damage in blood lymphocytes after G2 phase x irradiation, a marker of the ataxia-telangiectasia gene
    • Sanford, K.K., Parshad, R., Price, F.M., Jones, G.M., Tarone, R.E., Eierman, L., Hale, P. and Waldmann, T.A. (1990) Enhanced chromatid damage in blood lymphocytes after G2 phase x irradiation, a marker of the ataxia-telangiectasia gene. J. Natl. Cancer Inst., 82, 1050-1054.
    • (1990) J. Natl. Cancer Inst , vol.82 , pp. 1050-1054
    • Sanford, K.K.1    Parshad, R.2    Price, F.M.3    Jones, G.M.4    Tarone, R.E.5    Eierman, L.6    Hale, P.7    Waldmann, T.A.8
  • 55
    • 84890849140 scopus 로고    scopus 로고
    • Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11
    • Chen, C., Zhang, L., Huang, N.J., Huang, B. and Kornbluth, S. (2013) Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11. Proc. Natl. Acad. Sci. U.S.A., 110, 20605-20610.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 20605-20610
    • Chen, C.1    Zhang, L.2    Huang, N.J.3    Huang, B.4    Kornbluth, S.5
  • 56
    • 80355131376 scopus 로고    scopus 로고
    • Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways
    • Keimling, M., Volcic, M., Csernok, A., Wieland, B., Dork, T. and Wiesmuller, L. (2011) Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways. FASEB J., 25, 3849-3860.
    • (2011) FASEB J , vol.25 , pp. 3849-3860
    • Keimling, M.1    Volcic, M.2    Csernok, A.3    Wieland, B.4    Dork, T.5    Wiesmuller, L.6
  • 58
    • 51949118680 scopus 로고    scopus 로고
    • Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response
    • Morin, I., Ngo, H.P., Greenall, A., Zubko, M.K., Morrice, N. and Lydall, D. (2008) Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response. EMBO J., 27, 2400-2410.
    • (2008) EMBO J , vol.27 , pp. 2400-2410
    • Morin, I.1    Ngo, H.P.2    Greenall, A.3    Zubko, M.K.4    Morrice, N.5    Lydall, D.6
  • 59
    • 0034749425 scopus 로고    scopus 로고
    • DNA damage-dependent nuclear dynamics of the Mre11 complex
    • Mirzoeva, O.K. and Petrini, J.H. (2001) DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol. Cell. Biol., 21, 281-288.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 281-288
    • Mirzoeva, O.K.1    Petrini, J.H.2
  • 61
    • 0036500555 scopus 로고    scopus 로고
    • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
    • Kim, S.T., Xu, B. and Kastan, M.B. (2002) Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev., 16, 560-570.
    • (2002) Genes Dev , vol.16 , pp. 560-570
    • Kim, S.T.1    Xu, B.2    Kastan, M.B.3
  • 62
    • 46249131123 scopus 로고    scopus 로고
    • Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair
    • Bennardo, N., Cheng, A., Huang, N. and Stark, J.M. (2008) Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PLoS Genet., 4, e1000110.
    • (2008) PLoS Genet , vol.4
    • Bennardo, N.1    Cheng, A.2    Huang, N.3    Stark, J.M.4
  • 64
    • 84896703742 scopus 로고    scopus 로고
    • Quantitation of DNA double-strand break resection intermediates in human cells
    • Zhou, Y., Caron, P., Legube, G. and Paull, T.T. (2013) Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Res., 42, e19.
    • (2013) Nucleic Acids Res , vol.42 , pp. e19
    • Zhou, Y.1    Caron, P.2    Legube, G.3    Paull, T.T.4
  • 65
    • 0142186242 scopus 로고    scopus 로고
    • The MRN complex: Coordinating and mediating the response to broken chromosomes
    • van den Bosch, M., Bree, R.T. and Lowndes, N.F. (2003) The MRN complex: coordinating and mediating the response to broken chromosomes. EMBO Rep., 4, 844-849.
    • (2003) EMBO Rep , vol.4 , pp. 844-849
    • Van Den Bosch, M.1    Bree, R.T.2    Lowndes, N.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.