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Volumn 23, Issue 16, 2014, Pages 4232-4248

RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; CHECKPOINT KINASE 1; COHESIN; DNA; MRE11 PROTEIN; NIBRIN; RAD50 PROTEIN; DNA BINDING PROTEIN; DNA LIGASE; PROTEIN KINASE; RAD50 PROTEIN, HUMAN; SERINE;

EID: 84904761846     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu141     Document Type: Article
Times cited : (26)

References (48)
  • 1
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: making it safe to play with knives
    • Ciccia, A. and Elledge, S.J. (2010) The DNA damage response: making it safe to play with knives. Mol. Cell, 40, 179-204.
    • (2010) Mol. Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 2
    • 84887595526 scopus 로고    scopus 로고
    • Causes of genome instability
    • Aguilera, A. (2013) Causes of genome instability. Ann. Rev. Genet., 47, 1-32.
    • (2013) Ann. Rev. Genet. , vol.47 , pp. 1-32
    • Aguilera, A.1
  • 4
    • 35648986560 scopus 로고    scopus 로고
    • Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination
    • Takeda, S., Nakamura, K., Taniguchi, Y. and Paull, T.T. (2007) Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. Mol. Cell, 28, 351-352.
    • (2007) Mol. Cell , vol.28 , pp. 351-352
    • Takeda, S.1    Nakamura, K.2    Taniguchi, Y.3    Paull, T.T.4
  • 5
    • 80755187806 scopus 로고    scopus 로고
    • Double-strand breaks end resection and repair pathway choice
    • Symington, L.S. and Gautier, J. (2011) Double-strand breaks end resection and repair pathway choice. Ann. Rev. Genet., 45, 247-271.
    • (2011) Ann. Rev. Genet. , vol.45 , pp. 247-271
    • Symington, L.S.1    Gautier, J.2
  • 6
    • 84866381405 scopus 로고    scopus 로고
    • RAD50Zinc Hook is important for the MRE11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses
    • He, J., Shi, L.Z., Truong, L.N., Lu, C-S., Razavian, N., Li, Y., Negrete, A., Shiloach, J., Berns,M.W.and Wu,X. (2012)RAD50Zinc Hook is important for the MRE11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses. J. Biol. Chem., 287, 31747-31756.
    • (2012) J. Biol. Chem. , vol.287 , pp. 31747-31756
    • He, J.1    Shi, L.Z.2    Truong, L.N.3    Lu, C.-S.4    Razavian, N.5    Li, Y.6    Negrete, A.7    Shiloach, J.8    Berns, M.W.9    Wu, X.10
  • 8
    • 0032076248 scopus 로고    scopus 로고
    • The hMRE11/hRAD50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
    • Carney, J.P., Maser, R.S., Olivares, H., Davis, E.M., Beau, M.L., Yates, J.R., Hays, L., Morgan, W.F. and Petrini, J.H.J. (998) The hMRE11/hRAD50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response. Cell, 93, 477-486.
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1    Maser, R.S.2    Olivares, H.3    Davis, E.M.4    Beau, M.L.5    Yates, J.R.6    Hays, L.7    Morgan, W.F.8    Petrini, J.H.J.9
  • 10
    • 0142186242 scopus 로고    scopus 로고
    • The MRN complex: coordinating and mediating the response to broken chromosomes
    • van den Bosch, M., Bree, R.T. and Lowndes, N.F. (2003) The MRN complex: coordinating and mediating the response to broken chromosomes. EMBO Rep., 4, 844-849.
    • (2003) EMBO Rep. , vol.4 , pp. 844-849
    • van den Bosch, M.1    Bree, R.T.2    Lowndes, N.F.3
  • 11
    • 52449114574 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signaling and cancer
    • Lavin, M.F. (2008) Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signaling and cancer. Nat. Rev. Mol. Cell Biol., 9, 759-769.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 759-769
    • Lavin, M.F.1
  • 12
    • 84880594523 scopus 로고    scopus 로고
    • A nervous predisposition to unrepaired DNA double strand breaks
    • Reynolds, J.J. and Stewart, G.S. (2013) A nervous predisposition to unrepaired DNA double strand breaks. DNA Repair, 12, 588-599.
    • (2013) DNA Repair , vol.12 , pp. 588-599
    • Reynolds, J.J.1    Stewart, G.S.2
  • 15
    • 0037226818 scopus 로고    scopus 로고
    • DNAreplication-dependent nuclear dynamics of the MRE11 complex
    • Mirzoeva, O.K. and Petrini, J.H. (2003)DNAreplication-dependent nuclear dynamics of the MRE11 complex. Mol. Cancer Res., 1, 207-218.
    • (2003) Mol. Cancer Res. , vol.1 , pp. 207-218
    • Mirzoeva, O.K.1    Petrini, J.H.2
  • 16
    • 4544339736 scopus 로고    scopus 로고
    • Replication protein A and the MRE11-RAD50-NBS1 complex co-localize and interact at sites of stalled replication forks
    • Robison, J.G., Elliott, J., Dixon, K. and Oakley, G.G. (2004) Replication protein A and the MRE11-RAD50-NBS1 complex co-localize and interact at sites of stalled replication forks. J. Biol. Chem., 279, 34802-34810.
    • (2004) J. Biol. Chem. , vol.279 , pp. 34802-34810
    • Robison, J.G.1    Elliott, J.2    Dixon, K.3    Oakley, G.G.4
  • 17
    • 67349167663 scopus 로고    scopus 로고
    • The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress
    • Tittel-Elmer, M., Alabert, C., Pasero, P. and Cobb, J.A. (2009) The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress. EMBO J., 28, 1142-1156.
    • (2009) EMBO J. , vol.28 , pp. 1142-1156
    • Tittel-Elmer, M.1    Alabert, C.2    Pasero, P.3    Cobb, J.A.4
  • 19
    • 33747614605 scopus 로고    scopus 로고
    • Involvement of novel autophosphorylation sites in ATM activation
    • Kozlov, S.V., Graham, M.E., Peng, C., Chen, P., Robinson, P.J. and Lavin, M.F. (2006) Involvement of novel autophosphorylation sites in ATM activation. EMBO J., 25, 3504-3514.
    • (2006) EMBO J. , vol.25 , pp. 3504-3514
    • Kozlov, S.V.1    Graham, M.E.2    Peng, C.3    Chen, P.4    Robinson, P.J.5    Lavin, M.F.6
  • 20
    • 34447551681 scopus 로고    scopus 로고
    • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
    • Berkovich, E., Monnat, R.J. Jr. and Kastan, M.B. (2007) Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nature Cell Biol., 9, 683-690.
    • (2007) Nature Cell Biol. , vol.9 , pp. 683-690
    • Berkovich, E.1    Monnat Jr., R.J.2    Kastan, M.B.3
  • 22
    • 70349850935 scopus 로고    scopus 로고
    • PIKK-dependent phosphorylation of MRE11 induces MRN complex inactivation by disassembly from chromatin
    • Di Virgilio, M., Carol, Y., Ying, C.Y. and Gautier, J. (2009) PIKK-dependent phosphorylation of MRE11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair, 8, 1311-1320.
    • (2009) DNA Repair , vol.8 , pp. 1311-1320
    • Di Virgilio, M.1    Carol, Y.2    Ying, C.Y.3    Gautier, J.4
  • 24
    • 0036500690 scopus 로고    scopus 로고
    • SMC1 is a downstream effector in the ATM/NBS1 branch of the human S phase checkpoint
    • Yazdi, P.T.,Wang,Y., Zhao, S., Patel, N., Lee, E.Y. and Qin, J. (2002)SMC1 is a downstream effector in the ATM/NBS1 branch of the human S phase checkpoint. Genes Dev., 16, 571-582.
    • (2002) Genes Dev. , vol.16 , pp. 571-582
    • Yazdi, P.T.1    Wang, Y.2    Zhao, S.3    Patel, N.4    Lee, E.Y.5    Qin, J.6
  • 28
    • 34547950170 scopus 로고    scopus 로고
    • The MRE11-RAD50-NBS1 complex acts both upstream and downstream of ataxia telangiectasia mutated and rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment
    • Olson, E., Nievera, C.J., Lee, A.Y., Chen, L. and Wu, X. (2007) The MRE11-RAD50-NBS1 complex acts both upstream and downstream of ataxia telangiectasia mutated and rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. J. Biol. Chem., 282, 22939-22952.
    • (2007) J. Biol. Chem. , vol.282 , pp. 22939-22952
    • Olson, E.1    Nievera, C.J.2    Lee, A.Y.3    Chen, L.4    Wu, X.5
  • 30
    • 33646777679 scopus 로고    scopus 로고
    • Rapid activation of ATR by ionizing radiation requires ATM and MRE11
    • Myers, J.S. and Cortez, D. (2006) Rapid activation of ATR by ionizing radiation requires ATM and MRE11. J. Biol. Chem., 281, 9346-9350.
    • (2006) J. Biol. Chem. , vol.281 , pp. 9346-9350
    • Myers, J.S.1    Cortez, D.2
  • 31
    • 79955516080 scopus 로고    scopus 로고
    • MDC1 collaborates with TopBP1 in DNA replication checkpoint control
    • Wang, J., Gong, Z. and Chen, J. (2011) MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J. Cell Biol., 193, 267-273.
    • (2011) J. Cell Biol. , vol.193 , pp. 267-273
    • Wang, J.1    Gong, Z.2    Chen, J.3
  • 33
    • 84876097735 scopus 로고    scopus 로고
    • A Role for theMRNcomplex inATRactivation viaTOPBP1 recruitment
    • Duursma, A.M., Driscoll, R., Elias, J.E. and Cimprich, K.A. (2013) A Role for theMRNcomplex inATRactivation viaTOPBP1 recruitment. Mol. Cell, 50, 116-122.
    • (2013) Mol. Cell , vol.50 , pp. 116-122
    • Duursma, A.M.1    Driscoll, R.2    Elias, J.E.3    Cimprich, K.A.4
  • 35
    • 34249935010 scopus 로고    scopus 로고
    • Maintenance of fork integrity at damaged DNA and natural pause sites
    • Tourriere,H. and Pasero, P. (2007) Maintenance of fork integrity at damaged DNA and natural pause sites. DNA Repair, 1, 900-913.
    • (2007) DNA Repair , vol.1 , pp. 900-913
    • Tourriere, H.1    Pasero, P.2
  • 36
    • 34249946978 scopus 로고    scopus 로고
    • Interplay of replication checkpoints and repair proteins at stalled replication forks
    • Branzei, D. and Foiani, M. (2007) Interplay of replication checkpoints and repair proteins at stalled replication forks. DNA Repair, 6, 994-1003.
    • (2007) DNA Repair , vol.6 , pp. 994-1003
    • Branzei, D.1    Foiani, M.2
  • 39
    • 47749141560 scopus 로고    scopus 로고
    • ATR: an essential regulator of genome integrity
    • Cimprich, K.A. and Cortez, D. (2008)ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol., 9, 616-627.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 40
    • 0035032649 scopus 로고    scopus 로고
    • Involvement of Brca1 in S-phase and G2-phase checkpoints after ionizing irradiation
    • Xu, B., Kim, S.T. and Kastan, M.B. (2001) Involvement of Brca1 in S-phase and G2-phase checkpoints after ionizing irradiation. Mol. Cell Biol., 21, 3445-3450.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3445-3450
    • Xu, B.1    Kim, S.T.2    Kastan, M.B.3
  • 44
    • 34547122924 scopus 로고    scopus 로고
    • Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones
    • Biard, D.S.F. (2007) Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones. Nucleic Acids Res., 35, 3535-3550.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 3535-3550
    • Biard, D.S.F.1
  • 45
    • 0033756308 scopus 로고    scopus 로고
    • Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis
    • Méndez, J. and Stillman, B. (2000) Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol. Cell Biol., 22, 8602-8612.
    • (2000) Mol. Cell Biol. , vol.22 , pp. 8602-8612
    • Méndez, J.1    Stillman, B.2
  • 46
    • 76849109722 scopus 로고    scopus 로고
    • Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair
    • Petermann, E., Orta, M.L., Issaeva, N., Schultz, N. and Helleday, T. (2010) Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol. Cell, 37, 492-502.
    • (2010) Mol. Cell , vol.37 , pp. 492-502
    • Petermann, E.1    Orta, M.L.2    Issaeva, N.3    Schultz, N.4    Helleday, T.5
  • 47
    • 0026508007 scopus 로고
    • DNA double labelling with IdUrd and CldUrd for spatial and temporal analysis of cell proliferation and DNA replication
    • Aten, I.A., Bakker, P.J.I., Stap, J., Boschmann, G.A. and Veenhof, C.H.N. (1992) DNA double labelling with IdUrd and CldUrd for spatial and temporal analysis of cell proliferation and DNA replication. Histochem. J., 24, 251-259.
    • (1992) Histochem. J. , vol.24 , pp. 251-259
    • Aten, I.A.1    Bakker, P.J.I.2    Stap, J.3    Boschmann, G.A.4    Veenhof, C.H.N.5
  • 48
    • 84861843272 scopus 로고    scopus 로고
    • CDK targeting of NBS1 promotes DNA-end resection, replication restart andhomologous recombination
    • Falck, J., Forment, J.V., Coates, J., Mistrik, M., Lukas, J., Bartek, J. and Jackson, S.P. (2012) CDK targeting of NBS1 promotes DNA-end resection, replication restart andhomologous recombination. EMBORep., 6, 561-568.
    • (2012) EMBORep. , vol.6 , pp. 561-568
    • Falck, J.1    Forment, J.V.2    Coates, J.3    Mistrik, M.4    Lukas, J.5    Bartek, J.6    Jackson, S.P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.