Loss of the Oxidative Stress Sensor NPGPx Compromises GRP78 Chaperone Activity and Induces Systemic Disease

Molecular Cell

Volumn 48, Issue 5, 2012, Pages 747-759

  Wei, Pei Chi ^a,c   Hsieh, Yi Hsuan ^a,d   Su, Mei I ^b   Jiang, Xianzhi ^d   Hsu, Pang Hung ^b,g   Lo, Wen Ting ^a   Weng, Jui Yun ^a   Jeng, Yung Ming ^e   Wang, Ju Ming ^d   Chen, Phang lang ^d   Chang, Yi Cheng ^a   Lee, Kuo Fen ^f   Tsai, Ming Daw ^b   Shew, Jin Yuh ^a,c   Lee, Wen Hwa ^a,d  

^a GENOMICS RESEARCH CENTER   (Taiwan)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^f SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^g NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; DISULFIDE; GLUCOSE REGULATED PROTEIN 78; GLUTATHIONE PEROXIDASE; NPGPX PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; COVALENT BOND; ENDOPLASMIC RETICULUM; LIFESPAN; MOUSE; NONHUMAN; OXIDATIVE STRESS;

ANIMALS; CARRIER PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CYSTEINE; DISULFIDES; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; FIBROBLASTS; HEAT-SHOCK PROTEINS; HOMEOSTASIS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDANTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEROXIDASES; PROTEIN BINDING; PROTEIN FOLDING; PROTEOSTASIS DEFICIENCIES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

ANIMALIA;

EID: 84870877138     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.10.007     Document Type: Article

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