Ataxia-telangiectasia: Is ATM a sensor of oxidative damage and stress?

BioEssays

Volumn 19, Issue 10, 1997, Pages 911-917

  Rotman, Galit ^a   Shiloh, Yosef ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0031259793     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.950191011     Document Type: Article

References (83)

1. Lavin, M.F. and Shiloh, Y. (1997). The genetic defect in ataxia-telangiectasia. Annu. Rev. Immunol. 15, 177-202.
2. Taylor, A.M.R., Metcalfe, J.A., Thick, J. and Mak, Y.F. (1996). Leukemia and lymphoma in ataxia-telangiectasia. Blood 87, 423-438.
3. Beamish, H. and Lavin, M.F. (1994). Radiosensitivity in ataxia-telangiectasia: Anomalies in radiation-induced cell cycle delay. Int. J. Radiat. Biol. 65, 175-184.
4. Gatti, R.A. et al. (1988). Localization of an ataxia-telangiectasia gene to chromosome 11q22-23. Nature 336, 577-580.
5. Savitsky, K. et al. (1995). A single ataxia-telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749-1753.
6. Savitsky, K. et al. (1995). The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum. Mol. Genet. 4, 2025-2032.
7. Chen, G. and Lee, E.Y.P. (1996). The product of the ATM gene is a 370-kDa nuclear phosphoprotein. J. Biol. Chem. 271, 33693-33697.
8. Lakin, N.D., Weber, P., Stankovic, T., Rottinghaus, S.T., Taylor, A.M.R. and Jackson S.P. (1996). Analysis of the ATM protein in wild-type and ataxia-telangiectasia cells. Oncogene13, 2707-2716.
9. Watters, D. et al. (1997). Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms. Oncogene 14, 1911-1921.
10. Brown, K.D. et al. (1997). The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not upregulated following genome damage. Proc. Natl Acad. Sci. USA 94, 1840-1845.
11. Jackson, S.P. (1995). Ataxia-telangiectasia at the crossroads. Curr. Biol. 5, 1210-1212.
12. Hunter, T. (1995). When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell 83, 1-4.
13. Keegan, K.S. et al. (1996).The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev. 10, 2423-2437.
14. Jung, M., Kondratyev, A., Lee, S., Dimtchev, A. and Dritschilo, A. (1997). ATM gene product phosphorylates IκB-α. Cancer Res. 57, 24-27.
15. Baskaran, R. et al. (1997). Ataxia-telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 387, 516-519.
16. Barlow, C. et al. (1996). Atm-deficient mice: A paradigm of ataxia-telangiectasia. Cell 86, 159-171.
17. Elson, A. et al. (1996). Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc. Natl Acad. Sci. USA 93, 13084-13089.
18. Xu, Y. and Baltimore, D. (1996). Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev. 10, 2401-2410.
19. Xu, Y., Ashley, T., Brainerd, E.E., Bronson, R.T., Meyn, M.S. and Baltimore, D. (1996). Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10, 2411-2422.
20. Kyriakis, J.M. and Avruch, J. (1996). Sounding the alarm: Protein kinase cascades activated by stress and inflammation. J. Biol. Chem. 271, 24313-24316.
21. Karin, M. and Hunter, T. (1995). Transcriptional control by protein phosphorylation: signal transmision from the cell surface to the nucleus. Curr. Biol. 5, 747-757.
22. Gottlieb, T.M. and Oren, M. (1996). p53 in growth control and neoplasia. Biochim. Biophys. Acta 1287, 77-102.
23. Kastan, M.B. et al. (1992). A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71, 587-597.
24. Khanna, K.K. and Lavin, M.F. (1993). Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene 8, 3307-3312.
25. 1 cell cycle checkpoint pathway and ataxia-telangiectasia. Cancer Res. 54, 5054-5058.
26. Zhang, N., Song, Q., Lu, H. and Lavin, M.F. (1996). Induction of p53 and increased sensitivity to cisplatin in ataxia-telangiectasia cells. Oncogene 13, 655-659.
27. Price, B.D. and Park, S.J. (1994). DNA damage increases the levels of MDM2 messenger RNA in wtp53 human cells. Cancer Res. 54, 896-899.
28. Khanna, K.K. et al. (1995). Nature of G1/S cell cycle checkpoint defect in ataxia-telangiectasia. Oncogene 11, 609-618.
29. Duchaud, E., Ridet, A., Stoppa-Lyonnet, D., Janin, N., Moustacchi, E. and Rosselli, F. (1996). Deregulated apoptosis in ataxia-telangiectasia: Association with clinical stigmata and radiosensitivity. Cancer Res. 56, 1400-1404.
30. Meyn, M.S., Strasfeld, L. and Allen, C. (1994) Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia. Int. J. Radiat. Biol. 66, S141-S149.
31. Elledge, S.J. (1996). Cell cycle checkpoints: Preventing an identity crisis. Science 274, 1664-1671.
32. Larner, J.M., Lee, H. and Hamlin, J.L. (1997). S-phase damage-sensing checkpoints in mammalian cells. Cancer Surveys (in press).
33. Wold, M.S. (1997). RPA: A heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu. Rev. Biochem. (in press).
34. Houldsworth, J. and Lavin, M.F. (1980). Effect of ionizing radiation on DNA synthesis in ataxia-telangiectasia cells. Nucl. Acids Res. 8, 3709-3720.
35. Painter, R.B. and Young, B.R. (1980). Radiosensitivity in ataxia-telangiectasia: A new explanation. Proc. Natl Acad. Sci. USA 77, 7315-7317.
36. Liu, V.F. and Weaver, D.T. (1993). The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia-telangiectasia and normal human cells. Mol. Cell. Biol. 13, 7222-7231.
37. Cheng, X., Cheong, N., Wang, Y. and Iliakis, G. (1996). Ionizing radiation-induced phosphorylation of RPA p34 is deficient in ataxia-telangiectasia and reduced in aged normal fibroblasts. Radiother. Oncol. 39, 43-52.
38. Beamish, H., Williams, R., Chen, P. and Lavin, M.F. (1996). Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation. J. Biol. Chem. 271, 20486-20493.
39. Mirzayans, R., Famulski, K.S., Enns, L., Fraser, M. and Paterson, M.C. (1995). Characterization of the signal transduction pathway mediating γ ray-induced inhibition of DNA synthesis in human cells: indirect evidence for involvement of calmodulin but not protein kinase C nor p53. Oncogene 11, 1597-1605.
40. de Murcia, G. and de Murcia, J.M. (1994). Poly (ADP-ribose) polymerase: a molecular nick-sensor. Trends Biochem. Sci. 19, 172-176.
41. n and DNA synthesis in ataxia-telangiectasia cells following γ-irradiation. Nature 287, 745-747.
42. cdc2. Cancer Res. 54, 1412-1414.
43. Paules, R.S. et al. (1995). Defective 62 checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res. 55, 1763-1773.
44. King, R.W., Jackson P.K. and Kirschner M.W. (1994). Mitosis in transition. Cell 79, 563-571.
45. Karin, M. (1995). The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270, 16483-16486.
46. Shafman, T.D., Saleem, A., Kyriakis, J., Weichselbaum, R., Kharbanda, S. and Kufe D.W. (1995). Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation. Cancer Res. 55, 3242-3245.
47. Kharbanda, S. et al. (1995). Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Nature 376, 785-788.
48. Pendergast, A.M. (1996). Nuclear tyrosine kinases: from Abl to WEE1. Curr. Opin. Cell Biol. 8, 174-181.
49. Shafman, T. et al. (1997). Interaction between ATM protein and c-Abl in response to DNA damage. Nature 387, 520-523.
50. Yuan, A.M. et al. (1996). Role for c-Abl tyrosine kinase in growth arrest response to DNA damage. Nature 382, 272-274.
51. Wen, S.T., Jackson, P.K. and Van Etten, R.A. (1996). The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products. EMBO J. 15, 1583-1595.
52. Shu, J., Hitomi, M. and Stacey, D. (1996). Activation of JNK/SAPK pathway is not directly inhibitory for cell cycle progression in NIH3T3 cells. Oncogene 13, 2421-2430.
53. Baldwin, A.S. (1996). The NF-κB and IκB proteins: New discoveries and insights. Annu. Rev. Immunol. 14, 649-681.
54. Jung, M., Zhang, Y., Lee, S. and Dritschilo, A. (1995). Correction of radiation sensitivity in ataxia-telangiectasia cells by a truncated IκB-α. Science 268, 1619-1621.
55. Kastan, M.B. (1996). Signalling to p53: where does it all start? BioEssays 18, 617-619.
56. Devary, Y., Gottlieb, R.A., Smeal, T. and Karin, M. (1992). The mammalian ultraviolet response is triggered by activation of src tyrosin kinases. Cell 71, 1081-1091.
57. Devary, Y., Rosette, C., DiDonato, J.A. and Karin, M. (1993). NF-κB activation by ultraviolet light not dependent on a nuclear signal. Science 261, 1442-1445.
58. Sen, C.K. and Packer, L. (1996). Antioxidant and redox regulation of gene transcription. FASEB J. 10, 709-720.
59. Siddoo-Atwal, C., Haas, A.L. and Rosin, M.P. (1996). Elevation of interferon β-inducible proteins in ataxia-telangiectasia cells. Cancer Res. 56, 443-447.
60. Harper, J.W. and Elledge, S.J. (1996). Cdk inhibitors in development and cancer. Curr. Opin. Genet. Dev. 6, 56-64.
61. Russo, T. et al. (1995). A p53-independent pathway for activation of WAF1/CIP1 expression following oxidative stress. J. Biol. Chem. 270, 29386-29391.
62. Qiu, X., Forman, H.J., Schonthal, A.H. and Cadenas, E. (1996). Induction of p21 mediated by reactive oxygen species formed during the metabolism of aziridinylbenzoquinones by HCT116 cells. J. Biol. Chem. 271, 31915-31921.
63. Teale, B., Khanna, K.K., Singh, S.P. and Lavin, M.F. (1993). Radiation-activated DNA-binding protein constitutively present in ataxia-telangiectasia nuclei. J. Biol. Chem. 268, 22450-22455.
64. Conroy, L.A. and Alexander, D.R. (1996). The role of intracellular signalling pathways regulating thymocyte and leukemia T cell apoptosis. Leukemia 10, 1422-1435.
65. Lynn, W.S. and Wong, P.K.Y. (1995). Neuroimmunodegeneration: do neurons and T cells use common pathways for cell death? FASEB J. 9, 1147-1156.
66. Jaffrey, S.R. and Snyder, S.H. (1995). Nitric oxide: a neural messenger. Annu. Rev. Cell Biol. 11, 417-440.
67. Lipton, S.A. et al. (1993). A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364, 626-632.
68. Beal, M.F. (1995). Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38, 357-366.
69. Thompson, C.B. (1995). Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456-1462.
70. Dawson, V.L. and Dawson, T.M. (1996). Nitric oxide in neuronal degeneration. Proc. Soc. Exp. Biol. Med 211, 33-40
71. Kaltschmidt, B., Baeuerle, P.A. and Kaltschmidt, C. (1993). Potential involvement of the transcription factor NF-κB in neurological disorders. Mol. Asp. Med. 14, 171-190.
72. Stadtman, E.R. (1992). Protein oxidation and aging. Science 257, 1220-1224.
73. Harley, C.B. and Villeponteau, B. (1995) Telomeres and telomerase in aging and cancer. Curr. Opin. Genet. Dev. 5, 249-255.
74. Pandita, T.K., Pathak, S. and Geard, C. (1995). Chromosome end associations, telomeres and telomerase activity in ataxia-telangiectasia cells. Cytogenet. Cell Genet. 71, 86-93.
75. Metcalfe, J.A. et al. (1996). Accelerated telomere shortening in ataxia-telangiectasia. Nature Genet. 13, 350-353.
76. Zglinicki, T. V., Saretzki, G., Docke, W. and Lotze, C. (1995). Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence? Exp. Cell Res. 220, 186-193.
77. Hartwell, L.H. and Kastan, M.B. (1994). Cell cycle control and cancer. Science 266, 1821-1828.
78. Mirzayans, R. and Paterson, M.C. (1991). Lack of correlation between hypersensitivity to cell killing and impaired inhibition of DNA synthesis in ataxia-telangiectasia fibroblasts treated with 4-nitroquinoline 1-oxide. Carcinogenesis 12, 19-24.
79. Sasaki, M.S. and Taylor, A.M.R. (1994). Dissociation between radioresistant DNA replication and chromosomal radiosensitivity in ataxia-telangiectasia cells. Mut. Res. 307, 107-113.
80. Cornforth, M.N. and Bedford, J.S. (1985). On the nature of a defect in cells from individuals with ataxia-telangiectasia. Science 227, 1589-1591.
81. Cox, R., Masson, W.K., Weichselbaum, R.R., Nove, J. and Little, J.B. (1981). The repair of potentially lethal damage in X-irradiated cultures of normal and ataxia-telangiectasia human fibroblasts. Int. J. Radiat. Biol. 39, 357-365.
82. Slichenmyer, W.J., Nelson W.G., Slebos, R.J. and Kastan, M.B. (1993). Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Res. 53, 4164-4168.
83. Murnane, J.P. and Kapp, L.N. (1993). A critical look at the association of human genetic syndromes with sensitivity to ionizing radiation. Semin. Cancer Biol. 4, 93-104.