Ataxia Telangiectasia-Mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex

Journal of Biological Chemistry

Volumn 288, Issue 18, 2013, Pages 12840-12851

  Lee, Ji Hoon ^a   Mand, Michael R ^a   Deshpande, Rajashree A ^a   Kinoshita, Eri ^b   Yang, Soo Hyun ^a   Wyman, Claire ^b   Paull, Tanya T ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIA-TELANGIECTASIA MUTATED; CATALYTIC DOMAINS; COILED-COIL DOMAINS; CONFORMATIONAL CHANGE; CONFORMATIONAL STATE; DNA BINDING ABILITY; DOUBLE-STRAND DNAS; NUCLEASE ACTIVITY;

CONFORMATIONS; ENZYMES; HOOKS; HYDROLYSIS; PROTEINS; ZINC;

INTERNET PROTOCOLS;

ADENOSINE TRIPHOSPHATE; ATM PROTEIN; MONOMER; MRE11 PROTEIN; NIBRIN; RAD50 PROTEIN; ZINC;

ARTICLE; CATALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HYDROLYSIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

DNA REPAIR; PHOSPHORYLATION; PHOSPHORYLATION ENZYMES; PROTEIN CONFORMATION; PROTEIN DNA-INTERACTION;

ADENOSINE TRIPHOSPHATE; CELL CYCLE PROTEINS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; MULTIPROTEIN COMPLEXES; MUTATION; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA;

EID: 84877124011     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.460378     Document Type: Article

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