메뉴 건너뛰기




Volumn 25, Issue 10, 2011, Pages 1091-1104

Crystal structure of the Mre11-Rad50-ATPγS complex: Understanding the interplay between Mre11 and Rad50

Author keywords

DNA damage signaling; DNA repair; Genomic stability; Mre11 Rad50; Structural biology

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; DIMER; MRE11 PROTEIN; RAD50 PROTEIN;

EID: 79956301873     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.2037811     Document Type: Article
Times cited : (114)

References (49)
  • 2
    • 0035813227 scopus 로고    scopus 로고
    • Structure of the Rad50-Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy
    • Anderson DE, Trujillo KM, Sung P, Erickson HP. 2001. Structure of the Rad50-Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy. J Biol Chem 276: 37027-37033.
    • (2001) J Biol Chem , vol.276 , pp. 37027-37033
    • Anderson, D.E.1    Trujillo, K.M.2    Sung, P.3    Erickson, H.P.4
  • 3
    • 0033105094 scopus 로고    scopus 로고
    • Conserved domains in DNA repair proteins and evolution of repair systems
    • Aravind L, Walker DR, Koonin EV. 1999. Conserved domains in DNA repair proteins and evolution of repair systems. Nucleic Acids Res 27: 1223-1242.
    • (1999) Nucleic Acids Res , vol.27 , pp. 1223-1242
    • Aravind, L.1    Walker, D.R.2    Koonin, E.V.3
  • 4
    • 33750028445 scopus 로고    scopus 로고
    • Cohesin's ATPase activity is stimulated by the C-terminal winged-helix domain of its kleisin subunit
    • Arumugam P, Nishino T, Haering CH, Gruber S, Nasmyth K. 2006. Cohesin's ATPase activity is stimulated by the C-terminal winged-helix domain of its kleisin subunit. Curr Biol 16: 1998-2008.
    • (2006) Curr Biol , vol.16 , pp. 1998-2008
    • Arumugam, P.1    Nishino, T.2    Haering, C.H.3    Gruber, S.4    Nasmyth, K.5
  • 8
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/ hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
    • Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR, Hays L, Morgan WF, Petrini JH. 1998. The hMre11/ hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93: 477-486.
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1    Maser, R.S.2    Olivares, H.3    Davis, E.M.4    le Beau, M.5    Yates, J.R.6    Hays, L.7    Morgan, W.F.8    Petrini, J.H.9
  • 9
    • 0035930342 scopus 로고    scopus 로고
    • Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/ Mre11/Xrs2 and Hdf1/Hdf2 complexes
    • Chen L, Trujillo K, Ramos W, Sung P, Tomkinson AE. 2001. Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/ Mre11/Xrs2 and Hdf1/Hdf2 complexes. Mol Cell 8: 1105-1115.
    • (2001) Mol Cell , vol.8 , pp. 1105-1115
    • Chen, L.1    Trujillo, K.2    Ramos, W.3    Sung, P.4    Tomkinson, A.E.5
  • 11
    • 0032493294 scopus 로고    scopus 로고
    • The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA
    • Connelly JC, Kirkham LA, Leach DRF. 1998. The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA. Proc Natl Acad Sci 95: 7969-7974.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 7969-7974
    • Connelly, J.C.1    Kirkham, L.A.2    Leach, D.R.F.3
  • 12
    • 0036276388 scopus 로고    scopus 로고
    • The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling
    • D'Amours D, Jackson SP. 2002. The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling. Nat Rev Mol Cell Biol 3: 317-327.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 317-327
    • D'amours, D.1    Jackson, S.P.2
  • 17
  • 18
    • 34548396349 scopus 로고    scopus 로고
    • The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity
    • Ghosal G, Muniyappa K. 2007. The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity. J Mol Biol 372: 864-882.
    • (2007) J Mol Biol , vol.372 , pp. 864-882
    • Ghosal, G.1    Muniyappa, K.2
  • 20
    • 78951480110 scopus 로고    scopus 로고
    • Biochemical characterization of bacteriophage T4 Mre11/ Rad50 complex
    • Herdendorf TJ, Albrecht DW, Benkovic SJ, Nelson SW. 2010. Biochemical characterization of bacteriophage T4 Mre11/ Rad50 complex. J Biol Chem 286: 2382-2392.
    • (2010) J Biol Chem , vol.286 , pp. 2382-2392
    • Herdendorf, T.J.1    Albrecht, D.W.2    Benkovic, S.J.3    Nelson, S.W.4
  • 21
    • 17144390295 scopus 로고    scopus 로고
    • Condensins: Organizing and segregating the genome
    • doi: 10.1016/j.cub.2005.03.037
    • Hirano T. 2005. Condensins: organizing and segregating the genome. Curr Biol 15: R265-R275. doi: 10.1016/j.cub.2005.03.037.
    • (2005) Curr Biol , vol.15
    • Hirano, T.1
  • 22
    • 3343008805 scopus 로고    scopus 로고
    • Positive and negative regulation of SMC-DNA interactions by ATP and accessory proteins
    • Hirano M, Hirano T. 2004. Positive and negative regulation of SMC-DNA interactions by ATP and accessory proteins. EMBO J 23: 2664-2673.
    • (2004) EMBO J , vol.23 , pp. 2664-2673
    • Hirano, M.1    Hirano, T.2
  • 23
    • 0033759543 scopus 로고    scopus 로고
    • Mre11 and Rad50 from Pyrococcus furiosus: Cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine
    • Hopfner KP, Karcher A, Shin D, Fairley C, Tainer JA, Carney JP. 2000a. Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine. J Bacteriol 182: 6036-6041.
    • (2000) J Bacteriol , vol.182 , pp. 6036-6041
    • Hopfner, K.P.1    Karcher, A.2    Shin, D.3    Fairley, C.4    Tainer, J.A.5    Carney, J.P.6
  • 24
    • 0034705293 scopus 로고    scopus 로고
    • Structural biology of Rad50 ATPase: ATPdriven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily
    • Hopfner KP, Karcher A, Shin DS, Craig L, Arthur LM, Carney JP, Tainer JA. 2000b. Structural biology of Rad50 ATPase: ATPdriven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell 101: 789-800.
    • (2000) Cell , vol.101 , pp. 789-800
    • Hopfner, K.P.1    Karcher, A.2    Shin, D.S.3    Craig, L.4    Arthur, L.M.5    Carney, J.P.6    Tainer, J.A.7
  • 25
    • 0035906860 scopus 로고    scopus 로고
    • Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase
    • Hopfner KP, Karcher A, Craig L, Woo TT, Carney JP, Tainer JA. 2001. Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell 105: 473-485.
    • (2001) Cell , vol.105 , pp. 473-485
    • Hopfner, K.P.1    Karcher, A.2    Craig, L.3    Woo, T.T.4    Carney, J.P.5    Tainer, J.A.6
  • 26
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson SP, Bartek J. 2009. The DNA-damage response in human biology and disease. Nature 461: 1071-1078.
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 27
    • 39449092872 scopus 로고    scopus 로고
    • Quality control of DNA break metabolism: In the 'end', it's a good thing
    • Kanaar R, Wyman C, Rothstein R. 2008. Quality control of DNA break metabolism: in the 'end', it's a good thing. EMBO J 27: 581-588.
    • (2008) EMBO J , vol.27 , pp. 581-588
    • Kanaar, R.1    Wyman, C.2    Rothstein, R.3
  • 28
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna KK, Jackson SP. 2001. DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 27: 247-254.
    • (2001) Nat Genet , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 29
    • 33846945734 scopus 로고    scopus 로고
    • Structural conservation of RecF and Rad50: Implications for DNA recognition and RecF function
    • Koroleva O, Makharashvili N, Courcelle CT, Courcelle J, Korolev S. 2007. Structural conservation of RecF and Rad50: implications for DNA recognition and RecF function. EMBO J 26: 867-877.
    • (2007) EMBO J , vol.26 , pp. 867-877
    • Koroleva, O.1    Makharashvili, N.2    Courcelle, C.T.3    Courcelle, J.4    Korolev, S.5
  • 30
    • 4644220369 scopus 로고    scopus 로고
    • Structural biochemistry of ATP-driven dimerization and DNA-stimulated activation of SMC ATPases
    • Lammens A, Schele A, Hopfner KP. 2004. Structural biochemistry of ATP-driven dimerization and DNA-stimulated activation of SMC ATPases. Curr Biol 14: 1778-1782.
    • (2004) Curr Biol , vol.14 , pp. 1778-1782
    • Lammens, A.1    Schele, A.2    Hopfner, K.P.3
  • 31
    • 17644409069 scopus 로고    scopus 로고
    • ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
    • Lee JH, Paull TT. 2005. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science308: 551-554.
    • (2005) Science308 , pp. 551-554
    • Lee, J.H.1    Paull, T.T.2
  • 32
    • 10344240414 scopus 로고    scopus 로고
    • Chromosome fragmentation after induction of a doublestrand break is an active process prevented by the RMX repair complex
    • Lobachev K, Vitriol E, Stemple J, Resnick MA, Bloom K. 2004. Chromosome fragmentation after induction of a doublestrand break is an active process prevented by the RMX repair complex. Curr Biol 14: 2107-2112.
    • (2004) Curr Biol , vol.14 , pp. 2107-2112
    • Lobachev, K.1    Vitriol, E.2    Stemple, J.3    Resnick, M.A.4    Bloom, K.5
  • 33
    • 0033594904 scopus 로고    scopus 로고
    • Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
    • Luo G, Yao MS, Bender CF, Mills M, Bladl AR, Bradley A, Petrini JH. 1999. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad Sci 96: 7376-7381.
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 7376-7381
    • Luo, G.1    Yao, M.S.2    Bender, C.F.3    Mills, M.4    Bladl, A.R.5    Bradley, A.6    Petrini, J.H.7
  • 35
    • 24944540931 scopus 로고    scopus 로고
    • Mesoscale conformational changes in theDNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA
    • Moreno-Herrero F, de Jager M, Dekker NH, Kanaar R, Wyman C, Dekker C. 2005. Mesoscale conformational changes in theDNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA. Nature 437: 440-443.
    • (2005) Nature , vol.437 , pp. 440-443
    • Moreno-Herrero, F.1    de Jager, M.2    Dekker, N.H.3    Kanaar, R.4    Wyman, C.5    Dekker, C.6
  • 36
    • 0031059866 scopus 로고    scopus 로고
    • Processing of X-ray diffraction data collected in oscillation mode
    • Otwinowski Z, Minor W. 1997. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 276: 307-326.
    • (1997) Methods Enzymol , vol.276 , pp. 307-326
    • Otwinowski, Z.1    Minor, W.2
  • 37
    • 0032085295 scopus 로고    scopus 로고
    • The 39 to 59 exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
    • Paull TT, Gellert M. 1998. The 39 to 59 exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol Cell 1: 969-979.
    • (1998) Mol Cell , vol.1 , pp. 969-979
    • Paull, T.T.1    Gellert, M.2
  • 38
    • 0033563229 scopus 로고    scopus 로고
    • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
    • Paull TT, Gellert M. 1999. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev 13: 1276-1288.
    • (1999) Genes Dev , vol.13 , pp. 1276-1288
    • Paull, T.T.1    Gellert, M.2
  • 40
    • 3242889151 scopus 로고    scopus 로고
    • Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis
    • Taylor AM, Groom A, Byrd PJ. 2004. Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis. DNA Repair (Amst) 3: 1219-1225.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1219-1225
    • Taylor, A.M.1    Groom, A.2    Byrd, P.J.3
  • 41
    • 0035929667 scopus 로고    scopus 로고
    • DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50_Mre11 complex
    • Trujillo KM, Sung P. 2001. DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50_Mre11 complex. J Biol Chem 276: 35458-35464.
    • (2001) J Biol Chem , vol.276 , pp. 35458-35464
    • Trujillo, K.M.1    Sung, P.2
  • 42
    • 0032555480 scopus 로고    scopus 로고
    • Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
    • Trujillo KM, Yuan SS, Lee EY, Sung P. 1998. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J Biol Chem 273: 21447-21450.
    • (1998) J Biol Chem , vol.273 , pp. 21447-21450
    • Trujillo, K.M.1    Yuan, S.S.2    Lee, E.Y.3    Sung, P.4
  • 46
    • 58149152843 scopus 로고    scopus 로고
    • Structural studies of a bacterial condensin complex reveal ATP-dependent disruption of intersubunit interactions
    • Woo JS, Lim JH, Shin HC, Suh MK, Ku B, Lee KH, Joo K, Robinson H, Lee J, Park SY, et al. 2009. Structural studies of a bacterial condensin complex reveal ATP-dependent disruption of intersubunit interactions. Cell 136: 85-96.
    • (2009) Cell , vol.136 , pp. 85-96
    • Woo, J.S.1    Lim, J.H.2    Shin, H.C.3    Suh, M.K.4    Ku, B.5    Lee, K.H.6    Joo, K.7    Robinson, H.8    Lee, J.9    Park, S.Y.10
  • 47
    • 0030749867 scopus 로고    scopus 로고
    • Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
    • Xiao Y, Weaver DT. 1997. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res 25: 2985-2991.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2985-2991
    • Xiao, Y.1    Weaver, D.T.2
  • 49
    • 0035936554 scopus 로고    scopus 로고
    • Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
    • Zhu J, Petersen S, Tessarollo L, Nussenzweig A. 2001. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr Biol 11: 105-109.
    • (2001) Curr Biol , vol.11 , pp. 105-109
    • Zhu, J.1    Petersen, S.2    Tessarollo, L.3    Nussenzweig, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.