Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin

Molecular Cell

Volumn 55, Issue 5, 2014, Pages 723-732

  Kakarougkas, Andreas ^a   Ismail, Amani ^a   Chambers, AnnaL ^a   Riballo, Enriqueta ^a   Herbert, AlexD ^a   Künzel, Julia ^b   Löbrich, Markus ^b   Jeggo, PennyA ^a   Downs, JessicaA ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; BARRIER TO AUTOINTEGRATION FACTOR; BMI1 PROTEIN; HISTONE H2AX; POLYCOMB REPRESSIVE COMPLEX 2; RNA POLYMERASE II; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR EZH2; XRCC4 PROTEIN; HISTONE; NONHISTONE PROTEIN; NUCLEAR PROTEIN; PBRM1 PROTEIN, HUMAN; SWI-SNF-B CHROMATIN-REMODELING COMPLEX; TRANSCRIPTION FACTOR;

ARTICLE; CARCINOGENESIS; CHROMATIN; DNA FLANKING REGION; DNA REPAIR; DNA STRAND BREAKAGE; GENOMIC INSTABILITY; MISSENSE MUTATION; NONHUMAN; PROTEIN PHOSPHORYLATION; UBIQUITINATION; BINDING SITE; CHEMISTRY; DNA END JOINING REPAIR; GENE EXPRESSION REGULATION; HELA CELL LINE; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE;

BINDING SITES; CELL LINE, TUMOR; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA BREAKS; DNA END-JOINING REPAIR; DNA REPAIR; GENE EXPRESSION REGULATION; HELA CELLS; HISTONES; HUMANS; NUCLEAR PROTEINS; PHOSPHORYLATION; TRANSCRIPTION FACTORS; UBIQUITINATION;

EID: 84919451538     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2014.06.028     Document Type: Article

References (28)

1. Brownlee P.M., Chambers A.L., Cloney R., Bianchi A., Downs J.A. BAF180 promotes cohesion and prevents genome instability and aneuploidy. Cell Reports 2014, 6:973-981.
2. Campbell S., Ismail I.H., Young L.C., Poirier G.G., Hendzel M.J. Polycomb repressive complex 2 contributes to DNA double-strand break repair. Cell Cycle 2013, 12:2675-2683.
3. Cao R., Tsukada Y., Zhang Y. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol. Cell 2005, 20:845-854.
4. Chambers A.L., Downs J.A. The RSC and INO80 chromatin-remodeling complexes in DNA double-strand break repair. Prog. Mol. Biol. Transl. Sci. 2012, 110:229-261.
5. Chou D.M., Adamson B., Dephoure N.E., Tan X., Nottke A.C., Hurov K.E., Gygi S.P., Colaiácovo M.P., Elledge S.J. A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc. Natl. Acad. Sci. USA 2010, 107:18475-18480.
6. Fradet-Turcotte A., Canny M.D., Escribano-Díaz C., Orthwein A., Leung C.C., Huang H., Landry M.C., Kitevski-LeBlanc J., Noordermeer S.M., Sicheri F., Durocher D. 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature 2013, 499:50-54.
7. Francia S., Michelini F., Saxena A., Tang D., de Hoon M., Anelli V., Mione M., Carninci P., d'Adda di Fagagna F. Site-specific DICER and DROSHA RNA products control the DNA-damage response. Nature 2012, 488:231-235.
8. Ginjala V., Nacerddine K., Kulkarni A., Oza J., Hill S.J., Yao M., Citterio E., van Lohuizen M., Ganesan S. BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair. Mol. Cell. Biol. 2011, 31:1972-1982.
9. Goodarzi A.A., Jeggo P.A. The repair and signaling responses to DNA double-strand breaks. Adv. Genet. 2013, 82:1-45.
10. Khavari P.A., Peterson C.L., Tamkun J.W., Mendel D.B., Crabtree G.R. BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. Nature 1993, 366:170-174.
11. Lin C., Yang L., Tanasa B., Hutt K., Ju B.G., Ohgi K., Zhang J., Rose D.W., Fu X.D., Glass C.K., Rosenfeld M.G. Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell 2009, 139:1069-1083.
12. Mathas S., Kreher S., Meaburn K.J., Jöhrens K., Lamprecht B., Assaf C., Sterry W., Kadin M.E., Daibata M., Joos S., et al. Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma. Proc. Natl. Acad. Sci. USA 2009, 106:5831-5836.
13. Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R., Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007, 316:1160-1166.
14. Mattiroli F., Vissers J.H., van Dijk W.J., Ikpa P., Citterio E., Vermeulen W., Marteijn J.A., Sixma T.K. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling. Cell 2012, 150:1182-1195.
15. Mosesso P., Fonti E., Bassi L., Lorenti Garcia C., Palitti F. The involvement of chromatin condensation in camptothecin-induced chromosome breaks in G0 human lymphocytes. Mutagenesis 1999, 14:103-105.
16. Noon A.T., Shibata A., Rief N., Löbrich M., Stewart G.S., Jeggo P.A., Goodarzi A.A. 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat. Cell Biol. 2010, 12:177-184.
17. Oum J.H., Seong C., Kwon Y., Ji J.H., Sid A., Ramakrishnan S., Ira G., Malkova A., Sung P., Lee S.E., Shim E.Y. RSC facilitates Rad59-dependent homologous recombination between sister chromatids by promoting cohesin loading at DNA double-strand breaks. Mol. Cell. Biol. 2011, 31:3924-3937.
18. Papamichos-Chronakis M., Peterson C.L. Chromatin and the genome integrity network. Nat. Rev. Genet. 2013, 14:62-75.
19. Rulten S.L., Fisher A.E., Robert I., Zuma M.C., Rouleau M., Ju L., Poirier G., Reina-San-Martin B., Caldecott K.W. PARP-3 and APLF function together to accelerate nonhomologous end-joining. Mol. Cell 2011, 41:33-45.
20. Schaaf C.A., Misulovin Z., Gause M., Koenig A., Gohara D.W., Watson A., Dorsett D. Cohesin and polycomb proteins functionally interact to control transcription at silenced and active genes. PLoS Genet. 2013, 9:e1003560.
21. Shain A.H., Pollack J.R. The spectrum of SWI/SNF mutations, ubiquitous in human cancers. PLoS ONE 2013, 8:e55119.
22. Shanbhag N.M., Rafalska-Metcalf I.U., Balane-Bolivar C., Janicki S.M., Greenberg R.A. ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell 2010, 141:970-981.
23. Shema-Yaacoby E., Nikolov M., Haj-Yahya M., Siman P., Allemand E., Yamaguchi Y., Muchardt C., Urlaub H., Brik A., Oren M., Fischle W. Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription. Cell Reports 2013, 4:601-608.
24. Shibata A., Conrad S., Birraux J., Geuting V., Barton O., Ismail A., Kakarougkas A., Meek K., Taucher-Scholz G., Löbrich M., Jeggo P.A. Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J. 2011, 30:1079-1092.
25. Stiff T., O'Driscoll M., Rief N., Iwabuchi K., Löbrich M., Jeggo P.A. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 2004, 64:2390-2396.
26. Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 2011, 469:539-542.
27. Vissers J.H., van Lohuizen M., Citterio E. The emerging role of Polycomb repressors in the response to DNA damage. J. Cell Sci. 2012, 125:3939-3948.
28. Wei W., Ba Z., Gao M., Wu Y., Ma Y., Amiard S., White C.I., Rendtlew Danielsen J.M., Yang Y.G., Qi Y. A role for small RNAs in DNA double-strand break repair. Cell 2012, 149:101-112.