Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism

Toxicology

Volumn 177, Issue 2-3, 2002, Pages 123-130

  Yuan, Shyng Shiou F ^a,b   Chang, Hsueh Ling ^a   Hou, Ming Feng ^a   Chan, Te Fu ^a   Kao, Ying Hsien ^a   Wu, Yang Chang ^a   Su, Jinu Huang ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b NONE   (Taiwan)

Author keywords

Cell cycle; DNA double strand breaks; Neocarzinostatin; Nuclear focus formation; Phosphorylation

Indexed keywords

ANTIBIOTIC AGENT; ATM PROTEIN; NUCLEASE; PROTEIN NBS 1; UNCLASSIFIED DRUG; ZINOSTATIN;

ARTICLE; ATAXIA TELANGIECTASIA; CELL CYCLE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; NIJMEGEN BREAKAGE SYNDROME; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANTIBIOTICS, ANTINEOPLASTIC; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CELL NUCLEUS; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; EXODEOXYRIBONUCLEASES; HUMANS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE PROTEINS; TUMOR SUPPRESSOR PROTEINS; ZINOSTATIN;

EID: 0037102708     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00220-2     Document Type: Article

References (31)

1. Role of the human Rad51 protein in homologous recombination and double-stranded-break repair
2. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
3. The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae
4. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
5. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
6. The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage
7. ATM-dependent phosphorylation of fibrin in response to radiation exposure
8. Partners and pathways repairing a double-strand break
9. Checkpoints: Controls that ensure the order of cell cycle events
10. DNA double-strand breaks: Signaling, repair and the cancer connection
11. Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths
12. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
13. HMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks
14. DNA double-strand break rejoining in xrs5 cells is more rapid in the G2 than in the G1 phase of the cell cycle
15. In situ visualization of DNA double-strand break repair in human fibroblasts
16. Pharmacokinetics of neocarzinostatin in patients with malignant glioma. Quantitative analysis of tissue concentration
17. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
18. Genomic integrity and the repair of double-strand DNA breaks
19. DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: Bleomycin, neocarzinostatin and other enediyne
20. The molecular basis of drug-induced G2 arrest in mammalian cells
21. ATM: From gene to function
22. Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
23. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
24. Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T→G mutations, showing a less severe phenotype
25. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
26. Chromosomal stability and the DNA double-stranded break connection
27. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
28. BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo
29. Arsenic-induced Mre11 phosphorylation is cell cycle-dependent and defective in NBS cells
30. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
31. The DNA damage response: Putting checkpoints in perspective