DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

Immunity

Volumn 42, Issue 2, 2015, Pages 332-343

  Härtlova, Anetta ^a   Erttmann, Saskia F ^a   Raffi, Faizal A M ^a   Schmalz, Anja M ^a   Resch, Ulrike ^a   Anugula, Sharath ^a   Lienenklaus, Stefan ^b   Nilsson, Lisa M ^c   Kröger, Andrea ^b   Nilsson, Jonas A ^c   Ek, Torben ^d   Weiss, Siegfried ^b   Gekara, Nelson O ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d Region of Halland   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ATM PROTEIN; BETA INTERFERON; EXTRACHROMOSOMAL DNA; I KAPPA B ALPHA; INTERFERON; INTERFERON REGULATORY FACTOR 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NUCLEASE S1; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN STING; RETINOIC ACID INDUCIBLE PROTEIN I; TANK BINDING KINASE 1; TOLL LIKE RECEPTOR; TYPE 1 INTERFERON; UNCLASSIFIED DRUG; ATM PROTEIN, MOUSE; DNA; GAMMA INTERFERON; MEMBRANE PROTEIN; MPYS PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; TBK1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA TELANGIECTASIA; BACTERIAL IMMUNITY; BONE MARROW DERIVED MACROPHAGE; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; DNA DAMAGE; DNA REPAIR; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INNATE IMMUNITY; INTERFERON PRODUCTION; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RETROPOSON; SIGNAL TRANSDUCTION; STEADY STATE; VIRUS IMMUNITY; VIRUS LOAD; VIRUS REPLICATION; ANIMAL; BIOSYNTHESIS; BONE MARROW CELL; CELL LINE; ENZYME ACTIVATION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; KNOCKOUT MOUSE; LISTERIA MONOCYTOGENES; LISTERIOSIS; MACROPHAGE; METABOLISM; MICROBIOLOGY;

ANIMALS; ATAXIA TELANGIECTASIA; ATAXIA TELANGIECTASIA MUTATED PROTEINS; BONE MARROW CELLS; CELL LINE; CYTOSOL; DNA; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INTERFERON-ALPHA; INTERFERON-BETA; INTERFERON-GAMMA; LISTERIA MONOCYTOGENES; LISTERIOSIS; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING;

EID: 84922986861     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2015.01.012     Document Type: Article

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