Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions

Journal of Medicinal Chemistry

Volumn 59, Issue 24, 2016, Pages 10837-10858

  Jiang, Zheng Yu ^a   Lu, Meng Chen ^a   You, Qi Dong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1 NUCLEAR FACTOR ERYTHROID 2 RELATED FACTOR 2 PROTEIN PROTEIN INTERACTION INHIBITOR; LIGASE; NAPHTHALENE DERIVATIVE; PROTEIN INHIBITOR; SULFONAMIDE; TETRAHYDROISOQUINOLINE DERIVATIVE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; MOLECULAR LIBRARY; PROTEIN BINDING;

AMINO ACID SEQUENCE; BINDING ASSAY; DRUG DETERMINATION; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MEDICINAL CHEMISTRY; NONHUMAN; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; REVIEW; STRUCTURE ACTIVITY RELATION; UBIQUITINATION; VIRTUAL REALITY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; MOLECULAR LIBRARY; PHARMACOLOGY;

ANIMALS; DRUG DISCOVERY; HUMANS; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; NF-E2-RELATED FACTOR 2; PROTEIN BINDING; SMALL MOLECULE LIBRARIES;

EID: 85007247671     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00586     Document Type: Review

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