Structure Property Relationships of Carboxylic Acid Isosteres

Journal of Medicinal Chemistry

Volumn 59, Issue 7, 2016, Pages 3183-3203

  Lassalas, Pierrik ^a   Gay, Bryant ^a   Lasfargeas, Caroline ^a   James, Michael J ^b   Tran, Van ^a   Vijayendran, Krishna G ^a   Brunden, Kurt R ^b   Kozlowski, Marisa C ^a   Thomas, Craig J ^c   Smith, Amos B ^a   Huryn, Donna M ^a   Ballatore, Carlo ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZYL 3 HYDROXYCYCLOPENT 2 EN 1 ONE; 2 PHENYLETHANE 1 SULFONAMIDE; 3 PHENETHYL 1,2,4 OXADIAZOL 5(4H) ONE; 3 PHENETHYL 1,2,4 OXADIAZOLE 5(4H) THIONE; 3 PHENETHYL 1,2,4 THIADIAZOL 5(4H) ONE; 4 PHENETHYL 3H 1,2,3,5 OXATHIADIAZOLE; 5 BENZYL 3 HYDROXY 2 METHYLCYCLOPENT 2 EN 1 ONE; 5 BENZYL 3 HYDROXYCYCLOPENT 2 EN 1 ONE; 5 BENZYLISOXAZOL 3 OL; 5 BENZYLOXAZOLIDINE 2,4 DIONE; 5 BENZYLPYRROLIDINE 2,4 DIONE; 5 BENZYLTHIAZOLIDINE 2,4 DIONE; 5 PHENETHYL 1H TETRAZOLE; CARBOXYLIC ACID; HYDROCINNAMIC ACID; N (3 PHENYLPROPYL)METHANESULFONAMIDE; N (BENZYLCARBAMOYL)ACETAMIDE; N (BENZYLCARBAMOYL)METHANESULFONAMIDE; N (HYDROXY) 3 PHENYLPROPANAMIDE; N (METHYLSULFONYL) 3 PHENYLPROPANAMIDE; N (N,N DIMETHYLSULFAMOYL) 3 PHENYLPROPANAMIDE; N HYDROXYL N PHENETHYLACETAMIDE; N METHOXY 3 PHENYLPROPANAMIDE; N PHENETHOXYACETAMIDE; PHENETHYLPHOSPHINIC ACID; PHENETHYLPHOSPHONIC ACID; PHENYLPROPIONIC ACID DERIVATIVE; SODIUM 2 PHENYLETHANE 1 SULFINATE; SODIUM 2 PHENYLETHANE 1 SULFONATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; COLORIMETRY; DRUG PENETRATION; HYDROGEN BOND; LIPOPHILICITY; MEMBRANE PERMEABILITY; PHYSICAL CHEMISTRY; PLASMA PROTEIN BINDING; QUANTITATIVE STRUCTURE PROPERTY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; MASS SPECTROMETRY; MEDICINAL CHEMISTRY; MOLECULAR MODEL; PLASMA; STRUCTURE ACTIVITY RELATION;

CARBOXYLIC ACIDS; CHEMISTRY, PHARMACEUTICAL; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENYLPROPIONATES; PLASMA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84966333678     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01963     Document Type: Article

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