Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Wu, Kai Connie ^a   McDonald, Peter R ^b   Liu, Jie Jerry ^a   Chaguturu, Rathnam ^c   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c SRI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL DENSITY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROPHILICITY; ENZYME ACTIVATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; KEAP1 NRF2 ARE SIGNALING PATHWAY; LUMINESCENCE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROCESS OPTIMIZATION; PROTEIN BINDING; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUCIFERASES; LUMINESCENT MEASUREMENTS; MICE; MOLECULAR STRUCTURE; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; ORGANIC CHEMICALS; PROTEIN BINDING; PYRIDONES; PYRIMIDINONES; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES;

EID: 84867311317     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044686     Document Type: Article

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