Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells

Journal of Medicinal Chemistry

Volumn 54, Issue 12, 2011, Pages 4147-4159

  Kumar, Vineet ^a   Kumar, Sarvesh ^b   Hassan, Mohammad ^a   Wu, Hailong ^b   Thimmulappa, Rajesh K ^b   Kumar, Amit ^c   Sharma, Sunil K ^c   Parmar, Virinder S ^c   Biswal, Shyam ^b   Malhotra, Sanjay V ^a  

^a SAIC FREDERICK INC   (United States)

^b Johns Hopkins University   (United States)

^c UNIVERSITY OF DELHI   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHOXYPHENYL) 3 [2 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 1 (2 METHOXYPHENYL) 3 PHENYLPROP 2 EN 1 ONE; 1 (2,4 DIMETHOXYPHENYL) 3 [2 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 1 (2,5 DIMETHOXYPHENYL) 3 [2 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 1 (2,6 DIMETHOXYPHENYL) 3 [2 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 1 (3 METHOXYPHENYL) 3 [2 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 1 (3 METHOXYPHENYL) 3 PHENYLPROP 2 EN 1 ONE; 1 (3,4 DIMETHOXYPHENYL) 3 [2 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 1 (3,4,5 TRIMETHOXYPHENYL) 3 [2 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 1 (3,5 DIMETHOXYPHENYL) 3 [2 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 1 (4 METHOXYPHENYL) 3 [2 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 1 (4 METHOXYPHENYL) 3 PHENYLPROP 2 EN 1 ONE; 1 PHENYL 3 [2 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 2 TRIFLUOROMETHYL 2' METHOXYCHALONE; 2,3 DIPHENYLPROP 2 EN 1 ONE; 3 PHENYL 1 (2,3,4 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 PHENYL 1 (2,4 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 PHENYL 1 (2,4,6 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 PHENYL 1 (2,5 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 PHENYL 1 (2,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 PHENYL 1 (3,4 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 PHENYL 1 (3,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 PHENYL 1 (3,5 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; CHALCONE DERIVATIVE; GLUTAMATE CYSTEINE LIGASE; GLUTAMATE CYSTEINE LIGASE MODIFIER; HEME OXYGENASE 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANIMALS; BRONCHI; CELL LINE; CELL SURVIVAL; CHALCONES; ENZYME ACTIVATORS; EPITHELIAL CELLS; GLUTAMATE-CYSTEINE LIGASE; HEME OXYGENASE-1; HUMANS; MALE; MICE; MICE, INBRED C57BL; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REACTIVE OXYGEN SPECIES; STEREOISOMERISM; TRANSCRIPTION, GENETIC;

EID: 79959429766     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2002348     Document Type: Article

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