Synthesis, chemical reactivity as michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents(1)

Journal of Medicinal Chemistry

Volumn 55, Issue 10, 2012, Pages 4837-4846

  Zheng, Suqing ^a   Santosh Laxmi, Y R ^a   David, Emilie ^b   Dinkova Kostova, Albena T ^c,d   Shiavoni, Katherine H ^b   Ren, Yanqing ^b   Zheng, Ying ^a   Trevino, Isaac ^e   Bumeister, Ronald ^e   Ojima, Iwao ^a   Wigley, W Christian ^e   Bliska, James B ^a   Mierke, Dale F ^b   Honda, Tadashi ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b Dartmouth College   (United States)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Reata Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10A ETHINYL 4B,8,8 TRIMETHYL 3,7 DIOXO 3,4B,7,8,8A,9,10,10A OCTAHYDROPHENANTHRANE 2,6 DICARBONITRILE; ANTIINFLAMMATORY AGENT; BARDOXOLONE; BARDOXOLONE METHYL; CYANIC ACID DERIVATIVE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NQO1; NUCLEOPHILE; PENTACYCLIC TRITERPENE; PHENANTHRENE DERIVATIVE; TBE 31; THIOL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STIMULATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; GROWTH INHIBITION; MACROPHAGE; MICHAEL ADDITION; NONHUMAN;

ALKYNES; AMIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICARCINOGENIC AGENTS; APOPTOSIS; CELL LINE; CELL LINE, TUMOR; CYTOPROTECTION; I-KAPPA B KINASE; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NAD(P)H DEHYDROGENASE (QUINONE); NITRIC OXIDE; NITRILES; OLEANOLIC ACID; PHENANTHRENES; THIOPHENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84861494386     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3003922     Document Type: Article

References (42)

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